TLR10 and Its Unique Anti-Inflammatory Properties and Potential Use as a Target in Therapeutics
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TLRs are pattern recognition receptors (PRRs) whose cytoplasmic signalling domain is similar to that of IL-1. The extracellular domain of TLRs serve as the binding site of pathogen associated molecular patterns. TLRs are found on both plasma and endosomal membranes and they mainly exert their function by activating genes which lead to production of inflammatory factors. The latest TLR to be discovered, TLR10 is a unique TLR which exhibit anti-inflammatory properties. TLR10 is found on the plasma membrane with other TLRs namely TLR1, TLR2, TLR4, TLR5 and TLR6. Studies have revealed that TLR10 is found on the same gene cluster with TLR1 and TLR6 and is also a coreceptor of TLR2. Up to date, TLR10 is the only TLR which exhibit anti-inflammatory property. Previously, TLR10 was thought to be an “orphan receptor” but much recent studies have identified ligands for TLR10. Currently there is no review article on TLR10 that has been published. In this narrative review, we are going to give an account of TLR10, its functions mainly as an anti-inflammatory PRR and its possible applications as a target in therapeutics.
Abstract
TLRs are pattern recognition receptors (PRRs) whose cytoplasmic signalling domain is similar to that of IL-1. The extracellular domain of TLRs serve as the binding site of pathogen associated molecular patterns. TLRs are found on both plasma and endosomal membranes and they mainly exert their function by activating genes which lead to production of inflammatory factors. The latest TLR to be discovered, TLR10 is a unique TLR which exhibit anti-inflammatory properties. TLR10 is found on the plasma membrane with other TLRs namely TLR1, TLR2, TLR4, TLR5 and TLR6. Studies have revealed that TLR10 is found on the same gene cluster with TLR1 and TLR6 and is also a coreceptor of TLR2. Up to date, TLR10 is the only TLR which exhibit anti-inflammatory property. Previously, TLR10 was thought to be an “orphan receptor” but much recent studies have identified ligands for TLR10. Currently there is no review article on TLR10 that has been published. In this narrative review, we are going to give an account of TLR10, its functions mainly as an anti-inflammatory PRR and its possible applications as a target in therapeutics.
참고문헌 (49)
- Kumar H, "Pathogen recognition by the innate immune system", Int Rev Immunol, 30, pp.16~34 (2011)
- Moresco EM, "Toll-like receptors", Curr Biol, 21, pp.R488~ (2011)
- Akira S, "Toll-like receptor signalling", Nat Rev Immunol, 4, pp.499~511 (2004)
- Akira S, "Toll-like receptor signaling", J Biol Chem, 278, pp.38105~38108 (2003)
- Nie L, "Toll-like receptors, associated biological roles, and signaling networks in non-mammals", Front Immunol, 9, pp.1523~ (2018)
- Vidya MK, "Toll-like receptors : significance, ligands, signaling pathways, and functions in mammals", Int Rev Immunol, 37, pp.20~36 (2018)
- Kawasaki T, "Toll-like receptor signaling pathways", Front Immunol, 5, pp.461~ (2014)
- Jiménez-Dalmaroni MJ, "The critical role of toll-like receptors--from microbial recognition to autoimmunity : a comprehensive review", Autoimmun Rev, 15, pp.1~8 (2016)
- Kang JY, "Structural biology of the toll-like receptor family", Annu Rev Biochem, 80, pp.917~941 (2011)
- Takeda K, "Toll-like receptors in innate immunity", Int Immunol, 17, pp.1~14 (2005)
- Blasius AL, "Intracellular toll-like receptors", Immunity, 32, pp.305~315 (2010)
- Morgan AR, "Genetic variation within TLR10 is associated with Crohn's disease in a New Zealand population", Hum Immunol, 73, pp.416~420 (2012)
- Lim KH, "Toll-like receptor signaling", Cold Spring Harb Perspect Biol, 5, pp.a011247~ (2013)
- Henrick BM, "TLR10 senses HIV-1 proteins and significantly enhances HIV-1 infection", Front Immunol, 10, pp.482~ (2019)
- Oosting M, "Human TLR10 is an anti-inflammatory pattern-recognition receptor", Proc Natl Acad Sci U S A, 111, pp.E4478~ (2014)
- Torices S, "A functional variant of TLR10 modifies the activity of NFkB and may help predict a worse prognosis in patients with rheumatoid arthritis", Arthritis Res Ther, 18, pp.221~ (2016)
- Verma R, "1, 25-Dihydroxyvitamin D3 up-regulates TLR10 while down-regulating TLR2, 4, and 5 in human monocyte THP-1", J Steroid Biochem Mol Biol, 141, pp.1~6 (2014)
- Hasan U, "Human TLR10 is a functional receptor, expressed by B cells and plasmacytoid dendritic cells, which activates gene transcription through MyD88", J Immunol, 174, pp.2942~2950 (2005)
- Xiao W, "Polymorphisms in TLR1, TLR6 and TLR10 genes and the risk of Graves' disease", Autoimmunity, 48, pp.13~18 (2015)
