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The Effects of Methylene Blue on Hemodynamic Parameters and Cytokine Levels in Refractory Septic Shock.

고윤석|심태선|Won Dong Kim|Dong Soon Kim|Chae Man Lim|Byung Kyu Park|Sang Do Lee|Woo Sung Kim
대한내과학회 (The Korean Association Of Internal Medicine)|2005.06|The Korean Journal of Internal Medicine|제20권 제2호|pp. 123-128

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Abstract

Background : Endogenous nitric oxide (NO) induces the peripheral vasodilation via the activation of guanylate cyclase in patients with septic shock. The purpose of this study was to assess the acute effects of methylene blue (MB), which is an inhibitor of guanylate cyclase, on the hemodynamics and on the production of pro-inflammatory cytokines and nitric oxide (NO) in patients with refractory septic shock. Methods : Twenty consecutive patients with refractory septic shock, which was defined as shock refractory to a dopamine infusion of more than 20 μg/kg/min with the appropriate use of antibiotics and adequate volume replacement, received MB infusion of 1 mg/kg intravenously. The hemodynamic and respiratory variables were measured at baseline, 30, 60 and 120 min after an infusion of MB (1 mg/kg). The blood levels of NO, IL-1, IL-10 and TNF-α were measured at baseline, 30 and 120 min after MB infusion. Results : The administration of MB induced an increase in the systemic vascular resistance (SVR) that resulted in an increase of the mean arterial pressure (MAP) in patients with refractory septic shock, and this was without a decrease in cardiac output. The administered MB induced an increase in pulmonary vascular resistance (PVR) that resulted in an increase of pulmonary arterial pressure (PAP), without any deterioration of gas exchange. However, the increases in SVR and PVR were not associated with the alteration of endogenous production of NO, IL-1, IL-10 and TNF-α. Conclusion : MB transiently elevated the MAP by increasing the SVR without altering the endogenous productions of NO, IL-1, IL-10 and TNF-α during the study period in patients with refractory septic shock.

참고문헌 (37)

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