본문 바로가기
KERD
논문KCI 등재

Epitope발현 DNA vaccine과 recombinant vaccinia virus를 이용한 heterologous prime-boost vaccination에 의하여 유도되는 CD8+ T 세포 매개성 면역

CD8+ T Cell-mediated Immunity Induced by Heterologous Prime-boost Vaccination Based on DNA Vaccine and Recombinant Vaccinia Virus Expressing Epitope

윤현아|채준석|이존화|어성국|박성옥|Abi George Aleyas
대한면역학회 (The Korean Association of Immunologists)|2005.06|Immune Network|제5권 제2호|pp. 89-98

2

조회

0

다운로드

0

인용

0

참고문헌

초록

Abstract

Background: DNA vaccination represents an anticipated approach for the control of numerous infectious diseases. Used alone, however, DNA vaccine is weak immunogen inferior to viral vectors. In recent, heterologous prime-boost vaccination leads DNA vaccines to practical reality. Methods: We assessed prime-boost immunization strategies with a DNA vaccine (minigene, gB498-505 DNA) and recombinant vaccinia virus (vvgB498- 505) expressing epitope gB498-505 (SSIEFARL) of CD8 T cells specific for glycoprotein B (gB) of herpes simplex virus (HSV). Animals were immunized primarily with gB498-505 epitope-expressing DNA vaccine/recombinant vaccinia virus and boosted with alternative vaccine type expressing entire Ag. Results: In prime-boost protocols using vvgBw (recombinant vaccinia virus expressing entire Ag) and vvgB498-505, CD8 T cell-mediated immunity was induced maximally at both acute and memory stages if primed with vvgBw and boosted with vvgB498-505 as evaluated by CTL activity, intracellular IFN-staining, and MHC class I tetramer staining. Similarly gB498-505 DNA prime-gBw DNA (DNA vaccine expressing entire Ag) boost immunization elicited the strongest CD8 T cell responses in protocols based on DNA vaccine. However, the level of CD8 T cell-mediated immunity induced with prime-boost vaccination using DNA vaccine expressing epitope or entire Ag was inferior to those based on vvgBw and vvgB498-505. Of particular interest CD8 T cell-mediated immunity was optimally induced when vvgB498-505 was used to prime and gB DNA was used as alternative boost. Especially CD8 T cell responses induced by such protocol was longer lasted than other protocols. Conclusion: These facts direct to search for the effective strategy to induce optimal CD8 T cell-mediated immunity against cancer and viral infection.

참고문헌 (46)

