Endoscopic gastritis, serum pepsinogen assay, and Helicobacter pylori infection
1
조회
0
다운로드
14
인용
0
참고문헌
키워드
초록
Endoscopic findings of the background gastric mucosa are important in the Helicobacter pylori-seroprevalent population. It is strongly correlated not only with the risk of gastric cancer, but also with the excretion ability of gastric mucosa cells. In noninfected subjects, common endoscopic findings are regular arrangement of collecting venules, chronic superficial gastritis, and erosive gastritis. In cases of active H. pylori infection, nodularity on the antrum, hemorrhagic spots on the fundus, and thickened gastric folds are common endoscopic findings. The secreting ability of the gastric mucosa cells is usually intact in both noninfected and actively infected stomachs, and the intragastric condition becomes hyperacidic upon inflammation. Increased serum pepsinogen II concentration correlates well with active H. pylori infection, and also indicates an increased risk of diffuse-type gastric cancer. In chronic inactive H. pylori infection, metaplastic gastritis and atrophic gastritis extending from the antrum (closed-type chronic atrophic gastritis) toward the corpus (open-type chronic atrophic gastritis) are common endoscopic findings. The intragastric environment is hypoacidic and the risk of intestinal-type gastric cancer is increased in such conditions. Furthermore, there is a decrease in serum pepsinogen I concentration when the secreting ability of the gastric mucosa cells is damaged. Serologic and endoscopic changes that occur upon H. pylori infection are important findings for estimating the secreting ability of the gastric mucosa cells, and could be applied for the secondary prevention of gastric cancer.
Abstract
Endoscopic findings of the background gastric mucosa are important in the Helicobacter pylori-seroprevalent population. It is strongly correlated not only with the risk of gastric cancer, but also with the excretion ability of gastric mucosa cells. In noninfected subjects, common endoscopic findings are regular arrangement of collecting venules, chronic superficial gastritis, and erosive gastritis. In cases of active H. pylori infection, nodularity on the antrum, hemorrhagic spots on the fundus, and thickened gastric folds are common endoscopic findings. The secreting ability of the gastric mucosa cells is usually intact in both noninfected and actively infected stomachs, and the intragastric condition becomes hyperacidic upon inflammation. Increased serum pepsinogen II concentration correlates well with active H. pylori infection, and also indicates an increased risk of diffuse-type gastric cancer. In chronic inactive H. pylori infection, metaplastic gastritis and atrophic gastritis extending from the antrum (closed-type chronic atrophic gastritis) toward the corpus (open-type chronic atrophic gastritis) are common endoscopic findings. The intragastric environment is hypoacidic and the risk of intestinal-type gastric cancer is increased in such conditions. Furthermore, there is a decrease in serum pepsinogen I concentration when the secreting ability of the gastric mucosa cells is damaged. Serologic and endoscopic changes that occur upon H. pylori infection are important findings for estimating the secreting ability of the gastric mucosa cells, and could be applied for the secondary prevention of gastric cancer.
참고문헌 (62)
- Chu S, "Gastric secretion", Curr Opin Gastroenterol, 28, pp.587~593 (2012)
- Ghosh T, "Review article:methods of measuring gastric acid secretion", Aliment Pharmacol Ther, 33, pp.768~781 (2011)
- Sipponen P, "Importance of atrophic gastritis in diagnostics and prevention of gastric cancer:application of plasma biomarkers", Scand J Gastroenterol, 42, pp.2~10 (2007)
- Rehfeld JF, "Pitfalls in diagnostic gastrin measurements", Clin Chem, 58, pp.831~836 (2012)
- Miki K, "Gastric cancer screening using the serum pepsinogen test method", Gastric Cancer, 9, pp.245~253 (2006)
- Park HK, "The distribution of endoscopic gastritis in 25,536 heath check-up subjects in Korea", Korean J Helicobacter Up Gastrointest Res, 12, pp.237~243 (2012)
- Yoon H, "Helicobacter pylori-negative gastric cancer in South Korea: incidence and clinicopathologic characteristics", Helicobacter, 16, pp.382~388 (2011)
- Toh BH, "Diagnosis and classification of autoimmune gastritis", Autoimmun Rev, 13, pp.459~462 (2014)
- Reed C, "Clinical characteristics, treatment outcomes, and resource utilization in children and adults with eosinophilic gastroenteritis", Dig Liver Dis, 47, pp.197~201 (2015)
