본문 바로가기
KERD
논문KCI 등재

Mean platelet volume: a potential biomarker of the risk and prognosis of heart disease

2

조회

0

다운로드

1

인용

0

참고문헌

키워드

주제분류내과학

초록

Platelets are essential for progression of atherosclerotic lesions, plaque destabilization, and thrombosis. They secrete and express many substances that are crucial mediators of coagulation, inflammation, and atherosclerosis. Mean platelet volume (MPV) is a precise measure of platelet size, and is routinely reported during complete blood count analysis. Emerging evidence supports the use of MPV as a biomarker predicting the risk of ischemic stroke in patients with atrial fibrillation, and as a guide for prescription of anticoagulation and rhythm-control therapy. In addition, MPV may predict the clinical outcome of percutaneous coronary intervention (PCI) in patients with coronary artery disease and indicate whether additional adjunctive therapy is needed to improve clinical outcomes. This review focuses on the current evidence that MPV may be a biomarker of the risk and prognosis of common heart diseases, particularly atrial fibrillation and coronary artery disease treated via PCI.

Abstract

Platelets are essential for progression of atherosclerotic lesions, plaque destabilization, and thrombosis. They secrete and express many substances that are crucial mediators of coagulation, inflammation, and atherosclerosis. Mean platelet volume (MPV) is a precise measure of platelet size, and is routinely reported during complete blood count analysis. Emerging evidence supports the use of MPV as a biomarker predicting the risk of ischemic stroke in patients with atrial fibrillation, and as a guide for prescription of anticoagulation and rhythm-control therapy. In addition, MPV may predict the clinical outcome of percutaneous coronary intervention (PCI) in patients with coronary artery disease and indicate whether additional adjunctive therapy is needed to improve clinical outcomes. This review focuses on the current evidence that MPV may be a biomarker of the risk and prognosis of common heart diseases, particularly atrial fibrillation and coronary artery disease treated via PCI.

참고문헌 (73)

