T Cell Resistance: On the Mechanisms of T Cell Non-activation

키워드

참고문헌 (200)

1. Bouneaud C, "Impact of negative selection on the T cell repertoire reactive to a self-peptide : a large fraction of T cell clones escapes clonal deletion", Immunity, 13, pp.829~840 (2000)
2. Yu W, "Clonal deletion prunes but does not eliminate self-specific αβ CD8(+)T lymphocytes", Immunity, 42, pp.929~941 (2015)
3. Collier JL, "Not-so-opposite ends of the spectrum : CD8+ T cell dysfunction across chronic infection, cancer and autoimmunity", Nat Immunol, 22, pp.809~819 (2021)
4. Jenkins E, "The current state and future of T-cell exhaustion research", Oxf Open Immunol, 4, pp.iqad006~ (2023)
5. Fischer W, "HIV-1 and SARS-CoV-2 : patterns in the evolution of two pandemic pathogens", Cell Host Microbe, 29, pp.1093~1110 (2021)
6. Kondo T, "Abstract 6324 : antagonism-enforced braking system to enhance CAR T cell therapeutic specificity", Cancer Res, 84, pp.6324~ (2024)
7. Kumari S, "Actin foci facilitate activation of the phospholipase C-γ in primary T lymphocytes via the WASP pathway", Elife, 4, pp.e04953~ (2015)
8. Cai E, "Visualizing dynamic microvillar search and stabilization during ligand detection by T cells", Science, 356, pp.eaal3118~ (2017)
9. Gaud G, "Regulatory mechanisms in T cell receptor signalling", Nat Rev Immunol, 18, pp.485~497 (2018)
10. Zhao Y, "cis-B7 : CD28 interactions at invaginated synaptic membranes provide CD28 co-stimulation and promote CD8+ T cell function and anti-tumor immunity", Immunity, 56, pp.1187~1203 (2023)
11. Li B, "Cis interactions between CD2 and its ligands on T cells are required for T cell activation", Sci Immunol, 7, pp.eabn6373~ (2022)
12. Chen L, "Molecular mechanisms of T cell co-stimulation and co-inhibition", Nat Rev Immunol, 13, pp.227~242 (2013)
13. Skånland SS, "T-cell co-stimulation through the CD2 and CD28 co-receptors induces distinct signalling responses", Biochem J, 460, pp.399~410 (2014)
14. Yao S, "B7-h2 is a costimulatory ligand for CD28 in human", Immunity, 34, pp.729~740 (2011)
15. Demetriou P, "A dynamic CD2-rich compartment at the outer edge of the immunological synapse boosts and integrates signals", Nat Immunol, 21, pp.1232~1243 (2020)
16. Sckisel GD, "Out-of-sequence signal 3 paralyzes primary CD4(+)T-cell-dependent immunity", Immunity, 43, pp.240~250 (2015)
17. ElTanbouly MA, "Rethinking peripheral T cell tolerance : checkpoints across a T cell’s journey", Nat Rev Immunol, 21, pp.257~267 (2021)
18. Hawiger D, "Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo", J Exp Med, 194, pp.769~779 (2001)
19. Curtsinger JM, "Inflammatory cytokines as a third signal for T cell activation", Curr Opin Immunol, 22, pp.333~340 (2010)
20. Curtsinger JM, "Signal 3 determines tolerance versus full activation of naive CD8 T cells : dissociating proliferation and development of effector function", J Exp Med, 197, pp.1141~1151 (2003)
22. Céspedes PF, "T-cell trans-synaptic vesicles are distinct and carry greater effector content than constitutive extracellular vesicles", Nat Commun, 13, pp.3460~ (2022)
23. Chapman NM, "Metabolic coordination of T cell quiescence and activation", Nat Rev Immunol, 20, pp.55~70 (2020)
24. Buck MD, "Metabolic instruction of immunity", Cell, 169, pp.570~586 (2017)
25. Li QJ, "miR-181a is an intrinsic modulator of T cell sensitivity and selection", Cell, 129, pp.147~161 (2007)
26. Pettmann J, "The discriminatory power of the T cell receptor", Elife, 10, pp.e67092~ (2021)
