Th17 Cell and Inflammatory Infiltrate Interactions in Cutaneous Leishmaniasis: Unraveling Immunopathogenic Mechanisms
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
The inflammatory response during cutaneous leishmaniasis (CL) involves immune and non-immune cell cooperation to contain and eliminate Leishmania parasites. The orchestration of these responses is coordinated primarily by CD4+ T cells; however, the disease outcome depends on the Th cell predominant phenotype. Although Th1 and Th2 phenotypes are the most addressed as steers for the resolution or perpetuation of the disease, Th17 cell activities, especially IL-17 release, are recognized to be vital during CL development. Th17 cells perform vital functions during both acute and chronic phases of CL. Overall, Th17 cells induce the migration of phagocytes (neutrophils, macrophages) to the infection site and CD8+ T cells and NK cell activation. They also provoke granzyme and perforin secretion from CD8+ T cells, macrophage differentiation towards an M2 phenotype, and expansion of B and Treg cells. Likewise, immune cells from the inflammatory infiltrate have modulatory activities over Th17 cells involving their differentiation from naive CD4+ T cells and further expansion by generating a microenvironment rich in optimal cytokines such as IL-1β, TGF-β, IL-6, and IL-21. Th17 cell activities and synergies are crucial for the resistance of the infection during the early and acute stages; however, if unchecked, Th17 cells might lead to a chronic stage. This review discusses the synergies between Th17 cells and the inflammatory infiltrate and how these interactions might destine the course of CL.
Abstract
The inflammatory response during cutaneous leishmaniasis (CL) involves immune and non-immune cell cooperation to contain and eliminate Leishmania parasites. The orchestration of these responses is coordinated primarily by CD4+ T cells; however, the disease outcome depends on the Th cell predominant phenotype. Although Th1 and Th2 phenotypes are the most addressed as steers for the resolution or perpetuation of the disease, Th17 cell activities, especially IL-17 release, are recognized to be vital during CL development. Th17 cells perform vital functions during both acute and chronic phases of CL. Overall, Th17 cells induce the migration of phagocytes (neutrophils, macrophages) to the infection site and CD8+ T cells and NK cell activation. They also provoke granzyme and perforin secretion from CD8+ T cells, macrophage differentiation towards an M2 phenotype, and expansion of B and Treg cells. Likewise, immune cells from the inflammatory infiltrate have modulatory activities over Th17 cells involving their differentiation from naive CD4+ T cells and further expansion by generating a microenvironment rich in optimal cytokines such as IL-1β, TGF-β, IL-6, and IL-21. Th17 cell activities and synergies are crucial for the resistance of the infection during the early and acute stages; however, if unchecked, Th17 cells might lead to a chronic stage. This review discusses the synergies between Th17 cells and the inflammatory infiltrate and how these interactions might destine the course of CL.
참고문헌 (190)
- Burza S, "Leishmaniasis", Lancet, 392, pp.951~970 (2018)
- Knight CA, "Leishmaniasis : recent epidemiological studies in the Middle East", Front Microbiol, 13, pp.1052478~ (2023)
- Torres-Guerrero E, "Leishmaniasis : a review", F1000Res, 6, pp.750~ (2017)
- Machado GU, "Disseminated leishmaniasis : clinical, pathogenic, and therapeutic aspects", An Bras Dermatol, 94, pp.9~16 (2019)
- Mann S, "A review of leishmaniasis : current knowledge and future directions", Curr Trop Med Rep, 8, pp.121~132 (2021)
