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Clinical Significance of Toll-Like Receptor and Toll-Like Receptor Blocker

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초록

The mammalian Toll-like receptor (TLR) family, consisting of 13 members, plays an important role in innate recognition of specific patterns of microbial products. TLR-dependent recognition subsequently causes an activation of antigen-specific adaptive immunity. TLR-mediated signaling pathways consist of two pathways that induce gene expression: the myeloid differentiation primary response gene 88 (MyD88)-dependent pathway and Toll/interleukin-1 receptor-domain containing adaptor protein-inducing interferon-β-dependent pathway. Synthetic TLR agonists, as well as TLR antagonists, affect and manipulate the host defense systems, and some of these immunomodulating agents may help to overcome intrinsic disturbances of the TLR system to offer new treatment options in urinary tract infection (UTI). Future studies are necessary to clarify additional associations between TLRs and severity of UTI, which may help in developing new treatment options.

Abstract

The mammalian Toll-like receptor (TLR) family, consisting of 13 members, plays an important role in innate recognition of specific patterns of microbial products. TLR-dependent recognition subsequently causes an activation of antigen-specific adaptive immunity. TLR-mediated signaling pathways consist of two pathways that induce gene expression: the myeloid differentiation primary response gene 88 (MyD88)-dependent pathway and Toll/interleukin-1 receptor-domain containing adaptor protein-inducing interferon-β-dependent pathway. Synthetic TLR agonists, as well as TLR antagonists, affect and manipulate the host defense systems, and some of these immunomodulating agents may help to overcome intrinsic disturbances of the TLR system to offer new treatment options in urinary tract infection (UTI). Future studies are necessary to clarify additional associations between TLRs and severity of UTI, which may help in developing new treatment options.

참고문헌 (42)

