Coronavirus disease 2019 (COVID-19) vaccine platforms: how novel platforms can prepare us for future pandemics: a narrative review
1
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
More than 2 years after the explosion of the coronavirus disease 2019 (COVID-19) pandemic, extensive efforts have been made to develop safe and efficacious vaccines against infections with severe acute respiratory syndrome coronavirus 2. The pandemic has opened a new era of vaccine development based on next-generation platforms, including messenger RNA (mRNA)-based technologies, and paved the way for the future of mRNA-based therapeutics to provide protection against a wide range of infectious diseases. Multiple vaccines have been developed at an unprecedented pace to protect against COVID-19 worldwide. However, important knowledge gaps remain to be addressed, especially in terms of how vaccines induce immunogenicity and efficacy in those who are elderly. Here, we discuss the various vaccine platforms that have been utilized to combat COVID-19 and emphasize how these platforms can be a powerful tool to react quickly to future pandemics.
Abstract
More than 2 years after the explosion of the coronavirus disease 2019 (COVID-19) pandemic, extensive efforts have been made to develop safe and efficacious vaccines against infections with severe acute respiratory syndrome coronavirus 2. The pandemic has opened a new era of vaccine development based on next-generation platforms, including messenger RNA (mRNA)-based technologies, and paved the way for the future of mRNA-based therapeutics to provide protection against a wide range of infectious diseases. Multiple vaccines have been developed at an unprecedented pace to protect against COVID-19 worldwide. However, important knowledge gaps remain to be addressed, especially in terms of how vaccines induce immunogenicity and efficacy in those who are elderly. Here, we discuss the various vaccine platforms that have been utilized to combat COVID-19 and emphasize how these platforms can be a powerful tool to react quickly to future pandemics.
참고문헌 (57)
- "WHO coronavirus (COVID-19) dashboard" (2021)[URL]
- Stadler K, "SARS : beginning to understand a new virus", Nat Rev Microbiol, 1, pp.209~218 (2003)
- Janeway Jr CA, "Immunobiology: the immune system in health and disease" (2001), Garland Science
- "Tracking SARS-CoV-2 variants" (2021)[URL]
- "COVID data tracker: variant proportions" (2022)[URL]
- Beatty AL, "Analysis of COVID-19 vaccine type and adverse effects following vaccination", JAMA Netw Open, 4, pp.e2140364~ (2021)
- Bansal A, "Safety, immunogenicity, efficacy and effectiveness of inactivated influenza vaccines in healthy pregnant women and children under 5 years : an evidence-based clinical review", Front Immunol, 12, pp.744774~ (2021)
- Pepin S, "Efficacy, immunogenicity, and safety of a quadrivalent inactivated influenza vaccine in children aged 6-35 months : a multi-season randomised placebo-controlled trial in the Northern and Southern hemispheres", Vaccine, 37, pp.1876~1884 (2019)
- Ott JJ, "Single-dose administration of inactivated hepatitis A vaccination in the context of hepatitis A vaccine recommendations", Int J Infect Dis, 17, pp.e939~e944 (2013)
- "Polio vaccination" (2018)[URL]
- Zhang Y, "Safety, tolerability, and immunogenicity of an inactivated SARS-CoV-2 vaccine in healthy adults aged 18-59 years : a randomised, double-blind, placebo-controlled, phase 1", 2 clinical trial, 2021, pp.21, 181~192
