The Role of Serum Pepsinogen in the Detection of Gastric Cancer
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The incidence of gastric cancer is very high in Japan,Korea, and China. Reducing the morbidity and mortality associated with gastric cancer requires early diagnosis,which can be facilitated by applying gastroscopy more frequently in high-risk groups. A strategy of population screening for gastric cancer is currently being adopted in Korea, Japan, and the Matsu region of Taiwan, but using different screening methods. In addition, the history of pepsinogen (PG) in research as a gastric cancer biomarker has varied, in that the use of serum levels of PGI and PGII and the PGI/PGII ratio as gastric cancer screening tools was introduced in Japan before 1990, but in Korea the first research results were only reported in 2008. This review first evaluates the physiology of PG, followed by the usefulness or limitations of serum PG testing with regard to the detection of gastric cancer. Finally,the factors affecting the efficacy of PG tests as a gastric cancer biomarker (i.e., Helicobacter pylori infection status, gender, histopathologic features, and cancer location and depth) are evaluated. It was found that the strategies used to increase the efficacy of PG tests should be individualized in each country according to the seroprevalence of H. pylori.
Abstract
The incidence of gastric cancer is very high in Japan,Korea, and China. Reducing the morbidity and mortality associated with gastric cancer requires early diagnosis,which can be facilitated by applying gastroscopy more frequently in high-risk groups. A strategy of population screening for gastric cancer is currently being adopted in Korea, Japan, and the Matsu region of Taiwan, but using different screening methods. In addition, the history of pepsinogen (PG) in research as a gastric cancer biomarker has varied, in that the use of serum levels of PGI and PGII and the PGI/PGII ratio as gastric cancer screening tools was introduced in Japan before 1990, but in Korea the first research results were only reported in 2008. This review first evaluates the physiology of PG, followed by the usefulness or limitations of serum PG testing with regard to the detection of gastric cancer. Finally,the factors affecting the efficacy of PG tests as a gastric cancer biomarker (i.e., Helicobacter pylori infection status, gender, histopathologic features, and cancer location and depth) are evaluated. It was found that the strategies used to increase the efficacy of PG tests should be individualized in each country according to the seroprevalence of H. pylori.
참고문헌 (79)
- Parkin DM, "Global cancer statistics, 2002", CA Cancer J Clin, 55, pp.74~108 (2005)
- Hai-Rim Shin, "Nationwide Cancer Incidence in Korea, 1999~2001; First Result Using the National Cancer Incidence Database", Cancer Research and Treatment, 37(6), pp.325~331 (2005), 대한암학회
- Nomura K, "Cancer statistics in Japan 2005" (2005), Foundation for Promotion Cancer Research
- Correa P, "The future of gastric cancer prevention", Gastric Cancer, 7, pp.9~16 (2004)
- Fuchs CS, "Gastric carcinoma", N Engl J Med, 333, pp.32~41 (1995)
- Hill MJ, "Salt and gastric cancer", Eur J Cancer Prev, 7, pp.173~175 (1998)
- Sandor J, "Association between gastric cancer mortality and nitrate content of drinking water: ecological study on small area inequalities", Eur J Epidemiol, 17, pp.443~447 (2001)
- Serafini M, "Total antioxidant potential of fruit and vegetables and risk of gastric cancer", Gastroenterology, 123, pp.985~991 (2002)
- Terry P, "Protective effect of fruits and vegetables on stomach cancer in a cohort of Swedish twins", Int J Cancer, 76, pp.35~37 (1998)
