Inhibition of Leukocyte Adhesion by Developmental Endothelial Locus-1 (Del-1)
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The leukocyte adhesion to endothelium is pivotal in leukocyte recruitment which takes place during inflammatory, autoimmune and infectious conditions. The interaction between leukocytes and endothelium requires an array of adhesion molecules expressed on leukocytes and endothelial cells, thereby promoting leukocyte recruitment into sites of inflammation and tissue injury. Intervention with the adhesion molecules provides a platform for development of anti-inflammatory therapeutics. This review will focus on developmental endothelial locus-1 (Del-1), an endogenous inhibitor of leukocyte adhesion.
Abstract
The leukocyte adhesion to endothelium is pivotal in leukocyte recruitment which takes place during inflammatory, autoimmune and infectious conditions. The interaction between leukocytes and endothelium requires an array of adhesion molecules expressed on leukocytes and endothelial cells, thereby promoting leukocyte recruitment into sites of inflammation and tissue injury. Intervention with the adhesion molecules provides a platform for development of anti-inflammatory therapeutics. This review will focus on developmental endothelial locus-1 (Del-1), an endogenous inhibitor of leukocyte adhesion.
참고문헌 (40)
- von Andrian UH, "T-cell function and migration.Two sides of the same coin", N Engl J Med, 343, pp.1020~1034 (2000)
- Luster AD, "Immune cell migration in inflammation: present and future therapeutic targets", Nat Immunol, 6, pp.1182~1190 (2005)
- Ley K, "Getting to the site of inflammation: the leukocyte adhesion cascade updated", Nat Rev Immunol, 7, pp.678~689 (2007)
- Zarbock A, "New insights into leukocyte recruitment by intravital microscopy", Curr Top Microbiol Immunol, 334, pp.129~152 (2009)
- McEver RP, "Perspectives series; cell adhesion in vascular biology. Role of PSGL-1 binding to selectins in leukocyte recruitment", J Clin Invest, 100, pp.485~491 (1997)
- Alon R, "Glycolipid ligands for selectins support leukocyte tethering and rolling under physiologic flow conditions", J Immunol, 154, pp.5356~5366 (1995)
- Berlin C, "Alpha 4 integrins mediate lymphocyte attachment and rolling under physiologic flow", Cell, 80, pp.413~422 (1995)
- Sigal A, "The LFA-1 integrin supports rolling adhesions on ICAM-1 under physiological shear flow in a permissive cellular environment", J Immunol, 165, pp.442~452 (2000)
- Marshall BT, "Direct observation of catch bonds involving cell-adhesion molecules", Nature, 423, pp.190~193 (2003)
- Adams DH, "Chemokines: leucocyte recruitment and activation cytokines", Lancet, 349, pp.490~495 (1997)
- Campbell JJ, "Biology of chemokine and classical chemoattractant receptors:differential requirements for adhesion-triggering versus chemotactic responses in lymphoid cells", J Cell Biol, 134, pp.255~266 (1996)
- Johnson Z, "Interaction of chemokines and glycosaminoglycans: a new twist in the regulation of chemokine function with opportunities for therapeutic intervention", Cytokine Growth Factor Rev, 16, pp.625~636 (2005)
- Campbell JJ, "Chemokines and the arrest of lymphocytes rolling under flow conditions", Science, 279, pp.381~384 (1998)
- Tanaka Y, "Regulation of leukocyte recruitment by proadhesive cytokines immobilized on endothelial proteoglycan", Curr Top Microbiol Immunol, 184, pp.99~106 (1993)
- Dunne JL, "Control of leukocyte rolling velocity in TNF-alpha-induced inflammation by LFA-1 and Mac-1", Blood, 99, pp.336~341 (2002)
