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Ongoing Clinical Trials of Vaccines to Fight against COVID-19 Pandemic

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Coronavirus disease 2019 (COVID-19) has developed as a pandemic, and it created an outrageous effect on the current healthcare and economic system throughout the globe. To date, there is no appropriate therapeutics or vaccines against the disease. The entire human race is eagerly waiting for the development of new therapeutics or vaccines against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Efforts are being taken to develop vaccines at a rapid rate for fighting against the ongoing pandemic situation. Amongst the various vaccines under consideration, some are either in the preclinical stage or in the clinical stages of development (phase-I, -II, and -III). Even, phase-III trials are being conducted for some repurposed vaccines like Bacillus Calmette–Guérin, polio vaccine, and measles-mumps-rubella. We have highlighted the ongoing clinical trial landscape of the COVID-19 as well as repurposed vaccines. An insight into the current status of the available antigenic epitopes for SARS-CoV-2 and different types of vaccine platforms of COVID-19 vaccines has been discussed. These vaccines are highlighted throughout the world by different news agencies. Moreover, ongoing clinical trials for repurposed vaccines for COVID-19 and critical factors associated with the development of COVID-19 vaccines have also been described.

Abstract

Coronavirus disease 2019 (COVID-19) has developed as a pandemic, and it created an outrageous effect on the current healthcare and economic system throughout the globe. To date, there is no appropriate therapeutics or vaccines against the disease. The entire human race is eagerly waiting for the development of new therapeutics or vaccines against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Efforts are being taken to develop vaccines at a rapid rate for fighting against the ongoing pandemic situation. Amongst the various vaccines under consideration, some are either in the preclinical stage or in the clinical stages of development (phase-I, -II, and -III). Even, phase-III trials are being conducted for some repurposed vaccines like Bacillus Calmette–Guérin, polio vaccine, and measles-mumps-rubella. We have highlighted the ongoing clinical trial landscape of the COVID-19 as well as repurposed vaccines. An insight into the current status of the available antigenic epitopes for SARS-CoV-2 and different types of vaccine platforms of COVID-19 vaccines has been discussed. These vaccines are highlighted throughout the world by different news agencies. Moreover, ongoing clinical trials for repurposed vaccines for COVID-19 and critical factors associated with the development of COVID-19 vaccines have also been described.

참고문헌 (87)

  1. Sharpe HR, "The early landscape of coronavirus disease 2019 vaccine development in the UK and rest of the world", Immunology, 160, pp.223~232 (2020)
  2. Chakraborty C, "SARS-CoV-2 causing pneumoniaassociated respiratory disorder(COVID-19) : diagnostic and proposed therapeutic options", Eur Rev Med Pharmacol Sci, 24, pp.4016~4026 (2020)
  3. Liu K, "Clinical features of COVID-19 in elderly patients : a comparison with young and middle-aged patients", J Infect, 80, pp.e14~e18 (2020)
  4. Zhou F, "Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China : a retrospective cohort study", Lancet, 395, pp.1054~1062 (2020)
  5. Lythgoe MP, "Ongoing clinical trials for the management of the COVID-19 pandemic", Trends Pharmacol Sci, 41, pp.363~382 (2020)
  6. Chen W, "Promise and challenges in the development of COVID-19 vaccines", Hum Vaccin Immunother, 16, pp.2604~2608 (2020)
