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SARS-CoV-2-Specific T Cell Responses in Patients with COVID-19 and Unexposed Individuals

신의철|김아름|나민석
대한면역학회 (The Korean Association of Immunologists)|2021.02|Immune Network|제21권 제1호|pp. 1-11|DOI 10.4110/in.2021.21.e2

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참고문헌

키워드

COVID-19SARS-CoV-2T cell

초록

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causes coronavirus disease 2019 (COVID-19), an ongoing pandemic disease. In the current review, we describe SARS-CoV-2-specific CD4+ and CD8+ T-cell responses in acute and convalescent COVID-19 patients. We also discuss the relationships between COVID-19 severity and SARS-CoV-2-specific T-cell responses and summarize recent reports regarding SARS-CoV-2-reactive T cells in SARS-CoV-2-unexposed individuals. These T cells may be cross-reactive cells primed by previous infection with human common-cold coronaviruses. Finally, we outline SARS-CoV-2-specific T-cell responses in the context of vaccination. A better understanding of SARS-CoV-2-specific T-cell responses is needed to develop effective vaccines and therapeutics.

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causes coronavirus disease 2019 (COVID-19), an ongoing pandemic disease. In the current review, we describe SARS-CoV-2-specific CD4+ and CD8+ T-cell responses in acute and convalescent COVID-19 patients. We also discuss the relationships between COVID-19 severity and SARS-CoV-2-specific T-cell responses and summarize recent reports regarding SARS-CoV-2-reactive T cells in SARS-CoV-2-unexposed individuals. These T cells may be cross-reactive cells primed by previous infection with human common-cold coronaviruses. Finally, we outline SARS-CoV-2-specific T-cell responses in the context of vaccination. A better understanding of SARS-CoV-2-specific T-cell responses is needed to develop effective vaccines and therapeutics.

참고문헌 (44)