27. Mandl JN, "T cell-positive selection uses self-ligand binding strength to optimize repertoire recognition of foreign antigens", Immunity, 38, pp.263~274 (2013)
28. Martin B, "Highly self-reactive naive CD4 T cells are prone to differentiate into regulatory T cells", Nat Commun, 4, pp.2209~ (2013)
29. Henderson JG, "CD5 instructs extrathymic regulatory T cell development in response to self and tolerizing antigens", Immunity, 42, pp.471~483 (2015)
30. Salaman MR, "Breakdown of T-cell ignorance : the tolerance failure responsible for mainstream autoimmune diseases?", J Transl Autoimmun, 3, pp.100070~ (2020)
31. Linette GP, "Immunological ignorance is an enabling feature of the oligo-clonal T cell response to melanoma neoantigens", Proc Natl Acad Sci U S A, 116, pp.23662~23670 (2019)
32. Kurts C, "CD8 T cell ignorance or tolerance to islet antigens depends on antigen dose", Proc Natl Acad Sci U S A, 96, pp.12703~12707 (1999)
33. Fan Y, "Molecular control of cell density-mediated exit to quiescence", Cell Reports, 36, pp.109436~ (2021)
34. Marescal O, "Cellular mechanisms and regulation of quiescence", Dev Cell, 55, pp.259~271 (2020)
35. Newton RH, "Maintenance of CD4 T cell fitness through regulation of Foxo1", Nat Immunol, 19, pp.838~848 (2018)
36. Miller ML, "Basal NF-κB controls IL-7 responsiveness of quiescent naïve T cells", Proc Natl Acad Sci U S A, 111, pp.7397~7402 (2014)
37. Shyer JA, "Metabolic signaling in T cells", Cell Res, 30, pp.649~659 (2020)
38. Geltink RIK, "Unraveling the complex interplay between T cell metabolism and function", Annu Rev Immunol, 36, pp.461~488 (2018)
39. Rawlings JS, "Chromatin condensation via the condensin II complex is required for peripheral T-cell quiescence", EMBO J, 30, pp.263~276 (2011)
40. van der Burg SH, "Vaccines for established cancer : overcoming the challenges posed by immune evasion", Nat Rev Cancer, 16, pp.219~233 (2016)
41. Schwartz RH, "T cell anergy", Annu Rev Immunol, 21, pp.305~334 (2003)
42. Maggi J, "Therapeutic potential of hyporesponsive CD4(+)T cells in autoimmunity", Front Immunol, 6, pp.488~ (2015)
43. Tanchot C, "Adaptive tolerance of CD4+ T cells in vivo : multiple thresholds in response to a constant level of antigen presentation", J Immunol, 167, pp.2030~2039 (2001)
44. Nüssing S, "Revisiting T cell tolerance as a checkpoint target for cancer immunotherapy", Front Immunol, 11, pp.589641~ (2020)
45. Ardouin L, "Broad and largely concordant molecular changes characterize tolerogenic and immunogenic dendritic cell maturation in thymus and periphery", Immunity, 45, pp.305~318 (2016)
46. Macián F, "Transcriptional mechanisms underlying lymphocyte tolerance", Cell, 109, pp.719~731 (2002)
47. Mognol GP, "Targeting the NFAT : AP-1 transcriptional complex on DNA with a small-molecule inhibitor", Proc Natl Acad Sci U S A, 116, pp.9959~9968 (2019)
48. Soto-Nieves N, "Transcriptional complexes formed by NFAT dimers regulate the induction of T cell tolerance", J Exp Med, 206, pp.867~876 (2009)
49. Guram K, "A threshold model for T-cell activation in the era of checkpoint blockade immunotherapy", Front Immunol, 10, pp.491~ (2019)
50. Marchingo JM, "T cell signaling. Antigen affinity, costimulation, and cytokine inputs sum linearly to amplify T cell expansion", Science, 346, pp.1123~1127 (2014)
51. Mayya V, "Durable interactions of T cells with T cell receptor stimuli in the absence of a stable immunological synapse", Cell Reports, 22, pp.340~349 (2018)