- Scott P, "Immunoregulation of cutaneous leishmaniasis. T cell lines that transfer protective immunity or exacerbation belong to different T helper subsets and respond to distinct parasite antigens", J Exp Med, 168, pp.1675~1684 (1988)
- Scott P, "Cutaneous leishmaniasis : immune responses in protection and pathogenesis", Nat Rev Immunol, 16, pp.581~592 (2016)
- Ruiz de Morales JM, "Critical role of interleukin(IL)-17 in inflammatory and immune disorders : an updated review of the evidence focusing in controversies", Autoimmun Rev, 19, pp.102429~ (2020)
- Gonçalves-de-Albuquerque SD, "The equivocal role of Th17 cells and neutrophils on immunopathogenesis of leishmaniasis", Front Immunol, 8, pp.1437~ (2017)
- Harrington LE, "Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages", Nat Immunol, 6, pp.1123~1132 (2005)
- Yang L, "IL-21 and TGF-β are required for differentiation of human TH17 cells", Nature, 454, pp.350~352 (2008)
- Alunno A, "Mosaic of Autoimmunity", pp.37~44 (2019), Academic Press
- Agalioti T, "TH17 cell plasticity : the role of dendritic cells and molecular mechanisms", J Autoimmun, 87, pp.50~60 (2018)
- Torchinsky MB, "Innate immune recognition of infected apoptotic cells directs TH17 cell differentiation", Nature, 458, pp.78~82 (2009)
- Segura E, "Human inflammatory dendritic cells induce Th17 cell differentiation", Immunity, 38, pp.336~348 (2013)
- Boccasavia VL, "Antigen presentation between T cells drives Th17 polarization under conditions of limiting antigen", Cell Reports, 34, pp.108861~ (2021)
- Lee GR, "The balance of Th17 versus Treg cells in autoimmunity", Int J Mol Sci, 19, pp.730~ (2018)
- Dang EV, "Control of TH17", Treg balance by hypoxia-inducible factor 1, 2011, pp.146, 772~784
- Noack M, "Th17 and regulatory T cell balance in autoimmune and inflammatory diseases", Autoimmun Rev, 13, pp.668~677 (2014)
- Sun L, "Metabolism controls the balance of Th17", T-regulatory cells, 2017, pp.8, 1632~
- McGeachy MJ, "The IL-17 family of cytokines in health and disease", Immunity, 50, pp.892~906 (2019)
- Zambrano-Zaragoza JF, "Th17 cells in autoimmune and infectious diseases", Int J Inflamm, 2014, pp.651503~ (2014)
- Zhang Y, "Interleukin-17-induced neutrophil extracellular traps mediate resistance to checkpoint blockade in pancreatic cancer", J Exp Med, 217, pp.e20190354~ (2020)
- Maione F, "Interleukin 17 sustains rather than induces inflammation", Biochem Pharmacol, 77, pp.878~887 (2009)
- Griffin GK, "IL-17 and TNF-α sustain neutrophil recruitment during inflammation through synergistic effects on endothelial activation", J Immunol, 188, pp.6287~6299 (2012)
- Fujie H, "A distinct regulatory role of Th17 cytokines IL-17A and IL-17F in chemokine secretion from lung microvascular endothelial cells", Inflammation, 35, pp.1119~1131 (2012)
- Guglani L, "Th17 cytokines in mucosal immunity and inflammation", Curr Opin HIV AIDS, 5, pp.120~127 (2010)
- Spolski R, "Interleukin-21 : a double-edged sword with therapeutic potential", Nat Rev Drug Discov, 13, pp.379~395 (2014)
- Dudakov JA, "Interleukin-22 : immunobiology and pathology", Annu Rev Immunol, 33, pp.747~785 (2015)
- Li Y, "The Immunoregulation of Th17 in host against intracellular bacterial infection", Mediators Inflamm, 2018, pp.6587296~ (2018)
- Paidipally P, "NKG2D-dependent IL-17 production by human T cells in response to an intracellular pathogen", J Immunol, 183, pp.1940~1945 (2009)
- Pitta MG, "IL-17 and IL-22 are associated with protection against human kala azar caused by Leishmania donovani", J Clin Invest, 119, pp.2379~2387 (2009)
- Gonzalez K, "Involvement of the inflammasome and Th17 cells in skin lesions of human cutaneous leishmaniasis caused by Leishmania(Viannia)panamensis", Mediators Inflamm, 2020, pp.9278931~ (2020)
- Vargas-Inchaustegui DA, "Leishmania braziliensis infection induces dendritic cell activation, ISG15 transcription, and the generation of protective immune responses", J Immunol, 180, pp.7537~7545 (2008)