  1. "Seder RA: DNA vaccines: immunology, application, and optimization.", 18, pp.927~974 (2000)
  2. "the answer to stable", curr opin immu(l 15), pp.471~476 (2003)
  3. "Manipulation of the immune response to a plasmid-encoded viral antigen by coinoculation with plasmids expressing cytokines", 2, pp.129~135 (1995)
  4. "Cytokine-in-adjuvant steering of the immune response phenotype to HIV-1 vaccine constructs:granulocyte-macrophage colony-stimulating factor and TNF-alpha synergize with IL-12 to enhance induction of cytotoxic T lymphocytes", 158, pp.3947~3958 (1997)
  5. "CD8 positive T cells influence antigen-specific immune responses through the expression of chemokines", pp.1112~1124 (1998)
  6. "expression plasmid enhances DNA vaccine-induced immune response against HIV-1", 115, pp.335~341 (1999)
  7. "Deoxyribonucleic acid vaccines encoding antigens with rapid proteosome-dependent degradation are highly efficient inducers of cytolytic T lymphocytes", 159, pp.6037~6043 (1997)
  8. "Induction of MHC class I-CTL response by DNA immunization with ubiquitin-influenza virus nucleoproteinfusion antigens", 16, pp.1711~1717 (1998)
  9. "A prime-boost immunisation regimen using DNA followed by recombinant modified vaccinia virus Ankara induces strong cellular immune responses against the Plasmodium falciparum TRAP antigen in chimpanzees", 19, pp.4595~4602 (2001)
  10. "Multistage multiantigen heterologous prime boost vaccine for Plasmodium knowlesi malaria provides partial protection in rhesus macaques", 69, pp.5565~5572 (2001)
  11. "Enhanced T-cell immunogenicity and protective efficacy of a human immunodeficiency virus type 1 vaccine regimen consisting of consecutive priming with DNA and boosting with recombinant fowlpox virus", 72, pp.10180~10188 (1998)
  12. "Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA", MVA vaccine, 2002, pp.20, 1949~1955
  13. "Differential immunogenicity of various heterologous prime-boost vaccine regimens using DNA and viral vectors in healthy volunteers", 174, pp.449~455 (2005)
  14. "Generation of enhanced immune responses by consecutive immunization with DNA and recombinant fowlpox viruses", cha(ck h rrby e), pp.~95 (1995), Cold Spring Harber Laboratory Press
  15. "Immunology taught by viruses", 271, pp.173~178 (1996)
  16. "The number of long-lasting functional memory CD8 T cells generated depends on the nature of the initial nonspecific stimulation", 32, pp.1541~1549 (2001)
  17. "Requirement for CD4 T cell help in generating functional CD8 T cell memory", 300, pp.337~339 (2003)
  18. "Defective CD8 T cell memory following acute infection without CD4 T cell help", 300, pp.339~342 (2003)
  19. "CD4 T cells are required for secondary expansion and memory in CD8 T lymphocytes", 421, pp.852~856 (2003)
  20. "A role for CD40 expression on CD8 T cells in the generation of CD8 T cell memory", 297, pp.2060~2063 (2002)
  21. "Priming MHC- I-restricted cytotoxic T lymphocyte responses to exogenous hepatitis B surface antigen is CD4 T cell dependent", 163, pp.1880~1887 (1999)
  22. "NKT cells provide help for dendritic cell-dependent priming of MHC class I-restricted CD8 T cells in vivo", 170, pp.2540~2548 (2003)
  23. "Ld-restricted T cell response to hepatitis B surface antigen efficiently suppresses T cell priming to multiple Dd-", 168, pp.6253~6262 (2002)
  24. "Regulatory CD4 CD25 T cells restrict memory CD8 T cell responses", 196, pp.1585~1592 (2002)
  25. "CD25 CD4 T cells contribute to the control of memory CD8 T cells", 99, pp.8832~8837 (2002)
  26. "Induction of CD8 T-cell-specific systemic and mucosal immunity against herpes simplex virus with CpG-peptide complexes", 76, pp.6568~6576 (2002)
  27. "Poxviruses as expression vectors", 8, pp.573~577 (1997)
  28. "A striking property of recombinant poxviruses efficient inducers of in vivo expansion of primed CD8", 280, pp.155~159 (2001)
  29. "Induction of mucosal immunity against herpes simplex virus by plasmid DNA immunization", 71, pp.3138~3145 (1997)
  30. "Codelivery of CCR7 ligands as molecular adjuvants enhances the protective immune response against herpes simplex virus type 1", 77, pp.12742~12752 (2003)
  31. "Prime-boost immunization with DNA vaccine:mucosal route of administration changes the rules", 166, pp.5473~5479 (2001)
  32. "Plasmid DNA encoding CCR7 ligands compensate for dysfunctional CD8 T cell responses by effects on dendritic cells", 167, pp.3592~3599 (2001)
  33. "Application of the intracellular gamma interferon assay to recalculate the potency of CD8 T-cell responses to herpes simplex virus", 74, pp.5709~5711 (2000)
  34. "Regulation of adaptive immune responses by innate cells expressing NK markers and antigen-transporting macrophages", 67, pp.488~494 (2000)
  35. "DNA vaccines for immunodeficiency viruses", 11, pp.109~119 (1997)
  36. "The prime-boost strategy:exciting prospects for improved vaccination", 21, pp.163~165 (2000)
  37. "Recombinant vaccinia virus-induced T-cell immunity:quantitation of the response to the virus vector and the foreign epitope", 76, pp.3329~3337 (2002)
  38. "Programmed contraction of CD8 T cells after infection", nat immu(l 3), pp.619~626 (2002)
  39. "Viral immune evasion due to persistence of activated T cells without effector function", 188, pp.2205~2213 (1998)
  40. "IL-2 is not required for the initiation of CD8 T cell cycling but sustains expansion", 171, pp.5727~5735 (2003)
  41. "Progressive differentiation and selection of the fittest in the immune response", 2, pp.982~987 (2002)
  42. "T cell fitness determined by signal strength", 4, pp.355~360 (2003)
  43. "Cutting edge:antigen-independent CD8 T cell proliferation", 166, pp.5864~5868 (2001)
  44. "Memory CD8 T cell differentiation:initial antigen encounter triggers a developmental program in naive cells", 2, pp.415~422 (2001)
  45. "Naive CTLs require a single rief period of antigenic stimulation for clonal expansion and differentiation", 2, pp.423~429 (2001)
  46. "Shortening the infectious period does not alter expansion of CD8 T cells but diminishes their capacity to differentiate into memory cells", 173, pp.6694~6702 (2004)

