Exosomal Communication Between the Tumor Microenvironment and Innate Immunity and Its Therapeutic Application
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Exosomes, which are well-known nanoscale extracellular vesicles, are multifunctional biomaterials derived from endosomes and perform various functions. The exosome is a critical material in cell-cell communication. In addition, it regulates the pathophysiological conditions of the tumor microenvironment in particular. In the tumor microenvironment, exosomes play a controversial role in supporting or killing cancer by conveying biomaterials derived from parent cells. Innate immunity is a crucial component of the host defense mechanism, as it prevents foreign substances, such as viruses and other microbes and tumorigenesis from invading the body. Early in the tumorigenesis process, the innate immunity explicitly recognizes the tumor via Ags and educates the adaptive immunity to eliminate it. Recent studies have revealed that exosomes regulate immunity in the tumor microenvironment. Tumor-derived exosomes regulate immunity against tumor progression and metastasis. Furthermore, tumor-derived exosomes regulate polarization, differentiation, proliferation, and activation of innate immune cells. Exosomes produced from innate immune cells can inhibit or support tumor progression and metastasis via immune cell activation and direct cancer inhibition. In this study, we investigated current knowledge regarding the communication between tumor-derived exosomes and innate immune cell-derived exosomes (from macrophages, dendritic cells, NK cells, and neutrophils) in the tumor microenvironment. In addition, we discussed the potential development of exosomal immunotherapy using native or engineered exosomes against cancer.
Abstract
Exosomes, which are well-known nanoscale extracellular vesicles, are multifunctional biomaterials derived from endosomes and perform various functions. The exosome is a critical material in cell-cell communication. In addition, it regulates the pathophysiological conditions of the tumor microenvironment in particular. In the tumor microenvironment, exosomes play a controversial role in supporting or killing cancer by conveying biomaterials derived from parent cells. Innate immunity is a crucial component of the host defense mechanism, as it prevents foreign substances, such as viruses and other microbes and tumorigenesis from invading the body. Early in the tumorigenesis process, the innate immunity explicitly recognizes the tumor via Ags and educates the adaptive immunity to eliminate it. Recent studies have revealed that exosomes regulate immunity in the tumor microenvironment. Tumor-derived exosomes regulate immunity against tumor progression and metastasis. Furthermore, tumor-derived exosomes regulate polarization, differentiation, proliferation, and activation of innate immune cells. Exosomes produced from innate immune cells can inhibit or support tumor progression and metastasis via immune cell activation and direct cancer inhibition. In this study, we investigated current knowledge regarding the communication between tumor-derived exosomes and innate immune cell-derived exosomes (from macrophages, dendritic cells, NK cells, and neutrophils) in the tumor microenvironment. In addition, we discussed the potential development of exosomal immunotherapy using native or engineered exosomes against cancer.
참고문헌 (133)
- Raposo G, "Extracellular vesicles : exosomes, microvesicles, and friends", J Cell Biol, 200, pp.373~383 (2013)
- Colombo M, "Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles", Annu Rev Cell Dev Biol, 30, pp.255~289 (2014)
- Wu R, "Roles of exosomes derived from immune cells in cardiovascular diseases", Front Immunol, 10, pp.648~ (2019)
- Chen DS, "Oncology meets immunology : the cancer-immunity cycle", Immunity, 39, pp.1~10 (2013)
