본문 바로가기
KERD
논문KCI 등재

Regulation of Th2 Cell Immunity by Dendritic Cells

2

조회

0

다운로드

1

인용

0

참고문헌

키워드

초록

Th2 cell immunity is required for host defense against helminths, but it is detrimental in allergic diseases in humans. Unlike Th1 cell and Th17 cell subsets, the mechanism by which dendritic cells modulate Th2 cell responses has been obscure, in part because of the inability of dendritic cells to provide IL-4, which is indispensable for Th2 cell lineage commitment. In this regard, immune cells other than dendritic cells, such as basophils and innate lymphoid cells, have been suggested as Th2 cell inducers. More recently, multiple independent researchers have shown that specialized subsets of dendritic cells mediate Th2 cell responses. This review will discuss the current understanding related to the regulation of Th2 cell responses by dendritic cells and other immune cells.

Abstract

Th2 cell immunity is required for host defense against helminths, but it is detrimental in allergic diseases in humans. Unlike Th1 cell and Th17 cell subsets, the mechanism by which dendritic cells modulate Th2 cell responses has been obscure, in part because of the inability of dendritic cells to provide IL-4, which is indispensable for Th2 cell lineage commitment. In this regard, immune cells other than dendritic cells, such as basophils and innate lymphoid cells, have been suggested as Th2 cell inducers. More recently, multiple independent researchers have shown that specialized subsets of dendritic cells mediate Th2 cell responses. This review will discuss the current understanding related to the regulation of Th2 cell responses by dendritic cells and other immune cells.

참고문헌 (95)