- Tanriover MD, "Efficacy and safety of an inactivated whole-virion SARS-CoV-2 vaccine(CoronaVac) : interim results of a double-blind, randomised, placebo-controlled, phase 3 trial in Turkey", Lancet, 398, pp.213~222 (2021)
- Wang H, "Development of an inactivated vaccine candidate, BBIBP-CorV, with potent protection against SARS-CoV-2", Cell, 182, pp.713~721 (2020)
- Xia S, "Safety and immunogenicity of an inactivated SARS-CoV-2 vaccine, BBIBP-CorV : a randomised, double-blind, placebo-controlled, phase 1", 2 trial, 2021, pp.21, 39~51
- Guo W, "Safety and immunogenicity of an inactivated SARS-CoV-2 vaccine in healthy adults aged 18 years or older : a randomized, double-blind, placebo-controlled, phase 1", 2 trial, 2021, pp.38, 101010~
- Li XN, "Effectiveness of inactivated SARS-CoV-2 vaccines against the Delta variant infection in Guangzhou : a test-negative case-control real-world study", Emerg Microbes Infect, 10, pp.1751~1759 (2021)
- Russell WC, "Adenoviruses : update on structure and function", J Gen Virol, 90(Pt 1), pp.1~20 (2009)
- Buller RE, "A phase I", II trial of rAd, Cancer Gene Ther, pp.2002, 9[DOI]
- Tatsis N, "Adenoviruses as vaccine vectors", Mol Ther, 10, pp.616~629 (2004)
- Dolzhikova IV, "Safety and immunogenicity of GamEvac-Combi, a heterologous VSV-and Ad5-vectored Ebola vaccine : an open phase I", II trial in healthy adults in Russia, 2017, pp.13, 613~620
- Astuti I, "Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) : an overview of viral structure and host response", Diabetes Metab Syndr, 14, pp.407~412 (2020)
- Folegatti PM, "Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2 : a preliminary report of a phase 1", 2, single-blind, randomised controlled trial, 2020, pp.396, 467~478
- Voysey M, "Single-dose administration and the influence of the timing of the booster dose on immunogenicity and efficacy of ChAdOx1 nCoV-19(AZD1222)vaccine : a pooled analysis of four randomised trials", Lancet, 397, pp.881~891 (2021)
- SadoffJ, "Interim results of a phase 1-2a trial of Ad26. COV2. S COVID-19 vaccine", N Engl J Med, 384, pp.1824~1835 (2021)
- Bos R, "Ad26 vector-based COVID-19 vaccine encoding a prefusion-stabilized SARS-CoV-2 Spike immunogen induces potent humoral and cellular immune responses", NPJ Vaccines, 5, pp.91~ (2020)
- Logunov DY, "Safety and efficacy of an rAd26 and rAd5 vector-based heterologous prime-boost COVID-19 vaccine : an interim analysis of a randomised controlled phase 3 trial in Russia", Lancet, 397, pp.671~681 (2021)
- Eichinger S, "Thrombotic thrombocytopenia after ChAdOx1 nCoV-19 vaccination : reply", N Engl J Med, 385, pp.e11~ (2021)
- "Emergency preparedness and response: cases of cerebral venous sinus thrombosis with thrombocytopenia after receipt of the Johnson & Johnson COVID-19 vaccine" (2021)[URL]
- Polack FP, "Safety and efficacy of the BNT162b2 mRNA COVID-19 vaccine", N Engl J Med, 383, pp.2603~2615 (2020)
- Wrapp D, "Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation", Science, 367, pp.1260~1263 (2020)
- Thomas SJ, "Safety and efficacy of the BNT162b2 mRNA COVID-19 vaccine through 6 months", N Engl J Med, 385, pp.1761~1773 (2021)
- Sahin U, "BNT162b2 vaccine induces neutralizing antibodies and poly-specific T cells in humans", Nature, 595, pp.572~577 (2021)
- Ahmed SF, "SARS-CoV-2 T cell responses elicited by COVID-19 vaccines or infection are expected to remain robust against Omicron", Viruses, 14, pp.79~ (2022)