- Chuang T, "Identification of hTLR10 : a novel human toll-like receptor preferentially expressed in immune cells", Biochim Biophys Acta, 1518, pp.157~161 (2001)
- Tarlinton RE, "RNA expression of TLR10 in normal equine tissues", BMC Res Notes, 9, pp.353~ (2016)
- Shinkai H, "Porcine toll-like receptor 1, 6, and 10 genes : complete sequencing of genomic region and expression analysis", Mol Immunol, 43, pp.1474~1480 (2006)
- Nagase H, "Expression and function of toll-like receptors in eosinophils : activation by toll-like receptor 7 ligand", J Immunol, 171, pp.3977~3982 (2003)
- Bourke E, "The toll-like receptor repertoire of human B lymphocytes : inducible and selective expression of TLR9 and TLR10 in normal and transformed cells", Blood, 102, pp.956~963 (2003)
- Park HJ, "Association between toll-like receptor 10(TLR10)gene polymorphisms and childhood IgA nephropathy", Eur J Pediatr, 170, pp.503~509 (2011)
- Bell MP, "FOXP3 regulates TLR10 expression in human T regulatory cells", J Immunol, 179, pp.1893~1900 (2007)
- Kim D, "Reactive oxygen species enhance TLR10 expression in the human monocytic cell line THP-1", Int J Mol Sci, 11, pp.3769~3782 (2010)
- Sindhu S, "Increased expression of the innate immune receptor TLR10 in obesity and type-2 diabetes : association with ROS-mediated oxidative stress", Cell Physiol Biochem, 45, pp.572~590 (2018)
- Mourits VP, "The role of Toll-like receptor 10 in modulation of trained immunity", Immunology, 159, pp.289~297 (2020)
- Hess NJ, "TLR10 suppresses the activation and differentiation of monocytes with effects on DC-mediated adaptive immune responses", J Leukoc Biol, 101, pp.1245~1252 (2017)
- Jiménez-Sousa MÁ, "Vitamin D in human immunodeficiency virus infection : influence on immunity and disease", Front Immunol, 9, pp.458~ (2018)
- Verma R, "1, 25-Dihydroxyvitamin D3 facilitates M2 polarization and upregulates TLR10 expression on human microglial cells", Neuroimmunomodulation, 23, pp.75~80 (2016)
- Pachathundikandi SK, "Differential expression of interleukin 1β during Helicobacter pylori infection of toll-like receptor 2(TLR2)-and TLR10-expressing HEK293 cell lines", J Infect Dis, 214, pp.166~167 (2016)
- Zhang Y, "Increased expression of TLR10 in B cell subsets correlates with disease activity in rheumatoid arthritis", Mediators Inflamm, 2018, pp.9372436~ (2018)
- Nagashima H, "Toll-like receptor 10 in Helicobacter pylori infection", J Infect Dis, 212, pp.1666~1676 (2015)
- Regan T, "Identification of TLR10 as a key mediator of the inflammatory response to Listeria monocytogenes in intestinal epithelial cells and macrophages", J Immunol, 191, pp.6084~6092 (2013)
- Tang H, "TLR10 and NFKBIA contributed to the risk of hip osteoarthritis : systematic evaluation based on Han Chinese population", Sci Rep, 8, pp.10243~ (2018)
- Abad C, "Association of toll-like receptor 10 and susceptibility to Crohn's disease independent of NOD2", Genes Immun, 12, pp.635~642 (2011)
- Smith NL, "Reduced expression of TLR3, TLR10 and TREM1 by human macrophages in chronic cavitary pulmonary aspergillosis, and novel associations of VEGFA, DENND1B and PLAT", Clin Microbiol Infect, 20, pp.O960~O968 (2014)
- Ravishankar Ram M, "Polymorphisms at locus 4p14 of toll-like receptors TLR-1 and TLR-10 confer susceptibility to gastric carcinoma in Helicobacter pylori infection", PLoS One, 10, pp.e0141865~ (2015)
- Li M, "IRAK2 and TLR10 confer risk of Hashimoto's disease : a genetic association study based on the Han Chinese population", J Hum Genet, 64, pp.617~623 (2019)
- Kim SK, "A missense polymorphism(rs11466653, Met326Thr)of toll-like receptor 10(TLR10)is associated with tumor size of papillary thyroid carcinoma in the Korean population", Endocrine, 43, pp.161~169 (2013)
- Purdue MP, "A pooled investigation of toll-like receptor gene variants and risk of non-Hodgkin lymphoma", Carcinogenesis, 30, pp.275~281 (2009)
- Stevens VL, "Genetic variation in the toll-like receptor gene cluster(TLR10-TLR1-TLR6)and prostate cancer risk", Int J Cancer, 123, pp.2644~2650 (2008)
- Kızıldağ S, "Effect of TLR10(2322A", G, 720A, A)polymorphisms on the pathogenesis of Crimean Congo hemorrhagic fever disease, pp.J Med Virol, 2018[DOI]
- Tongtawee T, "Genetic polymorphisms in TLR1, TLR2, TLR4, and TLR10 of Helicobacter pylori-associated gastritis : a prospective cross-sectional study in Thailand", Eur J Cancer Prev, 27, pp.118~123 (2018)
- Ma X, "Full-exon resequencing reveals toll-like receptor variants contribute to human susceptibility to tuberculosis disease", PLoS One, 2, pp.e1318~ (2007)
- Zhou XX, "Sequence variants in toll-like receptor 10 are associated with nasopharyngeal carcinoma risk", Cancer Epidemiol Biomarkers Prev, 15, pp.862~866 (2006)
- Boutens L, "A role for TLR10 in obesity and adipose tissue morphology", Cytokine, 108, pp.205~212 (2018)
