부비동 내시경 수술 후 GUARDIX-SL？의 유착방지 효과
Anti-adhesive Effect of GUARDIX-SL? after Endoscopic Sinus Surgery
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Abstract
Background and Objectives：Adhesion after sinus surgery represents a potential source of surgical failure. GUARDIX-SL?? which is composed of sodium hyaluronate and sodium carboxymethyl cellulose, is an effective agent that can be used as a surgical adjuvant to decrease adhesion in the abdominal surgery. Therefore, we evaluated the clinical efficacy and safety of the GUARDIXSL ?? for the prevention of adhesion after endoscopic sinus surgery. Subjects and Method：This study was randomized and double-blinded. At the completion of endoscopic sinus surgery, 6 mL GUARDIX-SL was applied on Merocel and repeatedly applied on the middle meatus after removal of Merocel (n=22). As a control group, normal saline was applied instead of GUARDIX- SL (n=22). Endoscopic examination was performed at 3 days, 1 week, 2 weeks, and 4 weeks, postoperatively. Adhesion formation was graded as G0-G4, and CT scoring was also performed. Results：The rate of adhesion formation was the highest at 2 weeks after operation and was significantly lower in the GUARDIX-SL?? treated group than in the control throughout the period of observation. The cases were divided into 3 groups according to the CT scores at 2 weeks after operation：The groups with the GUARDIX-SL?? treatment also showed lower adhesion formation than the control. The safety profile of the patients was normal at 4 weeks postoperatively. Conclusion：The results suggest that GUARDIX-SL?? may be an efficacious and safe material in decreasing the incidence of adhesion after sinus surgery.
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