52. Bousso P, "T-cell activation by dendritic cells in the lymph node : lessons from the movies", Nat Rev Immunol, 8, pp.675~684 (2008)
53. Lee WT, "Anergy in CD4 memory T lymphocytes. II. Abrogation of TCR-induced formation of membrane signaling complexes", Cell Immunol, 276, pp.26~34 (2012)
54. Ise W, "Orally tolerized T cells can form conjugates with APCs but are defective in immunological synapse formation", J Immunol, 175, pp.829~838 (2005)
55. Doherty M, "Anergic CD4+ T cells form mature immunological synapses with enhanced accumulation of c-Cbl and Cbl-b", J Immunol, 184, pp.3598~3608 (2010)
56. Benvenuti F, "Dendritic cell maturation controls adhesion, synapse formation, and the duration of the interactions with naive T lymphocytes", J Immunol, 172, pp.292~301 (2004)
57. Alraies Z, "Cell shape sensing licenses dendritic cells for homeostatic migration to lymph nodes", Nat Immunol, 25, pp.1193~1206 (2024)
58. Blank CU, "Defining ‘T cell exhaustion’", Nat Rev Immunol, 19, pp.665~674 (2019)
59. Wherry EJ, "Molecular and cellular insights into T cell exhaustion", Nat Rev Immunol, 15, pp.486~499 (2015)
60. Martinez GJ, "The transcription factor NFAT promotes exhaustion of activated CD8+ T cells", Immunity, 42, pp.265~278 (2015)
61. Bending D, "Nr4a nuclear receptors : markers and modulators of antigen receptor signaling", Curr Opin Immunol, 81, pp.102285~ (2023)
62. Philips EA, "Transmembrane domain-driven PD-1 dimers mediate T cell inhibition", Sci Immunol, 9, pp.eade6256~ (2024)
63. Li K, "PD-1 suppresses TCR-CD8 cooperativity during T-cell antigen recognition", Nat Commun, 12, pp.2746~ (2021)
64. Sandu I, "Exhausted CD8+ T cells exhibit low and strongly inhibited TCR signaling during chronic LCMV infection", Nat Commun, 11, pp.4454~ (2020)
65. Ribas A, "Cancer immunotherapy using checkpoint blockade", Science, 359, pp.1350~1355 (2018)
66. Schneider H, "Reversal of the TCR stop signal by CTLA-4", Science, 313, pp.1972~1975 (2006)
67. Buchbinder EI, "CTLA-4 and PD-1 pathways : similarities, differences, and implications of their inhibition", Am J Clin Oncol, 39, pp.98~106 (2016)
68. Said EA, "Programmed death-1-induced interleukin-10 production by monocytes impairs CD4+ T cell activation during HIV infection", Nat Med, 16, pp.452~459 (2010)
69. West EE, "PD-L1 blockade synergizes with IL-2 therapy in reinvigorating exhausted T cells", J Clin Invest, 123, pp.2604~2615 (2013)
70. Yu YR, "Disturbed mitochondrial dynamics in CD8+ TILs reinforce T cell exhaustion", Nat Immunol, 21, pp.1540~1551 (2020)
71. Scharping NE, "Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion", Nat Immunol, 22, pp.205~215 (2021)
72. Liu YN, "Hypoxia induces mitochondrial defect that promotes T cell exhaustion in tumor microenvironment through MYC-regulated pathways", Front Immunol, 11, pp.1906~ (2020)
73. Gavazzi G, "Ageing and infection", Lancet Infect Dis, 2, pp.659~666 (2002)
74. Montecino-Rodriguez E, "Causes, consequences, and reversal of immune system aging", J Clin Invest, 123, pp.958~965 (2013)
75. Nakagami H, "Cellular senescence and senescence-associated T cells as a potential therapeutic target", Geriatr Gerontol Int, 20, pp.97~100 (2020)
76. Akbar AN, "Senescence of T lymphocytes : implications for enhancing human immunity", Trends Immunol, 37, pp.866~876 (2016)
77. Fulop T, "Immunosenescence and inflamm-aging as two sides of the same coin : friends or foes?", Front Immunol, 8, pp.1960~ (2018)
