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알츠하이머병과 혈관성치매에서의 진행 정도에 따른 임상 양상의 차이

The Differences of Clinical Features between Alzheimer's Disease and Vascular Dementia According to Progression

윤수진|김수영|정해관|김재우|윤성민|박경원|최문성|유봉구|김응규|안경숙|이상찬|홍태용|성상민|손태홍|김태유
대한신경과학회 (Korean Neurological Association)|2006.08|대한신경과학회지 (Journal of the Korean Neurological Association)|제24권 제4호|pp. 337-346

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참고문헌

주제분류신경과학

초록

Abstract

Background: The differences in clinical features are important when differentiating between Alzheimer's disease (AD) and vascular dementia (VD). There have been many studies comparing the severity of progression in both diseases. They have assessed individual symptoms but have not explained the differences and global change of progression comprehensively. We have evaluated the cognitive and non-cognitive functions at the same time and evaluated the differences between AD and VD. Methods: One hundred and thirty-eight dementia patients from Busan·Gyeongnam Dementia Association outpatient clinics were analyzed. All of the patients underwent the Korean version of the Mini-Mental State Examination (K-MMSE), the expanded version of the Korean Clinical Dementia Rating Scale (CDR), the Korean version of the Neuropsychiatric Inventory (K-NPI), the scales for activity of daily living, and the Short form of the Samsung Dementia Questionnaire (S-SDQ). Results: There were 93 patients with AD and 45 with VD. VD patients revealed more severe Barthel Index of Activity of Daily Living (B-ADL) deficits. AD patients had more severe memory and orientation deficiency in CDR 1 and CDR 2. VD patients revealed much faster decline of K-MMSE score between CDR 2 and CDR 3. Conclusions: These results suggest that VD patients display more severe B-ADL difficulty, while AD patients display more severe memory difficulty and disorientation. B-ADL progresses in the earlier stages in VD and in the later stages in AD. Global cognitive dysfunction progression is the opposite: in the earlier stages in AD and in the later stages in VD.

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