- Albanesi C, "Interleukin-17 is produced by both Th1 and Th2 lymphocytes, and modulates interferon-γ-and interleukin-4-induced activation of human keratinocytes", J Invest Dermatol, 115, pp.81~87 (2000)
- Novoa R, "IL-17 and regulatory cytokines(IL-10 and IL-27)in L. braziliensis infection", Parasite Immunol, 33, pp.132~136 (2011)
- Doni A, "The long pentraxin PTX3 as a link between innate immunity, tissue remodeling, and cancer", Front Immunol, 10, pp.712~ (2019)
- Balhara J, "Pentraxin 3 deletion aggravates allergic inflammation through a TH17-dominant phenotype and enhanced CD4 T-cell survival", J Allergy Clin Immunol, 139, pp.950~963 (2017)
- Gupta G, "The long pentraxin 3(PTX3)suppresses immunity to cutaneous leishmaniasis by regulating CD4+ T helper cell response", Cell Reports, 33, pp.108513~ (2020)
- Lopez Kostka S, "IL-17 promotes progression of cutaneous leishmaniasis in susceptible mice", J Immunol, 182, pp.3039~3046 (2009)
- Pedraza-Zamora CP, "Th17 cells and neutrophils : close collaborators in chronic Leishmania mexicana infections leading to disease severity", Parasite Immunol, 39, pp.e12420~ (2017)
- Sacks D, "The immunology of susceptibility and resistance to Leishmania major in mice", Nat Rev Immunol, 2, pp.845~858 (2002)
- David CV, "Cutaneous and mucocutaneous leishmaniasis", Dermatol Ther, 22, pp.491~502 (2009)
- Boaventura VS, "Human mucosal leishmaniasis : neutrophils infiltrate areas of tissue damage that express high levels of Th17-related cytokines", Eur J Immunol, 40, pp.2830~2836 (2010)
- Leon Rodriguez DA, "Investigation of the role of IL17A gene variants in Chagas disease", Genes Immun, 16, pp.536~540 (2015)
- Puşcaş AD, "Psoriasis : association of interleukin-17 gene polymorphisms with severity and response to treatment", Exp Ther Med, 18, pp.875~880 (2019)
- Gonçalves de Albuquerque SD, "Study of association of the rs2275913 IL-17A single nucleotide polymorphism and susceptibility to cutaneous leishmaniasis caused by Leishmania braziliensis", Cytokine, 123, pp.154784~ (2019)
- Liu XK, "Crucial role for nuclear factor of activated T cells in T cell receptor-mediated regulation of human interleukin-17", J Biol Chem, 279, pp.52762~52771 (2004)
- Zhang Y, "Exosome : a review of its classification, isolation techniques, storage, diagnostic and targeted therapy applications", Int J Nanomedicine, 15, pp.6917~6934 (2020)
- Zhang Y, "Exosomes : biogenesis, biologic function and clinical potential", Cell Biosci, 9, pp.19~ (2019)
- Atayde VD, "Exosome secretion by the parasitic protozoan Leishmania within the sand fly midgut", Cell Reports, 13, pp.957~967 (2015)
- González K, "Histopathological characteristics of cutaneous lesions caused by Leishmania Viannia panamensis in Panama", Rev Inst Med Trop Sao Paulo, 60, pp.e8~ (2018)
- Teixeira C, "Characterization of the early inflammatory infiltrate at the feeding site of infected sand flies in mice protected from vector-transmitted Leishmania major by exposure to uninfected bites", PLoS Negl Trop Dis, 8, pp.e2781~ (2014)
- Tibúrcio R, "Molecular aspects of dendritic cell activation in leishmaniasis : an immunobiological view", Front Immunol, 10, pp.227~ (2019)
- Vieira MG, "B-cell infiltration and frequency of cytokine producing cells differ between localized and disseminated human cutaneous leishmaniases", Mem Inst Oswaldo Cruz, 97, pp.979~983 (2002)
- Saldanha MG, "Characterization of the histopathologic features in patients in the early and late phases of cutaneous leishmaniasis", Am J Trop Med Hyg, 96, pp.645~652 (2017)
- Scorza BM, "Cutaneous manifestations of human and murine leishmaniasis", Int J Mol Sci, 18, pp.1296~ (2017)
- Liu T, "The IL-23", IL-17 pathway in inflammatory skin diseases : from bench to bedside, 2020, pp.11, 594735~
