Changes in the prevalence of hepatitis B and metabolic abnormalities among young men in Korea
0
조회
0
다운로드
3
인용
0
참고문헌
키워드
초록
Changes in the prevalence of disease over time provide valuable information from a public health perspective. We used data from Korea Military Manpower Administration medical examinations for conscription between 2003 and 2019 (n = 5,355,941), which involved young men aged 19 years, to observe changes in liver disease over time at a population level. Trends in the prevalence of hepatitis B surface antigen (HBsAg), elevated alanine aminotransferase (ALT) levels, the fibrosis-4 (FIB-4) index, obesity, and hypertension were assessed. The prevalence of HBsAg steadily decreased from 3.19% for men born in 1984 to 0.18% for men born in 2000. Among HBsAg-negative subjects, the prevalence of elevated ALT levels increased from 13.15% for men born in 1986 to 16.48% for men born in 2000. The prevalence of obesity, hypertension and the proportion with high FIB-4 scores (≥ 1.45) also increased. This population-based nationwide analysis showed a decreasing trend of HBsAg and increasing trends of possible non-alcoholic fatty liver disease.
Abstract
Changes in the prevalence of disease over time provide valuable information from a public health perspective. We used data from Korea Military Manpower Administration medical examinations for conscription between 2003 and 2019 (n = 5,355,941), which involved young men aged 19 years, to observe changes in liver disease over time at a population level. Trends in the prevalence of hepatitis B surface antigen (HBsAg), elevated alanine aminotransferase (ALT) levels, the fibrosis-4 (FIB-4) index, obesity, and hypertension were assessed. The prevalence of HBsAg steadily decreased from 3.19% for men born in 1984 to 0.18% for men born in 2000. Among HBsAg-negative subjects, the prevalence of elevated ALT levels increased from 13.15% for men born in 1986 to 16.48% for men born in 2000. The prevalence of obesity, hypertension and the proportion with high FIB-4 scores (≥ 1.45) also increased. This population-based nationwide analysis showed a decreasing trend of HBsAg and increasing trends of possible non-alcoholic fatty liver disease.
참고문헌 (12)
- Cho EJ, "Current status and strategies for hepatitis B control in Korea", Clin Mol Hepatol, 23, pp.205~211 (2017)
- 임선영, "The epidemiology of hepatitis B virus infection in Korea", The Korean Journal of Internal Medicine, 34(5), pp.945~953 (2019), 대한내과학회[DOI]
- Xiao G, "Comparison of diagnostic accuracy of aspartate aminotransferase to platelet ratio index and fibrosis-4 index for detecting liver fibrosis in adult patients with chronic hepatitis B virus infection : a systemic review and meta-analysis", Hepatology, 61, pp.292~302 (2015)
- Park NH, "Impacts of vaccination on hepatitis B viral infections in Korea over a 25-year period", Intervirology, 53, pp.20~28 (2010)
- 김혁, "Recent trends in hepatitis B virus infection in the general Korean population", The Korean Journal of Internal Medicine, 28(4), pp.413~419 (2013), 대한내과학회[DOI]
- Kim Y, "The Korea National Health and Nutrition Examination Survey(KNHANES) : current status and challenges", Epidemiol Health, 36, pp.e2014002~ (2014)
- Kweon S, "Data resource profile : the Korea National Health and Nutrition Examination Survey(KNHANES)", Int J Epidemiol, 43, pp.69~77 (2014)
- Lee YB, "Association of metabolic risk factors with risks of cancer and all-cause mortality in patients with chronic hepatitis B", Hepatology, 73, pp.2266~2277 (2021)
- Das K, "Nonobese population in a developing country has a high prevalence of nonalcoholic fatty liver and significant liver disease", Hepatology, 51, pp.1593~1602 (2010)
- Fan JG, "New trends on obesity and NAFLD in Asia", J Hepatol, 67, pp.862~873 (2017)
- Li J, "The changing epidemiology of liver disease among US children and adolescents from 1999 to 2016", Am J Gastroenterol, 116, pp.2068~2078 (2021)
- Kang SY, "Trends in the prevalence of non-alcoholic fatty liver disease and its future predictions in Korean men, 1998-2035", J Clin Med, 9, pp.2626~ (2020)