본문 바로가기
KERD
논문KCI 등재

알쯔하이머병 환자의 인지기능 변화 및 예후인자: 1년 추적

The Change of Cognitive Function and Prognostic Factor in Alzheimer's Disease: 1-Year Follow-up Study

윤성민|인연권|이은아|홍태용|성상민|곽강호|김상윤|김태유
대한신경과학회 (Korean Neurological Association)|2005.02|대한신경과학회지 (Journal of the Korean Neurological Association)|제23권 제1호|pp. 21-27

2

조회

0

다운로드

0

인용

0

참고문헌

주제분류신경과학

초록

Abstract

Background: The rate of cognitive change and prognostic factor in Alzheimer's disease are important for clinical management, but little is known in Korea. We report a one year follow-up study of comprehensive evaluation including cognitive functions, behavioral and psychological symptoms of dementia (BPSD) and activity of daily living (ADL). Methods: 43 patients with Alzheimer's disease were enrolled. All subjects received the Korean version of Mini-Mental State Examination (K-MMSE), the Severe Dementia Scale (SDS), the extended version of Korean Clinical Dementia Rating Scale (CDR) and Sum of Box (CDR-SB), the Barthel index of Activity of Daily Living (B-ADL), the Korean Instrumental Activity of Daily Living (K-IADL) and the Korean version of the Neuropsychiatric Inventory (K-NPI). We retested each scale after 1 year and evaluated the changes. Results: The mean change rates of K-MMSE, SDS, CDR, CDR-SB and B-ADL scores were 2.0±3.2 (-7~8) mean±SD (range), 3.5±4.9 (-7~14), -0.4±0.7 (-2~1), -0.8±4.4 (-10~9) and 1.5±3.7 (-7~9). The change of K-MMSE and B-ADLscore according to CDR were significantly different. The annual rates of changes of scores on K-MMSE, B-ADL and CDR were largest in CDR 1 group (K-MMSE: 4.0±2.7, B-ADL: 3.4±2.8, CDR: -1±0.7). The change rate of SDS was largest in CDR 4 (7.2±4.3). There were not any significant factors that affected the change of K-MMSE, SDS, B-ADL or CDR. Conclusions: These results suggest that K-MMSE is sensitive to the early stage and SDS is sensitive to the later stage. The deterioration rate of cognitive function in Alzheimer's disease is large at middle stage.

참고문헌 (33)

  1. "Patterns of cognitive decline in presymptomatic Alzheimer disease:a prospective community study", 58, pp.853~858 (2001)
  2. "Neuropsychological function in Alzheimer's disease.Pattern of impairment and rates of progression", 45, pp.263~268 (1988)
  3. "Longitudinal cognitive decline in patients with Alzheimer's disease", 3, pp.91~97 (1990)
  4. "Behavioral problem of dementia", 2, pp.10~13 (1999)
  5. "Introduction of dementia questionnaire activity of daily living neuropsychiatric inventory", pp.14~20 (1999)
  6. "The natural history of Alzheimer's disease.Description of study cohort and accuracy of diagnosis", 51, pp.585~594 (1994)
  7. "Mini-mental state.A practical method for grading the cognitive state of patients for the clinician", 12, pp.189~198 (1975)
  8. "Predictors of decline in Alzheimer's disease", 27, pp.9~17 (1991)
  9. "Reliability of clinical criteria for the diagnosis of dementia.A longitudinal multicenter study", 46, pp.646~648 (1989)
  10. "Longitudinal evaluation of dementia of the Alzheimer type:a comparison of 3 standardized mental status examinations", 40, pp.1225~1230 (1990)
  11. "Hearing impairment and cognitive decline in senile dementia of the Alzheimer's type", 34, pp.207~210 (1986)
  12. "Rates of change of common measures of impairment in senile dementia of the Alzheimer's type", 24, pp.531~534 (1988)
  13. "Clinical diagnosis and management of Alzheimer's disease", pp.130~135 (1996)
  14. "Monitoring progression in Alzheimer's disease", 39, pp.932~941 (1991)
  15. "American Psychiatric Association Committee on Nomenclature and Statistics Diagnostic and Statistical Manual of Mental Disorders" (1994)
  16. "Clinical diagnosis of Alzheimer's disease:report of the NINCDS-ADRDA Work Group under the auspices of the Department of Health and Human Services Task Force on Alzheimer's Disease", 34, pp.939~944 (1984)
  17. "A validity study on the Korean Mini-Mental State Examination(K-MMSE)in dementia patients", 15, pp.300~307 (1997)
  18. "Severe Dementia Rating Scale:The Mental Status Examination for Moderate to Severe Alzheimer's Disease Patients", 1, pp.113~116 (2002)
  19. "Estimating the validity of the Korean Version of Expanded Clinical Dementia Rating Scale", pp.585~591
  20. "The Korean version of the neuropsychiatric inventory:a scoring tool for neuropsychiatric disturbance in dementia patients", 15, pp.609~615 (2000)
  21. "The reliability and validity of the Korean instrumental activity of daily living", pp.14~20
  22. "Noncognitive disturbances in Alzheimer's disease:frequency,longitudinal course,and relationship to cognitive symptoms", 45, pp.1331~1338 (1997)
  23. "The methodology of studying decline in Alzheimer's disease", 41, pp.623~638 (1993)
  24. "Three-year follow-up of Mini-Mental State Examination score in community residents aged 85 and over", 25, pp.841~848 (1995)
  25. "The rate of progression of Alzheimer's disease in the later stages:evidence from the Severe Impairment Battery", 4, pp.512~516 (1998)
  26. "The rate of cognitive decline and risk of reaching clinical milestones in Alzheimer disease", 60, pp.1137~1142 (2003)
  27. "Neuropsychological detection and characterization of preclinical Alzheimer's disease", 45, pp.957~962 (1995)
  28. "Change in cognitive function in older persons from a community population:relation to age and Alzheimer disease", 56, pp.1274~1279 (1999)
  29. "Rates of cognitive decline in Alzheimer's disease and dementia with Lewy bodies", 15, pp.67~71 (2003)
  30. "The preclinical phase of Alzheimer disease:A 22-year prospective study of the Framingham Cohort", 57, pp.808~813 (2000)
  31. "Descriptive epidemiology and risk factors for Alzheimer's disease", 139, pp.21~25 (1992)
  32. "Predictors of disease course in patients with probable Alzheimer's disease", 37, pp.1649~1653 (1987)
  33. "Heterogeneity in Alzheimer's disease:progression rate segregated by distinct neuropsychological and cerebral metabolic profiles", 55, pp.956~959 (1992)

