본문 바로가기
KERD
논문KCI 등재

Relationship Between Serum Vitamin D Levels and Symptoms of Depression in Stroke Patients

2

조회

0

다운로드

0

인용

0

참고문헌

키워드

주제분류재활의학

초록

Objective To investigate the correlation between depressive symptoms and serum vitamin D levels in stroke patients.Methods In total, 126 stroke patients were analyzed. The 25-hydroxyvitamin D (25-OHD) concentration of each patient was used to determine their vitamin D status. Depressive symptoms were assessed using the Beck Depression Inventory II (BDI-II) and the Patient Health Questionnaire 9 (PHQ-9). Functional status was evaluated with the Korean version of the Modified Barthel Index (K-MBI). We compared the clinical questionnaires of a vitamin D-deficient group and a normal group, and evaluated the correlations between BDI-II, PHQ-9, K-MBI, and serum 25-OHD levels.Results In the vitamin D-deficient group, BDI-II (16.0±12.1) and PHQ-9 (7.4±4.2) scores were significantly higher than those of the normal group (BDI-II, 9.1±7.2; PHQ-9, 4.2±2.9; p<0.01). In a Spearman correlation analysis, a significant negative correlation was found between serum 25-OHD levels and BDI-II (Spearman r=0.177, p=0.048), but there were no significant correlations between serum 25-OHD levels and PHQ-9 or K-MBI. Conclusion Vitamin D deficiency was correlated with the symptoms of depression in stroke patients.

Abstract

Objective To investigate the correlation between depressive symptoms and serum vitamin D levels in stroke patients.Methods In total, 126 stroke patients were analyzed. The 25-hydroxyvitamin D (25-OHD) concentration of each patient was used to determine their vitamin D status. Depressive symptoms were assessed using the Beck Depression Inventory II (BDI-II) and the Patient Health Questionnaire 9 (PHQ-9). Functional status was evaluated with the Korean version of the Modified Barthel Index (K-MBI). We compared the clinical questionnaires of a vitamin D-deficient group and a normal group, and evaluated the correlations between BDI-II, PHQ-9, K-MBI, and serum 25-OHD levels.Results In the vitamin D-deficient group, BDI-II (16.0±12.1) and PHQ-9 (7.4±4.2) scores were significantly higher than those of the normal group (BDI-II, 9.1±7.2; PHQ-9, 4.2±2.9; p<0.01). In a Spearman correlation analysis, a significant negative correlation was found between serum 25-OHD levels and BDI-II (Spearman r=0.177, p=0.048), but there were no significant correlations between serum 25-OHD levels and PHQ-9 or K-MBI. Conclusion Vitamin D deficiency was correlated with the symptoms of depression in stroke patients.

참고문헌 (32)