  1. Kapsenberg, M. L., "Dendritic-cell control of pathogen-driven T-cell polarization", Nat. Rev. Immunol, 3, pp.984~993 (2003)
  2. 장재훈, "Regulatory T Cells in B Cell Follicles", Immune Network, 14(5), pp.227~236 (2014), 대한면역학회[DOI]
  3. Walsh, K. P., "Dendritic cells and other innate determinants of T helper cell polarisation", Trends Immunol, 34, pp.521~530 (2013)
  4. O'Neill, L. A., "The history of Toll-like receptors - redefining innate immunity", Nat. Rev. Immunol, 13, pp.453~460 (2013)
  5. Pulendran, B., "Lipopolysaccharides from distinct pathogens induce different classes of immune responses in vivo", J. Immunol, 167, pp.5067~5076 (2001)
  6. Pfeiffer, C., "Altered peptide ligands can control CD4 T lymphocyte differentiation in vivo", J. Exp. Med, 181, pp.1569~1574 (1995)
  7. King, I. L., "GM-CSF-dependent, CD103+dermal dendritic cells play a critical role in Th effector cell differentiation after subcutaneous immunization", J. Exp. Med, 207, pp.953~961 (2010)
  8. Edelson, B. T., "Batf3-dependent CD11b(low", -) peripheral dendritic cells are GM-CSF-independent and are not required for Th cell priming after subcutaneous immunization, 2011, pp.6, e25660~
  9. Persson, E. K., "IRF4 transcription-factor-dependent CD103(+)CD11b(+) dendritic cells drive mucosal T helper 17 cell differentiation", Immunity, 38, pp.958~969 (2013)
  10. Schlitzer, A., "IRF4 transcription factor-dependent CD11b+ dendritic cells in human and mouse control mucosal IL-17 cytokine responses", Immunity, 38, pp.970~983 (2013)
  11. Igyarto, B. Z., "Skin-resident murine dendritic cell subsets promote distinct and opposing antigen-specific T helper cell responses", Immunity, 35, pp.260~272 (2011)
  12. Lim, H., "Proatherogenic conditions promote autoimmune T helper 17 cell responses in vivo", Immunity, 40, pp.153~165 (2014)
  13. Ryu, H., "Regulation of IL-17 in atherosclerosis and related autoimmunity", Cytokine, 74, pp.219~227 (2015)
  14. Lalor, S. J., "Caspase-1-processed cytokines IL-1beta and IL-18 promote IL-17 production by gammadelta and CD4 T cells that mediate autoimmunity", J. Immunol, 186, pp.5738~5748 (2011)
  15. Bonifazi, P., "Balancing inflammation and tolerance in vivo through dendritic cells by the commensal Candida albicans", Mucosal Immunol, 2, pp.362~374 (2009)
  16. McGuirk, P., "Pathogen-specific T regulatory 1 cells induced in the respiratory tract by a bacterial molecule that stimulates interleukin 10 production by dendritic cells: a novel strategy for evasion of protective T helper type 1responses by Bordetella pertussis", J. Exp. Med, 195, pp.221~231 (2002)
  17. Depaolo, R. W., "Toll-like receptor 6 drives differentiation of tolerogenic dendritic cells and contributes to LcrV-mediated plague pathogenesis", Cell Host Microbe, 4, pp.350~361 (2008)
  18. Dillon, S., "Yeast zymosan, a stimulus for TLR2 and dectin-1, induces regulatory antigen-presenting cells and immunological tolerance", J. Clin. Invest, 116, pp.916~928 (2006)
  19. Coombes, J. L., "A functionally specialized population of mucosal CD103+DCs induces Foxp3+regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism", J. Exp. Med, 204, pp.1757~1764 (2007)
  20. Worthington, J. J., "Intestinal dendritic cells specialize to activate transforming growth factor-beta and induce Foxp3+regulatory T cells via integrin alphavbeta8", Gastroenterology, 141, pp.1802~1812 (2011)
  21. Jonuleit, H., "Induction of interleukin 10-producing, nonproliferating CD4(+) T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells", J. Exp. Med, 192, pp.1213~1222 (2000)
  22. 고현정, "Regulation of Intestinal Immune System by Dendritic Cells", Immune Network, 15(1), pp.1~8 (2015), 대한면역학회[DOI]
  23. van Rijt, L. S., "In vivo depletion of lung CD11c +dendritic cells during allergen challenge abrogates the characteristic features of asthma", J. Exp. Med, 201, pp.981~991 (2005)
  24. Lim, H., "Distinct regulation of Th2 and Th17 responses to allergens by pulmonary antigen presenting cells in vivo", Immunol. Lett, 156, pp.140~148 (2013)
  25. Phythian-Adams, A. T., "CD11c depletion severely disrupts Th2 induction and development in vivo", J. Exp. Med, 207, pp.2089~2096 (2010)
  26. Smith, K. A., "Chronic helminth infection promotes immune regulation in vivo through dominance of CD11cloC", J. Immunol, 186, pp.7098~7109 (2011)
  27. Maldonado-Lopez, R., "CD8alpha+ and CD8alpha− subclasses of dendritic cells direct the development of distinct T helper cells in vivo", J. Exp. Med, 189, pp.587~592 (1999)
  28. Pulendran, B., "Distinct dendritic cell subsets differentially regulate the class of immune response in vivo", Proc. Natl. Acad. Sci. U. S. A, 96, pp.1036~1041 (1999)
  29. Plantinga, M., "Conventional and monocyte-derived CD11b(+) dendritic cells initiate and maintain T helper 2 cell-mediated immunity to house dust mite allergen", Immunity, 38, pp.322~335 (2013)