관련 논문AI추천

알츠하이머병과 혈관성치매에서의 진행 정도에 따른 임상 양상의 차이김수영, 김응규, 김재우, 김태유, 박경원, 성상민, 손태홍, 안경숙, 유봉구, 윤성민, 윤수진, 이상찬, 정해관, 최문성, 홍태용대한신경과학회 · 대한신경과학회지2006 · 제24권 제4호알쯔하이머병의 진행 정동에 따른 행동심리적 증상의 변화김상윤, 김재우, 김태유, 박경원, 유봉구, 이상찬대한신경과학회 · 대한신경과학회지2004 · 제22권 제1호알쯔하이머병과 소혈관성 치매에서 Donepezil 복용 후 K-MMSE의 변화와 의미 있는 K-MMSE 변화를 보이는 알쯔하이머병 환자의 특징김준, 곽용태, 이유상, 한일우대한생물정신의학회 · 생물정신의학2005 · 제12권 제2호2회 이상 추적 관찰된 알츠하이머병환자들에서 일상생활능력저하의 예측인자강희진, 김성희, 양혜란, 정지향, 최경규, 최예지대한치매학회 · Dementia and Neurocognitive Disorders(대한치매학회지)2013 · 제12권 제4호경도인지장애의 아형 분류와 임상 양상김상윤, 김정은, 박성호, 백민재, 임준성대한신경과학회 · 대한신경과학회지2005 · 제23권 제3호알쯔하이머병 환자에서 아포지단백E 유전자형과 혈관성 위험인자와의 관계김명규, 김병채, 김요식, 김재민, 손의주, 조기현대한신경과학회 · 대한신경과학회지2003 · 제21권 제1호

이 간행물의 다른 논문 (13건)

뇌졸중 후 발생하는 감정장애: 우울, 불안, 감정조절장애, 분노조절장애, 그리고 피로김종성pp. 1-8허혈성 뇌졸중 환자에서 대사증후군과 호모시스테인의 관계신동진, 박종호, 이영배, 신원철, 박현미pp. 9-14지역사회 거주 노인에서 한국판 Instrumental Activities of Daily Living (K-IA이)에 영향을 미치는 인자들이승한, 정슬기pp. 15-20원발성 정상압수두증 환자에서 보행장애와 중뇌 크기의 상관관계허균, 안영환, 용석우, 이필휴pp. 35-40한국인의 파킨슨병 수면 척도백종삼, 박재현, 김정연pp. 41-48
원문 보기