- Kugeratski FG, "Exosomes as mediators of immune regulation and immunotherapy in cancer", FEBS J, 288, pp.10~35 (2021)
- Zhou X, "The function and clinical application of extracellular vesicles in innate immune regulation", Cell Mol Immunol, 17, pp.323~334 (2020)
- Joshi BS, "Endocytosis of extracellular vesicles and release of their cargo from endosomes", ACS Nano, 14, pp.4444~4455 (2020)
- Verweij FJ, "Intracellular signaling controlled by the endosomal-exosomal pathway", Commun Integr Biol, 5, pp.88~93 (2012)
- Hessvik NP, "Current knowledge on exosome biogenesis and release", Cell Mol Life Sci, 75, pp.193~208 (2018)
- Kowal J, "Biogenesis and secretion of exosomes", Curr Opin Cell Biol, 29, pp.116~125 (2014)
- Keerthikumar S, "Exocarta : a web-based compendium of exosomal cargo", J Mol Biol, 428, pp.688~692 (2016)
- Andreu Z, "Tetraspanins in extracellular vesicle formation and function", Front Immunol, 5, pp.442~ (2014)
- Hegmans JP, "Proteomic analysis of exosomes secreted by human mesothelioma cells", Am J Pathol, 164, pp.1807~1815 (2004)
- Utsugi-Kobukai S, "MHC class I-mediated exogenous antigen presentation by exosomes secreted from immature and mature bone marrow derived dendritic cells", Immunol Lett, 89, pp.125~131 (2003)
- Muntasell A, "T cell-induced secretion of MHC class II-peptide complexes on B cell exosomes", EMBO J, 26, pp.4263~4272 (2007)
- Chen G, "Exosomal PD-L1contributes to immunosuppression and is associated with anti-PD-1 response", Nature, 560, pp.382~386 (2018)
- ShurtleffMJ, "Broad role for YBX1 in defining the small noncoding RNA composition of exosomes", Proc Natl Acad Sci U S A, 114, pp.E8987~E8995 (2017)
- Wei Z, "Coding and noncoding landscape of extracellular RNA released by human glioma stem cells", Nat Commun, 8, pp.1145~ (2017)
- Shoae-Hassani A, "Nk cell-derived exosomes from NK cells previously exposed to neuroblastoma cells augment the antitumor activity of cytokine-activated NK cells", J Immunother, 40, pp.265~276 (2017)
- Liu YC, "Macrophage polarization in inflammatory diseases", Int J Biol Sci, 10, pp.520~529 (2014)
- Nonnenmacher Y, "Biochemistry of proinflammatory macrophage activation", Cell Mol Life Sci, 75, pp.2093~2109 (2018)
- Koh TJ, "Inflammation and wound healing : the role of the macrophage", Expert Rev Mol Med, 13, pp.e23~ (2011)
- Poh AR, "Targeting macrophages in cancer : From bench to bedside", Front Oncol, 8, pp.49~ (2018)
- Baig MS, "Tumor-derived exosomes in the regulation of macrophage polarization", Inflamm Res, 69, pp.435~451 (2020)
- Almatroodi SA, "Potential therapeutic targets of epigallocatechin gallate(EGCG), the most abundant catechin in green tea, and its role in the therapy of various types of cancer", Molecules, 25, pp.25~ (2020)
- Jang JY, "Exosome derived from epigallocatechin gallate treated breast cancer cells suppresses tumor growth by inhibiting tumor-associated macrophage infiltration and M2polarization", BMC Cancer, 13, pp.421~ (2013)
- Shao Y, "Colorectal cancerderived small extracellular vesicles establish an inflammatory premetastatic niche in liver metastasis", Carcinogenesis, 39, pp.1368~1379 (2018)
- Xiao M, "M1-like tumor-associated macrophages activated by exosometransferred THBS1 promote malignant migration in oral squamous cell carcinoma", J Exp Clin Cancer Res, 37, pp.143~ (2018)
- Wang M, "Role of tumor microenvironment in tumorigenesis", J Cancer, 8, pp.761~773 (2017)
- Chanmee T, "Tumor-associated macrophages as major players in the tumor microenvironment", Cancers(Basel), 6, pp.1670~1690 (2014)
- Piao YJ, "Breast cancer cell-derived exosomes and macrophage polarization are associated with lymph node metastasis", Oncotarget, 9, pp.7398~7410 (2017)
- Li X, "Regulation of macrophage activation and polarization by HCC-derived exosomal lncRNA TUC339", Int J Mol Sci, 19, pp.2958~ (2018)