  1. Coppinger JA, "Characterization of the proteins released from activated platelets leads to localization of novel platelet proteins in human atherosclerotic lesions", Blood, 103, pp.2096~2104 (2004)
  2. Gawaz M, "Platelets in inflammation and atherogenesis", J Clin Invest, 115, pp.3378~3384 (2005)
  3. Karpatkin S, "Heterogeneity of human platelets. II. Functional evidence suggestive of young and old platelets", J Clin Invest, 48, pp.1083~1087 (1969)
  4. Kamath S, "Platelet activation: assessment and quantification", Eur Heart J, 22, pp.1561~1571 (2001)
  5. Bath PM, "Platelet size: measurement, physiology and vascular disease", Blood Coagul Fibrinolysis, 7, pp.157~161 (1996)
  6. Tsiara S, "Platelets as predictors of vascular risk: is there a practical index of platelet activity?", Clin Appl Thromb Hemost, 9, pp.177~190 (2003)
  7. Gasparyan AY, "Mean platelet volume: a link between thrombosis and inflammation?", Curr Pharm Des, 17, pp.47~58 (2011)
  8. Chugh SS, "Global burden of atrial fibrillation in developed and developing nations", Glob Heart, 9, pp.113~119 (2014)
  9. Go AS, "Prevalence of diagnosed atrial fibrillation in adults: national implications for rhythm management and stroke prevention: the AnTicoagulation and Risk Factors in Atrial Fibrillation (ATRIA) Study", JAMA, 285, pp.2370~2375 (2001)
  10. Greisenegger S, "Is elevated mean platelet volume associated with a worse outcome in patients with acute ischemic cerebrovascular events?", Stroke, 35, pp.1688~1691 (2004)
  11. Ha SI, "Stroke prediction using mean platelet volume in patients with atrial fibrillation", Platelets, 22, pp.408~414 (2011)
  12. Bayar N, "Usefulness of mean platelet volume for predicting stroke risk in paroxysmal atrial fibrillation patients", Blood Coagul Fibrinolysis, 26, pp.669~672 (2015)
  13. Turfan M, "Usefulness of mean platelet volume for predicting stroke risk in atrial fibrillation patients", Blood Coagul Fibrinolysis, 24, pp.55~58 (2013)
  14. Hong SP, "Stroke prevention in patients with non-valvular atrial fibrillation: new insight in selection of rhythm or rate control therapy and impact of mean platelet volume", Curr Pharm Des, 19, pp.5824~5829 (2013)
  15. Xu XF, "The association between mean platelet volume and chronic atrial fibrillation and the presence of thrombotic events", Biomed Rep, 3, pp.388~394 (2015)
  16. Providencia R, "Mean platelet volume is associated with the presence of left atrial stasis in patients with non-valvular atrial fibrillation", BMC Cardiovasc Disord, 13, pp.40~ (2013)
  17. Hart RG, "Meta-analysis: antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation", Ann Intern Med, 146, pp.857~867 (2007)
  18. Gillis AM, "Canadian Cardiovascular Society atrial fibrillation guidelines 2010: rate and rhythm management", Can J Cardiol, 27, pp.47~59 (2011)
  19. Wyse DG, "A comparison of rate control and rhythm control in patients with atrial fibrillation", N Engl J Med, 347, pp.1825~1833 (2002)
  20. Van Gelder IC, "A comparison of rate control and rhythm control in patients with recurrent persistent atrial fibrillation", N Engl J Med, 347, pp.1834~1840 (2002)
  21. Hohnloser SH, "Rhythm or rate control in atrial fibrillation. Pharmacological Intervention in Atrial Fibrillation (PIAF): a randomised trial", Lancet, 356, pp.1789~1794 (2000)
  22. Carlsson J, "Randomized trial of rate-control versus rhythm-control in persistent atrial fibrillation: the Strategies of Treatment of Atrial Fibrillation (STAF) study", J Am Coll Cardiol, 41, pp.1690~1696 (2003)
  23. Opolski G, "Rate control vs rhythm control in patients with nonvalvular persistent atrial fibrillation: the results of the Polish How to Treat Chronic Atrial Fibrillation (HOT CAFE) Study", Chest, 126, pp.476~486 (2004)
  24. Tsadok MA, "Rhythm versus rate control therapy and subsequent stroke or transient ischemic attack in patients with atrial fibrillation", Circulation, 126, pp.2680~2687 (2012)
  25. Sherman DG, "Occurrence and characteristics of stroke events in the Atrial Fibrillation Follow-up Investigation of Sinus Rhythm Management (AFFIRM) study", Arch Intern Med, 165, pp.1185~1191 (2005)
  26. Huczek Z, "Mean platelet volume on admission predicts impaired reperfusion and long-term mortality in acute myocardial infarction treated with primary percutaneous coronary intervention", J Am Coll Cardiol, 46, pp.284~290 (2005)
