Changing Donor Source Pattern for Kidney Transplantation over 40 Years: A Single-Center Experience
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Background/Aims: Kidney transplantations at our center rely mainly on living donors. The purpose of this study was to suggest future donor supply directions by reviewing changing trends in donor type. Methods: During the past 40 years, 1,690 kidney transplantations were performed at our center. We divided the follow-up period into four decades and the donor population into three groups: living related, living unrelated, and deceased. We analyzed changing trends in donors from each group for each decade. Patients receiving overseas transplantation were also included. Results: The proportion of living related donors decreased from 84% (54/64) in the 1970s to 61% (281/458) in the 2000s. Living unrelated donors showed a sustained proportion of around 20% after 1990. However, among living unrelated donors, the proportion of spouse donors increased from 4.6% (17/369) in the 1980s to 8.5% (39/458) in the 2000s. Transplants from deceased donors were only 3.3% (12/369) in the 1980s. However the proportion of deceased donors increased gradually, reaching 13.2% (105/799) in the 1990s and 19.9% (91/458) after 2000. Overseas transplantations increased after 2000 and reached 20% of all cases treated in our center during the 2000s. Such transplantations peaked in 2006 and decreased markedly thereafter. Conclusions: The proportion of each donor type has continuously changed, and the changes were associated with changes in the social structure and system. We expect that this study could be an important reference for other countries to estimate future changes of donor type. (Korean J Intern Med 2010;25:288-293)
Abstract
Background/Aims: Kidney transplantations at our center rely mainly on living donors. The purpose of this study was to suggest future donor supply directions by reviewing changing trends in donor type. Methods: During the past 40 years, 1,690 kidney transplantations were performed at our center. We divided the follow-up period into four decades and the donor population into three groups: living related, living unrelated, and deceased. We analyzed changing trends in donors from each group for each decade. Patients receiving overseas transplantation were also included. Results: The proportion of living related donors decreased from 84% (54/64) in the 1970s to 61% (281/458) in the 2000s. Living unrelated donors showed a sustained proportion of around 20% after 1990. However, among living unrelated donors, the proportion of spouse donors increased from 4.6% (17/369) in the 1980s to 8.5% (39/458) in the 2000s. Transplants from deceased donors were only 3.3% (12/369) in the 1980s. However the proportion of deceased donors increased gradually, reaching 13.2% (105/799) in the 1990s and 19.9% (91/458) after 2000. Overseas transplantations increased after 2000 and reached 20% of all cases treated in our center during the 2000s. Such transplantations peaked in 2006 and decreased markedly thereafter. Conclusions: The proportion of each donor type has continuously changed, and the changes were associated with changes in the social structure and system. We expect that this study could be an important reference for other countries to estimate future changes of donor type. (Korean J Intern Med 2010;25:288-293)
참고문헌 (14)
- Satayathum S, "Kidney transplantation and wait-listing rates from the international Dialysis Outcomes and Practice Patterns Study (DOPPS)", Kidney Int, 68, pp.330~337 (2005)
- Sheehy E, "Estimating the number of potential organ donors in the United States", N Engl J Med, 349, pp.667~674 (2003)
- Baid-Agrawal S, "Living donor renal transplantation: recent developments and perspectives", Nat Clin Pract Nephrol, 3, pp.31~41 (2007)
- Kauffman HM, "Post-transplant de novo malignancies in renal transplant recipients: the past and present", Transpl Int, 19, pp.607~620 (2006)
- Ichimaru N, "Japan’s experience with living-donor kidney transplantation across ABO barriers", Nat Clin Pract Nephrol, 4, pp.682~692 (2008)
- "Current Renal Replacement Therapy in Korea, Insan Memorial Dialysis Registry"[URL]
- "Korean Statistical Information Service: Summary of census household"[URL]
- Ahmad N, "Living-unrelated donor renal transplantation: an alternative to living-related donor transplantation?", Ann R Coll Surg Engl, 90, pp.247~250 (2008)
- Roozbeh J, "Comparison of spousal with other donor groups: study of a single center", Transplant Proc, 38, pp.562~563 (2006)
- Sakai K, "The excellent results of spousal kidney transplantation: experience in a Japanese single center", Transplant Proc, 40, pp.2118~2120 (2008)
- Yoon HE, "Comparison of long-term outcomes between spousal transplants and other living unrelated donor transplants: single-center experience", Nephron Clin Pract, 113, pp.c241~c249 (2009)
- R.Randal Bollinger, "Organ Allocation for Transplantation in the USA and Korea: The Changing Roles of Equity and Utility", Yonsei Medical Journal, 45(6), pp.1035~1042 (2004), 연세대학교의과대학
- "2008 KONOS Annual Report"[URL]
- Budiani-Saberi DA, "Organ trafficking and transplant tourism: a commentary on the global realities", Am J Transplant, 8, pp.925~929 (2008)