- Takano Y, "Circulating exosomal microRNA-203 is associated with metastasis possibly via inducing tumorassociated macrophages in colorectal cancer", Oncotarget, 8, pp.78598~78613 (2017)
- Cheng L, "Exosomes from M1-polarized macrophages potentiate the cancer vaccine by creating a pro-inflammatory microenvironment in the lymph node", Mol Ther, 25, pp.1665~1675 (2017)
- Li Z, "Exosomal miRNA-16-5p derived from M1 macrophages enhances T cell-dependent immune response by regulating PD-L1 in gastric cancer", Front Cell Dev Biol, 8, pp.572689~ (2020)
- Wu XQ, "Emerging role of microRNAs in regulating macrophage activation and polarization in immune response and inflammation", Immunology, 148, pp.237~248 (2016)
- Wang H, "Exosomes derived from macrophages enhance aerobic glycolysis and chemoresistance in lung cancer by stabilizing c-Myc via the inhibition of NEDD4L", Front Cell Dev Biol, 8, pp.620603~ (2021)
- Yang Y, "M2 macrophagederived exosomes promote angiogenesis and growth of pancreatic ductal adenocarcinoma by targeting E2F2", Mol Ther, 29, pp.1226~1238 (2021)
- Shortman K, "Mouse and human dendritic cell subtypes", Nat Rev Immunol, 2, pp.151~161 (2002)
- Wculek SK, "Dendritic cells in cancer immunology and immunotherapy", Nat Rev Immunol, 20, pp.7~24 (2020)
- Gabrilovich D, "Mechanisms and functional significance of tumour-induced dendritic-cell defects", Nat Rev Immunol, 4, pp.941~952 (2004)
- Tesone AJ, "Pathological mobilization and activities of dendritic cells in tumor-bearing hosts : challenges and opportunities for immunotherapy of cancer", Front Immunol, 4, pp.435~ (2013)
- Hosseini R, "The roles of tumorderived exosomes in altered differentiation, maturation and function of dendritic cells", Mol Cancer, 20, pp.83~ (2021)
- Xiang X, "Induction of myeloid-derived suppressor cells by tumor exosomes", Int J Cancer, 124, pp.2621~2633 (2009)
- Grange C, "Role of HLA-G and extracellular vesicles in renal cancer stem cell-induced inhibition of dendritic cell differentiation", BMC Cancer, 15, pp.1009~ (2015)
- Vasaturo A, "Clinical implications of co-inhibitory molecule expression in the tumor microenvironment for dc vaccination : a game of stop and go", Front Immunol, 4, pp.417~ (2013)
- Truxova I, "Mature dendritic cells correlate with favorable immune infiltrate and improved prognosis in ovarian carcinoma patients", J Immunother Cancer, 6, pp.139~ (2018)
- Gao J, "Expression profiles and clinical value of plasma exosomal TIM-3 and galectin-9 in non-small cell lung cancer", Biochem Biophys Res Commun, 498, pp.409~415 (2018)
- Wang M, "Exosomal LGALS9 in the cerebrospinal fluid of glioblastoma patients suppressed dendritic cell antigen presentation and cytotoxic T-cell immunity", Cell Death Dis, 11, pp.896~ (2020)
- Rong L, "Immunosuppression of breast cancer cells mediated by transforming growth factor-β in exosomes from cancer cells", Oncol Lett, 11, pp.500~504 (2016)
- He JG, "Exosomes derived from IDO1-overexpressing rat bone marrow mesenchymal stem cells promote immunotolerance of cardiac allografts", Cell Transplant, 27, pp.1657~1683 (2018)
- Morrissey SM, "Exosomal PD-L1 : roles in tumor progression and immunotherapy", Trends Cancer, 6, pp.550~558 (2020)
- Tang Y, "The biogenesis, biology, and clinical significance of exosomal PD-L1 in cancer", Front Immunol, 11, pp.604~ (2020)
- Ning Y, "Tumor exosomes block dendritic cells maturation to decrease the T cell immune response", Immunol Lett, 199, pp.36~43 (2018)
- Norian LA, "Tumor-infiltrating regulatory dendritic cells inhibit CD8+ T cell function via L-arginine metabolism", Cancer Res, 69, pp.3086~3094 (2009)
- Czystowska-Kuzmicz M, "Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma", Nat Commun, 10, pp.3000~ (2019)
- Salimu J, "Dominant immunosuppression of dendritic cell function by prostate-cancer-derived exosomes", J Extracell Vesicles, 6, pp.1368823~ (2017)
