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A first case of high-flow nasal cannula oxygen therapy in patients with pulmonary tumor thrombotic microangiopathy

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In conclusion, PTTM is a rare pulmonary complication of cancer that is fatal because of its rapid progression. To make an early diagnosis and intervene therapeutically, it is important to include PTTM in the differential diagnosis of cancer patients with rapidly progressing hypoxemia without pulmonary thromboembolism. Although we could not change the clinical outcome using highflow nasal cannula oxygen therapy, we revealed that the cause of death in PTTM is circulatory failure, and not hypoxia. Nevertheless, further studies are needed to elucidate the pathogenesis and treatment of PTTM.

Abstract

In conclusion, PTTM is a rare pulmonary complication of cancer that is fatal because of its rapid progression. To make an early diagnosis and intervene therapeutically, it is important to include PTTM in the differential diagnosis of cancer patients with rapidly progressing hypoxemia without pulmonary thromboembolism. Although we could not change the clinical outcome using highflow nasal cannula oxygen therapy, we revealed that the cause of death in PTTM is circulatory failure, and not hypoxia. Nevertheless, further studies are needed to elucidate the pathogenesis and treatment of PTTM.

참고문헌 (5)

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  2. Hibbert M, "Tumour microembolism presenting as “primary pulmonary hypertension”", Thorax, 52, pp.1016~1017 (1997)
  3. Chinen K, "Pulmonary tumor thrombotic microangiopathy caused by a gastric carcinoma expressing vascular endothelial growth factor and tissue factor", Pathol Int, 55, pp.27~31 (2005)
  4. Miyano S, "Pulmonary tumor thrombotic microangiopathy", J Clin Oncol, 25, pp.597~599 (2007)
  5. Fukada I, "Imatinib alleviated pulmonary hypertension caused by pulmonary tumor thrombotic microangiopathy in a patient with metastatic breast cancer", Clin Breast Cancer, 15, pp.e167~e170 (2015)

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