Role of concurrent chemoradiation on locally advanced unresectable adenoid cystic carcinoma
1
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Background/Aims: Adenoid cystic carcinoma (ACC) is a rare salivary gland tumor characterized by indolence, with a high rate of local recurrence and distant metastasis. This study aimed to investigate the effect of concurrent chemoradiation (CCRT) on locally advanced unresectable ACC. Methods: We retrospectively analyzed clinical data from 10 patients with pathologically confirmed ACC of the head and neck who received CCRT with cisplatin in Seoul National University Hospital between 2013 and 2018. Results: Ten patients with unresectable disease at the time of diagnosis or with positive margins after surgical resection received CCRT with weekly cisplatin. Eight patients (80%) achieved complete remission, of which three later developed distant metastases without local relapse; one patient developed distant metastasis and local relapse. Two patient achieved partial remission without progression. Patients experienced several toxicities, including dry mouth, radiation dermatitis, nausea, and salivary gland inflammation of mostly grade 1 to 2. Only one patient showed grade 3 oral mucositis. Median relapse-free survival was 34.5 months (95% confidence interval, 22.8 months to not reached). Conclusions: CCRT with cisplatin is effective for local control of ACC with manageable toxicity and may be an effective treatment option for locally advanced unresectable ACC.
Abstract
Background/Aims: Adenoid cystic carcinoma (ACC) is a rare salivary gland tumor characterized by indolence, with a high rate of local recurrence and distant metastasis. This study aimed to investigate the effect of concurrent chemoradiation (CCRT) on locally advanced unresectable ACC. Methods: We retrospectively analyzed clinical data from 10 patients with pathologically confirmed ACC of the head and neck who received CCRT with cisplatin in Seoul National University Hospital between 2013 and 2018. Results: Ten patients with unresectable disease at the time of diagnosis or with positive margins after surgical resection received CCRT with weekly cisplatin. Eight patients (80%) achieved complete remission, of which three later developed distant metastases without local relapse; one patient developed distant metastasis and local relapse. Two patient achieved partial remission without progression. Patients experienced several toxicities, including dry mouth, radiation dermatitis, nausea, and salivary gland inflammation of mostly grade 1 to 2. Only one patient showed grade 3 oral mucositis. Median relapse-free survival was 34.5 months (95% confidence interval, 22.8 months to not reached). Conclusions: CCRT with cisplatin is effective for local control of ACC with manageable toxicity and may be an effective treatment option for locally advanced unresectable ACC.
참고문헌 (33)
- Spiro RH, "Salivary neoplasms : overview of a 35-year experience with 2, 807 patients", Head Neck Surg, 8, pp.177~184 (1986)
- Leeming R, "Adenoid cystic carcinoma of the breast", Arch Surg, 127, pp.233~235 (1992)
- Bennett AK, "Adenoid cystic carcinoma of the lung", Pathol Case Rev, 9, pp.253~258 (2004)
- Spiro RH, "Adenoid cystic carcinoma of salivary origin. A clinicopathologic study of 242cases", Am J Surg, 128, pp.512~520 (1974)
- Ju J, "The role of perineural invasion on head and neck adenoid cystic carcinoma prognosis : a systematic review and meta-analysis", Oral Surg Oral Med Oral Pathol Oral Radiol, 122, pp.691~701 (2016)
- Singh FM, "Patterns of spread of head and neck adenoid cystic carcinoma", Clin Radiol, 70, pp.644~653 (2015)
- Spiro RH, "Stage means more than grade in adenoid cystic carcinoma", Am J Surg, 164, pp.623~628 (1992)
- Mendenhall WM, "Radiotherapy alone or combined with surgery for adenoid cystic carcinoma of the head and neck", Head Neck, 26, pp.154~162 (2004)
- Maruya S, "Salivary gland carcinoma treated with concomitant chemoradiation with intraarterial cisplatin and docetaxel", Int J Clin Oncol, 11, pp.403~406 (2006)