78. Liu Z, "Immunosenescence : molecular mechanisms and diseases", Signal Transduct Target Ther, 8, pp.200~ (2023)
79. Abbas AA, "Induction of T cell senescence by cytokine induced bystander activation", Front Aging, 2, pp.714239~ (2021)
80. Covre LP, "The role of senescent T cells in immunopathology", Aging Cell, 19, pp.e13272~ (2020)
81. George RP, "Premature T cell senescence in pediatric CKD", J Am Soc Nephrol, 28, pp.359~367 (2017)
82. Pangrazzi L, "T cells, aging and senescence", Exp Gerontol, 134, pp.110887~ (2020)
83. Xu W, "Markers of T cell senescence in humans", Int J Mol Sci, 18, pp.1742~ (2017)
84. Pereira BI, "Sestrins induce natural killer function in senescent-like CD8+ T cells", Nat Immunol, 21, pp.684~694 (2020)
85. Martínez-Zamudio RI, "Senescence-associated β-galactosidase reveals the abundance of senescent CD8+ T cells in aging humans", Aging Cell, 20, pp.e13344~ (2021)
86. Zhang J, "Senescent T cells : a potential biomarker and target for cancer therapy", EBioMedicine, 68, pp.103409~ (2021)
87. Yu HT, "T cell senescence and cardiovascular diseases", Clin Exp Med, 16, pp.257~263 (2016)
88. Lanna A, "An intercellular transfer of telomeres rescues T cells from senescence and promotes long-term immunological memory", Nat Cell Biol, 24, pp.1461~1474 (2022)
89. García-Sáez AJ, "The secrets of the Bcl-2 family", Cell Death Differ, 19, pp.1733~1740 (2012)
90. Hernandez JB, "Life and death in the thymus--cell death signaling during T cell development", Curr Opin Cell Biol, 22, pp.865~871 (2010)
91. Grayson JM, "Role of Bim in regulating CD8+ T-cell responses during chronic viral infection", J Virol, 80, pp.8627~8638 (2006)
92. Masson F, "Bid and Bim collaborate during induction of T cell death in persistent infection", J Immunol, 186, pp.4059~4066 (2011)
93. Pandiyan P, "CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4+ T cells", Nat Immunol, 8, pp.1353~1362 (2007)
94. Chetoui N, "Interleukin-7 promotes the survival of human CD4+ effector", memory T cells by up-regulating Bcl-2 proteins and activating the JAK, Immunology, pp.2010, 130[DOI]
95. Zhang N, "The role of apoptosis in the development and function of T lymphocytes", Cell Res, 15, pp.749~769 (2005)
96. Volpe E, "Fas-Fas ligand : checkpoint of T cell functions in multiple sclerosis", Front Immunol, 7, pp.382~ (2016)
97. Dhuriya YK, "Necroptosis : a regulated inflammatory mode of cell death", J Neuroinflammation, 15, pp.199~ (2018)
98. Xia S, "Mechanism and regulation of gasdermin-mediated cell death", Cold Spring Harb Perspect Biol, 12, pp.a036400~ (2020)
99. Pan T, "Necroptosis takes place in human immunodeficiency virus type-1(HIV-1)-infected CD4+ T lymphocytes", PLoS One, 9, pp.e93944~ (2014)
100. Jiang X, "Ferroptosis : mechanisms, biology and role in disease", Nat Rev Mol Cell Biol, 22, pp.266~282 (2021)
101. Reis e Sousa C, "Dendritic cells in a mature age", Nat Rev Immunol, 6, pp.476~483 (2006)
102. Phillips BE, "Tolerogenic dendritic cells and T-regulatory cells at the clinical trials crossroad for the treatment of autoimmune disease; emphasis on type 1 diabetes therapy", Front Immunol, 10, pp.148~ (2019)
103. Brown CC, "Transcriptional basis of mouse and human dendritic cell heterogeneity", Cell, 179, pp.846~863 (2019)
104. Miller JC, "Deciphering the transcriptional network of the dendritic cell lineage", Nat Immunol, 13, pp.888~899 (2012)
105. Comi M, "Coexpression of CD163 and CD141 identifies human circulating IL-10-producing dendritic cells(DC-10)", Cell Mol Immunol, 17, pp.95~107 (2020)