- Ding G, "Pancreatic cancer-derived exosomes transfer miRNAs to dendritic cells and inhibit RFXAP expression via miR-212-3p", Oncotarget, 6, pp.29877~29888 (2015)
- Zhou M, "Pancreatic cancer derived exosomes regulate the expression of TLR4 in dendritic cells via miR-203", Cell Immunol, 292, pp.65~69 (2014)
- Pitt JM, "Dendritic cell-derived exosomes as immunotherapies in the fight against cancer", J Immunol, 193, pp.1006~1011 (2014)
- Zitvogel L, "Eradication of established murine tumors using a novel cell-free vaccine : dendritic cellderived exosomes", Nat Med, 4, pp.594~600 (1998)
- Wei G, "Dendritic cells derived exosomes migration to spleen and induction of inflammation are regulated by CCR7", Sci Rep, 7, pp.42996~ (2017)
- Nolte-’t Hoen EN, "Activated T cells recruit exosomes secreted by dendritic cells via LFA-1", Blood, 113, pp.1977~1981 (2009)
- Näslund TI, "Dendritic cell-derived exosomes need to activate both T and B cells to induce antitumor immunity", J Immunol, 190, pp.2712~2719 (2013)
- Romagnoli GG, "Dendritic cell-derived exosomes may be a tool for cancer immunotherapy by converting tumor cells into immunogenic targets", Front Immunol, 5, pp.692~ (2015)
- Guan S, "Umbilical cord blood-derived dendritic cells loaded with BGC823tumor antigens and DC-derived exosomes stimulate efficient cytotoxic T-lymphocyte responses and antitumor immunity in vitro and in vivo", Cent Eur J Immunol, 39, pp.142~151 (2014)
- Munich S, "Dendritic cell exosomes directly kill tumor cells and activate natural killer cells via TNF superfamily ligands", OncoImmunology, 1, pp.1074~1083 (2012)
- Huntington ND, "The cancer-natural killer cell immunity cycle", Nat Rev Cancer, 20, pp.437~454 (2020)
- Wu SY, "Natural killer cells in cancer biology and therapy", Mol Cancer, 19, pp.120~ (2020)
- Morvan MG, "NK cells and cancer : you can teach innate cells new tricks", Nat Rev Cancer, 16, pp.7~19 (2016)
- Batista IA, "The interplay of exosomes and NK cells in cancer biology", Cancers(Basel), 13, pp.473~ (2021)
- Vulpis E, "Cancer exosomes as conveyors of stress-induced molecules : new players in the modulation of NK cell response", Int J Mol Sci, 20, pp.611~ (2019)
- Hosseini R, "Cancer exosomes and natural killer cells dysfunction : biological roles, clinical significance and implications for immunotherapy", Mol Cancer, 21, pp.15~ (2022)
- Hong CS, "Circulating exosomes carrying an immunosuppressive cargo interfere with cellular immunotherapy in acute myeloid leukemia", Sci Rep, 7, pp.14684~ (2017)
- Liu C, "Murine mammary carcinoma exosomes promote tumor growth by suppression of NK cell function", J Immunol, 176, pp.1375~1385 (2006)
- Liu J, "Immune suppressed tumor microenvironment by exosomes derived from gastric cancer cells via modulating immune functions", Sci Rep, 10, pp.14749~ (2020)
- Zhao J, "Tumor-derived extracellular vesicles inhibit natural killer cell function in pancreatic cancer", Cancers(Basel), 11, pp.874~ (2019)
- Katsiougiannis S, "Saliva exosomes from pancreatic tumor-bearing mice modulate NK cell phenotype and antitumor cytotoxicity", FASEB J, 31, pp.998~1010 (2017)
- Hong CS, "Isolation of biologically active and morphologically intact exosomes from plasma of patients with cancer", J Extracell Vesicles, 5, pp.29289~ (2016)
- Azambuja JH, "Molecular profiles and immunomodulatory activities of glioblastoma-derived exosomes", Neurooncol Adv, 2, pp.vdaa056~ (2020)
- Xia Y, "Negative regulation of tumorinfiltrating NK cell in clear cell renal cell carcinoma patients through the exosomal pathway", Oncotarget, 8, pp.37783~37795 (2017)
- Lugini L, "Immune surveillance properties of human NK cell-derived exosomes", J Immunol, 189, pp.2833~2842 (2012)
- Jong AY, "Large-scale isolation and cytotoxicity of extracellular vesicles derived from activated human natural killer cells", J Extracell Vesicles, 6, pp.1294368~ (2017)