- Shin CM, "Stomach cancer risk in gastric cancer relatives: interaction between Helicobacter pylori infection and family history of gastric cancer for therisk of stomach cancer", J Clin Gastroenterol, 44, pp.e34~e39 (2010)
- Kikuchi S, "Survival after surgical treatment of early gastric cancer: surgical techniquesand long-term survival", Langenbecks Arch Surg, 389, pp.69~74 (2004)
- Onodera H, "Surgical outcome of 483 patients with gastric cancer: prognosis, postoperative morbidity and mortality, and gastric remnant cancer", Hepatogastroenterology, 51, pp.82~85 (2004)
- Gotoda T, "Endoscopic resection of early gastric cancer", Gastric Cancer, 10, pp.1~11 (2007)
- Kim JP, "Clinical analysis of early gastric cancer", Korean J Gastroenterol, 23, pp.428~435 (1991)
- 최일주, "위암의 스크리닝 및 진단", 대한소화기학회지, 54(2), pp.67~76 (2009), 대한소화기학회
- Hamashima C, "The Japanese guidelines for gastric cancer screening", Jpn J Clin Oncol, 38, pp.259~267 (2008)
- Liu CY, "Multistate and multifactorial progression of gastric cancer: results from community-based mass screening for gastriccancer", J Med Screen, 13(Suppl 1), pp.S2~S5 (2006)
- Parsonnet J, "Helicobacter pylori,pepsinogen, and risk of gastric adenocarcinoma", Cancer Epidemiol Biomarkers Prev, 2, pp.461~466 (1993)
- Kimura K, "Chronological transition of the fundic-pyloric border determined by stepwise biopsy of the lesser and greater curvatures of the stomach", Gastroenterology, 63, pp.584~592 (1972)
- Kuipers EJ, "Review article: relationship between Helicobacter pylori, atrophic gastritis and gastric cancer", Aliment Pharmacol Ther, 12(Suppl 1), pp.25~36 (1998)
- Miki K, "The significance of low serum pepsinogen levels to detect stomach cancer associated with extensive chronic gastritis in Japanese subjects", Jpn J Cancer Res, 80, pp.111~114 (1989)
- Samloff IM, "Relationships among serum pepsinogen I, serum pepsinogen II, and gastric mucosal histology. A study in relatives of patients with pernicious anemia", Gastroenterology, 83(1 Pt 2), pp.204~209 (1982)
- Aromaa A, "Circulating anti-Helicobacter pylori immunoglobulin A antibodies and low serum pepsinogen I level are associated with increased risk of gastric cancer", Am J Epidemiol, 144, pp.142~149 (1996)
- Watanabe Y, "Helicobacter pylori infection and gastric cancer. A nested case-control study in a rural area of Japan", Dig Dis Sci, 42, pp.1383~1387 (1997)
- Kitahara F, "Accuracy of screening for gastric cancer usingserum pepsinogen concentrations", Gut, 44, pp.693~697 (1999)
- Ohata H, "Progression of chronic atrophic gastritis asssociated with Helicobacter pylori infection increases risk of gastric cancer", Int J Cancer, 109, pp.138~143 (2004)
- Watabe H, "Predicting the development of gastric cancer from combining Helicobacter pylori antibodies and serum pepsinogen status: a prospectiveendoscopic cohort study", Gut, 54, pp.764~768 (2005)
- Normura AM, "Helicobacter pylori, pepsinogen, and gastric adenocarcinoma in Hawaii", J Infect Dis, 191, pp.2075~2081 (2005)
- Sasazuki S, "Effect of Helicobacter pylori infection combined with CagA and pepsinogen status on gastric cancer development among Japanese men and women: a nested case-control study", Cancer Epidemiol Biomarkers Prev, 15, pp.1341~1347 (2006)
- Yamada S, "elicobacter pylori infection in combination with the serum pepsinogen I", II ratio and interleukin-1beta-511 polymorphisms are independent risk factors for gastric cancer in Thais, 2006, pp.41, 1169~1177
- Oishi Y, "The serum pepsinogen test as a predictor of gastric cancer. The Hisayama study", Am J Epidemiol, 163, pp.629~637 (2006)
- Kang JM, "The role of serum pepsinogenand gastrin test for the detection of gastric cancer in Korea", Helicobacter, 13, pp.146~156 (2008)