  1. Hansson GK, "Toll to be paid at the gateway to the vessel wall", Arterioscler Thromb Vasc Biol, 25, pp.1085~1087 (2005)
  2. Medzhitov R, "A human homologue of the Drosophila Toll protein signals activation of adaptive immunity", Nature, 388, pp.394~397 (1997)
  3. Takeda K, "Toll-like receptors", Curr Protoc Immunol, 109, pp.1~10 (2015)
  4. Wullt B, "P-fimbriae trigger mucosal responses to Escherichia coli in the human urinary tract", Cell Microbiol, 3, pp.255~264 (2001)
  5. Fischer H, "Mechanism of pathogen-specific TLR4 activation in the mucosa: fimbriae, recognition receptors and adaptor protein selection", Eur J Immunol, 36, pp.267~277 (2005)
  6. Wyllie DH, "Evidence for an accessory protein function for Toll-like receptor 1 in anti-bacterial responses", J lmmunol, 165, pp.7125~7132 (2000)
  7. Takeuchi O, "Cutting edge : role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins", J lmmunol, 169, pp.10~14 (2002)
  8. Alexopoulou L, "Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1-and TLR2-deficient mice", Nat Med, 8, pp.878~884 (2002)
  9. Akira S, "Pathogen recognition and innate immunity", Cell, 124, pp.783~801 (2006)
  10. Tsuboi N, "Roles of toll-like receptors in C-C chemokine production by renal tubular epithelial cells", J Immunol, 169, pp.2026~2033 (2002)
  11. Alexopoulou L, "Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3", Nature, 413, pp.732~738 (2001)
  12. Schulz O, "Toll-like receptor 3 promotes crosspriming to virus-infected cells", Nature, 433, pp.887~892 (2005)
  13. Hoshino K, "Cutting edge : Toll-like receptor 4(TLR4)-deficient mice are hyporesponsive to lipopolysaccharide : evidence for TLR4 as the Lps gene product", J Immunol, 162, pp.3749~3752 (1999)
  14. Kawasaki K, "Mouse toll-like receptor 4. MD-2 complex mediates lipopolysaccharide-mimetic signal transduction by Taxol", J Biol Chem, 275, pp.2251~2254 (2000)
  15. Byrd-Leifer CA, "The role of MyD88 and TLR4 in the LPS-mimetic activity of Taxol", Eur J Immunol, 31, pp.2448~2457 (2001)
  16. Rassa JC, "Murine retroviruses activate B cells via interaction with Toll-like receptor 4", Proc Natl Acad Sci U S A, 99, pp.2281~2286 (2002)
  17. Schilling JD, "Bacterial invasion augments epithelial cytokine responses to Escherichia coli through a lipopolysaccharide-dependent mechanism", J Immunol, 166, pp.1148~1155 (2001)
  18. Chassin C, "Renal collecting duct epithelial cells react to pyelonephritis-associated Escherichia coli by activating distinct TLR4-dependent and-independent inflammatory pathways", J Immunol, 177, pp.4773~4784 (2006)
  19. Hayashi F, "The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5", Nature, 410, pp.1099~1103 (2001)
  20. Lane MC, "Expression of flagella is coincident with uropathogenic Escherichia coli ascension to the upper urinary tract", Proc Natl Acad Sci U S A, 104, pp.16669~16674 (2007)
  21. Hawn TR, "A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to legionnaires' disease", J Exp Med, 198, pp.1563~1572 (2003)
  22. Ozinsky A, "The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors", Proc Natl Acad Sci U S A, 97, pp.13766~13771 (2000)
  23. Hemmi H, "Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway", Nat Immunol, 3, pp.196~200 (2002)
  24. Diebold SS, "Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA", Science, 303, pp.1529~1531 (2004)
  25. Berland R, "Toll-like receptor 7-dependent loss of B cell tolerance in pathogenic autoantibody knockin mice", Immunity, 25, pp.429~440 (2006)
  26. Gorden KK, "Cutting edge : activation of murine TLR8 by a combination of imidazoquinoline immune response modifiers and PolyT oligodeoxynucleotides", J Immunol, 177, pp.6584~6587 (2006)
  27. Leadbetter EA, "Chromatin-IgG complexes activate B cells by dual engagement of IgM and toll-like receptors", Nature, 416, pp.603~607 (2002)
  28. Marshak-Rothstein A, "Toll-like receptors in systemic autoimmune disease", Nat Rev Immunol, 6, pp.823~835 (2006)
  29. Zhang D, "A toll-like receptor that prevents infection by uropathogenic bacteria", Science, 303, pp.1522~1526 (2004)
  30. Mathur R, "A mouse model of Salmonella typhi infection", Cell, 151, pp.590~602 (2012)
  31. Koblansky AA, "Recognition of profilin by Toll-like receptor 12 is critical for host resistance to Toxoplasma gondii", Immunity, 38, pp.119~130 (2013)
  32. Oldenburg M, "TLR13 recognizes bacterial 23S rRNA devoid of erythromycin resistance-forming modification", Science, 337, pp.1111~1115 (2012)
  33. Li XD, "Sequence specific detection of bacterial 23S ribosomal RNA by TLR13", Elife, 1, pp.e00102~ (2012)
  34. Akira S, "Toll-like receptor signaling", Nat Rev lmmunol, 4, pp.499~511 (2004)
  35. Horng T, "The adaptor molecule TIRAP provides signaling specificity for toll-like receptors", Nature, 420, pp.329~333 (2002)
  36. Honda K, "Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in toll-like receptor signaling", Proc Natl Acad Sci U S A, 101, pp.15416~15421 (2004)
  37. Fitzgerald KA, "LPS-TLR4 signaling to IRF-3", 7 and NF-kappaB involves the toll adapters TRAM and TRIF, 2003, pp.198, 1043~1055
  38. Hoebe K, "Identification of Lps2 as a key transducer of MyD88-independent TIR signaling", Nature, 424, pp.743~748 (2003)
  39. Meylan E, "RIP1 is an essential mediator of toll-like receptor 3-induced NF-kappa B activation", Nat Immunol, 5, pp.503~507 (2004)
  40. Scherberich JE, "Impact of Toll-like receptor signalling on urinary tract infection", Int J Antimicrob Agents, 31(Suppl 1), pp.S9~S14 (2008)
  41. Spies B, "Vaccination with plasmid DNA activates dendritic cells via Toll-like receptor 9(TLR9)but functions in TLR9-deficient mice", J Immunol, 171, pp.5908~5912 (2003)
  42. Decker T, "Sepsis : avoiding its deadly toll", J Clin Invest, 113, pp.1387~1389 (2004)

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