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펄스전 간격에 대한 이명 환자의 심리 음향학적 특성: 객관적인 이명 검사 개발을 위한 예비 연구

Psychoacoustic Characteristics of Prepulse Gap in Tinnitus Patients: A Preliminary Study to Develop an Objective Test Detecting Tinnitus

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참고문헌

키워드

주제분류이비인후과학

초록

Background and Objectives The objective of this study was to observe whether there are differences in detecting ability of pre-pulse gaps between tinnitus patients and normal subjects. Subjects and Method Ten tinnitus patients and eight normal subjects were recruited. Fifty stimuli composed of a background noise and a pulse noise were presented to the subjects. For certain stimuli, a short gap preceding the pulse noise was inserted but for others, no gaps were inserted. The two groups were subjected to a gap lasting 300 and 200 msec. The subjects were then asked if they detected the gap during the stimulus and the number of correct answers were counted. Results In the tinnitus patient group, the number of correct answers for gap-stimuli detection was significantly smaller when the gap was shortened to 200 msec. In the control group, however, there was only a slight difference in the score. When the length of the gap was shortened to 200 msec, the score significantly decreased in 50% of the tinnitus patients whereas the score increased in only 12% of the control group. Conclusion The ability to detect pre-pulse gaps is affected by tinnitus in humans just as in the animal models.

Abstract

Background and Objectives The objective of this study was to observe whether there are differences in detecting ability of pre-pulse gaps between tinnitus patients and normal subjects. Subjects and Method Ten tinnitus patients and eight normal subjects were recruited. Fifty stimuli composed of a background noise and a pulse noise were presented to the subjects. For certain stimuli, a short gap preceding the pulse noise was inserted but for others, no gaps were inserted. The two groups were subjected to a gap lasting 300 and 200 msec. The subjects were then asked if they detected the gap during the stimulus and the number of correct answers were counted. Results In the tinnitus patient group, the number of correct answers for gap-stimuli detection was significantly smaller when the gap was shortened to 200 msec. In the control group, however, there was only a slight difference in the score. When the length of the gap was shortened to 200 msec, the score significantly decreased in 50% of the tinnitus patients whereas the score increased in only 12% of the control group. Conclusion The ability to detect pre-pulse gaps is affected by tinnitus in humans just as in the animal models.

참고문헌 (10)

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  2. Turner JG, "Gap detection deficits in rats with tinnitus:a potential novel screening tool", Behav Neurosci, 120(1), pp.188~195 (2006)
  3. Lobarinas E, "Noise-Induced Tinnitus Assessed with Gap Prepulse Inhibition of Acoustic Startle in Rats", ARO midwintermeeting (2008)
  4. Sarbadhikari K, "rTMS on Persistent Noise Induced Tinnitus in Rats in a Pilot Study", presented in ARO midwintermeeting (2008)
  5. Sun W, "Acoustic Trauma Induced Auditory Cortex Enhancement and Tinnitus", presented in ARO midwintermeeting; (2008)
  6. Yang G, "Salicylate induced tinnitus: behavioral measures and neural activity in auditory cortex of awake rats", Hear Res, 226(1), pp.244~253 (2007)
  7. Turner JG, "Gap detection methods for assessing salicylateinduced tinnitus and hyperacusis in rats", Am J Audiol, 17(2), pp.S185~S192 (2008)
  8. Ralli M, "Comparison of salicylate-and quinine-induced tinnitus in rats:development,time course,and evaluation of audiologic correlates", Otol Neurotol, 31(5), pp.823~831 (2010)
  9. Pole N, "Prospective prediction of posttraumatic stress disorder symptoms using fear potentiated auditory startle responses", Biol Psychiatry, 65(3), pp.235~240 (2009)
  10. Bakker MJ, "Quantification of the auditory startle reflex in children", Clin Neurophysiol, 120(2), pp.424~430 (2009)

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