IL-15 in T-Cell Responses and Immunopathogenesis

키워드

참고문헌 (155)

1. Grabstein KH, "Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor", Science, 264, pp.965~968 (1994)
2. Giri JG, "Utilization of the beta and gamma chains of the IL-2 receptor by the novel cytokine IL-15", EMBO J, 13, pp.2822~2830 (1994)
3. Leonard WJ, "The gamma(c)family of cytokines : basic biology to therapeutic ramifications", Immunity, 50, pp.832~850 (2019)
4. Bamford RN, "The interleukin(IL)2 receptor beta chain is shared by IL-2 and a cytokine, provisionally designated IL-T, that stimulates T-cell proliferation and the induction of lymphokine-activated killer cells", Proc Natl Acad Sci U S A, 91, pp.4940~4944 (1994)
5. Kennedy MK, "Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice", J Exp Med, 191, pp.771~780 (2000)
6. Hu Q, "Discovery of a novel IL-15 based protein with improved developability and efficacy for cancer immunotherapy", Sci Rep, 8, pp.7675~ (2018)
7. Jabri B, "IL-15 functions as a danger signal to regulate tissue-resident T cells and tissue destruction", Nat Rev Immunol, 15, pp.771~783 (2015)
8. Lee H, "Significance of bystander T cell activation in microbial infection", Nat Immunol, 23, pp.13~22 (2022)
9. Yomogida K, "The transcription factor Aiolos restrains the activation of intestinal intraepithelial lymphocytes", Nat Immunol, 25, pp.77~87 (2024)
10. Ma S, "Harnessing IL-15 signaling to potentiate NK cell-mediated cancer immunotherapy", Trends Immunol, 43, pp.833~847 (2022)
11. Quinn LS, "Interleukin-15 : a novel anabolic cytokine for skeletal muscle", Endocrinology, 136, pp.3669~3672 (1995)
12. Musso T, "Human monocytes constitutively express membrane-bound, biologically active, and interferon-gamma-upregulated interleukin-15", Blood, 93, pp.3531~3539 (1999)
13. Rückert R, "Inhibition of keratinocyte apoptosis by IL-15 : a new parameter in the pathogenesis of psoriasis?", J Immunol, 165, pp.2240~2250 (2000)
14. Mattei F, "IL-15 is expressed by dendritic cells in response to type I IFN, double-stranded RNA, or lipopolysaccharide and promotes dendritic cell activation", J Immunol, 167, pp.1179~1187 (2001)
15. Shinozaki M, "IL-15, a survival factor for kidney epithelial cells, counteracts apoptosis and inflammation during nephritis", J Clin Invest, 109, pp.951~960 (2002)
16. Reinecker HC, "Intestinal epithelial cells both express and respond to interleukin 15", Gastroenterology, 111, pp.1706~1713 (1996)
17. Dubois S, "IL-15Ralpha recycles and presents IL-15 In trans to neighboring cells", Immunity, 17, pp.537~547 (2002)
18. Mortier E, "IL-15Ralpha chaperones IL-15 to stable dendritic cell membrane complexes that activate NK cells via trans presentation", J Exp Med, 205, pp.1213~1225 (2008)
19. Ota N, "No requirement of trans presentations of IL-15 for human CD8 T cell proliferation", J Immunol, 185, pp.6041~6048 (2010)
20. Bergamaschi C, "Circulating IL-15 exists as heterodimeric complex with soluble IL-15Rα in human and mouse serum", Blood, 120, pp.e1~ (2012)
21. Lucas M, "Dendritic cells prime natural killer cells by trans-presenting interleukin 15", Immunity, 26, pp.503~517 (2007)
22. Colpitts SL, "Cutting edge : the role of IFN-α receptor and MyD88 signaling in induction of IL-15 expression in vivo", J Immunol, 188, pp.2483~2487 (2012)
23. Colpitts SL, "Transcriptional regulation of IL-15 expression during hematopoiesis", J Immunol, 191, pp.3017~3024 (2013)
