Mean Platelet Volume and Vitamin D Level
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Background: Vitamin D deficiency and a high mean platelet volume (MPV) are related to cardiovascular disease. We investigated whether vitamin D deficiency is associated with high MPV. Methods: This study included 434 patients without chronic disease who were not taking vitamin D or calcium supplements. Vitamin D was measured by chemiluminescent mic- roparticle immunoassay on the Architect-I2000 system (Abbott Diagnostics, USA), and MPV was measured on the Cell-Dyn Ruby analyzer (Abbott Diagnostics). Patients were di- vided into Groups 1 (138 [men/women, 46/92]), 2 (148 [men/women, 54/94]), and 3 (148 [men/women, 50/98]) according to vitamin D levels of <10 ng/mL, 10-20 ng/mL, and >20 ng/mL, respectively. Results: The vitamin D level in Group 1 (7.7±1.9 ng/mL) was lower than that in Group 2 (15.1±1.6 ng/mL, P <0.001) and Group 3 (25.6±6.3 ng/mL, P <0.001). The MPV in Group 3 (7.5±1.0 fL) was lower than that in Group 1 (8.1±1.1 fL, P <0.001) and Group 2 (7.9±1.0 fL, P =0.009). Linear regression analysis showed that low levels of vitamin D (β=-0.109, P =0.019) was independently associated with increased MPV. Conclusions: There was a strong association between a low vitamin D level and a high MPV; therefore, vitamin D deficiency may be associated with increased MPV.
Abstract
Background: Vitamin D deficiency and a high mean platelet volume (MPV) are related to cardiovascular disease. We investigated whether vitamin D deficiency is associated with high MPV. Methods: This study included 434 patients without chronic disease who were not taking vitamin D or calcium supplements. Vitamin D was measured by chemiluminescent mic- roparticle immunoassay on the Architect-I2000 system (Abbott Diagnostics, USA), and MPV was measured on the Cell-Dyn Ruby analyzer (Abbott Diagnostics). Patients were di- vided into Groups 1 (138 [men/women, 46/92]), 2 (148 [men/women, 54/94]), and 3 (148 [men/women, 50/98]) according to vitamin D levels of <10 ng/mL, 10-20 ng/mL, and >20 ng/mL, respectively. Results: The vitamin D level in Group 1 (7.7±1.9 ng/mL) was lower than that in Group 2 (15.1±1.6 ng/mL, P <0.001) and Group 3 (25.6±6.3 ng/mL, P <0.001). The MPV in Group 3 (7.5±1.0 fL) was lower than that in Group 1 (8.1±1.1 fL, P <0.001) and Group 2 (7.9±1.0 fL, P =0.009). Linear regression analysis showed that low levels of vitamin D (β=-0.109, P =0.019) was independently associated with increased MPV. Conclusions: There was a strong association between a low vitamin D level and a high MPV; therefore, vitamin D deficiency may be associated with increased MPV.
참고문헌 (40)
- Davì G, "Platelet activation and atherothrombosis", N Engl J Med, 357, pp.2482~2494 (2007)
- Park Y, "Mean platelet volume as an indicator of platelet activation: methodological issues", Platelets, 13, pp.301~306 (2002)
- Rivera J, "Stability of glycoproteins Ib", IX and IIb, Vox Sang, pp.1994, 67[DOI]
- Cure MC, "The effects of Gilbert’s syndrome on the mean platelet volume and other hematological parameters", Blood Coagul Fibrinolysis, 24, pp.484~488 (2013)
- Khode V, "Mean platelet volume and other platelet volume indices in patients with stable coronary artery disease and acute myocardial infarction: a case control study", J Cardiovasc Dis Res, 3, pp.272~275 (2012)
- Kodiatte TA, "Mean platelet volume in Type 2 diabetes mellitus", J Lab Physicians, 4, pp.5~9 (2012)
- Cho SY, "Mean platelet volume in Korean patients with acute ischemic stroke: A gender difference", PLATELETS, 24(1), pp.75~76 (2013), INFORMA HEALTHCARE
- Bulur S, "Relation between indices of end-organ damage and mean platelet volume inhypertensive patients", Blood Coagul Fibrinolysis, 23, pp.367~369 (2012)
- Gulcan M, "Mean platelet volume is increased in patients with deep vein thrombosis", Clin Appl Thromb Hemost, 18, pp.427~430 (2012)
- Kuloğlu O, "Serum 25-hydroxyvitamin D level is associated with arterial Stiffness, left ventricle hypertrophy, and inflammation in newly diagnosed hypertension", J Investig Med, 61, pp.989~994 (2013)
- Yousef FM, "Vitamin D status and breast cancer in Saudi Arabian women: case-control study", Am J Clin Nutr, 98, pp.105~110 (2013)