- Hayashi S, "Endoscopic features of lymphoid follicles in Helicobacter pylori-associated chronic gastritis", Dig Endosc, 27, pp.53~60 (2015)
- Lee OJ, "Correlations among gastric juice pH and ammonia, Helicobacter pylori infection and gastric mucosal histology", Korean J Intern Med, 19, pp.205~212 (2004)
- Kitamura Y, "Diagnosis of Helicobacter pylori-induced gastritis by serum pepsinogen levels", J Gastroenterol Hepatol, 30, pp.1473~1477 (2015)
- Di Mario F, "Usefulness of serum pepsinogens in Helicobacter pylori chronic gastritis:relationship with inflammation, activity, and density of the bacterium", Dig Dis Sci, 51, pp.1791~1795 (2006)
- Kitamura S, "Prevalence and characteristics of nodular gastritis in Japanese elderly", J Gastroenterol Hepatol, 28, pp.1154~1160 (2013)
- Yoshida T, "Cancer development based on chronic active gastritis and resulting gastric atrophy as assessed by serum levels of pepsinogen and Helicobacter pylori antibody titer", Int J Cancer, 134, pp.1445~1457 (2014)
- Choi HS, "Combining the serum pepsinogen level and Helicobacter pylori antibody test for predicting the histology of gastric neoplasm", J Dig Dis, 15, pp.293~298 (2014)
- Bornschein J, "Serological assessment of gastric mucosal atrophy in gastric cancer", BMC Gastroenterol, 12, pp.10~ (2012)
- Lee SY, "Future candidates for indications of Helicobacter pylori eradication: do the indications need to be revised?", J Gastroenterol Hepatol, 27, pp.200~211 (2012)
- Asaka M, "Helicobacter pylori eradication to eliminate gastric cancer: the Japanese Strategy", Gastroenterol Clin North Am, 44, pp.639~648 (2015)
- Ahn SY, "Endoscopic diagnosis of open-type atrophic gastritis is related to the histological diagnosis of intestinal metaplasia and Cdx2 expression", Dig Dis Sci, 56, pp.1119~1126 (2011)
- Testoni PA, "In diffuse atrophic gastritis, routine histology underestimates Helicobacter pylori infection", J Clin Gastroenterol, 35, pp.234~239 (2002)
- Korstanje A, "Comparison between serology and histology in the diagnosis of advanced gastric body atrophy: a study in a Dutch primary community", J Clin Gastroenterol, 42, pp.18~22 (2008)
- Derakhshan MH, "Gastric histology, serological markers and age as predictors of gastric acid secretion in patients infected with Helicobacter pylori", J Clin Pathol, 59, pp.1293~1299 (2006)
- Do-Hoon Kim, "Endoscopic Grading of Atrophic Gastritis is Inversely Associated with Gastroesophageal Reflux and Gastropharyngeal Reflux", The Korean Journal of Internal Medicine, 22(4), pp.231~236 (2007), 대한내과학회
- 이주엽, "Correlations Among Endoscopic, Histologic and Serologic Diagnoses for the Assessment of Atrophic Gastritis", 대한암예방학회지, 19(1), pp.47~55 (2014), 대한암예방학회
- Takao T, "Multifaceted assessment of chronic gastritis: a study of correlations between serological, endoscopic, and histological diagnostics", Gastroenterol Res Pract, 2011, pp.631461~ (2011)
- Yang JH, "Changing trends of serum pepsinogen I", II ratio in asymptomatic subjects, 2012, pp.12, 96~102
- Kono S, "Can endoscopic atrophy predict histological atrophy? Historical study in United Kingdom and Japan", World J Gastroenterol, 21, pp.13113~13123 (2015)
- Rugge M, "Gastritis staging in clinical practice: the OLGA staging system", Gut, 56, pp.631~636 (2007)
- Sugano K, "Kyoto global consensus report on Helicobacter pylori gastritis", Gut, 64, pp.1353~1367 (2015)
- Ho June Song, "Low Levels of Pepsinogen I and Pepsinogen I", II Ratio are Valuable Serologic Markers for Predicting Extensive Gastric Corpus Atrophy in Patients Undergoing Endoscopic Mucosectomy, 2010, pp.4(4), 475~480[DOI]
- Nomura S, "Endoscopic diagnosis of gastric mucosal atrophy: multicenter prospective study", Dig Endosc, 26, pp.709~719 (2014)
- Storskrubb T, "A negative Helicobacter pylori serology test is more reliable for exclusion of premalignant gastric conditions than a negative test for current H. pylori infection: a report on histology and H. pylori detection in the general adult population", Scand J Gastroenterol, 40, pp.302~311 (2005)
- Kang HY, "Progression of atrophic gastritis and intestinal metaplasia drives Helicobacter pylori out of the gastric mucosa", Dig Dis Sci, 51, pp.2310~2315 (2006)
- Yoo JY, "Detection rate of Helicobacter pylori against a background of atrophic gastritis and", or intestinal metaplasia, 2007, pp.41, 751~755
- Kim CG, "Biopsy site for detecting Helicobacter pylori infection in patients with gastric cancer", J Gastroenterol Hepatol, 24, pp.469~474 (2009)
- Masuyama H, "Relationship between the degree of endoscopic atrophy of the gastric mucosa and carcinogenic risk", Digestion, 91, pp.30~36 (2015)