106. Takenaka MC, "Tolerogenic dendritic cells", Semin Immunopathol, 39, pp.113~120 (2017)
107. Švajger U, "Recent discoveries in dendritic cell tolerance-inducing pharmacological molecules", Int Immunopharmacol, 81, pp.106275~ (2020)
108. Robertson H, "Transcriptomic analysis identifies a tolerogenic dendritic cell signature", Front Immunol, 12, pp.733231~ (2021)
109. Jansen MAA, "Matured tolerogenic dendritic cells effectively inhibit autoantigen specific CD4+ T cells in a murine arthritis model", Front Immunol, 10, pp.2068~ (2019)
110. Zhang M, "Inhibition of microRNA let-7i depresses maturation and functional state of dendritic cells in response to lipopolysaccharide stimulation via targeting suppressor of cytokine signaling 1", J Immunol, 187, pp.1674~1683 (2011)
111. Mahnke K, "Induction of CD4+", CD25+ regulatory T cells by targeting of antigens to immature dendritic cells, 2003, pp.101, 4862~4869
112. Maldonado RA, "Polymeric synthetic nanoparticles for the induction of antigen-specific immunological tolerance", Proc Natl Acad Sci U S A, 112, pp.E156~ (2015)
113. "Synergistic activity of IL-2 mutein with tolerogenic ImmTOR nanoparticles leads to massive expansion of antigen-specific Tregs and protection against autoimmune disease" (2023)[URL]
114. Sage PT, "Dendritic cell PD-L1 limits autoimmunity and follicular T cell differentiation and function", J Immunol, 200, pp.2592~2602 (2018)
115. Raker VK, "Tolerogenic dendritic cells for regulatory T cell induction in man", Front Immunol, 6, pp.569~ (2015)
116. Sebastian M, "Helios controls a limited subset of regulatory T cell functions", J Immunol, 196, pp.144~155 (2016)
117. Weiss JM, "Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells", J Exp Med, 209, pp.1723~1742 (2012)
118. Komatsu N, "Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis", Nat Med, 20, pp.62~68 (2014)
119. Someya K, "Improvement of Foxp3 stability through CNS2 demethylation by TET enzyme induction and activation", Int Immunol, 29, pp.365~375 (2017)
120. Ohkura N, "T cell receptor stimulation-induced epigenetic changes and Foxp3 expression are independent and complementary events required for Treg cell development", Immunity, 37, pp.785~799 (2012)
121. Legoux FP, "CD4+ T cell tolerance to tissue-restricted self antigens is mediated by antigen-specific regulatory T cells rather than deletion", Immunity, 43, pp.896~908 (2015)
122. Duhen T, "Functionally distinct subsets of human FOXP3+ Treg cells that phenotypically mirror effector Th cells", Blood, 119, pp.4430~4440 (2012)
123. Levine AG, "Stability and function of regulatory T cells expressing the transcription factor T-bet", Nature, 546, pp.421~425 (2017)
124. Zheng Y, "Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T(H)2 responses", Nature, 458, pp.351~356 (2009)
125. Brüstle A, "The development of inflammatory T(H)-17 cells requires interferon-regulatory factor 4", Nat Immunol, 8, pp.958~966 (2007)
126. Chung Y, "Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions", Nat Med, 17, pp.983~988 (2011)
127. Linterman MA, "Foxp3+ follicular regulatory T cells control the germinal center response", Nat Med, 17, pp.975~982 (2011)
128. Joller N, "Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory Th1 and Th17 cell responses", Immunity, 40, pp.569~581 (2014)
129. Delacher M, "Rbpj expression in regulatory T cells is critical for restraining TH2 responses", Nat Commun, 10, pp.1621~ (2019)