24. Domínguez-Andrés J, "Inflammatory Ly6C(high)monocytes protect against candidiasis through IL-15-driven NK cell", neutrophil activation, 2017, pp.46, 1059~1072
25. Kim TS, "IFN-gamma induces IL-15 trans-presentation by epithelial cells via IRF1", J Immunol, 208, pp.338~346 (2022)
26. Lee N, "Human monocytes have increased IFN-γ-mediated IL-15 production with age alongside altered IFN-γ receptor signaling", Clin Immunol, 152, pp.101~110 (2014)
27. Xie CB, "Complement-activated interferon-γ-primed human endothelium transpresents interleukin-15 to CD8+ T cells", J Clin Invest, 130, pp.3437~3452 (2020)
28. Miyazaki T, "Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits", Science, 266, pp.1045~1047 (1994)
29. Lin JX, "The role of shared receptor motifs and common Stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15", Immunity, 2, pp.331~339 (1995)
30. Carson WE, "A potential role for interleukin-15 in the regulation of human natural killer cell survival", J Clin Invest, 99, pp.937~943 (1997)
31. Lord JD, "The IL-2 receptor promotes lymphocyte proliferation and induction of the c-myc, bcl-2, and bcl-x genes through the trans-activation domain of Stat5", J Immunol, 164, pp.2533~2541 (2000)
32. Huntington ND, "Interleukin 15-mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1", Nat Immunol, 8, pp.856~863 (2007)
33. Gu H, "New role for Shc in activation of the phosphatidylinositol 3-kinase", Akt pathway, 2000, pp.20, 7109~7120
34. Intlekofer AM, "Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin", Nat Immunol, 6, pp.1236~1244 (2005)
35. Li D, "mTORC1 and mTORC2 coordinate early NK cell development by differentially inducing E4BP4 and T-bet", Cell Death Differ, 28, pp.1900~1909 (2021)
36. Wang Y, "The IL-15-AKT-XBP1s signaling pathway contributes to effector functions and survival in human NK cells", Nat Immunol, 20, pp.10~17 (2019)
37. Miyazaki T, "Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation", Cell, 81, pp.223~231 (1995)
38. Bianchi T, "c-Myc acts downstream of IL-15 in the regulation of memory CD8 T-cell homeostasis", Blood, 107, pp.3992~3999 (2006)
39. Lin JX, "Critical role of STAT5 transcription factor tetramerization for cytokine responses and normal immune function", Immunity, 36, pp.586~599 (2012)
40. Lin JX, "Critical functions for STAT5 tetramers in the maturation and survival of natural killer cells", Nat Commun, 8, pp.1320~ (2017)
41. Delconte RB, "CIS is a potent checkpoint in NK cell-mediated tumor immunity", Nat Immunol, 17, pp.816~824 (2016)
42. Wang X, "IL-17 constrains natural killer cell activity by restraining IL-15-driven cell maturation via SOCS3", Proc Natl Acad Sci U S A, 116, pp.17409~17418 (2019)
43. Tan S, "Transcription factor Zhx2 restricts NK cell maturation and suppresses their antitumor immunity", J Exp Med, 218, pp.e20210009~ (2021)
44. Zhou X, "The deubiquitinase Otub1 controls the activation of CD8+ T cells and NK cells by regulating IL-15-mediated priming", Nat Immunol, 20, pp.879~889 (2019)
45. Bi J, "TIPE2 is a checkpoint of natural killer cell maturation and antitumor immunity", Sci Adv, 7, pp.eabi6515~ (2021)
46. Deng Y, "Transcription factor Foxo1 is a negative regulator of natural killer cell maturation and function", Immunity, 42, pp.457~470 (2015)
47. Becker TC, "Interleukin 15 is required for proliferative renewal of virus-specific memory CD8 T cells", J Exp Med, 195, pp.1541~1548 (2002)