관련 논문AI추천

HPV 16-E7 종양백신과 IL-12에 의한 항종양 면역능의 유도김도강, 김용완, 김종국, 박은경, 배수미, 안웅식, 윤주희, 윤철구, 이준모, 진태형, 최미나, 허승원, 남궁성은대한산부인과학회 · Obstetrics & Gynecology Science2003 · 제46권 제12호Efficient Induction of Th1-type Immune Responses to Hepatitis B Virus Antigens by DNA Prime-Adenovirus Boost박수형, 성영철, 송만기, 양세환, 이창근, 최소영대한면역학회 · Immune Network2005 · 제5권 제1호CD8+ T-cell Activation in Mice Injected with a Plasmid DNA Vaccine Encoding AMA-1 of the Reemerging Korean Plasmodium vivax김태우, 김태윤, 신은희, 정봉광, 채종일, 최병일, Hajime Hisaeda, Hyo-Jin Kim, Jin-Joo Lee, Kunisuke Himeno, Kyoung-Ho Pyo대한기생충학ㆍ열대의학회 · Parasites, Hosts and Diseases2011 · 제49권 제1호Enhancement of DNA Vaccine-induced Immune Responses by Influenza Virus NP Gene장준, 서유석, 성영철, 조재호, 진현탁, 최소영대한면역학회 · Immune Network2009 · 제9권 제5호Requirement of CD4 Help for Induction of CD8 T Cell Response Specific for Virally Derived H60장준, 강보라, 김석호, 김태우, 류수정, 최은영대한면역학회 · Immune Network2012 · 제12권 제3호종양 세포 용해액에 따른 수지상세포 유도 항원 특이 면역반응 차이의 기전 연구김명주, 백소영, 손혜진, 이강은, 이현아대한면역학회 · Immune Network2006 · 제6권 제3호

이 간행물의 다른 논문 (8건)

암백신인상환, 손은화, 표석능pp. 55-67Opposite Roles of B7.1 and CD28 Costimulatory Molecules for Protective Immunity against HSV-2 Challenge in a gD DNA Vaccine ModelDavid B. Weiner, 신정임pp. 68-77콜라겐 유도 관절염에서 콜라겐 항원 특이 V？3+CD4+ T 세포의 선택적 증식민준기, 조미라, 민소연, 김완욱, 이정은, 박성환, 김호연, 윤종현, 이재선pp. 78-88A combination of PG490 and lipopolysaccharide induce apoptosis through activation of casapase-3 and down-regulation of cIAP1 and XIAP in human astroglioma cell우경진, 권택규, 이태진, 박종욱pp. 99-104The Expression of Galectin-3, a beta-galactoside binding protein, in Dendritic Cells주홍구, 김미형pp. 105-109
원문 보기