  1. Hackett ML, "Frequency of depression after stroke: a systematic review of observational studies", Stroke, 36, pp.1330~1340 (2005)
  2. Gillen R, "Depressive symptoms and history of depression predict rehabilitation efficiency in stroke patients", Arch Phys Med Rehabil, 82, pp.1645~1649 (2001)
  3. Wei N, "Post-stroke depression and lesion location: a systematic review", J Neurol, 262, pp.81~90 (2015)
  4. Krishnan V, "Linking molecules to mood:new insight into the biology of depression", Am J Psychiatry, 167, pp.1305~1320 (2010)
  5. Holick MF, "Vitamin D deficiency", N Engl J Med, 357, pp.266~281 (2007)
  6. Berk M, "Vitamin D deficiency may play a role in depression", Med Hypotheses, 69, pp.1316~1319 (2007)
  7. Bertone-Johnson ER, "Vitamin D and the occurrence of depression: causal association or circumstantial evidence?", Nutr Rev, 67, pp.481~492 (2009)
  8. Kwasky AN, "Vitamin D and depression: is there a relationship in young women?", J Am Psychiatr Nurses Assoc, 18, pp.236~243 (2012)
  9. Siegert RJ, "An examination of the factor structure of the Beck Depression Inventory-II in a neurorehabilitation inpatient sample", J Int Neuropsychol Soc, 15, pp.142~147 (2009)
  10. Williams LS, "Performance of the PHQ-9 as a screening tool for depression after stroke", Stroke, 36, pp.635~638 (2005)
  11. Turner A, "Depression screening in stroke: a comparison of alternative measures with the structured diagnostic interview for the diagnostic and statistical manual of mental disorders, fourth edition (major depressive episode) as criterion standard", Stroke, 43, pp.1000~1005 (2012)
  12. Kroenke K, "The PHQ-9: validity of a brief depression severity measure", J Gen Intern Med, 16, pp.606~613 (2001)
  13. Eyles DW, "Vitamin D, effects on brain development, adult brain function and the links between low levels of vitamin D and neuropsychiatric disease", Front Neuroendocrinol, 34, pp.47~64 (2013)
  14. Pardridge WM, "Restricted transport of vitamin D and A derivatives through the rat blood-brain barrier", J Neurochem, 44, pp.1138~1141 (1985)
  15. Balabanova S, "25-Hydroxyvitamin D, 24, 25-dihydroxyvitamin D and 1,25-dihydroxyvitamin D in human cerebrospinal fluid", Klin Wochenschr, 62, pp.1086~1090 (1984)
  16. Malabanan A, "Redefining vitamin D insufficiency", Lancet, 351, pp.805~806 (1998)
  17. Ganji V, "Serum vitamin D concentrations are related to depression in young adult US population: the Third National Health and Nutrition Examination Survey", Int Arch Med, 3, pp.29~ (2010)
  18. Kjaergaard M, "Low serum 25-hydroxyvitamin D levels are associated with depression in an adult Norwegian population", Psychiatry Res, 190, pp.221~225 (2011)
  19. Han QQ, "Inflammation: a mechanism of depression?", Neurosci Bull, 30, pp.515~523 (2014)
  20. Hayley S, "The pathogenesis of clinical depression: stressor- and cytokine-induced alterations of neuroplasticity", Neuroscience, 135, pp.659~678 (2005)
  21. Cekic M, "Combination treatment with progesterone and vitamin D hormone may be more effective than monotherapy for nervous system injury and disease", Front Neuroendocrinol, 30, pp.158~172 (2009)
  22. Kesby JP, "The effects of vitamin D on brain development and adult brain function", Mol Cell Endocrinol, 347, pp.121~127 (2011)
  23. Lefebvre d’Hellencourt C, "Vitamin D3 inhibits proinflammatory cytokines and nitric oxide production by the EOC13microglial cell line", J Neurosci Res, 71, pp.575~582 (2003)
  24. Newmark HL, "Vitamin D and Parkinson’s disease: a hypothesis", Mov Disord, 22, pp.461~468 (2007)
  25. Patrick RP, "Vitamin D hormone regulates serotonin synthesis. Part 1: relevance for autism", FASEB J, 28, pp.2398~2413 (2014)
  26. Blier P, "Neurotransmitter targeting in the treatment of depression", J Clin Psychiatry, 74(Suppl 2), pp.19~24 (2013)
  27. Tekes K, "Influence of neonatal vitamin A or vitamin D treatment on the concentration of biogenic amines and their metabolites in the adult rat brain", Horm Metab Res, 41, pp.277~280 (2009)
  28. Smith MP, "Calcitriol protection against dopamine loss induced by intracerebroventricular administration of 6-hydroxydopamine", Neurochem Res, 31, pp.533~539 (2006)
  29. Bertone-Johnson ER, "Vitamin D intake from foods and supplements and depressive symptoms in a diverse population of older women", Am J Clin Nutr, 94, pp.1104~1112 (2011)
  30. Polak MA, "Serum 25-hydroxyvitamin D concentrations and depressive symptoms among young adult men and women", Nutrients, 6, pp.4720~4730 (2014)
  31. Lee DM, "Lower vitamin D levels are associated with depression among community-dwelling European men", J Psychopharmacol, 25, pp.1320~1328 (2011)
  32. Holmoy T, "25-hydroxyvitamin D in cerebrospinal fluid during relapse and remission of multiple sclerosis", Mult Scler, 15, pp.1280~1285 (2009)

관련 논문AI추천

Vitamin D Deficiency/Insufficiency among Inpatients with Depressive SymptomsJong Hyun Jeong, Moon Doo Kim, Sangha Kim, Won-Myong Bahk, Young-Eun Jung, Young Sup Woo대한정신약물학회 · Clinical Psychopharmacology and Neuroscience2019 · 제17권 제1호The Association Between Serum Leptin Levels and Post-Stroke Depression: A Retrospective Clinical Study김참, 박기덕, 박용범, 윤진원, 이주강, 이진영, 임오경대한재활의학회 · Annals of Rehabilitation Medicine2015 · 제39권 제5호The Difference between Serum Vitamin D Level and Depressive Symptoms in Korean Adult Women before and after Menopause: The 5th (2010–2012) Korean National Health and Nutrition Examination Survey배우경, 신은영, 이수미, 최희원대한임상건강증진학회 · Korean Journal of Health Promotion2023 · 제23권 제1호Decrement of Serum Vitamin D Level After Stroke김기영, 김민영, 유정훈, 임상희, 조계희, 최재우대한재활의학회 · Annals of Rehabilitation Medicine2017 · 제41권 제6호Association between Stroke Status and Depression in a Community Setting: The 2014 Korea National Health and Nutrition Examination Survey김미나, 오경재, 이영훈대한신경과학회 · Journal of Clinical Neurology2017 · 제13권 제1호The Relationship between Serum Vitamin D Levels, C-Reactive Protein, and Anxiety Symptoms박재현, Dong-Won Shin, Kang-Seob Oh, Sang-Won Jeon, Sung Joon Cho, Sun-Young Kim, Weon-Jeong Lim, Young-Chul Shin대한신경정신의학회 · PSYCHIATRY INVESTIGATION2020 · 제17권 제4호

이 간행물의 다른 논문 (23건)