48. Gattinoni L, "A human memory T cell subset with stem cell-like properties", Nat Med, 17, pp.1290~1297 (2011)
49. Yajima T, "IL-15 regulates CD8+ T cell contraction during primary infection", J Immunol, 176, pp.507~515 (2006)
50. Kaech SM, "Effector and memory T-cell differentiation : implications for vaccine development", Nat Rev Immunol, 2, pp.251~262 (2002)
51. Deshpande P, "IL-7-and IL-15-mediated TCR sensitization enables T cell responses to self-antigens", J Immunol, 190, pp.1416~1423 (2013)
52. Banerjee A, "A reengineered common chain cytokine augments CD8+ T cell-dependent immunotherapy", JCI Insight, 7, pp.e158889~ (2022)
53. Richer MJ, "Inflammatory IL-15 is required for optimal memory T cell responses", J Clin Invest, 125, pp.3477~3490 (2015)
54. Setoguchi R, "IL-15 boosts the function and migration of human terminally differentiated CD8+ T cells by inducing a unique gene signature", Int Immunol, 28, pp.293~305 (2016)
55. Sharif-Askari E, "Interleukin 15-mediated induction of cytotoxic effector cells capable of eliminating Epstein-Barr virus-transformed", immortalized lymphocytes in culture, 2001, pp.93, 1724~1732
56. Schluns KS, "Cutting edge : requirement for IL-15 in the generation of primary and memory antigen-specific CD8 T cells", J Immunol, 168, pp.4827~4831 (2002)
57. Mueller YM, "IL-15 enhances survival and function of HIV-specific CD8+ T cells", Blood, 101, pp.1024~1029 (2003)
58. Saito K, "Impaired protection against Mycobacterium bovis bacillus Calmette-Guerin infection in IL-15-deficient mice", J Immunol, 176, pp.2496~2504 (2006)
59. Yajima T, "Memory phenotype CD8(+)T cells in IL-15 transgenic mice are involved in early protection against a primary infection with Listeria monocytogenes", Eur J Immunol, 31, pp.757~766 (2001)
60. Khan IA, "Treatment with soluble interleukin-15Ralpha exacerbates intracellular parasitic infection by blocking the development of memory CD8+ T cell response", J Exp Med, 195, pp.1463~1470 (2002)
61. Henson SM, "p38 signaling inhibits mTORC1-independent autophagy in senescent human CD8+ T cells", J Clin Invest, 124, pp.4004~4016 (2014)
62. Plunkett FJ, "The loss of telomerase activity in highly differentiated CD8+CD28-CD27-T cells is associated with decreased Akt(Ser473)phosphorylation", J Immunol, 178, pp.7710~7719 (2007)
63. Romero P, "Four functionally distinct populations of human effector-memory CD8+ T lymphocytes", J Immunol, 178, pp.4112~4119 (2007)
64. Chiu WK, "Generation and growth of CD28nullCD8+ memory T cells mediated by IL-15 and its induced cytokines", J Immunol, 177, pp.7802~7810 (2006)
65. Goronzy JJ, "Signaling pathways in aged T cells-a reflection of T cell differentiation, cell senescence and host environment", Semin Immunol, 24, pp.365~372 (2012)
66. Choi YJ, "CD5 suppresses IL-15-induced proliferation of human memory CD8(+)T cells by inhibiting mTOR pathways", J Immunol, 209, pp.1108~1117 (2022)
67. Morris SR, "Inflammescent CX3CR1+CD57+CD8+ T cells are generated and expanded by IL-15", JCI Insight, 5, pp.e132963~ (2020)
68. Herndler-Brandstetter D, "Post-thymic regulation of CD5 levels in human memory T cells is inversely associated with the strength of responsiveness to interleukin-15", Hum Immunol, 72, pp.627~631 (2011)
69. Kim YJ, "CD5 expression dynamically changes during the differentiation of human CD8(+)T cells predicting clinical response to immunotherapy", Immune Netw, 23, pp.e35~ (2023)