  27. Maden O, "Relationship of admission hematological indexes with myocardial reperfusion abnormalities in acute ST segment elevation myocardial infarction patients treated with primary percutaneous coronary interventions", Can J Cardiol, 25, pp.e164~e168 (2009)
  28. Pereg D, "Mean platelet volume on admission correlates with impaired response to thrombolysis in patients with ST-elevation myocardial infarction", Platelets, 21, pp.117~121 (2010)
  29. Acar Z, "Mean platelet volume on admission is associated with further left ventricular functions in primary PTCA patients", Eur Rev Med Pharmacol Sci, 16, pp.1567~1569 (2012)
  30. Akgul O, "Prognostic value of elevated mean platelet volume in patients undergoing primary angioplasty for ST-elevation myocardial infarction", Acta Cardiol, 68, pp.307~314 (2013)
  31. Rechcinski T, "Prognostic value of platelet indices after acute myocardial infarction treated with primary percutaneous coronary intervention", Cardiol J, 20, pp.491~498 (2013)
  32. Celik T, "Predictive value of admission platelet volume indices for in-hospital major adverse cardiovascular events in acute ST-segment elevation myocardial infarction", Angiology, 66, pp.155~162 (2015)
  33. Elbasan Z, "Association of mean platelet volume and pre- and postinterventional flow with infarct-related artery in ST-segment elevation myocardial infarction", Angiology, 64, pp.440~446 (2013)
  34. Sarli B, "Mean platelet volume is associated with poor postinterventional myocardial blush grade in patients with ST-segment elevation myocardial infarction", Coron Artery Dis, 24, pp.285~289 (2013)
  35. Karahan Z, "Effect of hematologic parameters on microvascular reperfusion in patients with ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention", Angiology, 67, pp.151~156 (2016)
  36. Lai HM, "Association of mean platelet volume with impaired myocardial reperfusion and short-term mortality in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention", Blood Coagul Fibrinolysis, 27, pp.5~12 (2016)
  37. Lai HM, "Association of mean platelet volume with angiographic thrombus burden and shortterm mortality in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention", Catheter Cardiovasc Interv, 85(Suppl 1), pp.724~733 (2015)
  38. Cakici M, "Predictors of thrombus burden and no-reflow of infarct-related artery in patients with ST-segment elevation myocardial infarction: importance of platelet indices", Blood Coagul Fibrinolysis, 25, pp.709~715 (2014)
  39. Wang XY, "Serial changes of mean platelet volume in relation to Killip Class in patients with acute myocardial infarction and primary percutaneous coronary intervention", Thromb Res, 135, pp.652~658 (2015)
  40. Duygu H, "Effect of mean platelet volume on postintervention coronary blood flow in patients with chronic stable angina pectoris", J Invasive Cardiol, 20, pp.120~124 (2008)
  41. Goncalves SC, "Usefulness of mean platelet volume as a biomarker for long-term outcomes after percutaneous coronary intervention", Am J Cardiol, 107, pp.204~209 (2011)
  42. Eisen A, "Mean platelet volume as a predictor for long-term outcome after percutaneous coronary intervention", J Thromb Thrombolysis, 36, pp.469~474 (2013)
  43. Ki YJ, "Usefulness of mean platelet volume as a biomarker for long-term clinical outcomes after percutaneous coronary intervention in Korean cohort: a comparable and additive predictive value to high-sensitivity cardiac troponin T and N-terminal pro-B type natriuretic peptide", Platelets, 25, pp.427~432 (2014)
  44. Seo HJ, "Brachial-ankle pulse wave velocity and mean platelet volume as predictive values after percutaneous coronary intervention for long-term clinical outcomes in Korea: a comparable and additive study", Platelets, 26, pp.665~671 (2015)
  45. Moon AR, "High-sensitivity C-reactive protein and mean platelet volume as predictive values after percutaneous coronary intervention for longterm clinical outcomes: a comparable and additive study", Blood Coagul Fibrinolysis, 27, pp.70~76 (2016)
  46. Seyyed-Mohammadzad MH, "Prognostic value of mean platelet volume in patients undergoing elective percutaneous coronary intervention", Anatol J Cardiol, 15, pp.25~30 (2015)
  47. Choi SW, "Clinical outcome prediction from mean platelet volume in patients undergoing percutaneous coronary intervention in Korean cohort: implications of more simple and useful test than platelet function testing", Platelets, 25, pp.322~327 (2014)