  7. Lurie N, "Developing COVID-19 vaccines at pandemic speed", N Engl J Med, 382, pp.1969~1973 (2020)
  8. Peeples L, "News feature : avoiding pitfalls in the pursuit of a COVID-19 vaccine", Proc Natl Acad Sci U S A, 117, pp.8218~8221 (2020)
  9. Heaton PM, "The COVID-19 vaccine-development multiverse", N Engl J Med, 383, pp.1986~1988 (2020)
  10. Martin JE, "A SARS DNA vaccine induces neutralizing antibody and cellular immune responses in healthy adults in a phase I clinical trial", Vaccine, 26, pp.6338~6343 (2008)
  11. Folegatti PM, "Safety and immunogenicity of a candidate Middle East respiratory syndrome coronavirus viral-vectored vaccine : a dose-escalation, open-label, non-randomised, uncontrolled, phase 1 trial", Lancet Infect Dis, 20, pp.816~826 (2020)
  12. Fuller DH, "Amplifying RNA vaccine development", N Engl J Med, 382, pp.2469~2471 (2020)
  13. Yi C, "mRNA vaccines : possible tools to combat SARS-COV-2", Virol Sin, 35, pp.259~262 (2020)
  14. Huang C, "Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China", Lancet, 395, pp.497~506 (2020)
  15. Chen WH, "The SARS-CoV-2 vaccine pipeline : an overview", Curr Trop Med Rep, pp.1~4 (2020)
  16. Cao Z, "Potent and persistent antibody responses against the receptor-binding domain of SARS-CoV spike protein in recovered patients", Virol J, 7, pp.299~ (2010)
  17. Hotez PJ, "COVID-19 vaccine design : the Janus face of immune enhancement", Nat Rev Immunol, 20, pp.347~348 (2020)
  18. Du L, "Receptor-binding domain of SARS-CoV spike protein induces long-term protective immunity in an animal model", Vaccine, 25, pp.2832~2838 (2007)
  19. De Groot AS, "Clinical applications of immunomics", pp.39~69 (2009), Springer
  20. Bhattacharya M, "Development of epitope-based peptide vaccine against novel coronavirus 2019(SARS-CoV-2) : immunoinformatics approach", J Med Virol, 92, pp.618~631 (2020)
  21. Bhattacharya M, "A SARS-CoV-2 vaccine candidate : in-silico cloning and validation", Inform Med Unlocked, 20, pp.100394~ (2020)
  22. Giurgea LT, "Universal coronavirus vaccines : the time to start is now", NPJ Vaccines, 5, pp.43~ (2020)
  23. Yuan M, "A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV", Science, 368, pp.630~633 (2020)
  24. Tian X, "Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibody", Emerg Microbes Infect, 9, pp.382~385 (2020)
  25. Wrapp D, "Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation", Science, 367, pp.1260~1263 (2020)
  26. Lan J, "Structure of the SARSCoV-2 spike receptor-binding domain bound to the ACE2 receptor", Nature, 581, pp.215~220 (2020)
  27. Wang C, "A human monoclonal antibody blocking SARS-CoV-2 infection", Nat Commun, 11, pp.1~6 (2020)
  28. Ella KM, "Coronavirus vaccine : light at the end of the tunnel", Indian Pediatr, 57, pp.407~410 (2020)
  29. Melgaço JG, "Protective immunity after COVID-19 has been questioned : what can we do without SARS-CoV-2-IgG detection", Cell Immunol, 353, pp.104114~ (2020)
  30. Priyanka, "Protective immunity against COVID-19 : Unravelling the evidences for humoral vs. cellular components", Travel Med Infect Dis, 39, pp.101911~ (2020)
  31. Casanova JL, "A global effort to define the human genetics of protective immunity to SARS-CoV-2 infection", Cell, 181, pp.1194~1199 (2020)
  32. Manners C, "Protective adaptive immunity against severe acute respiratory syndrome coronaviruses 2 (SARS-CoV-2) and implications for vaccines", Cureus, 12, pp.e8399~ (2020)
  33. Yang J, "A vaccine targeting the RBD of the S protein of SARS-CoV-2 induces protective immunity", Nature, 586, pp.572~577 (2020)
  34. Bakker WA, "Inactivated polio vaccine development for technology transfer using attenuated Sabin poliovirus strains to shift from Salk-IPV to Sabin-IPV", Vaccine, 29, pp.7188~7196 (2011)
  35. Gao Q, "Development of an inactivated vaccine candidate for SARS-CoV-2", Science, 369, pp.77~81 (2020)