- Samant S, "Concurrent chemoradiation for adenoid cystic carcinoma of the head and neck", Head Neck, 34, pp.1263~1268 (2012)
- Groen HJ, "Carboplatin-and cisplatin-induced potentiation of moderate-dose radiation cytotoxicity in human lung cancer cell lines", Br J Cancer, 72, pp.1406~1411 (1995)
- Sears CR, "DNA damage response(DDR)pathway engagement in cisplatin radiosensitization of non-small cell lung cancer", DNA Repair(Amst), 40, pp.35~46 (2016)
- Eisenhauer EA, "New response evaluation criteria in solid tumours : revised RECIST guideline(version 1. 1)", Eur J Cancer, 45, pp.228~247 (2009)
- Haddad RI, "Chemoradiotherapy for adenoid cystic carcinoma : preliminary results of an organ sparing approach", Am J Clin Oncol, 29, pp.153~157 (2006)
- Gomez DR, "Outcomes and prognostic variables in adenoid cystic carcinoma of the head and neck : a recent experience", Int J Radiat Oncol Biol Phys, 70, pp.1365~1372 (2008)
- Kokemueller H, "Adenoid cystic carcinoma of the head and neck : a 20years experience", Int J Oral Maxillofac Surg, 33, pp.25~31 (2004)
- Ellington CL, "Adenoid cystic carcinoma of the head and neck : incidence and survival trends based on 1973-2007 Surveillance, Epidemiology, and End Results data", Cancer, 118, pp.4444~4451 (2012)
- Bhandari V, "Definitive radiotherapy for inoperable adenoid cystic carcinoma of the trachea : a rare case report", Lung India, 34, pp.73~75 (2017)
- Bhattasali O, "Definitive proton radiation therapy and concurrent cisplatin for unresectable head and neck adenoid cystic carcinoma : a series of 9 cases and a critical review of the literature", Head Neck, 38(Suppl 1), pp.E1472~E1480 (2016)
- Douglas JG, "Treatment of locally advanced adenoid cystic carcinoma of the head and neck with neutron radiotherapy", Int J Radiat Oncol Biol Phys, 46, pp.551~557 (2000)
- Cerda T, "A rationale for chemoradiation(vs radiotherapy)in salivary gland cancers? On behalf of the REFCOR(French rare head and neck cancer network)", Crit Rev Oncol Hematol, 91, pp.142~158 (2014)
- Chopra S, "Outcomes of nonsurgical management of locally advanced carcinomas of the sinonasal cavity", Laryngoscope, 127, pp.855~861 (2017)
- Allen AM, "Unresectable adenoid cystic carcinoma of the trachea treated with chemoradiation", J Clin Oncol, 25, pp.5521~5523 (2007)
- Rosenberg L, "Concurrent chemoradiotherapy for locoregionally advanced salivary gland malignancies", Head Neck, 34, pp.872~876 (2012)
- Kim KS, "Radiotherapy as a first-line modality for tongue base adenoid cystic carcinoma : report of 3 cases", Korean J Head Neck Oncol, 30, pp.104~108 (2014)
- Morse E, "Positive surgical margins in parotid malignancies : Institutional variation and survival association", Laryngoscope, 129, pp.129~137 (2019)
- Li Q, "Surgery alone provides longterm survival rates comparable to those of surgery plus postoperative radiotherapy for patients with adenoid cystic carcinoma of the palate", Oral Oncol, 47, pp.170~173 (2011)
- Dautruche A, "Three-year results after radiotherapy for locally advanced sinonasal adenoid cystic carcinoma, using highly conformational radiotherapy techniques proton therapy and", or tomotherapy, 2018, pp.22, 411~416
- Ko YH, "Prognostic factors affecting the clinical outcome of adenoid cystic carcinoma of the head and neck", Jpn J Clin Oncol, 37, pp.805~811 (2007)
- Lee AW, "Preliminary results of a randomized study(NPC-9902 Trial)on therapeutic gain by concurrent chemotherapy and", or accelerated fractionation for locally advanced nasopharyngeal carcinoma, 2006, pp.66, 142~151
- Lee AW, "Preliminary results of a randomized study on therapeutic gain by concurrent chemotherapy for regionally-advanced nasopharyngeal carcinoma : NPC-9901 Trial by the Hong Kong Nasopharyngeal Cancer Study Group", J Clin Oncol, 23, pp.6966~6975 (2005)
- Yu Y, "Platinum-based concurrent chemotherapy remains the optimal regimen for nasopharyngeal carcinoma : a large institutional-based cohort study from an endemic area", J Cancer Res Clin Oncol, 144, pp.2231~2243 (2018)
- Hashmi H, "Concurrent cisplatin-based chemoradiation in squamous cell carcinoma of cervix", J Coll Physicians Surg Pak, 26, pp.302~305 (2016)