  30. Kitajima, M., "Cutting edge: identification of the thymic stromal lymphopoietin-responsive dendritic cell subset critical for initiation of type 2 contact hypersensitivity", J. Immunol, 191, pp.4903~4907 (2013)
  31. Steinfelder, S., "The major component in schistosome eggs responsible for conditioning dendritic cells for Th2 polarization is a T2ribonuclease (omega-1)", J. Exp. Med, 206, pp.1681~1690 (2009)
  32. Everts, B., "Schistosome-derived omega-1drives Th2 polarization by suppressing protein synthesis following internalization by the mannose receptor", J. Exp. Med, 209, pp.1753~1767 (2012)
  33. Dillon, S., "A Toll-like receptor 2 ligand stimulates Th2 responses in vivo, via induction of extracellular signal-regulated kinase mitogen-activated protein kinase and c-Fos in dendritic cells", J. Immunol, 172, pp.4733~4743 (2004)
  34. Eisenbarth, S. C., "Lipopolysaccharide-enhanced, toll-like receptor 4-dependent T helper cell type 2 responses to inhaled antigen", J. Exp. Med, 196, pp.1645~1651 (2002)
  35. Barrett, N. A., "Dectin-2 mediates Th2 immunity through the generation of cysteinyl leukotrienes", J. Exp. Med, 208, pp.593~604 (2011)
  36. Kool, M., "Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells", J. Exp. Med, 205, pp.869~882 (2008)
  37. Yang, D., "High-mobility group nucleosome-binding protein 1 acts as an alarmin and is critical for lipopolysaccharide-induced immune responses", J. Exp. Med, 209, pp.157~171 (2012)
  38. Kitajima, M., "TSLP enhances the function of helper type 2 cells", Eur. J. Immunol, 41, pp.1862~1871 (2011)
  39. He, R., "TSLP acts on infiltrating effector T cells to drive allergic skin inflammation", Proc. Natl. Acad. Sci. U. S. A, 105, pp.11875~11880 (2008)
  40. Schmitz, J., "IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines", Immunity, 23, pp.479~490 (2005)
  41. Abraham, S. N., "Mast cell-orchestrated immunity to pathogens", Nat. Rev. Immunol, 10, pp.440~452 (2010)
  42. Lloyd, C. M., "IL-33 family members and asthma - bridging innate and adaptive immune responses", Curr. Opin. Immunol, 22, pp.800~806 (2010)
  43. Angkasekwinai, P., "Interleukin 25 promotes the initiation of proallergic type 2responses", J. Exp. Med, 204, pp.1509~1517 (2007)
  44. Caruso, R., "Interleukin-25 inhibits interleukin-12 production and Th1 cell-driven inflammation in the gut", Gastroenterology, 136, pp.2270~2279 (2009)
  45. Kleinschek, M. A., "IL-25 regulates Th17 function in autoimmune inflammation", J. Exp. Med, 204, pp.161~170 (2007)
  46. Licona-Limon, P., "TH2, allergy and group 2 innate lymphoid cells", Nat. Immunol, 14, pp.536~542 (2013)
  47. Mjosberg, J. M., "Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161", Nat. Immunol, 12, pp.1055~1062 (2011)
  48. 우연덕, "The Roles of Innate Lymphoid Cells in the Development of Asthma", Immune Network, 14(4), pp.171~181 (2014), 대한면역학회
  49. Klein Wolterink, R. G., "Pulmonary innate lymphoid cells are major producers of IL-5 and IL-13 in murine models of allergic asthma", Eur. J. Immunol, 42, pp.1106~1116 (2012)
  50. Kim, B. S., "TSLP elicits IL-33-independent innate lymphoid cell responses to promote skin inflammation", Sci. Transl. Med, 5, pp.170ra16~ (2013)
  51. Halim, T. Y., "Lung natural helper cells are a critical source of Th2 cell-type cytokines in protease allergen-induced airway inflammation", Immunity, 36, pp.451~463 (2012)
  52. Neill, D. R., "Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity", Nature, 464, pp.1367~1370 (2010)
  53. Fukuoka, A., "Identification of a novel type 2 innate immunocyte with the ability to enhance IgE production", Int. Immunol, 25, pp.373~382 (2013)
  54. Sokol, C. L., "Basophils function as antigen-presenting cells for an allergen-induced T helper type 2 response", Nat. Immunol, 10, pp.713~720 (2009)
  55. Perrigoue, J. G., "MHC class II-dependent basophil-CD4+T cell interactions promote T(H)2 cytokine-dependent immunity", Nat. Immunol, 10, pp.697~705 (2009)
  56. Tang, H., "The T helper type 2 response to cysteine proteases requires dendritic cell-basophil cooperation via ROS-mediated signaling", Nat. Immunol, 11, pp.608~617 (2010)
  57. Nakanishi, K., "Basophils as APC in Th2 response in allergic inflammation and parasite infection", Curr. Opin. Immunol, 22, pp.814~820 (2010)
  58. Galli, S. J., "Mast cells in allergy and infection:versatile effector and regulatory cells in innate and adaptive immunity", Eur. J. Immunol, 40, pp.1843~1851 (2010)
  59. Ryan, J. J., "Mast cell homeostasis: a fundamental aspect of allergic disease", Crit. Rev. Immunol, 27, pp.15~32 (2007)
  60. Woolley, D. E., "The mast cell in inflammatory arthritis", N. Engl. J. Med, 348, pp.1709~1711 (2003)
  61. Ozdamar, S. O., "Mast cells in psoriasis", Dermatology, 192, pp.190~ (1996)
  62. Theoharides, T. C., "Mast cells: the immune gate to the brain", Life Sci, 46, pp.607~617 (1990)
  63. Nakae, S., "Mast cells enhance T cell activation:importance of mast cell costimulatory molecules and secreted TNF", J. Immunol, 176, pp.2238~2248 (2006)
