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Differential Signaling via Tumor Necrosis Factor-Associated Factors (TRAFs) by CD27 and CD40 in Mouse B Cells

박혜경|우소연|Gail A. Bishop
대한면역학회 (The Korean Association of Immunologists)|2004.09|Immune Network|제4권 제3호|pp. 143-154

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Abstract

Background: CD27 is recently known as a memory B cell marker and is mainly expressed in activated T cells, some B cell population and NK cells. CD27 is a member of tumor necrosis factor receptor family. Like CD40 molecule, CD27 has (P/S/T/A) X(Q/E)E motif for interacting with TNF receptor-associated factors (TRAFs), and TRAF2 and TRAF5 bindings to CD27 in 293T cells were reported. Methods: To investigate the CD27 signaling effect in B cells, human CD40 extracellular domain containing mouse CD27 cytoplamic domain construct (hCD40-mCD27) was transfected into mouse B cell line CH12.LX and M12.4.1. Results: Through the stimulation of hCD40-mCD27 molecule via anti-human CD40 antibody or CD154 ligation, expression of CD11a, CD23, CD54, CD70 and CD80 were increased and secretion of IgM was induced, which were comparable to the effect of CD40 stimulation. TRAF2 and TRAF3 were recruited into lipid-enriched membrane raft and were bound to CD27 in M12.4.1 cells. CD27 stimulation, however, did not increase TRAF2 or TRAF3 degradation. Conclusion: In contrast to CD40 signaling pathway, TRAF2 and TRAF3 degradation was not observed after CD27 stimulation and it might contribute to prolonged B cell activation through CD27 signaling. (Immune Network 2004;4(3):143-154)

참고문헌 (30)

  1. "The TNF and TNF receptor superfamilies:integrating mammalian biology", 104, pp.487~501 (2001)
  2. "Tumor necrosis factor receptor (TNFR)- associated factor 2A (TRAF2A) a TRAF2 splice variant with an extended RING finger domain that inhibits TNFR2- mediated NF-kappaB activation", 273, pp.4129~4134 (1998)
  3. "Tumor necrosis factor receptor- associated factors (TRAFs).", 20, pp.6482~6491 (2001)
  4. "CD40- CD154 interactions in B-cell signaling", 245, pp.73~99 (2000)
  5. "TRAF2- mediated activation of NF-kappa B by TNF receptor 2 and CD40", 269, pp.1424~1427 (1995)
  6. "A novel RING finger protein interacts with the cytoplasmic domain of CD40", 269, pp.30069~30072 (1994)
  7. "TRAF5, a novel tumor necrosis factor receptor-associated factor family protein, mediates CD40 signaling.", 93, pp.9437~9442 (1996)
  8. "Identification of TRAF6 a novel tumor necrosis factor receptor-associated factor protein that mediates signaling from an amino-terminal domain of the CD40 cytoplasmic region", 271, pp.28745~29748 (1996)
  9. "Molecular mechanisms of CD40 signaling", 49, pp.129~137 (2001)
  10. "The CD40-TRAF6 axis controls affinity maturation and the generation of long-lived plasma cells", 3, pp.451~456 (2002)
  11. "Tissue distribution and biochemical and functional properties of Tp55", j immu(l 139), pp.1589~1596 (1987)
  12. "Human immunoglobulin (Ig)M IgD peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B cells.", 188, pp.1679~1689 (1998)
  13. "CD27 expression in the human splenic marginal zone:the infant marginal zone is populated by naive B cells", 58, pp.234~242 (2001)
  14. "CD27 expression by a distinct subpopulation of human B lymphocytes", 20, pp.2679~2684 (1990)
  15. "CD27-CD70 interactions regulate B-cell activation by T cells", 92, pp.11249~11253 (1995)
  16. "CD27, a member of the tumor necrosis factor receptor superfamily, activates NF-kappaB and stress-activated protein kinase", c-Jun N-terminal kinase via TRAF2, TRAF5, and NF-kappaB-inducing kinase, 1998, pp.273, 13353~13358
  17. "CD27", CD70 interaction augments IgE secretion by promoting the differentiation of memory B cells into plasma cells, 1998, pp.161, 6496~6502
  18. "Establishment of B cell hybridomas with B cell surface antigens", 129, pp.1403~1406 (1982)
  19. "Induced differentiation of a transformed clone of Ly-1 B cells by clonal T cells and antigen", pp.7410~414 (1986)
  20. "Phosphatidyl choline is recognized by a series of Ly-1 murine B cell lymphomas specific for erythrocyte membranes", 163, pp.155~165 (1986)
  21. "Signaling via MHC class II molecules and antigen receptors enhances the B cell response to gp39", CD40 ligand, 1995, pp.25, 1230~1238
  22. "Induction of germ-line γ1 and ε Ig gene expression in murine B cells IL-4 and the CD40L- CD40 interaction provide distinct but synergistic signals", 155, pp.5637~5646 (1995)
  23. "Requirements of class II-mediated B cell differentiation for class II crosslinking and cAMP", j immu(l), pp.1107~1114 (1991)
  24. "Engagement of T cell receptor triggers its recruitment to low-density detergent-insoluble membrane domains", 17, pp.5334~5348 (1998)
  25. "Recruitment of CD40 TRAF2 and TRAF3 to membrane microdomains during CD40 signaling", pp.15392~15398 (2000)
  26. "Characterization of CD40 signaling determinants regulating NF-κB activation in lymphocytes", 159, pp.4898~4906 (1997)
  27. "TRAF2- mediated activation of NF-kB by TNF receptor 2 and CD40", 269, pp.1424~1427 (1995)
  28. "Cutting Edge:Contrasting roles of TRAF2 and TRAF3 in CD40-mediated B lymphocyte activation", 162, pp.6307~6311 (1999)
  29. "Regulation of TRAF2 signaling by self-induced degradation" (2002)
  30. "Differential signaling and tumor necrosis factor receptor-associated factor (TRAF)degradation mediated by CD40 and the Epstein-Barr virus oncoprotein latent membrane protein 1 (LMP1).", 193, pp.943~954 (2001)

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