- Miki K, "Usefulness of gastric cancer screening using the serum pepsinogen test method", Am J Gastroenterol, 98, pp.735~739 (2003)
- Miki K, "Gastric cancer screening using the serum pepsinogen test method", Gastric Cancer, 9, pp.245~253 (2006)
- Ang TL, "Racial differences in Helicobacter pylori, serum pepsinogen and gastric cancer incidence in an urban Asian population", J Gastroenterol Hepatol, 20, pp.1603~1609 (2005)
- Huang SC, "Pepsinogens I and II ingastric cancer: an immunohistochemical study using monoclonal antibodies", Jpn J Cancer Res, 79, pp.1139~1146 (1988)
- Samloff IM, "Cellular localization of group I pepsinogens in human gastric mucosa by immunofluorescence", Gastroenterology, 61, pp.185~188 (1971)
- Miki K, "Serum pepsinogens as a screening test of extensive chronic gastritis", Gastroenterology Jpn, 22, pp.133~141 (1987)
- Feldman M, "Comparison of gastric acid secretion rates and serum pepsinogen I and II concentrations in occidental and oriental duodenal ulcer patients", Gastroenterology, 95, pp.630~635 (1988)
- Kinoshita Y, "Helicobacter pyloriin dependent chronological change in gastric acid secretion in the Japanese", Gut, 41, pp.452~458 (1997)
- Yasunaga Y, "Serum pepsinogenI levels and acid secretion in Helicobacter pylori associated enlarged fold gastritis", Ital J Gastroenterol, 28, pp.457~461 (1996)
- Iijima K, "Serum pepsinogen concentrations as a measure of gastric acid secretion in Helicobacter pylori-negative and -positive Japanese subjects", J Gastroenterol, 40, pp.938~944 (2005)
- Kim HY, "Clinical meaning of pepsinogen test and Helicobacter pylori serology in the health check-up population in Korea", Eur J Gastroenterol Hepatol, 21, pp.606~612 (2009)
- Wagner S, "Helicobacter pyloriinfection and serum pepsinogen A, pepsinogen C, and gastrin in gastritis and peptic ulcer: significance of inflammation and effect of bacterial eradication", Am J Gastroenterol, 89, pp.1211~1218 (1994)
- Asaka M, "Relationship of Helicobacter pylori to serum pepsinogens in asymptomatic Japanese population", Gastroenterology, 102, pp.760~766 (1992)
- Cave TR, "Helicobacter pylori stimulates pepsin secretion from isolated rabbit gastric glands", Scand J Gastroenterol, 181(Suppl), pp.9~14 (1991)
- Young GO, "Helicobacter pylori lipopolysaccharide stimulates gastric mucosal pepsinogen secretion", Aliment Pharmacol Ther, 6, pp.169~177 (1992)
- Gisbert JP, "Basal andstimulated gastrin and pepsinogen levels after eradication of Helicobacter pylori: a 1-year follow-up study", Eur J Gastroenterol Hepatol, 11, pp.189~200 (1999)
- Knight T, "Variability in serum pepsinogen levels in an asymptomatic population", Eur J Gastroenterol Hepatol, 7, pp.647~654 (1995)
- Kikuchi S, "The association of smoking and drinking habits with serum pepsinogens", Int J Epidemiol, 24, pp.346~353 (1995)
- Denda K, "Relationship between factors examined at health examination and serum pepsinogen levels in healthy adults. Physical measurements, blood chemical tests, drinking and smoking", Nippon Koshu Eisei Zasshi, 45, pp.336~342 (1998)
- Hokkanen S, "Normal serum pepsinogen I levels in adults: a population-based study with special reference to Helicobacter pylori infection and parietal cell antibodies", Scand J Clin Lab Invest, 65, pp.291~299 (2005)
- Ichinose M, "Radioimmunoassay of serum group I and group II pepsinogens in normal controls and patients with various disorders", Clin Chim Acta, 126, pp.183~191 (1982)
- Samloff IM, "Pepsinogen I and II: purification from gastric mucosa and radioimmunoassay in serum", Gastroenterology, 82, pp.26~33 (1982)
- Mukoubayashi C, "Serum pepsinogen and gastric cancer screening", Intern Med, 46, pp.261~266 (2007)
- Ren JS, "Serum pepsinogens and risk of gastric and oesophgeal cancers in the General Population Nutrition Intervention Trial Cohort", Gut, 58, pp.636~642 (2009)
