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The New Classification Criteria of Systemic Lupus Erythematosus
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초록
Systemic lupus erythematosus (SLE) is a prototype for multi-system, autoimmune diseases of unknown etiology, characterizedby the production of autoantibodies. SLE can involve any organ system of the body with constitutional symptoms, including musculoskeletal,skin, renal, neuropsychiatric, cardiovascular, respiratory and gastrointestinal systems. These wide spectra of diseasemanifestations have made disease classification difficult. American College of Rheumatology (ACR) proposed classification criteriafor SLE for research purpose in 1982, which had been widely used for research purpose and not for diagnosis. In 1997, thesecriteria were updated with further recognition of antiphospholipid antibodies, but not validated. But ACR criteria didn't still meetthe necessity for earlier diagnosis of SLE. In order to improve clinical relevance and incorporate new knowledge to the field of lupusimmunology, the Systemic Lupus Erythematosus International Collaborating Clinics (SLICC), an international lupus expertgroup dedicated to clinical research on lupus, revised the ACR systemic lupus classification criteria in 2012. The new 2012 SLICCcriteria were validated using a large set of patient scenarios rated by experts. The history and diagnostic utility of SLE criteria arecovered in this review
Abstract
Systemic lupus erythematosus (SLE) is a prototype for multi-system, autoimmune diseases of unknown etiology, characterizedby the production of autoantibodies. SLE can involve any organ system of the body with constitutional symptoms, including musculoskeletal,skin, renal, neuropsychiatric, cardiovascular, respiratory and gastrointestinal systems. These wide spectra of diseasemanifestations have made disease classification difficult. American College of Rheumatology (ACR) proposed classification criteriafor SLE for research purpose in 1982, which had been widely used for research purpose and not for diagnosis. In 1997, thesecriteria were updated with further recognition of antiphospholipid antibodies, but not validated. But ACR criteria didn't still meetthe necessity for earlier diagnosis of SLE. In order to improve clinical relevance and incorporate new knowledge to the field of lupusimmunology, the Systemic Lupus Erythematosus International Collaborating Clinics (SLICC), an international lupus expertgroup dedicated to clinical research on lupus, revised the ACR systemic lupus classification criteria in 2012. The new 2012 SLICCcriteria were validated using a large set of patient scenarios rated by experts. The history and diagnostic utility of SLE criteria arecovered in this review
참고문헌 (13)
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