70. Correia MP, "IL-15 induces CD8+ T cells to acquire functional NK receptors capable of modulating cytotoxicity and cytokine secretion", Immunobiology, 216, pp.604~612 (2011)
71. Balin SJ, "Human antimicrobial cytotoxic T lymphocytes, defined by NK receptors and antimicrobial proteins, kill intracellular bacteria", Sci Immunol, 3, pp.eaat7668~ (2018)
72. Correia MP, "Distinct human circulating NKp30+FcεRIγ+CD8+ T cell population exhibiting high natural killer-like antitumor potential", Proc Natl Acad Sci U S A, 115, pp.E5980~ (2018)
73. Laphanuwat P, "Senescent T cells : beneficial and detrimental roles", Immunol Rev, 316, pp.160~175 (2023)
74. Lanna A, "A sestrin-dependent Erk-Jnk-p38 MAPK activation complex inhibits immunity during aging", Nat Immunol, 18, pp.354~363 (2017)
75. Pereira BI, "Sestrins induce natural killer function in senescent-like CD8+ T cells", Nat Immunol, 21, pp.684~694 (2020)
76. Seok J, "Roles of virtual memory T cells in diseases", Immune Netw, 23, pp.e11~ (2023)
77. White JT, "Antigen-inexperienced memory CD8+ T cells : where they come from and why we need them", Nat Rev Immunol, 17, pp.391~400 (2017)
78. Sosinowski T, "CD8α+ dendritic cell trans presentation of IL-15 to naive CD8+ T cells produces antigen-inexperienced T cells in the periphery with memory phenotype and function", J Immunol, 190, pp.1936~1947 (2013)
79. White JT, "Virtual memory T cells develop and mediate bystander protective immunity in an IL-15-dependent manner", Nat Commun, 7, pp.11291~ (2016)
80. Jacomet F, "Evidence for eomesodermin-expressing innate-like CD8(+)KIR", NKG2A(+)T cells in human adults and cord blood samples, 2015, pp.45, 1926~1933
81. Quinn KM, "Age-related decline in primary CD8(+)T cell responses is associated with the development of senescence in virtual memory CD8(+)T cells", Cell Rep, 23, pp.3512~3524 (2018)
82. Choi SJ, "KIR+CD8+ and NKG2A+CD8+ T cells are distinct innate-like populations in humans", Cell Rep, 42, pp.112236~ (2023)
83. Kok L, "The precursors of CD8+ tissue resident memory T cells : from lymphoid organs to infected tissues", Nat Rev Immunol, 22, pp.283~293 (2022)
84. Schenkel JM, "T cell memory. Resident memory CD8 T cells trigger protective innate and adaptive immune responses", Science, 346, pp.98~101 (2014)
85. Ariotti S, "T cell memory. Skin-resident memory CD8+ T cells trigger a state of tissue-wide pathogen alert", Science, 346, pp.101~105 (2014)
86. Mackay LK, "The developmental pathway for CD103(+)CD8+ tissue-resident memory T cells of skin", Nat Immunol, 14, pp.1294~1301 (2013)
87. Holz LE, "CD8(+)T cell activation leads to constitutive formation of liver tissue-resident memory T cells that seed a large and flexible niche in the liver", Cell Rep, 25, pp.68~79 (2018)
88. Mackay LK, "T-box transcription factors combine with the cytokines TGF-beta and IL-15 to control tissue-resident memory T cell fate", Immunity, 43, pp.1101~1111 (2015)
89. Schenkel JM, "IL-15-independent maintenance of tissue-resident and boosted effector memory CD8 T cells", J Immunol, 196, pp.3920~3926 (2016)
90. Adachi T, "Hair follicle-derived IL-7 and IL-15 mediate skin-resident memory T cell homeostasis and lymphoma", Nat Med, 21, pp.1272~1279 (2015)
91. Jarjour NN, "Responsiveness to interleukin-15 therapy is shared between tissue-resident and circulating memory CD8+ T cell subsets", Proc Natl Acad Sci U S A, 119, pp.e2209021119~ (2022)
