T Cell Receptor Signaling That Regulates the Development of Intrathymic Natural Regulatory T Cells
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T cell receptor (TCR) signaling plays a critical role in T cell development, survival and differentiation. In the thymus,quantitative and/or qualitative differences in TCR signaling determine the fate of developing thymocytes and lead to positive and negative selection. Recently, it has been suggested that self-reactive T cells, escape from negative selection,should be suppressed in the periphery by regulatory T cells (Tregs) expressing Foxp3 transcription factor. Foxp3 is a master factor that is critical for not only development and survival but also suppressive activity of Treg. However, signals that determine Treg fate are not completely understood. The availability of mutant mice which harbor mutations in TCR signaling mediators will certainly allow to delineate signaling events that control intrathymic (natural) Treg (nTreg)development. Thus, we summarize the recent progress on the role of TCR signaling cascade components in nTreg development from the studies with murine model.
Abstract
T cell receptor (TCR) signaling plays a critical role in T cell development, survival and differentiation. In the thymus,quantitative and/or qualitative differences in TCR signaling determine the fate of developing thymocytes and lead to positive and negative selection. Recently, it has been suggested that self-reactive T cells, escape from negative selection,should be suppressed in the periphery by regulatory T cells (Tregs) expressing Foxp3 transcription factor. Foxp3 is a master factor that is critical for not only development and survival but also suppressive activity of Treg. However, signals that determine Treg fate are not completely understood. The availability of mutant mice which harbor mutations in TCR signaling mediators will certainly allow to delineate signaling events that control intrathymic (natural) Treg (nTreg)development. Thus, we summarize the recent progress on the role of TCR signaling cascade components in nTreg development from the studies with murine model.
참고문헌 (40)
- Zúñiga-Pflücker JC, "CD4 and CD8 act as co-receptors during thymic selection of the T cell repertoire", Semin Immunol, 3, pp.167~175 (1991)
- Sakaguchi S, "Organ-specific autoimmune diseases induced in mice by elimination of T cell subset. I. Evidence for the active participation of T cells in natural self-tolerance; deficit of a T cell subset as a possible cause of autoimmune disease", J Exp Med, 161, pp.72~87 (1985)
- Kim JM, "Regulatory T cells prevent catastrophic autoimmunity throughout the life span", Nature Immunol, 8, pp.191~197 (2007)
- Sauer S, "T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR", Proc Natl Acad Sci USA, 105, pp.7797~7802 (2008)
- Starr TK, "Positive and negative selection of T cells", Annu Rev Immunol, 21, pp.139~176 (2002)
- Au-Yeung BB, "The structure, regulation, and function of ZAP-70", Immunol Rev, 228, pp.41~57 (2009)
- Samelson LE, "Signal transduction mediated by the T cell antigen receptor: the role of adapter proteins", Annu Rev Immunol, 20, pp.371~394 (2002)
- Sommers CL, "LAT: a T lymphocyte adapter protein that couples the antigen receptor to downstream signaling pathways", Bioessays, 26, pp.61~67 (2004)
- Fuller DM, "A tale of two TRAPs: LAT and LAB in the regulation of lymphocyte development, activation, and autoimmunity", Immunol Res, 49, pp.97~108 (2011)
- Wange RL, "LAT, the linker for activation of T cells: a bridge between T cell-specific and general signaling pathways", Sci STIKE, 63, pp.re1~ (2000)
- Samelson LE, "Signal transduction mediated by the T cell antigen receptor: the role of adapter proteins", Annu Rev Immunol, 20, pp.371~394 (2002)
