Presence of Foxp3-expressing CD19(＋)CD5(＋) B Cells in Human Peripheral Blood Mononuclear Cells: Human CD19(＋)CD5(＋)Foxp3(＋) Regulatory B Cell (Breg)
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Foxp3 is a transcript factor for regulatory T cell development. Interestingly, Foxp3-expressing cells were identified in B cells, especially in CD19(＋)CD5(＋) B cells, while those were not examined in CD19(＋)CD5(−) B cells. Foxp3- expressing CD5(＋) B cells in this study were identified in human PBMCs and were found to consist of 8.5±3.5% of CD19(＋)CD5(＋) B cells. CD19(＋)CD5(＋)Foxp3(＋) B cells showed spontaneous apoptosis. Rare CD19(＋)CD5(＋) Foxp3(＋) regulatory B cell (Breg) population was unveiled in human peripheral blood mononuclear cells and suggested as possible regulatory B cells (Breg) as regulatory T cells (Treg). The immunologic and the clinical relevant of Breg needs to be further investigated.
Abstract
Foxp3 is a transcript factor for regulatory T cell development. Interestingly, Foxp3-expressing cells were identified in B cells, especially in CD19(＋)CD5(＋) B cells, while those were not examined in CD19(＋)CD5(−) B cells. Foxp3- expressing CD5(＋) B cells in this study were identified in human PBMCs and were found to consist of 8.5±3.5% of CD19(＋)CD5(＋) B cells. CD19(＋)CD5(＋)Foxp3(＋) B cells showed spontaneous apoptosis. Rare CD19(＋)CD5(＋) Foxp3(＋) regulatory B cell (Breg) population was unveiled in human peripheral blood mononuclear cells and suggested as possible regulatory B cells (Breg) as regulatory T cells (Treg). The immunologic and the clinical relevant of Breg needs to be further investigated.
참고문헌 (9)
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