- Zhu L, "Exosomes derived from natural killer cells exert therapeutic effect in melanoma", Theranostics, 7, pp.2732~2745 (2017)
- Di Pace AL, "Characterization of human NK cell-derived exosomes: role of DNAM1 receptor in exosome-mediated cytotoxicity against tumor", Cancers(Basel), 12, pp.661~ (2020)
- Neviani P, "Natural killerderived exosomal miR-186 inhibits neuroblastoma growth and immune escape mechanisms", Cancer Res, 79, pp.1151~1164 (2019)
- Sun H, "Natural killer cell-derived exosomal miR-3607-3p inhibits pancreatic cancer progression by targeting IL-26", Front Immunol, 10, pp.2819~ (2019)
- Cooper MA, "Cytokine-induced memory-like natural killer cells", Proc Natl Acad Sci U S A, 106, pp.1915~1919 (2009)
- Romee R, "Cytokine-induced memory-like natural killer cells exhibit enhanced responses against myeloid leukemia", Sci Transl Med, 8, pp.357~ (2016)
- Paust S, "Critical role for the chemokine receptor CXCR6 in NK cell-mediated antigen-specific memory of haptens and viruses", Nat Immunol, 11, pp.1127~1135 (2010)
- Zhu L, "Enhancement of antitumor potency of extracellular vesicles derived from natural killer cells by IL-15 priming", Biomaterials, 190-191, pp.38~50 (2019)
- Aarsund M, "Comparison of characteristics and tumor targeting properties of extracellular vesicles derived from primary NK cells or NK-cell lines stimulated with IL-15 or IL-12", 15, Cancer Immunol Immunother, pp.2022, 71[DOI]
- Coffelt SB, "Neutrophils in cancer : neutral no more", Nat Rev Cancer, 16, pp.431~446 (2016)
- Zhang X, "Tumor-derived exosomes induce N2 polarization of neutrophils to promote gastric cancer cell migration", Mol Cancer, 17, pp.146~ (2018)
- Hwang WL, "Tumor stem-like cell-derived exosomal RNAs prime neutrophils for facilitating tumorigenesis of colon cancer", J Hematol Oncol, 12, pp.10~ (2019)
- Jiao Y, "Exosomal miR-30d-5p of neutrophils induces M1 macrophage polarization and primes macrophage pyroptosis in sepsis-related acute lung injury", Crit Care, 25, pp.356~ (2021)
- Zhang J, "Engineered neutrophilderived exosome-like vesicles for targeted cancer therapy", Sci Adv, 8, pp.eabj8207~ (2022)
- Gabrilovich DI, "Myeloid-derived suppressor cells as regulators of the immune system", Nat Rev Immunol, 9, pp.162~174 (2009)
- Safarzadeh E, "Circulating myeloid-derived suppressor cells : an independent prognostic factor in patients with breast cancer", J Cell Physiol, 234, pp.3515~3525 (2019)
- Youn JI, "Subsets of myeloid-derived suppressor cells in tumorbearing mice", J Immunol, 181, pp.5791~5802 (2008)
- Park MJ, "Interleukin-10 produced by myeloid-derived suppressor cells is critical for the induction of Tregs and attenuation of rheumatoid inflammation in mice", Sci Rep, 8, pp.3753~ (2018)
- Kumar V, "CD45 phosphatase inhibits STAT3 transcription factor activity in myeloid cells and promotes tumor-associated macrophage differentiation", Immunity, 44, pp.303~315 (2016)
- Bruno A, "Myeloid derived suppressor cells interactions with natural killer cells and pro-angiogenic activities : roles in tumor progression", Front Immunol, 10, pp.771~ (2019)
- Chen Z, "Roles of the exosomes derived from myeloid-derived suppressor cells in tumor immunity and cancer progression", Front Immunol, 13, pp.817942~ (2022)
- Rashid MH, "Critical immunosuppressive effect of MDSC-derived exosomes in the tumor microenvironment", Oncol Rep, 45, pp.1171~1181 (2021)
- Li X, "The tumor vessel targeting strategy : a double-edged sword in tumor metastasis", Cells, 8, pp.1602~ (2019)
- 이상훈, "Pivotal role of vascular endothelial growth factor pathway in tumor angiogenesis", Annals of Surgical Treatment and Research, 89(1), pp.1~8 (2015), 대한외과학회
- Qu X, "Induction of Bv8 expression by granulocyte colony-stimulating factor in CD11b+Gr1+ cells : key role of STAT3 signaling", J Biol Chem, 287, pp.19574~19584 (2012)