- Nauseef WM, "Neutrophils at work", Nat Immunol, 15, pp.602~611 (2014)
- Hurrell BP, "Rapid sequestration of Leishmania mexicana by neutrophils contributes to the development of chronic lesion", PLoS Pathog, 11, pp.e1004929~ (2015)
- Peters NC, "In vivo imaging reveals an essential role for neutrophils in leishmaniasis transmitted by sand flies", Science, 321, pp.970~974 (2008)
- Regli IB, "Survival mechanisms used by some Leishmania species to escape neutrophil killing", Front Immunol, 8, pp.1558~ (2017)
- Regli IB, "TLR7 sensing by neutrophils is critical for the control of cutaneous leishmaniasis", Cell Reports, 31, pp.107746~ (2020)
- Novais FO, "Neutrophils and macrophages cooperate in host resistance against Leishmania braziliensis infection", J Immunol, 183, pp.8088~8098 (2009)
- de Souza Carmo EV, "Neutrophils reduce the parasite burden in Leishmania(Leishmania)amazonensis-infected macrophages", PLoS One, 5, pp.e13815~ (2010)
- Tacchini-Cottier F, "An immunomodulatory function for neutrophils during the induction of a CD4+ Th2 response in BALB", c mice infected with Leishmania major, 2000, pp.165, 2628~2636
- Carreira JC, "The role of neutrophils in the interaction with Leishmania : far beyond a simple Trojan horse?", Open J Anim Sci, 11, pp.399~421 (2021)
- Laskay T, "Neutrophil granulocytes--Trojan horses for Leishmania major and other intracellular microbes?", Trends Microbiol, 11, pp.210~214 (2003)
- Zenobia C, "Basic biology and role of interleukin-17 in immunity and inflammation", Periodontol 2000, 69, pp.142~159 (2015)
- Lee JW, "Differential regulation of chemokines by IL-17 in colonic epithelial cells", J Immunol, 181, pp.6536~6545 (2008)
- Capucetti A, "Multiple roles for chemokines in neutrophil biology", Front Immunol, 11, pp.1259~ (2020)
- Pelletier M, "Evidence for a cross-talk between human neutrophils and Th17 cells", Blood, 115, pp.335~343 (2010)
- Morales-Primo AU, "Neutrophil extracellular trap-associated molecules : a review on their immunophysiological and inflammatory roles", Int Rev Immunol, 41, pp.253~274 (2022)
- Minns D, "The neutrophil antimicrobial peptide cathelicidin promotes Th17 differentiation", Nat Commun, 12, pp.1285~ (2021)
- Arango Duque G, "Leishmania survival in the macrophage : where the ends justify the means", Curr Opin Microbiol, 26, pp.32~40 (2015)
- Taraghian M, "The comparison of the IFN-γ, TNF-α and IL-10 cytokines in healing and non-healing cutaneous leishmaniasis", Iran J Parasitol, 16, pp.490~498 (2021)
- Liu D, "The early interaction of Leishmania with macrophages and dendritic cells and its influence on the host immune response", Front Cell Infect Microbiol, 2, pp.83~ (2012)
- Hamid Q, "Encyclopedia of Respiratory Medicine", pp.395~400 (2006), Academic Press
- Shahrara S, "IL-17 induces monocyte migration in rheumatoid arthritis", J Immunol, 182, pp.3884~3891 (2009)
- Shen J, "IL-17 induces macrophages to M2-like phenotype via NF-κB", Cancer Manag Res, 10, pp.4217~4228 (2018)
- França-Costa J, "Arginase I, polyamine, and prostaglandin E2 pathways suppress the inflammatory response and contribute to diffuse cutaneous leishmaniasis", J Infect Dis, 211, pp.426~435 (2015)
- Tomiotto-Pellissier F, "Macrophage polarization in leishmaniasis : broadening horizons", Front Immunol, 9, pp.2529~ (2018)
- Tomiotto-Pellissier F, "Murine susceptibility to Leishmania amazonensis Infection is influenced by arginase-1 and macrophages at the lesion site", Front Cell Infect Microbiol, 11, pp.687633~ (2021)
- Jian L, "IL-21 regulates macrophage activation in human monocytic THP-1-derived macrophages", Rheumatol Autoimmun, 1, pp.18~29 (2021)
- Patente TA, "Human dendritic cells : their heterogeneity and clinical application potential in cancer immunotherapy", Front Immunol, 9, pp.3176~ (2019)
