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Expression Pattern of Immunoproteasome Subunits in Human Thymus

서재남|오권익
대한면역학회 (The Korean Association of Immunologists)|2009.12|Immune Network|제9권 제6호|pp. 285-288

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참고문헌

키워드

selectionpeptideimmunoproteasomeMHC (major histocompatibility complex)

초록

The expression pattern of immunoproteasomes in human thymus has not been analyzed but may have important consequences during thymic selection. Here we examined the expression patterns of immunoproteasome subunits in fetal and adult thymic tissues by immunohistochemistry and found that all three subunits are expressed in both cortical and medullary stromal cells. These data suggest that thymic selection in human can be affected by peptide repertoires generated by immunoproteasomes.

Abstract

The expression pattern of immunoproteasomes in human thymus has not been analyzed but may have important consequences during thymic selection. Here we examined the expression patterns of immunoproteasome subunits in fetal and adult thymic tissues by immunohistochemistry and found that all three subunits are expressed in both cortical and medullary stromal cells. These data suggest that thymic selection in human can be affected by peptide repertoires generated by immunoproteasomes.

참고문헌 (15)

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