- Ho SN, "NFATc3, a lymphoid-specific NFATc family member that is calcium-regulated and exhibits distinct DNA binding specificity", J Biol Chem, 270, pp.19898~19907 (1995)
- Michie AM, "Regulation of thymocyte differentiation: pre-TCR signals and beta-selection", Semin Immunol, 14, pp.311~323 (2002)
- Ellmeier W, "The regulation of CD4 and CD8 coreceptor gene expression during T cell development", Annu Rev Immunol, 17, pp.523~554 (1999)
- Werlen G, "Signaling life and death in the thymus: timing is everything", Science, 299, pp.1859~1863 (2003)
- Gascoigne NR, "Signaling in thymic selection", Curr Opin Immunol, 23, pp.207~212 (2011)
- Burchill MA, "Linked T cell receptor and cytokine signaling govern the development of the regulatory T cell repertoire", Immunity, 28, pp.112~121 (2008)
- Lio CW, "A two-step process for thymic regulatory T cell development", Immunity, 28, pp.100~111 (2008)
- Cheng G, "T-cell tolerance and the multi-functional role of IL-2R signaling in T-regulatory cells", Immunol Rev, 241, pp.63~76 (2011)
- Bensinger SJ, "Major histocompatibility complex class II-positive cortical epithelium mediates the selection of CD4+25+ immunoregulatory T cells", J Exp Med, 194, pp.427~438 (2001)
- Tai X, "CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2", Nat Immunol, 6, pp.152~162 (2005)
- Fontenot JD, "Developmental regulation of Foxp3 expression during ontogeny", J Exp Med, 202, pp.901~916 (2005)
- Wan YY, "Identifying Foxp3-expressing suppressor cells with a bicistronic reporter", Proc Natl Acad Sci USA, 102, pp.5126~5131 (2005)
- Lio CW, "Becoming self-aware: the thymic education of regulatory T cells", Curr Opin Immunol, 23, pp.213~219 (2011)
- Robey E, "Selective events in T cell development", Annu Rev Immunol, 12, pp.675~705 (1994)
- Kim JK, "Impact of the TCR signal on regulatory T cell homeostasis, function, and trafficking", PLoS One, 4, pp.e6580~ (2009)
- Mamchak AA, "Unaltered negative selection and Treg development of self-reactive thymocytes in TCR transgenic Fyn-deficient mice", Eur J Immunol, 40, pp.539~547 (2010)
- Hsu LY, "A hypomorphic allele of ZAP-70 reveals a distinct thymic threshold for autoimmune disease versus autoimmune reactivity", J Exp Med, 206, pp.2527~2541 (2009)
- Tanaka S, "Graded attenuation of TCR signaling elicits distinct autoimmune diseases by altering thymic T cell selection and regulatory T cell function", J Immunol, 185, pp.2295~2305 (2010)
- Sommers CL, "A LAT mutation that inhibits T cell development yet induces lymphoproliferation", Science, 296, pp.2040~2043 (2002)
- Koonpaew S, "LAT-mediated signaling in CD4+CD25+ regulatory T cell development", J Exp Med, 203, pp.119~129 (2006)
- Chuck MI, "The role of the LATPLC- gamma1 interaction in T regulatory cell function", J Immunol, 184, pp.2476~2486 (2010)
- Willoughby JE, "Raf signaling but not the ERK effector SAP-1 is required for regulatory T cell development", J Immunol, 179, pp.6836~6844 (2007)
- Fu G, "Phospholipase Cγ1 is essential for T cell development, activation, and tolerance", J Exp Med, 207, pp.309~318 (2010)
- Chen X, "Preferential development of CD4 and CD8 T regulatory cells in RasGRP1-deficient mice", J Immunol, 180, pp.5973~5982 (2008)
- Tarakhovsky A, "A role for CD5 in TCR-mediated signal transduction and thymocyte selection", Science, 269, pp.535~537 (1995)
- Ordoñez-Rueda D, "Increased numbers of thymic and peripheral CD4+ CD25+Foxp3+ cells in the absence of CD5 signaling", Eur J Immunol, 39, pp.2233~2247 (2009)
- Turner M, "VAV proteins as signal integrators for multi-subunit immune-recognition receptors", Nat Rev Immunol, 2, pp.476~486 (2002)
- Tybulewicz VL, "Vav-family proteins in T-cell signalling", Curr Opin Immunol, 17, pp.267~274 (2005)
- Colacios C, "The p.Arg63Trp polymorphism controls Vav1 functions and Foxp3 regulatory T cell development", J Exp Med, 208, pp.2183~2191 (2011)