- Kim MK, "Properties of immature and mature dendritic cells : phenotype, morphology, phagocytosis, and migration", RSC Advances, 9, pp.11230~11238 (2019)
- León B, "Monocyte-derived dendritic cells formed at the infection site control the induction of protective T helper 1 responses against Leishmania", Immunity, 26, pp.519~531 (2007)
- Feijó D, "Dendritic cells and Leishmania infection : adding layers of complexity to a complex disease", J Immunol Res, 2016, pp.3967436~ (2016)
- Henry CJ, "IL-12 produced by dendritic cells augments CD8+ T cell activation through the production of the chemokines CCL1 and CCL17", J Immunol, 181, pp.8576~8584 (2008)
- Gomez MA, "Leishmania GP63 alters host signaling through cleavage-activated protein tyrosine phosphatases", Sci Signal, 2, pp.ra58~ (2009)
- Hallé M, "The Leishmania surface protease GP63 cleaves multiple intracellular proteins and actively participates in p38 mitogen-activated protein kinase inactivation", J Biol Chem, 284, pp.6893~6908 (2009)
- Matheoud D, "Leishmania evades host immunity by inhibiting antigen cross-presentation through direct cleavage of the SNARE VAMP8", Cell Host Microbe, 14, pp.15~25 (2013)
- Dietze-Schwonberg K, "Insufficient generation of Th17 cells in IL-23p19-deficient BALB", c mice protects against progressive cutaneous leishmaniasis, 2018, pp.27, 101~103
- Terada S, "IL-17 regulates Toll-like receptor-mediated activation of dendritic cells(TUM4P. 905)", J Immun, 192, pp.138~ (2014)
- Merad M, "Origin, homeostasis and function of Langerhans cells and other langerin-expressing dendritic cells", Nat Rev Immunol, 8, pp.935~947 (2008)
- Mizumoto N, "CD1a and langerin : acting as more than Langerhans cell markers", J Clin Invest, 113, pp.658~660 (2004)
- Valladeau J, "Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules", Immunity, 12, pp.71~81 (2000)
- Zuluaga M, "Langerhans cells in immunity to leishmaniasis", Biomed, 24, pp.302~317 (2004)
- Moll H, "Langerhans cells transport Leishmania major from the infected skin to the draining lymph node for presentation to antigen-specific T cells", Eur J Immunol, 23, pp.1595~1601 (1993)
- Kautz-Neu K, "Langerhans cells are negative regulators of the anti-Leishmania response", J Exp Med, 208, pp.885~891 (2011)
- Karram S, "Transepidermal elimination in cutaneous leishmaniasis : a multiregional study", J Cutan Pathol, 39, pp.406~412 (2012)
- Fernandez-Flores A, "Morphological and immunohistochemical clues for the diagnosis of cutaneous leishmaniasis and the interpretation of CD1a status", J Am Acad Dermatol, 74, pp.536~543 (2016)
- Aliahmadi E, "TLR2-activated human Langerhans cells promote Th17 polarization via IL-1β, TGF-β and IL-23", Eur J Immunol, 39, pp.1221~1230 (2009)
- Forestier CL, "Leishmania lipophosphoglycan : how to establish structure-activity relationships for this highly complex and multifunctional glycoconjugate?", Front Cell Infect Microbiol, 4, pp.193~ (2015)
- de Veer MJ, "MyD88 is essential for clearance of Leishmania major : possible role for lipophosphoglycan and Toll-like receptor 2 signaling", Eur J Immunol, 33, pp.2822~2831 (2003)
- Thoma-Uszynski S, "Activation of toll-like receptor 2 on human dendritic cells triggers induction of IL-12, but not IL-10", J Immunol, 165, pp.3804~3810 (2000)
- Kolkhir P, "Understanding human mast cells : lesson from therapies for allergic and non-allergic diseases", Nat Rev Immunol, 22, pp.294~308 (2022)
- Krystel-Whittemore M, "Mast cell : a multi-functional master cell", Front Immunol, 6, pp.620~ (2016)
- Möllerherm H, "Antimicrobial activity of mast cells : role and relevance of extracellular DNA traps", Front Immunol, 7, pp.265~ (2016)
- Mukai K, "Mast cells as sources of cytokines, chemokines, and growth factors", Immunol Rev, 282, pp.121~150 (2018)
