What are the illnesses associated with frailty in community-dwelling older adults: the Korean Frailty and Aging Cohort Study
1
조회
0
다운로드
3
인용
0
참고문헌
키워드
초록
Background/Aims: Frailty is mainly due to an age-related decrease in the physiological reserves needed to maintain biological homeostasis, but it can also occur as a result of chronic diseases. The purpose of this study was to identify illnesses associated with frailty in Korean community-dwelling older adults. Methods: This was a cross-sectional study that included 2,936 older adults aged between 70 and 84 years who had completed both interviews and physical function assessments for the Korean Frailty and Aging Cohort Study. Current illnesses diagnosed by physicians were included in the analysis. The definition of frailty was derived from the Fried frailty phenotype. Results: The prevalence of hypertension, diabetes mellitus (DM), arthritis, osteoporosis, urinary incontinence, and lung disease (including asthma, chronic obstructive pulmonary disease, and chronic bronchitis) was higher in the frail group (p < 0.05). After adjusting for age, sex, physical activity, alcohol, smoking, education, and presence of a spouse, the odds ratios for DM and urinary incontinence in frailty were 1.51 (95% confidence interval [CI], 1.10 to 2.01; p = 0.01) and 1.88 (95% CI, 1.11 to 3.18; p = 0.02). Conclusions: In Korean community-dwelling older adults, DM and urinary incontinence were associated with frailty after adjusting for various factors. In the future, the list of comorbid diseases that are appropriate for Korean population- specific frailty assessment should be inventoried.
Abstract
Background/Aims: Frailty is mainly due to an age-related decrease in the physiological reserves needed to maintain biological homeostasis, but it can also occur as a result of chronic diseases. The purpose of this study was to identify illnesses associated with frailty in Korean community-dwelling older adults. Methods: This was a cross-sectional study that included 2,936 older adults aged between 70 and 84 years who had completed both interviews and physical function assessments for the Korean Frailty and Aging Cohort Study. Current illnesses diagnosed by physicians were included in the analysis. The definition of frailty was derived from the Fried frailty phenotype. Results: The prevalence of hypertension, diabetes mellitus (DM), arthritis, osteoporosis, urinary incontinence, and lung disease (including asthma, chronic obstructive pulmonary disease, and chronic bronchitis) was higher in the frail group (p < 0.05). After adjusting for age, sex, physical activity, alcohol, smoking, education, and presence of a spouse, the odds ratios for DM and urinary incontinence in frailty were 1.51 (95% confidence interval [CI], 1.10 to 2.01; p = 0.01) and 1.88 (95% CI, 1.11 to 3.18; p = 0.02). Conclusions: In Korean community-dwelling older adults, DM and urinary incontinence were associated with frailty after adjusting for various factors. In the future, the list of comorbid diseases that are appropriate for Korean population- specific frailty assessment should be inventoried.
참고문헌 (60)
- World Health Organization, "World Report on Ageing and Health" (2015), World Health Organization
- Fried LP, "Frailty in older adults : evidence for a phenotype", J Gerontol A Biol Sci Med Sci, 56, pp.M146~M156 (2001)
- 정휘수, "한국형 노쇠측정도구로 평가된 노쇠와 관련된 임상적 요인들", Annals of geriatric medicine and research, 17(2), pp.71~78 (2013), 대한노인병학회[DOI]
- Rockwood K, "Frailty in relation to the accumulation of deficits", J Gerontol A Biol Sci Med Sci, 62, pp.722~727 (2007)
- Weiss CO, "Frailty and chronic diseases in older adults", Clin Geriatr Med, 27, pp.39~52 (2011)
- Chaves PH, "Impact of anemia and cardiovascular disease on frailty status of community-dwelling older women : the Women’s Health and Aging Studies I and II", J Gerontol A Biol Sci Med Sci, 60, pp.729~735 (2005)
- Carneiro JA, "Prevalence and factors associated with frailty in non-institutionalized older adults", Rev Bras Enferm, 69, pp.435~442 (2016)