92. Koh JY, "Human CD8(+)T-cell populations that express natural killer receptors", Immune Netw, 23, pp.e8~ (2023)
93. Arlettaz L, "Activating CD94 : NKG2C and inhibitory CD94 : NKG2A receptors are expressed by distinct subsets of committed CD8+ TCR alphabeta lymphocytes", Eur J Immunol, 34, pp.3456~3464 (2004)
94. Gumá M, "The CD94", NKG2C killer lectin-like receptor constitutes an alternative activation pathway for a subset of CD8+ T cells, 2005, pp.35, 2071~2080
95. Kefalakes H, "Liver-resident bystander CD8+ T cells contribute to liver disease pathogenesis in chronic hepatitis D virus infection", Gastroenterology, 161, pp.1567~1583 (2021)
96. Koh JY, "Identification of a distinct NK-like hepatic T-cell population activated by NKG2C in a TCR-independent manner", J Hepatol, 77, pp.1059~1070 (2022)
97. Ruf B, "Innate lymphoid cells and innate-like T cells in cancer-at the crossroads of innate and adaptive immunity", Nat Rev Cancer, 23, pp.351~371 (2023)
98. Godfrey DI, "The biology and functional importance of MAIT cells", Nat Immunol, 20, pp.1110~1128 (2019)
99. Tao H, "Differential controls of MAIT cell effector polarization by mTORC1", mTORC2 via integrating cytokine and costimulatory signals, 2021, pp.12, 2029~
100. van Wilgenburg B, "MAIT cells are activated during human viral infections", Nat Commun, 7, pp.11653~ (2016)
101. Sattler A, "IL-15 dependent induction of IL-18 secretion as a feedback mechanism controlling human MAIT-cell effector functions", Eur J Immunol, 45, pp.2286~2298 (2015)
102. Silva-Santos B, "γδ T cells : pleiotropic immune effectors with therapeutic potential in cancer", Nat Rev Cancer, 19, pp.392~404 (2019)
103. Lee HW, "Heterogeneity of human gammadelta T cells and their role in cancer immunity", Immune Netw, 20, pp.e5~ (2020)
104. Hu Y, "γδ T cells : origin and fate, subsets, diseases and immunotherapy", Signal Transduct Target Ther, 8, pp.434~ (2023)
105. Baccala R, "Gamma delta T cell homeostasis is controlled by IL-7 and IL-15 together with subset-specific factors", J Immunol, 174, pp.4606~4612 (2005)
106. Wang H, "Interleukin-15 enhanced the survival of human γδT cells by regulating the expression of Mcl-1 in neuroblastoma", Cell Death Dis, 8, pp.139~ (2022)
107. Van Acker HH, "Interleukin-15 enhances the proliferation, stimulatory phenotype, and antitumor effector functions of human gamma delta T cells", J Hematol Oncol, 9, pp.101~ (2016)
108. Waldmann TA, "The biology of interleukin-2 and interleukin-15 : implications for cancer therapy and vaccine design", Nat Rev Immunol, 6, pp.595~601 (2006)
109. Liu RB, "IL-15 in tumor microenvironment causes rejection of large established tumors by T cells in a noncognate T cell receptor-dependent manner", Proc Natl Acad Sci U S A, 110, pp.8158~8163 (2013)
110. Mathios D, "Therapeutic administration of IL-15 superagonist complex ALT-803 leads to long-term survival and durable antitumor immune response in a murine glioblastoma model", Int J Cancer, 138, pp.187~194 (2016)
111. Kim KH, "PD-1 blockade-unresponsive human tumor-infiltrating CD8+ T cells are marked by loss of CD28 expression and rescued by IL-15", Cell Mol Immunol, 18, pp.385~397 (2021)
112. Lee J, "IL-15 promotes self-renewal of progenitor exhausted CD8 T cells during persistent antigenic stimulation", Front Immunol, 14, pp.1117092~ (2023)
113. Wrangle JM, "ALT-803, an IL-15 superagonist, in combination with nivolumab in patients with metastatic non-small cell lung cancer : a non-randomised, open-label, phase 1b trial", Lancet Oncol, 19, pp.694~704 (2018)
