Realities of KRAS-mutated non-small cell lung cancer
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The most common histologic subtype of non-small cell lung cancer is adenocarcinoma. Adenocarcinoma has targetable gene alterations such as epidermal growth factor receptor (EGFR) mutations and anaplastic lymphoma kinase and ROS1 translocations, and targeting of these molecules has dramatically improved therapeutic results over the past decade. KRAS mutations, which occur more often in smokers and Western populations, are also found in adenocarcinomas.
Abstract
The most common histologic subtype of non-small cell lung cancer is adenocarcinoma. Adenocarcinoma has targetable gene alterations such as epidermal growth factor receptor (EGFR) mutations and anaplastic lymphoma kinase and ROS1 translocations, and targeting of these molecules has dramatically improved therapeutic results over the past decade. KRAS mutations, which occur more often in smokers and Western populations, are also found in adenocarcinomas.
참고문헌 (2)
- Matikas A, "Targeting KRAS mutated non-small cell lung cancer: a history of failures and a future of hope for a diverse entity", Crit Rev Oncol Hematol, 110, pp.1~12 (2017)
- 박세훈, "KRAS G12C mutation as a poor prognostic marker of pemetrexed treatment in non-small cell lung cancer", The Korean Journal of Internal Medicine, 32(3), pp.514~522 (2017), 대한내과학회[DOI]