  64. Liu, Z. Q., "Mast cell-derived serine proteinase regulates T helper 2 polarization", Sci. Rep, 4, pp.4649~ (2014)
  65. Mazzoni, A., "Histamine regulates cytokine production in maturing dendritic cells, resulting in altered T cell polarization", J. Clin. Invest, 108, pp.1865~1873 (2001)
  66. Skokos, D., "Mast cell-derived exosomes induce phenotypic and functional maturation of dendritic cells and elicit specific immune responses in vivo", J. Immunol, 170, pp.3037~3045 (2003)
  67. Smith, K. A., "Type 2 innate immunity in helminth infection is induced redundantly and acts autonomously following CD11c(+) cell depletion", Infect. Immun, 80, pp.3481~3489 (2012)
  68. Tjota, M. Y., "IL-33-dependent induction of allergic lung inflammation by FcgammaRIII signaling", J. Clin. Invest, 123, pp.2287~2297 (2013)
  69. Connor, L. M., "Helminth-conditioned dendritic cells prime CD4+T cells to IL-4 production in vivo", J. Immunol, 193, pp.2709~2717 (2014)
  70. Kumamoto, Y., "CD301b(+) dermal dendritic cells drive T helper 2 cell-mediated immunity", Immunity, 39, pp.733~743 (2013)
  71. Kumamoto, Y., "MGL2 Dermal dendritic cells are sufficient to initiate contact hypersensitivity in vivo", PLoS One, 4, pp.e5619~ (2009)
  72. Williams, J. W., "Transcription factor IRF4 drives dendritic cells to promote Th2differentiation", Nat. Commun, 4, pp.2990~ (2013)
  73. Halim, T. Y., "Group 2 innate lymphoid cells license dendritic cells to potentiate memory TH2cell responses", Nat. Immunol, 17, pp.57~64 (2016)
  74. Bell, B. D., "The transcription factor STAT5is critical in dendritic cells for the development of TH2 but not TH1 responses", Nat. Immunol, 14, pp.364~371 (2013)
  75. Ito, T., "TSLPactivated dendritic cells induce an inflammatory T helper type 2cell response through OX40 ligand", J. Exp. Med, 202, pp.1213~1223 (2005)
  76. Tussiwand, R., "Klf4 expression in conventional dendritic cells is required for T helper 2 cell responses", Immunity, 42, pp.916~928 (2015)
  77. Leon, B., "Regulation of T(H)2 development by CXCR5+dendritic cells and lymphotoxin-expressing B cells", Nat. Immunol, 13, pp.681~690 (2012)
  78. Murakami, R., "A unique dermal dendritic cell subset that skews the immune response toward Th2", PLoS One, 8, pp.e73270~ (2013)
  79. Al-Shami, A., "A role for TSLP in the development of inflammation in an asthma model", J. Exp. Med, 202, pp.829~839 (2005)
  80. Sato, K., "Contribution of dermal macrophage trafficking in the sensitization phase of contact hypersensitivity", J. Immunol, 161, pp.6835~6844 (1998)
  81. Suzuki, N., "Molecular cloning and expression of cDNA encoding human macrophage C-type lectin. Its unique carbohydrate binding specificity for Tn antigen", J. Immunol, 156, pp.128~135 (1996)
  82. Latchman, Y., "PD-L2 is a second ligand for PD-1 and inhibits T cell activation", Nat. Immunol, 2, pp.261~268 (2001)
  83. Tseng, S. Y., "B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells", J. Exp. Med, 193, pp.839~846 (2001)
  84. Loke, P., "PD-L1 and PD-L2 are differentially regulated by Th1 and Th2 cells", Proc. Natl. Acad. Sci. U. S. A, 100, pp.5336~5341 (2003)
  85. Ishiwata, K., "Costimulator B7-DC attenuates strong Th2 responses induced by Nippostrongylus brasiliensis", J. Immunol, 184, pp.2086~2094 (2010)
  86. Lewkowich, I. P., "PD-L2 modulates asthma severity by directly decreasing dendritic cell IL-12 production", Mucosal Immunol, 6, pp.728~739 (2013)
  87. Akbari, O., "PD-L1 and PD-L2 modulate airway inflammation and iNKT-cell-dependent airway hyperreactivity in opposing directions", Mucosal Immunol, 3, pp.81~91 (2010)
  88. Gao, Y., "Control of T helper 2 responses by transcription factor IRF4-dependent dendritic cells", Immunity, 39, pp.722~732 (2013)
  89. Nakano, H., "Migratory properties of pulmonary dendritic cells are determined by their developmental lineage", Mucosal Immunol, 6, pp.678~691 (2013)
  90. Raymond, M., "Selective control of SIRP-alpha-positive airway dendritic cell trafficking through CD47 is critical for the development of T(H)2-mediated allergic inflammation", J. Allergy Clin. Immunol, 124, pp.1333~1342 (2009)
  91. Beaty, S. R., "Diverse and potent chemokine production by lung CD11bhigh dendritic cells in homeostasis and in allergic lung inflammation", J. Immunol, 178, pp.1882~1895 (2007)
  92. Iwasaki, A., "Unique functions of CD11b +, CD8 alpha +, and double-negative Peyer's patch dendritic cells", J. Immunol, 166, pp.4884~4890 (2001)
  93. Larson, R. P., "Cutting edge: allergen-specific CD4 T cells respond indirectly to thymic stromal lymphopoietin to promote allergic responses in the skin", J. Immunol, 190, pp.4474~4477 (2013)
  94. Rimoldi, M., "Intestinal immune homeostasis is regulated by the crosstalk between epithelial cells and dendritic cells", Nat. Immunol, 6, pp.507~514 (2005)
  95. Lehtonen, A., "Differential expression of IFN regulatory factor 4 gene in human monocyte-derived dendritic cells and macrophages", J. Immunol, 175, pp.6570~6579 (2005)

관련 논문AI추천

이 간행물의 다른 논문 (7건)