130. Beriou G, "IL-17-producing human peripheral regulatory T cells retain suppressive function", Blood, 113, pp.4240~4249 (2009)
131. Feng Y, "Control of the inheritance of regulatory T cell identity by a cis element in the Foxp3 locus", Cell, 158, pp.749~763 (2014)
132. Walker LS, "The emerging role of CTLA4 as a cell-extrinsic regulator of T cell responses", Nat Rev Immunol, 11, pp.852~863 (2011)
133. Francisco LM, "PD-L1 regulates the development, maintenance, and function of induced regulatory T cells", J Exp Med, 206, pp.3015~3029 (2009)
134. Sierro S, "The CD4-like molecule LAG-3, biology and therapeutic applications", Expert Opin Ther Targets, 15, pp.91~101 (2011)
135. del Rio ML, "HVEM", LIGHT, CD160 cosignaling pathways as targets for immune regulation, pp.J Leukoc Biol, 2010[DOI]
136. Dilek N, "Targeting CD28, CTLA-4 and PD-L1 costimulation differentially controls immune synapses and function of human regulatory and conventional T-cells", PLoS One, 8, pp.e83139~ (2013)
137. Tomiyama T, "Antigen-specific suppression and immunological synapse formation by regulatory T cells require the Mst1 kinase", PLoS One, 8, pp.e73874~ (2013)
138. Zanin-Zhorov A, "Protein kinase C-θ mediates negative feedback on regulatory T cell function", Science, 328, pp.372~376 (2010)
139. Tadokoro CE, "Regulatory T cells inhibit stable contacts between CD4+ T cells and dendritic cells in vivo", J Exp Med, 203, pp.505~511 (2006)
140. Onishi Y, "Foxp3+ natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation", Proc Natl Acad Sci U S A, 105, pp.10113~10118 (2008)
141. Yokosuka T, "Spatiotemporal basis of CTLA-4 costimulatory molecule-mediated negative regulation of T cell activation", Immunity, 33, pp.326~339 (2010)
142. Qureshi OS, "Trans-endocytosis of CD80 and CD86 : a molecular basis for the cell-extrinsic function of CTLA-4", Science, 332, pp.600~603 (2011)
143. Akkaya B, "Regulatory T cells mediate specific suppression by depleting peptide-MHC class II from dendritic cells", Nat Immunol, 20, pp.218~231 (2019)
144. Tang Q, "Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice", Nat Immunol, 7, pp.83~92 (2006)
145. Matheu MP, "Imaging regulatory T cell dynamics and CTLA4-mediated suppression of T cell priming", Nat Commun, 6, pp.6219~ (2015)
146. Chen J, "Strong adhesion by regulatory T cells induces dendritic cell cytoskeletal polarization and contact-dependent lethargy", J Exp Med, 214, pp.327~338 (2017)
147. Leithner A, "Dendritic cell actin dynamics control contact duration and priming efficiency at the immunological synapse", J Cell Biol, 220, pp.e202006081~ (2021)
148. Brezar V, "PKC-theta in regulatory and effector T-cell functions", Front Immunol, 6, pp.530~ (2015)
149. McDonald-Hyman C, "The vimentin intermediate filament network restrains regulatory T cell suppression of graft-versus-host disease", J Clin Invest, 128, pp.4604~4621 (2018)
150. Gupta S, "Differential requirement of PKC-theta in the development and function of natural regulatory T cells", Mol Immunol, 46, pp.213~224 (2008)
151. Di Pilato M, "Targeting the CBM complex causes Treg cells to prime tumours for immune checkpoint therapy", Nature, 570, pp.112~116 (2019)
152. Nakagawa H, "New insights into the biology of CD8 regulatory T cells", Adv Immunol, 140, pp.1~20 (2018)
153. Kenison JE, "Therapeutic induction of antigen-specific immune tolerance", Nat Rev Immunol, 24, pp.338~357 (2024)