- Naqvi N, "Host mast cells in leishmaniasis : friend or foe?", Trends Parasitol, 36, pp.952~956 (2020)
- Rodríguez NE, "Eosinophils and mast cells in leishmaniasis", Immunol Res, 59, pp.129~141 (2014)
- Maurer M, "Skin mast cells control T cell-dependent host defense in Leishmania major infections", FASEB J, 20, pp.2460~2467 (2006)
- Naqvi N, "Role of mast cells in clearance of Leishmania through extracellular trap formation", Sci Rep, 7, pp.13240~ (2017)
- Romão PR, "Mast cell degranulation contributes to susceptibility to Leishmania major", Parasite Immunol, 31, pp.140~146 (2009)
- Dudeck A, "Mast cells promote Th1 and Th17 responses by modulating dendritic cell maturation and function", Eur J Immunol, 41, pp.1883~1893 (2011)
- Suurmond J, "Expansion of Th17 cells by human mast cells is driven by inflammasome-independent IL-1β", J Immunol, 197, pp.4473~4481 (2016)
- da Silva Santos C, "The role of CD4 and CD8 T cells in human cutaneous leishmaniasis", Front Public Health, 2, pp.165~ (2014)
- Luger D, "Either a Th17 or a Th1 effector response can drive autoimmunity : conditions of disease induction affect dominant effector category", J Exp Med, 205, pp.799~810 (2008)
- Awasthi D, "Oxidized LDL induced extracellular trap formation in human neutrophils via TLR-PKC-IRAK-MAPK and NADPH-oxidase activation", Free Radic Biol Med, 93, pp.190~203 (2016)
- Yeh WI, "IFNγ inhibits Th17 differentiation and function via Tbet-dependent and Tbet-independent mechanisms", J Neuroimmunol, 267, pp.20~27 (2014)
- Gonzalez-Lombana C, "IL-17 mediates immunopathology in the absence of IL-10 following Leishmania major infection", PLoS Pathog, 9, pp.e1003243~ (2013)
- Walker JA, "TH2 cell development and function", Nat Rev Immunol, 18, pp.121~133 (2018)
- Alexander J, "T helper1", T helper2 cells and resistance, Front Immunol, pp.2012, 3[DOI]
- Shahi M, "Comparison of Th1 and Th2 responses in non-healing and healing patients with cutaneous leishmaniasis", Rep Biochem Mol Biol, 1, pp.43~48 (2013)
- Hurdayal R, "The role of IL-4 and IL-13 in cutaneous Leishmaniasis", Immunol Lett, 161, pp.179~183 (2014)
- Choy DF, "TH2 and TH17 inflammatory pathways are reciprocally regulated in asthma", Sci Transl Med, 7, pp.301~ (2015)
- Cooney LA, "Sensitivity and resistance to regulation by IL-4 during Th17 maturation", J Immunol, 187, pp.4440~4450 (2011)
- Wang YH, "A novel subset of CD4+ TH2 memory", effector cells that produce inflammatory IL-17 cytokine and promote the exacerbation of chronic allergic asthma, 2010, pp.207, 2479~2491
- Shevyrev D, "Treg heterogeneity, function, and homeostasis", Front Immunol, 10, pp.3100~ (2020)
- Vignali DA, "How regulatory T cells work", Nat Rev Immunol, 8, pp.523~532 (2008)
- Shevach EM, "tTregs, pTregs, and iTregs : similarities and differences", Immunol Rev, 259, pp.88~102 (2014)
- Maizels RM, "Regulatory T cells in infection", Adv Immunol, 112, pp.73~136 (2011)
- Gu Y, "Interleukin 10 suppresses Th17 cytokines secreted by macrophages and T cells", Eur J Immunol, 38, pp.1807~1813 (2008)
- Ehrlich A, "The immunotherapeutic role of regulatory T cells in Leishmania(Viannia)panamensis infection", J Immunol, 193, pp.2961~2970 (2014)
- Belkaid Y, "CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity", Nature, 420, pp.502~507 (2002)
- Chen X, "Th17 cells and Tregs : unlikely allies", J Leukoc Biol, 95, pp.723~731 (2014)
- Veldhoen M, "TGFβ in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells", Immunity, 24, pp.179~189 (2006)
- Chen Y, "Foxp3+ regulatory T cells promote T helper 17 cell development in vivo through regulation of interleukin-2", Immunity, 34, pp.409~421 (2011)
- Katara GK, "Analysis of localized immune responses reveals presence of Th17 and Treg cells in cutaneous leishmaniasis due to Leishmania tropica", BMC Immunol, 14, pp.52~ (2013)
