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Interplay between Inflammatory Responses and Lymphatic Vessels

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초록

Lymphatic vessels are routes for leukocyte migration and fluid drainage. In addition to their passive roles in migration of leukocytes, increasing evidence indicates their active roles in immune regulation. Tissue inflammation rapidly induces lymphatic endothelial cell proliferation and chemokine production, thereby resulting in lymphangiogenesis. Furthermore, lymphatic endothelial cells induce T cell tolerance through various mechanisms. In this review, we focus on the current knowledge on how inflammatory cytokines affect lymphangiogenesis and the roles of lymphatic vessels in modulating immune responses.

Abstract

Lymphatic vessels are routes for leukocyte migration and fluid drainage. In addition to their passive roles in migration of leukocytes, increasing evidence indicates their active roles in immune regulation. Tissue inflammation rapidly induces lymphatic endothelial cell proliferation and chemokine production, thereby resulting in lymphangiogenesis. Furthermore, lymphatic endothelial cells induce T cell tolerance through various mechanisms. In this review, we focus on the current knowledge on how inflammatory cytokines affect lymphangiogenesis and the roles of lymphatic vessels in modulating immune responses.

참고문헌 (49)

  1. Adams, R. H., "Molecular regulation of angiogenesis and lymphangiogenesis", Nat. Rev. Mol. Cell Biol, 8, pp.464~478 (2007)
  2. Oliver, G., "Lymphatic vasculature development", Nat. Rev. Immunol, 4, pp.35~45 (2004)
  3. Oliver, G., "The lymphatic vasculature: recent progress and paradigms", Annu. Rev. Cell Dev. Biol, 21, pp.457~483 (2005)
  4. Cueni, L. N., "New insights into the molecular control of the lymphatic vascular system and its role in disease", J. Iinvest. Dermatol, 126, pp.2167~2177 (2006)
  5. Cueni, L. N., and, "The lymphatic system in health and disease", Lymphat. Res. Biol, 6, pp.109~122 (2008)
  6. Schulte-Merker, "Lymphatic vascular morphogenesis in development, physiology, and disease", J. Cell Biol, 193, pp.607~618 (2011)
  7. Pflicke, H., "Preformed portals facilitate dendritic cell entry into afferent lymphatic vessels", J. Exp. Med, 206, pp.2925~2935 (2009)
  8. Alitalo, K., "Lymphangiogenesis in development and human disease", Nature, 438, pp.946~953 (2005)
  9. He, Y., "Vascular endothelial cell growth factor receptor 3-mediated activation of lymphatic endothelium is crucial for tumor cell entry and spread via lymphatic vessels", Cancer Res, 65, pp.4739~4746 (2005)
  10. Achen, M. G, "Tumor lymphangiogenesis and metastatic spread-new players begin to emerge", Int. J. Cancer, 119, pp.1755~1760 (2006)
  11. Kataru, R. P., "Critical role of CD11b+ macrophages and VEGF in inflammatory lymphangiogenesis, antigen clearance, and inflammation resolution", Blood, 113, pp.5650~5659 (2009)
  12. Jeltsch, M., "Hyperplasia of lymphatic vessels in VEGF-C transgenic mice", Science, 276, pp.1423~1425 (1997)
  13. Makinen, T, "Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C", D receptor VEGFR-3, 2001, pp.20, 4762~4773
  14. Wirzenius, M., "Distinct vascular endothelial growth factor signals for lymphatic vessel enlargement and sprouting", J. Exp. Med, 204, pp.1431~1440 (2007)
  15. Halin, C, "Inhibition of chronic and acute skin inflammation by treatment with a vascular endothelial growth factor receptor tyrosine kinase inhibitor", Am. J. Pathol, 173, pp.265~277 (2008)
  16. Furtado, G. C, "Lymphotoxin beta receptor signaling is required for inflammatory lymphangiogenesis in the thyroid", Proc. Natl. Acad. Sci. U. S. A, 104, pp.5026~5031 (2007)
  17. Mounzer, R. H, "Lymphotoxin-alpha contributes to lymphangiogenesis", Blood, 116, pp.2173~2182 (2010)
  18. Choi, I., "Interleukin-8 reduces post-surgical lymphedema formation by promoting lymphatic vessel regeneration", Angiogenesis, 16, pp.29~44 (2013)
  19. Saito, Y, "Transfection of human hepatocyte growth factor gene ameliorates secondary lymphedema via promotion of lymphangiogenesis", Circulation, 114, pp.1177~1184 (2006)
  20. Platonova, N, "Evidence for the interaction of fibroblast growth factor-2 with the lymphatic endothelial cell marker LYVE-1", Blood, 121, pp.1229~1237 (2013)
  21. Chang, L. K, "Dose-dependent response of FGF-2 for lymphangiogenesis", Proc. Natl. Acad. Sci. U. S. A, 101, pp.11658~11663 (2004)