154. Hu D, "Analysis of regulatory CD8 T cells in Qa-1-deficient mice", Nat Immunol, 5, pp.516~523 (2004)
155. Kim HJ, "Regulatory T cells subdue an autoimmune disease", Nature, 572, pp.443~445 (2019)
156. Kim HJ, "Stable inhibitory activity of regulatory T cells requires the transcription factor Helios", Science, 350, pp.334~339 (2015)
157. Mishra S, "TGF-β and Eomes control the homeostasis of CD8+ regulatory T cells", J Exp Med, 218, pp.e20200030~ (2021)
158. París-Muñoz A, "Helios expression is downregulated on CD8+ Treg in two mouse models of lupus during disease progression", Front Immunol, 13, pp.922958~ (2022)
159. Grossman WJ, "Human T regulatory cells can use the perforin pathway to cause autologous target cell death", Immunity, 21, pp.589~601 (2004)
160. Kim HJ, "Inhibition of follicular T-helper cells by CD8(+)regulatory T cells is essential for self tolerance", Nature, 467, pp.328~332 (2010)
161. Saligrama N, "Opposing T cell responses in experimental autoimmune encephalomyelitis", Nature, 572, pp.481~487 (2019)
162. Levescot A, "Regulatory CD8+ T cells suppress disease", Science, 376, pp.243~244 (2022)
163. Miyazaki T, "The role of macrophages in antigen presentation and T cell tolerance", Int Immunol, 5, pp.1023~1033 (1993)
164. Yamazaki T, "Blockade of B7-H1 on macrophages suppresses CD4+ T cell proliferation by augmenting IFN-gamma-induced nitric oxide production", J Immunol, 175, pp.1586~1592 (2005)
165. Lukacs-Kornek V, "Regulated release of nitric oxide by nonhematopoietic stroma controls expansion of the activated T cell pool in lymph nodes", Nat Immunol, 12, pp.1096~1104 (2011)
166. Diskin B, "PD-L1 engagement on T cells promotes self-tolerance and suppression of neighboring macrophages and effector T cells in cancer", Nat Immunol, 21, pp.442~454 (2020)
167. Kersten K, "Spatiotemporal co-dependency between macrophages and exhausted CD8+ T cells in cancer", Cancer Cell, 40, pp.624~638 (2022)
168. Nixon BG, "Tumor-associated macrophages expressing the transcription factor IRF8 promote T cell exhaustion in cancer", Immunity, 55, pp.2044~2058 (2022)
169. Galazka G, "NK cell induced T cell anergy depends on GRAIL expression", Cells, 8, pp.790~ (2019)
170. Lindsay RS, "NK cells reduce anergic T cell development in early-stage tumors by promoting myeloid cell maturation", Front Oncol, 12, pp.1058894~ (2022)
171. Malhotra D, "Tolerance is established in polyclonal CD4(+)T cells by distinct mechanisms, according to self-peptide expression patterns", Nat Immunol, 17, pp.187~195 (2016)
172. Truckenbrod EN, "CD8+ T cell self-tolerance permits responsiveness but limits tissue damage", Elife, 10, pp.e65615~ (2021)
173. Upadhaya S, "Challenges and opportunities in the PD1", PDL1 inhibitor clinical trial landscape, 2022, pp.21, 482~483
174. Scottà C, "Impact of immunosuppressive drugs on the therapeutic efficacy of ex vivo expanded human regulatory T cells", Haematologica, 101, pp.91~100 (2016)
175. Dijke IE, "Regulatory T cells after organ transplantation : where does their action take place?", Hum Immunol, 69, pp.389~398 (2008)
176. MacMillan ML, "First-in-human phase 1 trial of induced regulatory T cells for graft-versus-host disease prophylaxis in HLA-matched siblings", Blood Adv, 5, pp.1425~1436 (2021)
177. He J, "Low-dose interleukin-2 treatment selectively modulates CD4(+)T cell subsets in patients with systemic lupus erythematosus", Nat Med, 22, pp.991~993 (2016)