  48. Kim YG, "Platelet volume indices are associated with high residual platelet reactivity after antiplatelet therapy in patients undergoing percutaneous coronary intervention", J Atheroscler Thromb, 21, pp.445~453 (2014)
  49. Koh YY, "Relation between the change in mean platelet volume and clopidogrel resistance in patients undergoing percutaneous coronary intervention", Curr Vasc Pharmacol, 13, pp.687~693 (2015)
  50. Cameron HA, "Platelet size in myocardial infarction", Br Med J(Clin Res Ed), 287, pp.449~451 (1983)
  51. Kilicli-Camur N, "Could mean platelet volume be a predictive marker for acute myocardial infarction?", Med Sci Monit, 11, pp.CR387~CR392 (2015)
  52. Martin JF, "Changes in volume and density of platelets in myocardial infarction", wBr Med J (Clin Res Ed), 287, pp.456~459 (1983)
  53. Tschoepe D, "Evidence for abnormal platelet glycoprotein expression in diabetes mellitus", Eur J Clin Invest, 20, pp.166~170 (1990)
  54. Giles H, "Platelet glycoprotein IIb-IIIa and size are increased in acute myocardial infarction", Eur J Clin Invest, 24, pp.69~72 (1994)
  55. Pabon Osuna P, "The effect of the mean platelet volume on the shortterm prognosis of acute myocardial infarct", Rev Esp Cardiol, 51, pp.816~822 (1998)
  56. Lekston A, "Prognostic significance of mean platelet volume in diabetic patients with ST-elevation myocardial infarction", J Diabetes Complications, 28, pp.652~657 (2014)
  57. Sezer M, "Association of haematological indices with the degree of microvascular injury in patients with acute anterior wall myocardial infarction treated with primary percutaneous coronary intervention", Heart, 93, pp.313~318 (2007)
  58. Chu SG, "Mean platelet volume as a predictor of cardiovascular risk: a systematic review and meta-analysis", J Thromb Haemost, 8, pp.148~156 (2010)
  59. Shah B, "Mean platelet volume and long-term mortality in patients undergoing percutaneous coronary intervention", Am J Cardiol, 111, pp.185~189 (2013)
  60. Braekkan SK, "Mean platelet volume is a risk factor for venous thromboembolism: the Tromso Study, Tromso, Norway", J Thromb Haemost, 8, pp.157~162 (2010)
  61. Kostrubiec M, "Mean platelet volume predicts early death in acute pulmonary embolism", Heart, 96, pp.460~465 (2010)
  62. Shanker J, "Platelet function and antiplatelet therapy in cardiovascular disease:implications of genetic polymorphisms", Curr Vasc Pharmacol, 9, pp.479~489 (2011)
  63. Gasparyan AY, "The role of aspirin in cardiovascular prevention: implications of aspirin resistance", J Am Coll Cardiol, 51, pp.1829~1843 (2008)
  64. Snoep JD, "Clopidogrel nonresponsiveness in patients undergoing percutaneous coronary intervention with stenting: a systematic review and meta-analysis", Am Heart J, 154, pp.221~231 (2007)
  65. Patti G, "Point-of-care measurement of clopidogrel responsiveness predicts clinical outcome in patients undergoing percutaneous coronary intervention results of the ARMYDA-PRO (Antiplatelet therapy for Reduction of MYocardial Damage during Angioplasty-Platelet Reactivity Predicts Outcome) study", J Am Coll Cardiol, 52, pp.1128~1133 (2008)
  66. Price MJ, "Prognostic significance of post-clopidogrel platelet reactivity assessed by a point-of-care assay on thrombotic events after drug-eluting stent implantation", Eur Heart J, 29, pp.992~1000 (2008)
  67. Bonello L, "High on-treatment platelet reactivity after prasugrel loading dose and cardiovascular events after percutaneous coronary intervention in acute coronary syndromes", J Am Coll Cardiol, 58, pp.467~473 (2011)
  68. Paulu P, "Lack of association between clopidogrel responsiveness tested using point of-care assay and prognosis of patients with coronary artery disease", J Thromb Thrombolysis, 36, pp.1~6 (2013)
  69. Collet JP, "Bedside monitoring to adjust antiplatelet therapy for coronary stenting", N Engl J Med, 367, pp.2100~2109 (2012)
  70. Michelson AD, "Methods for the measurement of platelet function", Am J Cardiol, 103(3 Suppl), pp.20A~26A (2009)
  71. Leader A, "Are platelet volume indices of clinical use? A multidisciplinary review", Ann Med, 44, pp.805~816 (2012)
  72. Brummitt DR, "The determination of a reference range for new platelet parameters produced by the Bayer ADVIA120 full blood count analyser", Clin Lab Haematol, 22, pp.103~107 (2000)
  73. 송영희, "혈소판증가증 감별진단을 위한 ADVIA 120을 이용한 혈소판지수의 유용성 평가", Annals of Laboratory Medicine, 29(6), pp.505~509 (2009), 대한진단검사의학회

관련 논문AI추천

이 간행물의 다른 논문 (24건)