- Tarke A, "Impact of SARS-CoV-2 variants on the total CD4+ and CD8+ T cell reactivity in infected or vaccinated individuals", Cell Rep Med, 2, pp.100355~ (2021)
- Stanojevic M, "Spike-directed vaccination elicits robust spike-specific T-cell response, including to mutant strains", Cytotherapy, 24, pp.10~15 (2022)
- Lopez Bernal J, "Effectiveness of COVID-19 vaccines against the B. 1. 617. 2(Delta)variant", N Engl J Med, 385, pp.585~594 (2021)
- Groß R, "Heterologous ChAdOx1 nCoV-19 and BNT162b2 prime-boost vaccination elicits potent neutralizing antibody responses and T cell reactivity against prevalent SARS-CoV-2 variants", EBioMedicine, 75, pp.103761~ (2022)
- Bar-On YM, "Protection against COVID-19 by BNT162b2 booster across age groups", N Engl J Med, 385, pp.2421~2430 (2021)
- Perrie Y, "Designing liposomal adjuvants for the next generation of vaccines", Adv Drug Deliv Rev, 99(Pt A), pp.85~96 (2016)
- Anderson EJ, "Safety and immunogenicity of SARS-CoV-2 mRNA-1273 vaccine in older adults", N Engl J Med, 383, pp.2427~2438 (2020)
- El Sahly HM, "Efficacy of the mRNA-1273 SARS-CoV-2 vaccine at completion of blinded phase", N Engl J Med, 385, pp.1774~1785 (2021)
- Self WH, "Comparative effectiveness of moderna, Pfizer-BioNTech, and Janssen(Johnson & Johnson)vaccines in preventing COVID-19 hospitalizations among adults without immunocompromising conditions : United States, March-August 2021", MMWR Morb Mortal Wkly Rep, 70, pp.1337~1343 (2021)
- Castiello T, "COVID-19 and myocarditis : a systematic review and overview of current challenges", Heart Fail Rev, 27, pp.251~261 (2022)
- Barda N, "Safety of the BNT162b2 mRNA COVID-19 vaccine in a nationwide setting", N Engl J Med, 385, pp.1078~1090 (2021)
- Colella G, "Bell’s palsy following COVID-19 vaccination", J Neurol, 268, pp.3589~3591 (2021)
- Repajic M, "Bell’s Palsy after second dose of Pfizer COVID-19 vaccination in a patient with history of recurrent Bell’s palsy", Brain Behav Immun Health, 13, pp.100217~ (2021)
- OzonoffA, "Bell’s palsy and SARS-CoV-2 vaccines", Lancet Infect Dis, 21, pp.450~452 (2021)
- Teixeira FM, "DNA vaccine using Mycobacterium bovis Ag85B antigen induces partial protection against experimental infection in BALB", c mice, 2006, pp.13, 930~935
- Kodihalli S, "Strategies for inducing protection against avian influenza A virus subtypes with DNA vaccines", Vaccine, 18, pp.2592~2599 (2000)
- Rai N, "Development of rabies DNA vaccine using a recombinant plasmid", Acta Virol, 49, pp.207~210 (2005)
- Tebas P, "Safety and immunogenicity of INO-4800 DNA vaccine against SARS-CoV-2 : a preliminary report of an open-label, Phase 1 clinical trial", EClinicalMedicine, 31, pp.100689~ (2021)
- Pallesen J, "Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen", Proc Natl Acad Sci U S A, 114, pp.E7348~E7357 (2017)
- Magnusson SE, "Matrix-M™ adjuvant enhances immunogenicity of both protein-and modified vaccinia virus Ankara-based influenza vaccines in mice", Immunol Res, 66, pp.224~233 (2018)
- Reimer JM, "Matrix-M™ adjuvant induces local recruitment, activation and maturation of central immune cells in absence of antigen", PLoS One, 7, pp.e41451~ (2012)
- Heath PT, "Safety and efficacy of NVX-CoV2373 COVID-19 vaccine", N Engl J Med, 385, pp.1172~1183 (2021)
- Arunachalam PS, "Adjuvanting a subunit COVID-19 vaccine to induce protective immunity", Nature, 594, pp.253~258 (2021)