- Deng Z, "Exosomes miR-126a released from MDSC induced by DOX treatment promotes lung metastasis", Oncogene, 36, pp.639~651 (2017)
- Gao F, "Exosomes derived from myeloid-derived suppressor cells facilitate castration-resistant prostate cancer progression via S100A9", circMID1, MID1, pp.J Transl Med, 2022[DOI]
- Jiang M, "Cancer exosome-derived miR-9 and miR-181a promote the development of early-stage MDSCs via interfering with SOCS3 and PIAS3 respectively in breast cancer", Oncogene, 39, pp.4681~4694 (2020)
- Guo X, "Immunosuppressive effects of hypoxia-induced glioma exosomes through myeloid-derived suppressor cells via the miR-10a", Rora and miR-21, Oncogene, pp.2018, 37[DOI]
- Ren W, "Exosomal miRNA-107 induces myeloid-derived suppressor cell expansion in gastric cancer", Cancer Manag Res, 11, pp.4023~4040 (2019)
- Guo X, "Glioma exosomes mediate the expansion and function of myeloid-derived suppressor cells through microRNA-29a", Hbp1and microRNA-92a, Int J Cancer, pp.2019, 144[DOI]
- Barros FM, "Exosomes and immune response in cancer : friends or foes", Front Immunol, 9, pp.730~ (2018)
- Gutiérrez-Vázquez C, "Transfer of extracellular vesicles during immune cell-cell interactions", Immunol Rev, 251, pp.125~142 (2013)
- Chen H, "Tumor-derived exosomes : Nanovesicles made by cancer cells to promote cancer metastasis", Acta Pharm Sin B, 11, pp.2136~2149 (2021)
- Syn NL, "Exosomes in cancer nanomedicine and immunotherapy : prospects and challenges", Trends Biotechnol, 35, pp.665~676 (2017)
- Bell BM, "Designer exosomes as next-generation cancer immunotherapy", Nanomedicine, 12, pp.163~169 (2016)
- Ha D, "Exosomes as therapeutic drug carriers and delivery vehicles across biological membranes : current perspectives and future challenges", Acta Pharm Sin B, 6, pp.287~296 (2016)
- André F, "Exosomes as potent cell-free peptide-based vaccine. I. Dendritic cell-derived exosomes transfer functional MHC class I", peptide complexes to dendritic cells, 2004, pp.172, 2126~2136
- Dai S, "Phase I clinical trial of autologous ascites-derived exosomes combined with GM-CSF for colorectal cancer", Mol Ther, 16, pp.782~790 (2008)
- KantoffPW, "Sipuleucel-T immunotherapy for castration-resistant prostate cancer", N Engl J Med, 363, pp.411~422 (2010)
- Besse B, "Dendritic cell-derived exosomes as maintenance immunotherapy after first line chemotherapy in NSCLC", OncoImmunology, 5, pp.e1071008~ (2015)
- Schreiner B, "Interferon-beta enhances monocyte and dendritic cell expression of B7-H1(PD-L1), a strong inhibitor of autologous T-cell activation : relevance for the immune modulatory effect in multiple sclerosis", J Neuroimmunol, 155, pp.172~182 (2004)
- Yi DH, "Current status and future perspectives of dendritic cell-based cancer immunotherapy", Scand J Immunol, 78, pp.167~171 (2013)
- Sabado RL, "Directing dendritic cell immunotherapy towards successful cancer treatment", Immunotherapy, 2, pp.37~56 (2010)
- Temchura VV, "Enhancement of immunostimulatory properties of exosomal vaccines by incorporation of fusioncompetent G protein of vesicular stomatitis virus", Vaccine, 26, pp.3662~3672 (2008)
- Wolfers J, "Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming", Nat Med, 7, pp.297~303 (2001)
- Harding C, "Endocytosis and intracellular processing of transferrin and colloidal gold-transferrin in rat reticulocytes : demonstration of a pathway for receptor shedding", Eur J Cell Biol, 35, pp.256~263 (1984)
- Escudier B, "Vaccination of metastatic melanoma patients with autologous dendritic cell(DC)derived-exosomes : results of thefirst phase I clinical trial", J Transl Med, 3, pp.10~ (2005)
- Sung-Jin Choi, "Immune cell-derived small extracellular vesicles in cancer treatment", BMB Reports, 55(1), pp.48~56 (2022), 생화학분자생물학회
- Nam GH, "Emerging prospects of exosomes for cancer treatment : from conventional therapy to immunotherapy", Adv Mater, 32, pp.e2002440~ (2020)