  36. Risson E, "Inactivated vaccine for SARS-CoV-2", Nat Rev Immunol, 20, pp.353~ (2020)
  37. Lazar M, "Characterisation of measles after the introduction of the combined measles-mumps-rubella(MMR)vaccine in 2004 with focus on the laboratory data, 2016 to 2019 outbreak, Romania", Euro Surveill, 24, pp.1900041~ (2019)
  38. Grenga L, "Shotgun proteomics analysis of SARS-CoV-2-infected cells and how it can optimize whole viral particle antigen production for vaccines", Emerg Microbes Infect, 9, pp.1712~1721 (2020)
  39. Jiang S, "Roadmap to developing a recombinant coronavirus S protein receptor-binding domain vaccine for severe acute respiratory syndrome", Expert Rev Vaccines, 11, pp.1405~1413 (2012)
  40. Moyle PM, "Modern subunit vaccines : development, components, and research opportunities", ChemMedChem, 8, pp.360~376 (2013)
  41. Flood A, "Development of a freeze-dried, heat-stable influenza subunit vaccine formulation", PLoS One, 11, pp.e0164692~ (2016)
  42. Kalita P, "Design of a peptide-based subunit vaccine against novel coronavirus SARS-CoV-2", Microb Pathog, 145, pp.104236~ (2020)
  43. Shang W, "The outbreak of SARS-CoV-2 pneumonia calls for viral vaccines", NPJ Vaccines, 5, pp.18~ (2020)
  44. Qi X, "Construction and immunogenic studies of a mFc fusion receptor binding domain(RBD)of spike protein as a subunit vaccine against SARS-CoV-2 infection", Chem Commun(Camb), 56, pp.8683~8686 (2020)
  45. Deering RP, "Nucleic acid vaccines : prospects for non-viral delivery of mRNA vaccines", Expert Opin Drug Deliv, 11, pp.885~899 (2014)
  46. Saha RP, "Repurposing drugs, ongoing vaccine and new therapeutic development initiatives against COVID-19", Front Pharmacol, 11, pp.1258~ (2020)
  47. Smith TR, "Immunogenicity of a DNA vaccine candidate for COVID-19", Nat Commun, 11, pp.2601~ (2020)
  48. Yu J, "DNA vaccine protection against SARS-CoV-2 in rhesus macaques", Science, 369, pp.806~811 (2020)
  49. Walker SN, "SARS-CoV-2 assays to detect functional antibody responses that block ACE2 recognition in vaccinated animals and infected patients", J Clin Microbiol, 58, pp.e01533~20 (2020)
  50. Kaur SP, "COVID-19 Vaccine : a comprehensive status report", Virus Res, 288, pp.198114~ (2020)
  51. Amanat F, "SARS-CoV-2 vaccines : Status report", Immunity, 52, pp.583~589 (2020)
  52. Corbett KS, "Evaluation of the mRNA-1273 vaccine against SARS-CoV-2 in nonhuman primates", N Engl J Med, 383, pp.1544~1555 (2020)
  53. Anderson EJ, "Safety and immunogenicity of SARS-CoV-2 mRNA-1273 vaccine in older adults", N Engl J Med, 383, pp.2427~2438 (2020)
  54. Mulligan MJ, "Phase I", II study of COVID-19 RNA vaccine BNT162b1 in adults, 2020, pp.586, 589~593
  55. Krammer F, "SARS-CoV-2 vaccines in development", Nature, 586, pp.516~527 (2020)
  56. Koch T, "Safety and immunogenicity of a modified vaccinia virus Ankara vector vaccine candidate for Middle East respiratory syndrome : an open-label, phase 1 trial", Lancet Infect Dis, 20, pp.827~838 (2020)
  57. Lei C, "Neutralization of SARS-CoV-2 spike pseudotyped virus by recombinant ACE2-Ig", Nat Commun, 11, pp.2070~ (2020)
  58. Kim E, "Microneedle array delivered recombinant coronavirus vaccines : immunogenicity and rapid translational development", EBioMedicine, 55, pp.102743~ (2020)
  59. Deangelis CD, "Clinical trial registration : a statement from the international committee of medical journal editors", Arch Dermatol, 141, pp.76~77 (2005)
  60. Nascimento IP, "Recombinant vaccines and the development of new vaccine strategies", Braz J Med Biol Res, 45, pp.1102~1111 (2012)
  61. Funk CD, "A snapshot of the global race for vaccines targeting SARS-CoV-2 and the COVID-19 pandemic", Front Pharmacol, 11, pp.937~ (2020)