178. Willekens B, "Tolerogenic dendritic cell-based treatment for multiple sclerosis(MS) : a harmonised study protocol for two phase I clinical trials comparing intradermal and intranodal cell administration", BMJ Open, 9, pp.e030309~ (2019)
179. Kim SH, "Generation, characteristics and clinical trials of ex vivo generated tolerogenic dendritic cells", Yonsei Med J, 59, pp.807~815 (2018)
180. Haseda F, "CD4+ CD45RA-FoxP3high activated regulatory T cells are functionally impaired and related to residual insulin-secreting capacity in patients with type 1 diabetes", Clin Exp Immunol, 173, pp.207~216 (2013)
181. Tselios K, "The influence of therapy on CD4+CD25(high)FOXP3+ regulatory T cells in systemic lupus erythematosus patients : a prospective study", Scand J Rheumatol, 44, pp.29~35 (2015)
182. Wehrens EJ, "Functional human regulatory T cells fail to control autoimmune inflammation due to PKB", c-akt hyperactivation in effector cells, 2011, pp.118, 3538~3548
183. Alexander T, "Foxp3+ Helios+ regulatory T cells are expanded in active systemic lupus erythematosus", Ann Rheum Dis, 72, pp.1549~1558 (2013)
184. Zhou X, "Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo", Nat Immunol, 10, pp.1000~1007 (2009)
185. Anderson AE, "LPS activation is required for migratory activity and antigen presentation by tolerogenic dendritic cells", J Leukoc Biol, 85, pp.243~250 (2009)
186. Xia G, "Ex vivo-expanded natural CD4+CD25+ regulatory T cells synergize with host T-cell depletion to promote long-term survival of allografts", Am J Transplant, 8, pp.298~306 (2008)
187. Trzonkowski P, "Hurdles in therapy with regulatory T cells", Sci Transl Med, 7, pp.304~ (2015)
188. McElwee MK, "The CD4+ T cell repertoire specific for citrullinated peptides shows evidence of immune tolerance", J Exp Med, 220, pp.e20230209~ (2023)
189. Zhu J, "Resistance to cancer immunotherapy mediated by apoptosis of tumor-infiltrating lymphocytes", Nat Commun, 8, pp.1404~ (2017)
190. Zhu J, "Apoptosis of tumor-infiltrating T lymphocytes : a new immune checkpoint mechanism", Cancer Immunol Immunother, 68, pp.835~847 (2019)
191. Oda SK, "A Fas-4-1BB fusion protein converts a death to a pro-survival signal and enhances T cell therapy", J Exp Med, 217, pp.e20191166~ (2020)
192. Fan J, "Development of CAR-T cell persistence in adoptive immunotherapy of solid tumors", Front Oncol, 10, pp.574860~ (2021)
193. Lee YG, "Modulation of BCL-2 in both T cells and tumor cells to enhance chimeric antigen receptor T-cell immunotherapy against cancer", Cancer Discov, 12, pp.2372~2391 (2022)
194. Weber EW, "Transient rest restores functionality in exhausted CAR-T cells through epigenetic remodeling", Science, 372, pp.eaba1786~ (2021)
195. Wang L, "Exploiting senescence for the treatment of cancer", Nat Rev Cancer, 22, pp.340~355 (2022)
196. Ye J, "Controlling T cell senescence in the tumor microenvironment for tumor immunotherapy", OncoImmunology, 4, pp.e994398~ (2015)
197. Aiello A, "Immunosenescence and its hallmarks: how to oppose aging strategically? A review of potential options for therapeutic intervention", Front Immunol, 10, pp.2247~ (2019)
198. Derhovanessian E, "Immunity, ageing and cancer", Immun Ageing, 5, pp.11~ (2008)
199. Patrick M, "Expression and regulation of telomerase in human T cell differentiation, activation, aging and diseases", Cell Immunol, 345, pp.103989~ (2019)
200. Kasakovski D, "T cell senescence and CAR-T cell exhaustion in hematological malignancies", J Hematol Oncol, 11, pp.91~ (2018)

관련 논문AI추천