114. Leidner R, "First-in-human phase I", Ib study of NIZ985, a recombinant heterodimer of IL-15 and IL-15Rα, as a single agent and in combination with spartalizumab in patients with advanced and metastatic solid tumors, 2023, pp.11, e007725~
115. Miyazaki T, "NKTR-255, a novel polymer-conjugated rhIL-15 with potent antitumor efficacy", J Immunother Cancer, 9, pp.e002024~ (2021)
116. Rhode PR, "Comparison of the superagonist complex, ALT-803, to IL15 as cancer immunotherapeutics in animal models", Cancer Immunol Res, 4, pp.49~60 (2016)
117. Kim PS, "IL-15 superagonist", IL-15RαSushi-Fc fusion complex(IL-15SA, Oncotarget, pp.2016, 7[DOI]
118. Knudson KM, "Rationale for IL-15 superagonists in cancer immunotherapy", Expert Opin Biol Ther, 20, pp.705~709 (2020)
119. Chamie K, "Preliminary phase 2 clinical results of IL-15RαFc superagonist N-803 with BCG in BCG-unresponsive non-muscle invasive bladder cancer(NMIBC)patients", J Clin Oncol, 37, pp.4561~ (2019)
120. Alizadeh D, "IL15 enhances CAR-T cell antitumor activity by reducing mTORC1 activity and preserving their stem cell memory phenotype", Cancer Immunol Res, 7, pp.759~772 (2019)
121. Singh N, "Early memory phenotypes drive T cell proliferation in patients with pediatric malignancies", Sci Transl Med, 8, pp.320~ (2016)
122. Kochenderfer JN, "Lymphoma remissions caused by anti-CD19 chimeric antigen receptor T cells are associated with high serum interleukin-15 levels", J Clin Oncol, 35, pp.1803~1813 (2017)
123. Hurton LV, "Tethered IL-15 augments antitumor activity and promotes a stem-cell memory subset in tumor-specific T cells", Proc Natl Acad Sci U S A, 113, pp.E7788~ (2016)
124. Simoni Y, "Bystander CD8+ T cells are abundant and phenotypically distinct in human tumour infiltrates", Nature, 557, pp.575~579 (2018)
125. Tietze JK, "Delineation of antigen-specific and antigen-nonspecific CD8(+)memory T-cell responses after cytokine-based cancer immunotherapy", Blood, 119, pp.3073~3083 (2012)
126. Liu K, "IL-15 mimics T cell receptor crosslinking in the induction of cellular proliferation, gene expression, and cytotoxicity in CD8+ memory T cells", Proc Natl Acad Sci U S A, 99, pp.6192~6197 (2002)
127. Maurice NJ, "The ugly duckling turned to swan : a change in perception of bystander-activated memory CD8 T cells", J Immunol, 206, pp.455~462 (2021)
128. Younes SA, "IL-15 promotes activation and expansion of CD8+ T cells in HIV-1 infection", J Clin Invest, 126, pp.2745~2756 (2016)
129. Chu T, "Bystander-activated memory CD8 T cells control early pathogen load in an innate-like, NKG2D-dependent manner", Cell Rep, 3, pp.701~708 (2013)
130. Yajima T, "A novel role of IL-15 in early activation of memory CD8+ CTL after reinfection", J Immunol, 174, pp.3590~3597 (2005)
131. Soudja SM, "Inflammatory monocytes activate memory CD8(+)T and innate NK lymphocytes independent of cognate antigen during microbial pathogen invasion", Immunity, 37, pp.549~562 (2012)
132. Bastidas S, "CD8+ T cells are activated in an antigen-independent manner in HIV-infected individuals", J Immunol, 192, pp.1732~1744 (2014)
133. Kim J, "Innate-like cytotoxic function of bystander-activated CD8(+)T cells is associated with liver injury in acute hepatitis a", Immunity, 48, pp.161~173 (2018)
