Clinical characteristics of male and female Korean patients with systemic lupus erythematosus: a comparative study
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Background/Aims: To compare the clinical characteristics and outcomes of systemiclupus erythematosus between male and female Korean patients. Methods: A retrospective analysis was performed at a single tertiary hospitalfrom August 1994 to May 2010. Male patients were matched with two to three femalepatients based on age and disease duration. Organ damage was assessed usingthe Systemic Lupus International Collaborating Clinics/American College ofRheumatology damage index (SLICC/ACR DI). Results: Fifty-three male patients were compared with 150 female patients. Renaldisorders were found more frequently in male patients at disease onset (p <0.001); the adjusted odds ratio (OR) demonstrated a significant sex preponderancefor renal manifestations (OR, 3.26; 95% confidence interval [CI], 1.62 to 6.57). Diffuseproliferative lupus nephritis and end-stage renal disease requiring dialysisduring the disease course were more prevalent in male patients (p = 0.025 and p< 0.001, respectively). The risk for requiring long-term dialysis was significantlyhigher in male than in female patients (OR, 4.02; 95% CI, 1.07 to 15.06), as was themean SLICC/ACR DI (1.55 ± 1.35 vs. 1.02 ± 1.57, respectively; p = 0.028). Conclusions: Our data demonstrate that Korean patients with lupus have characteristicssimilar to those of cohorts reported previously. Male patients had significantlyhigher incidences of renal manifestations and organ damage.
Abstract
Background/Aims: To compare the clinical characteristics and outcomes of systemiclupus erythematosus between male and female Korean patients. Methods: A retrospective analysis was performed at a single tertiary hospitalfrom August 1994 to May 2010. Male patients were matched with two to three femalepatients based on age and disease duration. Organ damage was assessed usingthe Systemic Lupus International Collaborating Clinics/American College ofRheumatology damage index (SLICC/ACR DI). Results: Fifty-three male patients were compared with 150 female patients. Renaldisorders were found more frequently in male patients at disease onset (p <0.001); the adjusted odds ratio (OR) demonstrated a significant sex preponderancefor renal manifestations (OR, 3.26; 95% confidence interval [CI], 1.62 to 6.57). Diffuseproliferative lupus nephritis and end-stage renal disease requiring dialysisduring the disease course were more prevalent in male patients (p = 0.025 and p< 0.001, respectively). The risk for requiring long-term dialysis was significantlyhigher in male than in female patients (OR, 4.02; 95% CI, 1.07 to 15.06), as was themean SLICC/ACR DI (1.55 ± 1.35 vs. 1.02 ± 1.57, respectively; p = 0.028). Conclusions: Our data demonstrate that Korean patients with lupus have characteristicssimilar to those of cohorts reported previously. Male patients had significantlyhigher incidences of renal manifestations and organ damage.
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