  22. Cao, R, "Collaborative interplay between FGF-2 and VEGF-C promotes lymphangiogenesis and metastasis", Proc. Natl. Acad. Sci. U. S. A, 109, pp.15894~15899 (2012)
  23. Chauhan, S. K., "A novel pro-lymphangiogenic function for Th17", IL-17, 2011, pp.118, 4630~4634
  24. Kataru, R. P., "T lymphocytes negatively regulate lymph node lymphatic vessel formation", Immunity, 34, pp.96~107 (2011)
  25. Avraham, T, "Blockade of transforming growth factor-beta1 accelerates lymphatic regeneration during wound repair", Am. J. Pathol, 177, pp.3202~3214 (2010)
  26. Oka, M., "Inhibition of endogenous TGF-beta signaling enhances lymphangiogenesis", Blood, 111, pp.4571~4579 (2008)
  27. Lammermann, T, "Rapid leukocyte migration by integrin-independent flowing and squeezing", Nature, 453, pp.51~55 (2008)
  28. Johnson, L. A., "An inflammation-induced mechanism for leukocyte transmigration across lymphatic vessel endothelium", J. Exp. Med, 203, pp.2763~2777 (2006)
  29. Vigl, B, "Tissue inflammation modulates gene expression of lymphatic endothelial cells and dendritic cell migration in a stimulus-dependent manner", Blood, 118, pp.205~215 (2011)
  30. Forster, R., "Lymph node homing of T cells and dendritic cells via afferent lymphatics", Trends Immunol, 33, pp.271~280 (2012)
  31. Issa, A, "Vascular endothelial growth factor-C and C-C chemokine receptor 7 in tumor cell-lymphatic cross-talk promote invasive phenotype", Cancer Res, 69, pp.349~357 (2009)
  32. Martln-Fontecha, A., "Regulation of dendritic cell migration to the draining lymph node: impact on T lymphocyte traffic and priming", J. Exp. Med, 198, pp.615~621 (2003)
  33. Kabashima, K, "CXCL12-CXCR4 engagement is required for migration of cutaneous dendritic cells", Am. J. Pathol, 171, pp.1249~1257 (2007)
  34. Johnson, L. A, "The chemokine CX3CL1 promotes trafficking of dendritic cells through inflamed lymphatics", J. Cell Sci, 126, pp.5259~5270 (2013)
  35. Amatschek, S., "Blood and lymphatic endothelial cell-specific differentiation programs are stringently controlled by the tissue environment", Blood, 109, pp.4777~4785 (2007)
  36. Tripp, C. H., "The lymph vessel network in mouse skin visualised with antibodies against the hyaluronan receptor LYVE-1", Immunobiology, 213, pp.715~728 (2008)
  37. Lund, A. W., "VEGF-C promotes immune tolerance in B16 melanomas and cross-presentation of tumor antigen by lymph node lymphatics", Cell Rep, 1, pp.191~199 (2012)
  38. Tewalt, E. F., "Lymphatic endothelial cells induce tolerance via PD-L1 and lack of costimulation leading to high-level PD-1 expression on CD8 T cells", Blood, 120, pp.4772~4782 (2012)
  39. Norder, M., "Lymph node-derived lymphatic endothelial cells express functional costimulatory molecules and impair dendritic cell-induced allogenic T-cell proliferation", FASEB J, 26, pp.2835~2846 (2012)
  40. Lee, J. W, "Peripheral antigen display by lymph node stroma promotes T cell tolerance to intestinal self", Nat. Immunol, 8, pp.181~190 (2007)
  41. Nichols, L. A., "Deletional self-tolerance to a melanocyte", melanoma antigen derived from tyrosinase is mediated by a radio-resistant cell in peripheral and mesenteric lymph nodes, 2007, pp.179, 993~1003
  42. Gardner, J. M, "Deletional tolerance mediated by extrathymic Aire-expressing cells", Science, 321, pp.843~847 (2008)
  43. Cohen, J. N, "Lymph node-resident lymphatic endothelial cells mediate peripheral tolerance via Aire-independent direct antigen presentation", J. Exp. Med, 207, pp.681~688 (2010)
  44. Fletcher, A. L, "Lymph node fibroblastic reticular cells directly present peripheral tissue antigen under steady-state and inflammatory conditions", J. Exp. Med, 207, pp.689~697 (2010)
  45. Harding, F. A, "CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones", Nature, 356, pp.607~609 (1992)
  46. Hawiger, D, "Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo", J. Exp. Med, 194, pp.769~779 (2001)
  47. Hernandez, J., "Uncoupling of proliferative potential and gain of effector function by CD8(+) T cells responding to self-antigens", J. Exp. Med, 196, pp.323~333 (2002)
  48. Martin-Orozco, N, "Cutting Edge: Programmed death (PD) ligand-1", PD-1 interaction is required for CD8+ T cell tolerance to tissue antigens, 2006, pp.177, 8291~8295
  49. Liu, X, "Cutting edge: A critical role of B and T lymphocyte attenuator in peripheral T cell tolerance induction", J. Immunol, 182, pp.4516~4520 (2009)

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