134. Seo IH, "IL-15 enhances CCR5-mediated migration of memory CD8+ T cells by upregulating CCR5 expression in the absence of TCR stimulation", Cell Rep, 36, pp.109438~ (2021)
135. Huang CH, "Innate-like bystander-activated CD38+ HLA-DR+ CD8+ T cells play a pathogenic role in patients with chronic hepatitis C", Hepatology, 76, pp.803~818 (2022)
136. Freeman CM, "Cytotoxic potential of lung CD8(+)T cells increases with chronic obstructive pulmonary disease severity and with in vitro stimulation by IL-18 or IL-15", J Immunol, 184, pp.6504~6513 (2010)
137. Sacramento LA, "NKG2D promotes CD8 T cell-mediated cytotoxicity and is associated with treatment failure in human cutaneous leishmaniasis", PLoS Negl Trop Dis, 17, pp.e0011552~ (2023)
138. Shin EC, "Immune responses and immunopathology in acute and chronic viral hepatitis", Nat Rev Immunol, 16, pp.509~523 (2016)
139. Wilkinson PC, "Chemoattraction of human blood T lymphocytes by interleukin-15", J Exp Med, 181, pp.1255~1259 (1995)
140. Verbist KC, "A role for IL-15 in the migration of effector CD8 T cells to the lung airways following influenza infection", J Immunol, 186, pp.174~182 (2011)
141. Nolz JC, "IL-15 regulates memory CD8+ T cell O-glycan synthesis and affects trafficking", J Clin Invest, 124, pp.1013~1026 (2014)
142. Rha MS, "Human liver CD8+ MAIT cells exert TCR", MR1-independent innate-like cytotoxicity in response to IL-15, 2020, pp.73, 640~650
143. Lee H, "Better understanding CD8+ T cells in cancer and viral infections", Nat Immunol, 24, pp.1794~1796 (2023)
144. Jeong S, "IFITM3 is upregulated characteristically in IL-15-mediated bystander-activated CD8(+)T cells during influenza infection", J Immunol, 208, pp.1901~1911 (2022)
145. Meresse B, "Coordinated induction by IL15 of a TCR-independent NKG2D signaling pathway converts CTL into lymphokine-activated killer cells in celiac disease", Immunity, 21, pp.357~366 (2004)
146. Hüe S, "A direct role for NKG2D", MICA interaction in villous atrophy during celiac disease, 2004, pp.21, 367~377
147. Hoytema van Konijnenburg DP, "Intestinal epithelial and intraepithelial T cell crosstalk mediates a dynamic response to infection", Cell, 171, pp.783~794 (2017)
148. Zhao H, "Interleukin 15 controls the generation of the restricted T cell receptor repertoire of gamma delta intestinal intraepithelial lymphocytes", Nat Immunol, 6, pp.1263~1271 (2005)
149. Mayassi T, "A multilayered immune system through the lens of unconventional T cells", Nature, 595, pp.501~510 (2021)
150. Simpson SJ, "Expression of pro-inflammatory cytokines by TCR alpha beta+ and TCR gamma delta+ T cells in an experimental model of colitis", Eur J Immunol, 27, pp.17~25 (1997)
151. Kawaguchi-Miyashita M, "An accessory role of TCRgammadelta(+)cells in the exacerbation of inflammatory bowel disease in TCRalpha mutant mice", Eur J Immunol, 31, pp.980~988 (2001)
152. Xing L, "Alopecia areata is driven by cytotoxic T lymphocytes and is reversed by JAK inhibition", Nat Med, 20, pp.1043~1049 (2014)
153. Seok J, "A virtual memory CD8+ T cell-originated subset causes alopecia areata through innate-like cytotoxicity", Nat Immunol, 24, pp.1308~1317 (2023)
154. Masle-Farquhar E, "STAT3 gain-of-function mutations connect leukemia with autoimmune disease by pathological NKG2Dhi CD8+ T cell dysregulation and accumulation", Immunity, 55, pp.2386~2404 (2022)
155. Dudek M, "Auto-aggressive CXCR6+ CD8 T cells cause liver immune pathology in NASH", Nature, 592, pp.444~449 (2021)

관련 논문AI추천