- Phillipson M, "Intraluminal crawling of neutrophils to emigration sites; a molecularly distinct process from adhesion in the recruitment cascade", J Exp Med, 203, pp.2569~2575 (2006)
- Schenkel AR, "Locomotion of monocytes on endothelium is a critical step during extravasation", Nat Immunol, 5, pp.393~400 (2004)
- Barreiro O, "Dynamic interaction of VCAM-1 and ICAM-1 with moesin and ezrin in a novel endothelial docking structure for adherent leukocytes", J Cell Biol, 157, pp.1233~1245 (2002)
- Carman CV, "A transmigratory cup in leukocyte diapedesis both through individual vascular endothelial cells and between them", J Cell Biol, 167, pp.377~388 (2004)
- Huang AJ, "Endothelial cell cytosolic free calcium regulates neutrophil migration across monolayers of endothelial cells", J Cell Biol, 120, pp.1371~1380 (1993)
- Millan J, "Rho GTPases and leucocyte-induced endothelial remodelling", Biochem J, 385, pp.329~337 (2005)
- Hyun Wee, "ICAM-1", LFA-1 interaction contributes to the induction of endothelial cell-cell separation: implication for enhanced leukocyte diapedesis, 2009, pp.41(5), 341~348[DOI]
- Wittchen ES, "Endothelial signaling in paracellular and transcellular leukocyte transmigration", Front Biosci, 14, pp.2522~2545 (2009)
- Lou O, "CD99 is a key mediator of the transendothelial migration of neutrophils", J Immunol, 178, pp.1136~1143 (2007)
- Bixel MG, "A CD99-related antigen on endothelial cells mediates neutrophil but not lymphocyte extravasation in vivo", Blood, 109, pp.5327~5336 (2007)
- Wakelin MW, "An anti-platelet-endothelial cell adhesion molecule-1 antibody inhibits leukocyte extravasation from mesenteric microvessels in vivo by blocking the passage through the basement membrane", J Exp Med, 184, pp.229~239 (1996)
- Schenkel AR, "CD99 plays a major role in the migration of monocytes through endothelial junctions", Nat Immunol, 3, pp.143~150 (2002)
- Woodfin A, "Endothelial cell activation leads to neutrophil transmigration as supported by the sequential roles of ICAM-2, JAM-A, and PECAM-1", Blood, 113, pp.6246~6257 (2009)
- Garrido-Urbani S, "Vascular and epithelial junctions: a barrier for leucocyte migration", Biochem Soc Trans, 36, pp.203~211 (2008)
- Pfeiffer F, "Distinct molecular composition of blood and lymphatic vascular endothelial cell junctions establishes specific functional barriers within the peripheral lymph node", Eur J Immunol, 38, pp.2142~2155 (2008)
- Wegmann F, "ESAM supports neutrophil extravasation, activation of Rho, and VEGF-induced vascular permeability", J Exp Med, 203, pp.1671~1677 (2006)
- Butcher EC, "Lymphocyte homing and homeostasis", Science, 272, pp.60~66 (1996)
- Lalor PF, "The liver: a model of organ-specific lymphocyte recruitment", Expert Rev Mol Med, 4, pp.1~16 (2002)
- Robert C, "Inflammatory skin diseases, T cells,and immune surveillance", N Engl J Med, 341, pp.1817~1828 (1999)
- Shetty S, "Lymphocyte recruitment to the liver: molecular insights into the pathogenesis of liver injury and hepatitis", Toxicology, 254, pp.136~146 (2008)
- Lee WY, "Leukocyte adhesion in the liver: distinct adhesion paradigm from other organs", J Hepatol, 48, pp.504~512 (2008)
- Wong J, "A minimal role for selectins in the recruitment of leukocytes into the inflamed liver microvasculature", J Clin Invest, 99, pp.2782~2790 (1997)
- Choi EY, "Del-1,an endogenous leukocyte-endothelial adhesion inhibitor,limits inflammatory cell recruitment", Science, 322, pp.1101~1104 (2008)
- Hidai C, "Discoidin domain of Del1 protein contributes to its deposition in the extracellular matrix", Cell Tissue Res, 330, pp.83~95 (2007)
- Hidai C, "an embryonic endothelial cell protein that binds the alphavbeta3 integrin receptor", Genes Dev, 12, pp.21~33 (1998)