- Ijima K, "Serum biomarker tests are useful in delineating between patients with gastric atrophy and normal, healthy stomach", World J Gastroenterol, 15, pp.853~859 (2009)
- Correa P, "Helicobacter pylori and gastric carcinogenesis", Am J Surg Pathol, 19(Suppl 1), pp.S37~S43 (1995)
- Kim N, "Prevalence and risk factors of atrophic gastritis and intestinal metaplasia in a Korean population without significant gastroduodenal disease", Helicobacter, 13, pp.245~255 (2008)
- Sipponen P, "Gastric cancer risk in chronic atrophic gastritis: statistical calculations of cross-sectional data", Int J Cancer, 35, pp.173~177 (1985)
- Bodger K, "Variation in serum pepsinogens with severity and topography of Helicobacter pylori-associated chronic gastritis in dyspeptic patients referred for endoscopy", Helicobacter, 6, pp.216~224 (2001)
- Broutet N, "Pepsinogen A, pepsinogen C, and gastrin as markers of atrophic chronic gastritis in European dyspeptics", Br J Cancer, 88, pp.1239~1247 (2003)
- Ricci C, "Serological markers for gastric atrophy in asymptomatic patients infected with Helicobacter pylori", Am J Gastroenterol, 99, pp.1910~1915 (2004)
- Shin CM, "Validation of diagnostic tests for Helicobacter pylori with regard to grade of atrophic gastritis and", or intestinal metaplasia, 2009, pp.14, 512~519
- Lee JH, "Long-term follow-up of Helicobacter pylori IgG serology after eradication and reinfection rate of H. pylori in South Korea", Helicobacter, 13, pp.288~294 (2008)
- Kang HY, "Progression of atrophic gastritis and intestinal metaplasia drives Helicobacter pylori out of the gastric mucosa", Dig Dis Sci, 51, pp.2310~2315 (2006)
- Webb PM, "The epidemiology of low serum pepsinogen A levels and an international association with gastric cancer rates. EUROGAST Study Group", Gastroenterology, 107, pp.1335~1344 (1994)
- Yoshihara M, "Correlation of ratio of serum pepsinogen I and II with prevalence of gastric cancer and adenoma in Japanese subjects", Am J Gastroenterol, 93, pp.1090~1096 (1998)
- Lauren P, "The two histological main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma. An attempt at a histo-clinical classification", Acta Pathol Microbiol Scand, 64, pp.31~39 (1965)
- Seoane A, "Helicobacter pylori and gastric cancer: relationship with histological subtype and tumor location", Gastroenterol Hepatol, 28, pp.60~64 (2005)
- Trajkov D, "Helicobacter pylori and gastric carcinoma", Prilozi, 28, pp.39~46 (2007)
- Nardone G, "Reveiw article: molecular basis of gastric carcinogenesis", Aliment Pharmacol Ther, 17(Suppl 2), pp.75~81 (2003)
- Fujishiro M, "Correlation of serum pepsinogens and gross appearances combined with histology in early gastric cancer", J Exp Clin Cancer Res, 25, pp.207~212 (2006)
- Hansen S, "Two distinct aetiologies of cardia cancer: evidence from premorbid serological markers of gastric atrophy and Helicobacter pylori status", Gut, 56, pp.918~925 (2007)
- Kokkola A, "Helicobacter pylori infection and low serum pepsinogen I level as risk factors for gastric carcinoma", World J Gastroenterol, 11, pp.1032~1036 (2005)
- Kitahara F, "Severe atrophic gastritis with Helicobacter pylori infection and gastric cancer", Gastric Cancer, 1, pp.118~124 (1998)
- Kiyohira K, "Serum pepsinogen concentration as a marker of Helicobacter pylori infection and the histologic grade of gastritis; evaluation of gastric mucosa by serum pepsinogen levels", J Gastroenterol, 38, pp.332~338 (2003)
- Yamagata H, "Impact of Helicobacter pylori infection on gastric cancer incidence in a general Japanese population: the Hisayama study", Arch Intern Med, 160, pp.1962~1968 (2000)
- Yim JY, "Seroprevalence of Helicobacter pylori in South Korea", Helicobacter, 12, pp.333~340 (2007)