- Zhang N, "CD8+ T cells : foot soldiers of the immune system", Immunity, 35, pp.161~168 (2011)
- Maimela NR, "Fates of CD8+ T cells in tumor microenvironment", Comput Struct Biotechnol J, 17, pp.1~13 (2018)
- Cox MA, "Cytokines and the inception of CD8 T cell responses", Trends Immunol, 32, pp.180~186 (2011)
- Novais FO, "CD8+ T cells in cutaneous leishmaniasis : the good, the bad, and the ugly", Semin Immunopathol, 37, pp.251~259 (2015)
- Kima PE, "Presentation via the class I pathway by Leishmania amazonensis-infected macrophages of an endogenous leishmanial antigen to CD8+ T cells", J Immunol, 159, pp.1828~1834 (1997)
- Müller I, "Expansion of gamma interferon-producing CD8+ T cells following secondary infection of mice immune to Leishmania major", Infect Immun, 62, pp.2575~2581 (1994)
- Faria DR, "Recruitment of CD8+ T cells expressing granzyme A is associated with lesion progression in human cutaneous leishmaniasis", Parasite Immunol, 31, pp.432~439 (2009)
- Novais FO, "Cytotoxic T cells mediate pathology and metastasis in cutaneous leishmaniasis", PLoS Pathog, 9, pp.e1003504~ (2013)
- Duan MC, "Th17 cell enhances CD8 T-cell cytotoxicity via IL-21 production in emphysema mice", Mediators Inflamm, 2012, pp.898053~ (2012)
- Ankathatti Munegowda M, "Th17 and Th17-stimulated CD8+ T cells play a distinct role in Th17-induced preventive and therapeutic antitumor immunity", Cancer Immunol Immunother, 60, pp.1473~1484 (2011)
- Wang D, "Th17 cells inhibit CD8+ T cell migration by systematically downregulating CXCR3 expression via IL-17A", STAT3 in advanced-stage colorectal cancer patients, 2020, pp.13, 68~
- Amezcua Vesely MC, "B-cell response during protozoan parasite infections", J Parasitol Res, 2012, pp.362131~ (2012)
- Youinou P, "B cell conducts the lymphocyte orchestra", J Autoimmun, 28, pp.143~151 (2007)
- García-Gil A, "Beyond the antibody : B cells as a target for bacterial infection", J Leukoc Biol, 105, pp.905~913 (2019)
- Upasani V, "Antibody-independent functions of B cells during viral infections", PLoS Pathog, 17, pp.e1009708~ (2021)
- Sacks DL, "Cutaneous leishmaniasis in anti-IgM-treated mice : enhanced resistance due to functional depletion of a B cell-dependent T cell involved in the suppressor pathway", J Immunol, 132, pp.2072~2077 (1984)
- Ronet C, "Leishmania major-specific B cells are necessary for Th2 cell development and susceptibility to L. major LV39 in BALB", c mice, 2008, pp.180, 4825~4835
- Cyster JG, "B cell responses – cell interaction dynamics and decisions", Cell, 177, pp.524~540 (2019)
- Griffin DO, "Human b1 cell frequency : isolation and analysis of human b1 cells", Front Immunol, 3, pp.122~ (2012)
- Firmino-Cruz L, "Freire-de-Lima CG, de Matos Guedes HL. How to B(e)-1 Important Cell During Leishmania Infection", Front Cell Infect Microbiol, 9, pp.424~ (2020)
- Babai B, "Depletion of peritoneal CD5+ B cells has no effect on the course of Leishmania major infection in susceptible and resistant mice", Clin Exp Immunol, 117, pp.123~129 (1999)
- Ronet C, "Regulatory B cells shape the development of Th2 immune responses in BALB", c mice infected with Leishmania major through IL-10 production, 2010, pp.184, 886~894
- Vanloubbeeck Y, "Protection of C3HeB", FeJ mice against Leishmania amazonensis challenge after previous Leishmania major infection, 2004, pp.71, 407~411
- Mukbel R, "Soluble factors from Leishmania major-specific CD4+T cells and B cells limit L. amazonensis amastigote survival within infected macrophages", Microbes Infect, 8, pp.2547~2555 (2006)
- Dasgupta D, "Ligation of Fc receptor of macrophages stimulates protein kinase C and anti-leishmanial activity", Mol Cell Biochem, 209, pp.1~8 (2000)
- Mitsdoerffer M, "Proinflammatory T helper type 17 cells are effective B-cell helpers", Proc Natl Acad Sci U S A, 107, pp.14292~14297 (2010)