- Wilkins CH, "Vitamin D deficiency is associated with worse cognitive performance and lower bone density in older African Americans", J Natl Med Assoc, 101, pp.349~354 (2009)
- Annweiler C, "Dietary intake of vitamin D and cognition in older women: a large population-based study", Neurology, 75, pp.1810~1816 (2010)
- Dong Y, "A 16-week randomized clinical trial of 2000 international units daily vitamin D3 supplementation in black youth: 25-hydroxyvitamin D, adiposity, and arterial stiffness", J Clin Endocrinol Metab, 95, pp.4584~4591 (2010)
- Beilfuss J, "Effects of a 1-year supplementation with cholecalciferol on interleukin-6, tumor necrosis factor-alpha and insulin resistance in overweight and obese subjects", Cytokine, 60, pp.870~874 (2012)
- Di Rosa M, "Immuno-modulatory effects of vitamin D3 in human monocyte and macrophages", Cell Immunol, 280, pp.36~43 (2012)
- Chakhtoura M, "The role of vitamin D deficiency in the incidence, progression, and complications of type 1 diabetes mellitus", Int J Endocrinol, 2013, pp.148673~ (2013)
- Erkan Cure, "Is the Mean Platelet Volume Predictive of Hip Fractures in the Elderly?", Annals of Laboratory Medicine, 33(5), pp.367~370 (2013), 대한진단검사의학회
- Sorenson M, "Does vitamin D deficiency contribute to erectile dysfunction?", Dermatoendocrinol, 4, pp.128~136 (2012)
- Correia LC, "Relation of severe deficiency of vitamin D to cardiovascular mortality during acute coronary syndromes", Am J Cardiol, 111, pp.324~327 (2013)
- Hovsepian S, "Prevalence of Vitamin D Deficiency among Adult Population of Isfahan City", Iran J Health Popul Nutr, 29, pp.149~155 (2011)
- Roeters van Lennep JE, "Risk factors for coronary heart disease: implications of gender", Cardiovasc Res, 53, pp.538~549 (2002)
- Kirbas A, "Investigation of the relationship between vitamin D and bone mineral density in newly diagnosed multiple sclerosis", Acta Neurol Belg, 113, pp.43~47 (2013)
- Mithal A, "IOF Committee of Scientific Advisors (CSA) Nutrition Working Group. Global vitamin D status and determinants of hypovitaminosis D", Osteoporos Int, 20, pp.1807~1820 (2009)
- Ku YC, "Relationship between vitamin D deficiency and cardiovascular disease", World J Cardiol, 5, pp.337~346 (2013)
- Cigolini M, "Serum 25-hydroxyvitamin D3 concentrations and prevalence of cardiovascular disease among type 2 diabetic patients", Diabetes Care, 29, pp.722~724 (2006)
- Zittermann A, "Poor outcome in end-stage heart failure patients with low circulating calcitriol levels", Eur J Heart Fail, 10, pp.321~327 (2008)
- Wang TJ, "Vitamin D deficiency and risk of cardiovascular disease", Circulation, 117, pp.503~511 (2008)
- Liu ZM, "The role of vitamin D in blood pressure, endothelial and renal function in postmenopausal women", Nutrients, 5, pp.2590~2610 (2013)
- Wang C, "Role of vitamin D in cardiometabolic diseases", J Diabetes Res, 2013, pp.243934~ (2013)
- Judd SE, "Vitamin D deficiency and risk for cardiovascular disease", Am J Med Sci, 338, pp.40~44 (2009)
- Simpson RU, "Characterization of heart size and blood pressure in the vitamin D receptor knockout mouse", J Steroid Biochem Mol Biol, 103, pp.521~524 (2007)
- Torun E, "vitamin D deficiency and insufficiency in obese children and adolescents and its relationship with insulin resistance", Int J Endocrinol, 2013, pp.631845~ (2013)
- Sung CC, "Role of vitamin D in insulin resistance", J Biomed Biotechnol, 2012, pp.634195~ (2012)
- Pourdjabbar A, "The role of vitamin D in chronic heart failure", Curr Opin Cardiol, 28, pp.216~222 (2013)
- Schleithoff SS, "Vitamin D supplementation improves cytokine profiles in patients with congestive heart failure: a double-blind, randomized, placebo controlled trial", Am J Clin Nutr, 83, pp.754~759 (2006)
- Koyama T, "Anticoagulant effects of synthetic retinoids and activated vitamin D3", Semin Thromb Hemost, 24, pp.217~226 (1998)
- Kebapcilar AG, "Relationship between mean platelet volume and low-grade systemic coagulation with vitamin D deficiency in primary ovarian insufficiency", Arch Gynecol Obstet, 288, pp.207~212 (2013)
- Kodiatte TA, "Mean platelet volume in Type 2 diabetes mellitus", J Lab Physicians, 4, pp.5~9 (2012)
- Song Y, "Blood 25-hydroxy vitamin D levels and incident type 2 diabetes: a meta-analysis of prospective studies", Diabetes Care, 36, pp.1422~1428 (2013)