  1. Huang C, "Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China", Lancet, 395, pp.497~506 (2020)
  2. Lee JS, "Immunophenotyping of COVID-19 and influenza highlights the role of type I interferons in development of severe COVID-19", Sci Immunol, 5, pp.eabd1554~ (2020)
  3. Merad M, "Pathological inflammation in patients with COVID-19 : a key role for monocytes and macrophages", Nat Rev Immunol, 20, pp.355~362 (2020)
  4. Petersen E, "Comparing SARS-CoV-2 with SARS-CoV and influenza pandemics", Lancet Infect Dis, 20, pp.e238~e244 (2020)
  5. Lionel Piroth, "Comparison of the characteristics, morbidity, and mortality of COVID-19 and seasonal influenza: a nationwide, population-based retrospective cohort study", The Lancet Respiratory Medicine, 9(3), pp.251~259 (2021), Elsevier BV[DOI]
  6. Mathew D, "Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications", Science, 369, pp.eabc8511~ (2020)
  7. Mazzoni A, "Impaired immune cell cytotoxicity in severe COVID-19 is IL-6 dependent", J Clin Invest, 130, pp.4694~4703 (2020)
  8. Chen G, "Clinical and immunological features of severe and moderate coronavirus disease 2019", J Clin Invest, 130, pp.2620~2629 (2020)
  9. Kuri-Cervantes L, "Comprehensive mapping of immune perturbations associated with severe COVID-19", Sci Immunol, 5, pp.eabd7114~ (2020)
  10. Zheng HY, "Elevated exhaustion levels and reduced functional diversity of T cells in peripheral blood may predict severe progression in COVID-19 patients", Cell Mol Immunol, 17, pp.541~543 (2020)
  11. De Biasi S, "Marked T cell activation, senescence, exhaustion and skewing towards TH17 in patients with COVID-19 pneumonia", Nat Commun, 11, pp.3434~ (2020)
  12. Diao B, "Reduction and functional exhaustion of T cells in patients with coronavirus disease 2019(COVID-19)", Front Immunol, 11, pp.827~ (2020)
  13. Song JW, "Immunological and inflammatory profiles in mild and severe cases of COVID-19", Nat Commun, 11, pp.3410~ (2020)
  14. Zheng M, "Functional exhaustion of antiviral lymphocytes in COVID-19 patients", Cell Mol Immunol, 17, pp.533~535 (2020)
  15. Peng Y, "Broad and strong memory CD4+and CD8+T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19", Nat Immunol, 21, pp.1336~1345 (2020)
  16. Sekine T, "Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19", Cell, 183, pp.158.e14~168.e14 (2020)
  17. Schulien I, "Characterization of pre-existing and induced SARS-CoV-2-specific CD8+T cells", Nat Med, 27, pp.78~85 (2021)
  18. Habel JR, "Suboptimal SARS-CoV-2-specific CD8+T cell response associated with the prominent HLA-A*02 : 01 phenotype", Proc Natl Acad Sci U S A, 117, pp.24384~24391 (2020)
  19. Rha MS, "PD-1-expressing SARS-CoV-2-specific CD8+T cells are not exhausted, but functional in patients with COVID-19", Immunity, 54, pp.44.e3~52.e3 (2021)
  20. Shomuradova AS, "SARS-CoV-2 epitopes are recognized by a public and diverse repertoire of human T cell receptors", Immunity, 53, pp.1245.e5~1257.e5 (2020)
  21. Ferretti AP, "Unbiased screens show CD8+T cells of COVID-19 patients recognize shared epitopes in SARS-CoV-2 that largely reside outside the spike protein", Immunity, 53, pp.1095.e3~1107.e3 (2020)
  22. Meckiff BJ, "Imbalance of regulatory and cytotoxic SARS-CoV-2-reactive CD4+T cells in COVID-19", Cell, 183, pp.1340.e16~1353.e16 (2020)
  23. Ni L, "Detection of SARS-CoV-2-specific humoral and cellular immunity in COVID-19 convalescent individuals", Immunity, 52, pp.971.e3~977.e3 (2020)
  24. Le Bert N, "SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls", Nature, 584, pp.457~462 (2020)
  25. Grifoni A, "Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals", Cell, 181, pp.1489.e15~1501.e15 (2020)
  26. Zhou R, "Acute SARS-CoV-2infection impairs dendritic cell and T cell responses", Immunity, 53, pp.864.e5~877.e5 (2020)
  27. Rydyznski Moderbacher C, "Antigen-specific adaptive immunity to SARS-CoV-2 in acute COVID-19 and associations with age and disease severity", Cell, 183, pp.996.e19~1012.e19 (2020)
  28. Kim J, "Innate-like cytotoxic function of bystander-activated CD8+T cells is associated with liver injury in acute hepatitis A", Immunity, 48, pp.161.e5~173.e5 (2018)
  29. Tae-Shin Kim, "The activation of bystander CD8+ T cells and their roles in viral infection", Experimental and Molecular Medicine, 51, pp.1~9 (2019), 생화학분자생물학회[DOI]
  30. Xu Z, "Pathological findings of COVID-19 associated with acute respiratory distress syndrome", Lancet Respir Med, 8, pp.420~422 (2020)
  31. Kang CK, "Aberrant hyperactivation of cytotoxic T-cell as a potential determinant of COVID-19 severity", Int J Infect Dis, 97, pp.313~321 (2020)
  32. Chang JT, "Molecular regulation of effector and memory T cell differentiation", Nat Immunol, 15, pp.1104~1115 (2014)
  33. Kaech SM, "Heterogeneity and cell-fate decisions in effector and memory CD8+T cell differentiation during viral infection", Immunity, 27, pp.393~405 (2007)
  34. Sette A, "Pre-existing immunity to SARS-CoV-2 : the knowns and unknowns", Nat Rev Immunol, 20, pp.457~458 (2020)
  35. Braun J, "SARS-CoV-2-reactive T cells in healthy donors and patients with COVID-19", Nature, 587, pp.270~274 (2020)
  36. Mateus J, "Selective and cross-reactive SARS-CoV-2 T cell epitopes in unexposed humans", Science, 370, pp.89~94 (2020)
  37. Nelde A, "SARS-CoV-2-derived peptides define heterologous and COVID-19-induced T cell recognition", Nat Immunol, 22, pp.74~85 (2021)
  38. Klenerman P, "Original antigenic sin impairs cytotoxic T lymphocyte responses to viruses bearing variant epitopes", Nature, 394, pp.482~485 (1998)
  39. Sagar M, "Recent endemic coronavirus infection is associated with less-severe COVID-19", J Clin Invest, 131, pp.e143380~ (2021)
  40. Anderson EJ, "Safety and immunogenicity of SARS-CoV-2 mRNA-1273 vaccine in older adults", N Engl J Med, 383, pp.2427~2438 (2020)
  41. Sahin U, "COVID-19 vaccine BNT162b1 elicits human antibody and TH1 T cell responses", Nature, 586, pp.594~599 (2020)
  42. Katie J. Ewer, "T cell and antibody responses induced by a single dose of ChAdOx1 nCoV-19 (AZD1222) vaccine in a phase 1", 2 clinical trial, 2021, pp.27(2), 270~278[DOI]
  43. Keech C, "Phase 1-2 trial of a SARS-CoV-2 recombinant spike protein nanoparticle vaccine", N Engl J Med, 383, pp.2320~2332 (2020)
  44. Katherine McMahan, "Correlates of protection against SARS-CoV-2 in rhesus macaques", Nature, 590(7847), pp.630~634 (2021), Springer Science and Business Media LLC[DOI]

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