- Thorpe RJ Jr, "Transitions among disability levels or death in African American and white older women", J Gerontol A Biol Sci Med Sci, 64, pp.670~674 (2009)
- Morley JE, "A simple frailty questionnaire(FRAIL)predicts outcomes in middle aged African Americans", J Nutr Health Aging, 16, pp.601~608 (2012)
- 정희원, "The Korean version of the FRAIL scale: clinical feasibility and validity of assessing the frailty status of Korean elderly", The Korean Journal of Internal Medicine, 31(3), pp.594~600 (2016), 대한내과학회
- Leem AY, "Incidence and risk of chronic obstructive pulmonary disease in a Korean community-based cohort", Int J Chron Obstruct Pulmon Dis, 13, pp.509~517 (2018)
- 이영훈, "한국 성인의 심뇌혈관질환 인지도 관련 요인: 2013년 지역사회건강조사", Korean Journal of Health Promotion, 17(2), pp.99~108 (2017), 대한임상건강증진학회[DOI]
- 원장원, "Starting Construction of Frailty Cohort for Elderly and Intervention Study", Annals of geriatric medicine and research, 20(3), pp.114~117 (2016), 대한노인병학회[DOI]
- Charlson ME, "A new method of classifying prognostic comorbidity in longitudinal studies : development and validation", J Chronic Dis, 40, pp.373~383 (1987)
- Lee KS, "Prevalence of urinary incontinence in Korean women : results of a National Health Interview Survey", World J Urol, 26, pp.179~185 (2008)
- 김윤미, "골다공증 유병률, 인지율, 치료율 및 영향요인의 성별 비교: 국민건강영양조사 자료(2008~2011년) 활용", Journal of Korean Academy of Nursing, 45(2), pp.293~305 (2015), 한국간호과학회
- Oh YH, "The health status of older Koreans and policy considerations", Health and Welfare Forum, 223, pp.29~39 (2015)
- Kyoung Jin Kim, "Discrepancies in the Prevalence of Known Frailty Scales: Korean Frailty and Aging Cohort Study", Annals of geriatric medicine and research, 22(3), pp.137~144 (2018), 대한노인병학회[DOI]
- Chen LK, "Sarcopenia in Asia : consensus report of the Asian Working Group for Sarcopenia", J Am Med Dir Assoc, 15, pp.95~101 (2014)
- Orme JG, "Factorial and discriminant validity of the Center for Epidemiological Studies Depression (CES-D) scale", J Clin Psychol, 42, pp.28~33 (1986)
- Studenski S, "Bradypedia : is gait speed ready for clinical use", J Nutr Health Aging, 13, pp.878~880 (2009)
- Seino S, "Reference values and age and sex differences in physical performance measures for community-dwelling older Japanese : a pooled analysis of six cohort studies", PLoS One, 9, pp.e99487~ (2014)
- Sustakoski A, "The impact of testing protocol on recorded gait speed", Gait Posture, 41, pp.329~331 (2015)
- 정희원, "Cross-Comparisons of Gait Speeds by Automatic Sensors and a Stopwatch to Provide Converting Formula Between Measuring Modalities", Annals of geriatric medicine and research, 23(2), pp.71~76 (2019), 대한노인병학회[DOI]
- Son JH, "Physical frailty predicts medical expenses in community-dwelling, elderly patients : three-year prospective findings from living profiles of older people surveys in Korea", Eur Geriatr Med, 6, pp.412~416 (2015)
- Kang MG, "Association between frailty and hypertension prevalence, treatment, and control in the elderly Korean population", Sci Rep, 7, pp.7542~ (2017)
- Bastos-Barbosa RG, "Association of frailty syndrome in the elderly with higher blood pressure and other cardiovascular risk factors", Am J Hypertens, 25, pp.1156~1161 (2012)
- Vetrano DL, "Hypertension and frailty : a systematic review and meta-analysis", BMJ Open, 8, pp.e024406~ (2018)
- Weiss CO, "Relationships of cardiac, pulmonary, and muscle reserves and frailty to exercise capacity in older women", J Gerontol A Biol Sci Med Sci, 65, pp.287~294 (2010)
- Afilalo J, "Frailty assessment in the cardiovascular care of older adults", J Am Coll Cardiol, 63, pp.747~762 (2014)
- Khan H, "Frailty and risk for heart failure in older adults : the health, aging, and body composition study", Am Heart J, 166, pp.887~894 (2013)
- Chaudhry SI, "Risk factors for hospital admission among older persons with newly diagnosed heart failure : findings from the Cardiovascular Health Study", J Am Coll Cardiol, 61, pp.635~642 (2013)
- Cacciatore F, "Frailty predicts long-term mortality in elderly subjects with chronic heart failure", Eur J Clin Invest, 35, pp.723~730 (2005)