- Patakas A, "Th17 effector cells support B cell responses outside of germinal centres", PLoS One, 7, pp.e49715~ (2012)
- Shibui A, "Th17 cell-derived IL-17 is dispensable for B cell antibody production", Cytokine, 59, pp.108~114 (2012)
- León B, "IL-17-producing B cells combat parasites", Nat Immunol, 14, pp.419~421 (2013)
- Schlegel PM, "B cells contribute to heterogeneity of IL-17 producing cells in rheumatoid arthritis and healthy controls", PLoS One, 8, pp.e82580~ (2013)
- Bermejo DA, "Trypanosoma cruzi trans-sialidase initiates a program independent of the transcription factors RORγt and Ahr that leads to IL-17 production by activated B cells", Nat Immunol, 14, pp.514~522 (2013)
- Yoon SR, "Understanding of molecular mechanisms in natural killer cell therapy", Exp Mol Med, 47, pp.e141~ (2015)
- Orange JS, "Formation and function of the lytic NK-cell immunological synapse", Nat Rev Immunol, 8, pp.713~725 (2008)
- Becker I, "Leishmania lipophosphoglycan(LPG)activates NK cells through toll-like receptor-2", Mol Biochem Parasitol, 130, pp.65~74 (2003)
- Wilhelm P, "Rapidly fatal leishmaniasis in resistant C57BL", 6 mice lacking TNF, 2001, pp.166, 4012~4019
- Prajeeth CK, "Leishmania-infected macrophages are targets of NK cell-derived cytokines but not of NK cell cytotoxicity", Infect Immun, 79, pp.2699~2708 (2011)
- del Giudice P, "Cutaneous leishmaniasis due to Leishmania infantum. Case reports and literature review", Arch Dermatol, 134, pp.193~198 (1998)
- Lieke T, "The interplay between Leishmania promastigotes and human Natural Killer cells in vitro leads to direct lysis of Leishmania by NK cells and modulation of NK cell activity by Leishmania promastigotes", Parasitology, 138, pp.1898~1909 (2011)
- Borg C, "NK cell activation by dendritic cells(DCs)requires the formation of a synapse leading to IL-12 polarization in DCs", Blood, 104, pp.3267~3275 (2004)
- Brittingham A, "Role of the Leishmania surface protease gp63 in complement fixation, cell adhesion, and resistance to complement-mediated lysis", J Immunol, 155, pp.3102~3111 (1995)
- Lieke T, "Leishmania surface protein gp63 binds directly to human natural killer cells and inhibits proliferation", Clin Exp Immunol, 153, pp.221~230 (2008)
- Cañeda-Guzmán IC, "NK cell activity differs between patients with localized and diffuse cutaneous leishmaniasis infected with Leishmania mexicana : a comparative study of TLRs and cytokines", PLoS One, 9, pp.e112410~ (2014)
- Campos TM, "Granzyme B produced by natural killer cells enhances inflammatory response and contributes to the immunopathology of cutaneous leishmaniasis", J Infect Dis, 221, pp.973~982 (2020)
- Al Omar S, "The effects of IL-17 upon human natural killer cells", Cytokine, 62, pp.123~130 (2013)
- Mingari MC, "Regulation of KIR expression in human T cells : a safety mechanism that may impair protective T-cell responses", Immunol Today, 19, pp.153~157 (1998)
- Liu Z, "Il-21 enhances NK cell activation and cytolytic activity and induces Th17 cell differentiation in inflammatory bowel disease", Inflamm Bowel Dis, 15, pp.1133~1144 (2009)
- Osero BO, "Unravelling the unsolved paradoxes of cytokine families in host resistance and susceptibility to Leishmania infection", Cytokine X, 2, pp.100043~ (2020)
- Fu B, "Natural killer cells promote immune tolerance by regulating inflammatory TH17 cells at the human maternal-fetal interface", Proc Natl Acad Sci U S A, 110, pp.E231~ (2013)
- Lunding L, "The role of IL-17 producing NK cells and other innate immune cells in poly(I : C)triggered exacerbation of experimental asthma", Eur Respir J, 48, pp.PA1102~ (2016)
- Babic M, "NK cell receptor NKG2D enforces proinflammatory features and pathogenicity of Th1 and Th17 cells", J Exp Med, 217, pp.e20190133~ (2020)