- Yanaoka K, "Cancer high-risk subjects identified by serum pepsinogen tests: outcomes after 10-year follow-up in asymptomatic middle-aged males", Cancer Epidemiol Biomarkers Prev, 17, pp.838~845 (2008)
- Imagawa S, "Evaluation of gastric cancer risk using topography of histological gastritis:a large-scaled cross-sectional study", Dig Dis Sci, 53, pp.1818~1823 (2008)
- Shichijo S, "Distribution of intestinal metaplasia as a predictor of gastric cancer development", J Gastroenterol Hepatol, 30, pp.1260~1264 (2015)
- Shiotani A, "Histologic and serum risk markers for noncardia early gastric cancer", Int J Cancer, 115, pp.463~469 (2005)
- Ohkusa T, "Improvement in serum pepsinogens and gastrin in long-term monitoring after eradication of Helicobacter pylori: comparison with H. pylori-negative patients", Aliment Pharmacol Ther, 1, pp.25~32 (2004)
- Pimanov SI, "Helicobacter pylori eradication improves gastric histology and decreases serum gastrin, pepsinogen I and pepsinogen II levels in patients with duodenal ulcer", J Gastroenterol Hepatol, 23, pp.1666~1671 (2008)
- Massarrat S, "Pepsinogen II can be a potential surrogate marker of morphological changes in corpus before and after H. pylori eradication", Biomed Res Int, 2014, pp.481607~ (2014)
- Ito M, "Helicobacter pylori eradication therapy improves atrophic gastritis and intestinal metaplasia: a 5-year prospective study of patients with atrophic gastritis", Aliment Pharmacol Ther, 16, pp.1449~1456 (2002)
- Kokkola A, "The effect of Helicobacter pylori eradication on the natural course of atrophic gastritis with dysplasia", Aliment Pharmacol Ther, 16, pp.515~520 (2002)
- Kang JM, "Predictive factors for improvement of atrophic gastritis and intestinal metaplasia after Helicobacter pylori eradication: a three-year follow-up study in Korea", Helicobacter, 17, pp.86~95 (2012)
- Kawanaka M, "Effects of Helicobacter pylori eradication on the development of metachronous gastric cancer after endoscopic treatment: analysis of molecular alterations by a randomised controlled trial", Br J Cancer, 114, pp.21~29 (2016)
- Yanaoka K, "Eradication of Helicobacter pylori prevents cancer development in subjects with mild gastric atrophy identified by serum pepsinogen levels", Int J Cancer, 125, pp.2697~2703 (2009)
- Shiotani A, "Predictive factors for metachronous gastric cancer in high-risk patients after successful Helicobacter pylori eradication", Digestion, 78, pp.113~119 (2008)
- Miki K, "Longterm results of gastric cancer screening using the serum pepsinogen test method among an asymptomatic middle-aged Japanese population", Dig Endosc, 21, pp.78~81 (2009)
- Venerito M, "Preneoplastic conditions in the stomach: always a point of no return?", Dig Dis, 33, pp.5~10 (2015)
- 최일주, "Current evidence of effects of Helicobacter pylori eradication on prevention of gastric cancer", The Korean Journal of Internal Medicine, 28(5), pp.525~537 (2013), 대한내과학회[DOI]
- 방창석, "Time to learn from the past and prepare for the future in Helicobacter pylori eradication", The Korean Journal of Internal Medicine, 30(6), pp.789~791 (2015), 대한내과학회[DOI]
- David Y. Graham, "Roadmap for elimination of gastric cancer in Korea", The Korean Journal of Internal Medicine, 30(2), pp.133~139 (2015), 대한내과학회[DOI]
- 김광하, "Is screening and surveillance for early detection of gastric cancer needed in Korean Americans?", The Korean Journal of Internal Medicine, 30(6), pp.747~758 (2015), 대한내과학회[DOI]
- Kokkola A, "Spontaneous disappearance of Helicobacter pylori antibodies in patients with advanced atrophic corpus gastritis", APMIS, 111, pp.619~624 (2003)
- Camorlinga-Ponce M, "Age and severity of mucosal lesions influence the performance of serologic markers in Helicobacter pylori-associated gastroduodenal pathologies", Cancer Epidemiol Biomarkers Prev, 17, pp.2498~2504 (2008)
- Kishikawa H, "Fasting gastric pH of Japanese subjects stratified by IgG concentration against Helicobacter pylori and pepsinogen status", Helicobacter, 16, pp.427~433 (2011)
- Watabe H, "Predicting the development of gastric cancer from combining Helicobacter pylori antibodies and serum pepsinogen status: a prospective endoscopic cohort study", Gut, 54, pp.764~768 (2005)
- Zhang X, "Low serum pepsinogen I and pepsinogen I", II ratio and Helicobacter pylori infection are associated with increased risk of gastric cancer:14-year follow up result in a rural Chinese community, 2012, pp.130, 1614~1619
- Mizuno S, "Prescreening of a highrisk group for gastric cancer by serologically determined Helicobacter pylori infection and atrophic gastritis", Dig Dis Sci, 55, pp.3132~3137 (2010)