- Singh M, "Influence of frailty and health status on outcomes in patients with coronary disease undergoing percutaneous revascularization", Circ Cardiovasc Qual Outcomes, 4, pp.496~502 (2011)
- Gharacholou SM, "Comparison of frail patients versus nonfrail patients ≥65 years of age undergoing percutaneous coronary intervention", Am J Cardiol, 109, pp.1569~1575 (2012)
- Stewart R, "Cardiovascular disease and frailty : what are the mechanistic links", Clin Chem, 65, pp.80~86 (2019)
- Yanase T, "Frailty in elderly diabetes patients", Endocr J, 65, pp.1~11 (2018)
- Guan C, "Frailty assessment in older adults with chronic obstructive respiratory diseases", Clin Interv Aging, 13, pp.1513~1524 (2018)
- Bone AE, "Sarcopenia and frailty in chronic respiratory disease", Chron Respir Dis, 14, pp.85~99 (2017)
- Carrero JJ, "Etiology of the protein-energy wasting syndrome in chronic kidney disease:a consensus statement from the International Society of Renal Nutrition and Metabolism (ISRNM)", J Ren Nutr, 23, pp.77~90 (2013)
- Kim JC, "Frailty and protein-energy wasting in elderly patients with end stage kidney disease", J Am Soc Nephrol, 24, pp.337~351 (2013)
- Winovich DT, "Factors associated with ischemic stroke survival and recovery in older adults", Stroke, 48, pp.1818~1826 (2017)
- Misra D, "Knee osteoarthritis and frailty : findings from the Multicenter Osteoarthritis Study and Osteoarthritis Initiative", J Gerontol A Biol Sci Med Sci, 70, pp.339~344 (2015)
- Nygaard IE, "Physical activity and the pelvic floor", Am J Obstet Gynecol, 214, pp.164~171 (2016)
- Wang CJ, "Urinary incontinence and its association with frailty among men aged 80 years or older in Taiwan : a cross-sectional study", Rejuvenation Res, 20, pp.111~117 (2017)
- Berardelli M, "Urinary incontinence in the elderly and in the oldest old : correlation with frailty and mortality", Rejuvenation Res, 16, pp.206~211 (2013)
- Kang J, "Association between urinary incontinence and physical frailty in Korea", Australas J Ageing, 37, pp.E104~E109 (2018)
- Schumpf LF, "Urinary incontinence and its association with functional physical and cognitive health among female nursing home residents in Switzerland", BMC Geriatr, 17, pp.17~ (2017)
- John G, "Urinary incontinence as a predictor of death : a systematic review and meta-analysis", PLoS One, 11, pp.e0158992~ (2016)
- Hirsch C, "The association of race with frailty : the cardiovascular health study", Ann Epidemiol, 16, pp.545~553 (2006)
- Bandeen-Roche K, "Phenotype of frailty : characterization in the women’s health and aging studies", J Gerontol A Biol Sci Med Sci, 61, pp.262~266 (2006)
- 안태준, "만성폐쇄성폐질환의 유병률 및 사회 경제적 부담", 대한의사협회지, 61(9), pp.533~538 (2018), 대한의사협회[DOI]
- Yoo KH, "Prevalence of chronic obstructive pulmonary disease in Korea : the fourth Korean National Health and Nutrition Examination Survey, 2008", Respirology, 16, pp.659~665 (2011)
- 황용일, "Recent Trends in the Prevalence of Chronic Obstructive Pulmonary Disease in Korea", Tuberculosis and Respiratory Diseases, 80(3), pp.226~229 (2017), 대한결핵및호흡기학회
- Jung EK, "Chronic Disease Status and Issues, Chronic Disease Fact Book", pp.1~92 (2017), Korea Center for Disease Control and Prevention
- 이양근, "Overlap Between Asthma and COPD: Where the Two Diseases Converge", Allergy, Asthma & Immunology Research, 2(4), pp.209~214 (2010), 대한천식알레르기학회
- 전희란, "Accuracy of Self-reported Hypertension, Diabetes, and Hypercholesterolemia: Analysis of a Representative Sample of Korean Older Adults", Osong Public Health and Research Perspectives, 7(2), pp.108~115 (2016), 질병관리청
- Lopez AD, "Global and regional burden of disease and risk factors, 2001 : systematic analysis of population health data", Lancet, 367, pp.1747~1757 (2006)
- Song Y, "Chronic diseases knowledge and related factors among the elderly I Jinan, China", PLoS One, 8, pp.e68599~ (2013)
- Wada K, "Self-reported medical history was generally accurate among Japanese workplace population", J Clin Epidemiol, 62, pp.306~313 (2009)
