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Differences in Their Proliferation and Differentiation between B-1 and B-2 Cell.

차창일|박동춘|여승근
대한면역학회 (The Korean Association of Immunologists)|2006.03|Immune Network|제6권 제1호|pp. 1-5

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Abstract

Background: B cell subset has been divided into B-1 cells and B-2 cells. B-1 cells are found most prominently in the peritoneal cavity, as well as constituting a small proportion of splenic B cells and they are larger and less dense than B-2 cells in morphology. This study was designed to compare the differences in their proliferation and differentiation between B-1 and B-2 cell. Methods: We obtained sorted B-1 cells from peritoneal fluid and B-2 cells from spleens of mice. Secreted IgM was measured by enzyme-linked immunosorbent assay. Entering of S phase in response to LPS-stimuli was measured by proliferative assay. Cell cycle analysis by propidium iodide was performed. p21 expression was assessed by real time PCR. Results: Cell proliferation and cell cycle progression in B-1 and B-2 cells, which did not occur in the absence of LPS, required LPS stimulation. After LPS stimulation, B-1 and B-2 cells were shifted to S and G2/M phases. p21 expression by resting B-1 cells was higher than that of resting B-2 cells. Conclusion: B-1 cells differ from conventional B-2 cells in proliferation, differentiation and cell cycle. (Immune Network 2006;6(1):1-5)

참고문헌 (27)

  1. "Cutting Edge", 168, pp.4257~4261 (2002)
  2. "Immunofluorescence analysis of B-1 cell ontogeny in the mouse", 6, pp.355~361 (1994)
  3. "Decreased surface IgM receptor mediated activation of phospholipase C gamma 2 in B-1 lymphocytes", 6, pp.1011~1016 (1994)
  4. "CD5-mediated negative regulation of antigen receptor-induced growth signals in B-1 B cells", 274, pp.1906~1909 (1996)
  5. "Negative regulation of antigen receptor-mediated signaling by constitutive association of CD5 with the SHP-1 protein tyrosine phosphatase in B-1 B cells", 29, pp.3319~3328 (1999)
  6. "Peritoneal B cells respond to phorbol esters in the absence of co-mitogen", 140, pp.2880~2885 (1988)
  7. "Early induction of cyclin D2 expression in phorbol ester-responsive B-1 lymphocytes", 189, pp.1685~1690 (1999)
  8. "The absence of p21Cip1", WAF1 alters keratinocyte growth and differentiation and promotes ras-tumor progression, 1996, pp.10, 3065~3075
  9. "Effect of p21 (Waf1", Cip1) transgene on radiation induced apoptosis in T cells, 1999, pp.18, 3652~3658
  10. "The functions of the cdk- cyclin kinase inhibitor p21WAF1", 48, pp.190~202 (2000)
  11. "Protection of mice from infection with streptococcus pneumoniae by anti-phosphocholine antibody", 36, pp.184~188 (1982)
  12. "Commitment of B lymphocytes to a plasma cell fate is associated with Blimp-1 expression in vivo", 165, pp.5462~5471 (2000)
  13. "Transcriptional regulatory cascades controlling plasma cell differentiation", 194, pp.19~28 (2003)
  14. "Regulatory mechanisms that determine the development and function of plasma cells", 21, pp.205~230 (2003)
  15. "Cutting edge", 174, pp.3173~3177 (2005)
  16. "Cholesteatoma epithelium is characterized by increased expression of Ki-67, p53 and p21, with minimal apoptosis", 123, pp.377~382 (2003)
  17. "T cell-dependent induction of NF-κB in B cells", 177, pp.1215~1219
  18. "CD40 signaling induces interleukin-4 independent IgE switching in vivo", 26, pp.2911~2915 (1996)
  19. "Regulation of cell morphology in B ymphocytes by interleukin 4", 160, pp.5366~5373 (1998)
  20. "Peritoneal cavity B cells are precursors of splenic IgM natural antibody-producing cells", 171, pp.5406~5414 (2003)
  21. "p21cipl is required for the differentiation of oligodendrocytes independently of cell cycle withdrawal", 2, pp.27~34 (2001)
  22. "CDK inhibitor p18 (INK4c) is required for the generation of functional plasma cells", 17, pp.179~189 (2002)
  23. "Deficiency of the cyclin kinase inhibitor p21 (WAF-1", CIP-1) promotes apoptosis of activated, pp.2004, 199[DOI]
  24. "The absence of p21Cip1", WAF1 alters keratinocyte growth and differentiation and promotes ras-tumor progression, 1996, pp.1, 3065~3075
  25. "The role of the cyclin-dependent kinase inhibitor p21 in Apoptosis", 1, pp.639~649 (2002)
  26. "Cell cycle control mechanisms in B-1 and B-2 lymphoid subsets", 27, pp.31~52 (2003)
  27. "Cutting edge", 166, pp.4273~4277 (2001)

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