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Vitamin D Deficiency/Insufficiency among Inpatients with Depressive Symptoms

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초록

Objective: Although the association between low vitamin D levels and depressive symptoms has been widely reported, studies investigating the relationship between hypovitaminosis D and depressive symptomatology are scarce. Methods: We retrospectively studied the relationship between vitamin D status and depressive symptoms in 196 patients hospitalized for a major depressive episode. Results: The baseline 17-item Hamilton Depression Rating Scale total and depression factor (item 1, 2, 3, 7) scores were significantly higher in the vitamin-D-insufficiency/deficiency group than in the vitamin-D-sufficiency group. Conclusion: It is important to consider measuring the vitamin D levels of patients with severe and core depressive symptoms and providing vitamin D supplementation when necessary.

Abstract

Objective: Although the association between low vitamin D levels and depressive symptoms has been widely reported, studies investigating the relationship between hypovitaminosis D and depressive symptomatology are scarce. Methods: We retrospectively studied the relationship between vitamin D status and depressive symptoms in 196 patients hospitalized for a major depressive episode. Results: The baseline 17-item Hamilton Depression Rating Scale total and depression factor (item 1, 2, 3, 7) scores were significantly higher in the vitamin-D-insufficiency/deficiency group than in the vitamin-D-sufficiency group. Conclusion: It is important to consider measuring the vitamin D levels of patients with severe and core depressive symptoms and providing vitamin D supplementation when necessary.

참고문헌 (10)

  1. Anglin RE, "Vitamin D deficiency and depression in adults : systematic review and meta-analysis", Br J Psychiatry, 202, pp.100~107 (2013)
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  3. Adamson J, "Correlates of vitamin D in psychotic disorders : A comprehensive systematic review", Psychiatry Res, 249, pp.78~85 (2017)
  4. Hatice Altun, "The Levels of Vitamin D, Vitamin D Receptor, Homocysteine and Complex B Vitamin in Children with Autism Spectrum Disorders", Clinical Psychopharmacology and Neuroscience, 16(4), pp.383~390 (2018), 대한정신약물학회[DOI]
  5. Eyles DW, "Vitamin D, effects on brain development, adult brain function and the links between low levels of vitamin D and neuropsychiatric disease", Front Neuroendocrinol, 34, pp.47~64 (2013)
  6. Holick MF, "Vitamin D deficiency", N Engl J Med, 357, pp.266~281 (2007)
  7. Shafer AB, "Meta-analysis of the factor structures of four depression questionnaires : Beck, CES-D, Hamilton, and Zung", J Clin Psychol, 62, pp.123~146 (2006)
  8. von Känel R, "Vitamin D deficiency and depressive symptomatology in psychiatric patients hospitalized with a current depressive episode : a factor analytic study", PLoS One, 10, pp.e0138550~ (2015)
  9. Milaneschi Y, "The association between low vitamin D and depressive disorders", Mol Psychiatry, 19, pp.444~451 (2014)
  10. Bagby RM, "The Hamilton Depression Rating Scale : has the gold standard become a lead weight", Am J Psychiatry, 161, pp.2163~2177 (2004)

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