  62. Li W, "Peptide vaccine: progress and challenges", Vaccines(Basel), 2, pp.515~536 (2014)
  63. Grgacic EV, "Virus-like particles : passport to immune recognition", Methods, 40, pp.60~65 (2006)
  64. Rohovie MJ, "Virus-like particles : next-generation nanoparticles for targeted therapeutic delivery", Bioeng Transl Med, 2, pp.43~57 (2017)
  65. Mullard A, "COVID-19 vaccine development pipeline gears up", Lancet, 395, pp.1751~1752 (2020)
  66. Saeidnia S, "From in vitro experiments to in vivo and clinical studies; pros and cons", Curr Drug Discov Technol, 12, pp.218~224 (2015)
  67. Raimondi MT, "Bioengineering tools to speed up the discovery and preclinical testing of vaccines for SARS-CoV-2 and therapeutic agents for COVID-19", Theranostics, 10, pp.7034~7052 (2020)
  68. Cohen J, "Vaccine designers take first shots at COVID-19", Science, 368, pp.14~16 (2020)
  69. Kim YC, "COVID-19 vaccines : breaking record times to first-in-human trials", NPJ Vaccines, 5, pp.34~ (2020)
  70. Escobar LE, "BCG vaccine protection from severe coronavirus disease 2019(COVID-19)", Proc Natl Acad Sci U S A, 117, pp.17720~17726 (2020)
  71. Prasanta Raghab Mohapatra, "BCG vaccination induced protection from COVID-19", Indian Journal of Tuberculosis, 68(1), pp.119~124 (2021), Elsevier BV[DOI]
  72. Banday AH, "Potential repurposed therapeutics and new vaccines against COVID-19and their clinical status", SLAS Discov, 25, pp.1097~1107 (2020)
  73. Mahase E, "COVID-19: Moderna vaccine is nearly 95% effective, trial involving high risk and elderly people shows", BMJ, 371, pp.m4471~ (2020)
  74. Elie Dolgin, "COVID-19 vaccines poised for launch, but impact on pandemic unclear", Nature Biotechnology (2020), Springer Science and Business Media LLC[DOI]
  75. Thanh Le T, "The COVID-19vaccine development landscape", Nat Rev Drug Discov, 19, pp.305~306 (2020)
  76. Bar-Zeev N, "Encouraging results from phase 1", 2 COVID-19 vaccine trials, 2020, pp.396, 448~449
  77. Zhu FC, "Safety, tolerability, and immunogenicity of a recombinant adenovirus type-5 vectored COVID-19 vaccine : a doseescalation, open-label, non-randomised, first-in-human trial", Lancet, 395, pp.1845~1854 (2020)
  78. Zhu FC, "Immunogenicity and safety of a recombinant adenovirus type-5-vectored COVID-19 vaccine in healthy adults aged 18 years or older : a randomised, double-blind, placebo-controlled, phase 2 trial", Lancet, 396, pp.479~488 (2020)
  79. Martin C, "mRNA vaccines : intellectual property landscape", Nat Rev Drug Discov, 19, pp.578~ (2020)
  80. van Doremalen N, "ChAdOx1 nCoV-19 vaccine prevents SARS-CoV-2pneumonia in rhesus macaques", Nature, 586, pp.578~582 (2020)
  81. Folegatti PM, "Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2 : a preliminary report of a phase 1", 2, single-blind, randomised controlled trial, 2020, pp.396, 467~478
  82. Ramasamy MN, "Safety and immunogenicity of ChAdOx1 nCoV-19 vaccine administered in a prime-boost regimen in young and old adults(COV002) : a single-blind, randomised, controlled, phase 2", 3 trial, 2020, pp.6736, 32466~32461
  83. Chakraborty C, "India's cost-effective COVID-19 vaccine development initiatives", Vaccine, 38, pp.7883~7884 (2020)
  84. Bregu M, "Accelerating vaccine development and deployment : report of a Royal Society satellite meeting", Philos Trans R Soc Lond B Biol Sci, 366, pp.2841~2849 (2011)
  85. Gouglas D, "Estimating the cost of vaccine development against epidemic infectious diseases : a cost minimisation study", Lancet Glob Health, 6, pp.e1386~e1396 (2018)
  86. Chakraborty C, "Extensive partnership, collaboration, and teamwork is required to stop the COVID-19 outbreak", Arch Med Res, 51, pp.728~730 (2020)
  87. Corey L, "A strategic approach to COVID-19 vaccine R&D", Science, 368, pp.948~950 (2020)

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