Exploring the Potential of Glycolytic Modulation in Myeloid-Derived Suppressor Cells for Immunotherapy and Disease Management

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참고문헌 (100)

1. Pawelec G, "Myeloid-derived suppressor cells : Not only in tumor immunity", Front Immunol, 10, pp.1099~ (2019)
2. Nalawade SA, "Selectively targeting myeloid-derived suppressor cells through TRAIL receptor 2 to enhance the efficacy of CAR T cell therapy for treatment of breast cancer", J Immunother Cancer, 9, pp.e003237~ (2021)
3. Colligan SH, "Inhibiting the biogenesis of myeloid-derived suppressor cells enhances immunotherapy efficacy against mammary tumor progression", J Clin Invest, 132, pp.e158661~ (2022)
4. Sun SH, "Effect of immune checkpoint blockade on myeloid-derived suppressor cell populations in patients with melanoma", Front Immunol, 12, pp.740890~ (2021)
5. Tobin RP, "Targeting MDSC differentiation using ATRA : a phase I", II clinical trial combining pembrolizumab and all-trans retinoic acid for metastatic melanoma, 2023, pp.29, 1209~1219
6. Owen DH, "Deep and durable response to nivolumab and temozolomide in small-cell lung cancer associated with an early decrease in myeloid-derived suppressor cells", Clin Lung Cancer, 22, pp.e487~ (2021)
7. Xiong X, "Diverse functions of myeloid-derived suppressor cells in autoimmune diseases", Immunol Res, 72, pp.34~49 (2024)
8. Park MJ, "Myeloid-derived suppressor cells induce the expansion of regulatory B cells and ameliorate autoimmunity in the sanroque mouse model of systemic lupus erythematosus", Arthritis Rheumatol, 68, pp.2717~2727 (2016)
9. Wang Z, "Increased CD14(+)HLA-DR(-", low)myeloid-derived suppressor cells correlate with disease severity in systemic lupus erythematosus patients in an iNOS-dependent manner, 2019, pp.10, 1202~
10. Wu H, "Arginase-1-dependent promotion of TH17 differentiation and disease progression by MDSCs in systemic lupus erythematosus", Sci Transl Med, 8, pp.331~ (2016)
11. Crook KR, "Myeloid-derived suppressor cells regulate T cell and B cell responses during autoimmune disease", J Leukoc Biol, 97, pp.573~582 (2015)
12. Zhang H, "Myeloid-derived suppressor cells are proinflammatory and regulate collagen-induced arthritis through manipulating Th17 cell differentiation", Clin Immunol, 157, pp.175~186 (2015)
13. Zhang R, "Dextran sulphate sodium increases splenic Gr1(+)CD11b(+)cells which accelerate recovery from colitis following intravenous transplantation", Clin Exp Immunol, 164, pp.417~427 (2011)
14. Kontaki E, "Aberrant function of myeloid-derived suppressor cells(MDSCs)in experimental colitis and in inflammatory bowel disease(IBD)immune responses", Autoimmunity, 50, pp.170~181 (2017)
15. Wang Y, "G-MDSC-derived exosomes mediate the differentiation of M-MDSC into M2 macrophages promoting colitis-to-cancer transition", J Immunother Cancer, 11, pp.e006166~ (2023)
16. Oren R, "Metabolic patterns in three types of phagocytizing cells", J Cell Biol, 17, pp.487~501 (1963)
17. Purohit V, "Systems-based approaches to study immunometabolism", Cell Mol Immunol, 19, pp.409~420 (2022)
18. Baker SA, "Metabolites as signalling molecules", Nat Rev Mol Cell Biol, 24, pp.355~374 (2023)
19. Xu Y, "Glycolysis in innate immune cells contributes to autoimmunity", Front Immunol, 13, pp.920029~ (2022)
20. Martins CP, "Glycolysis inhibition induces functional and metabolic exhaustion of cd4(+)t cells in type 1 diabetes", Front Immunol, 12, pp.669456~ (2021)
21. Gabrilovich DI, "The terminology issue for myeloid-derived suppressor cells", Cancer Res, 67, pp.425~ (2007)
22. Almand B, "Increased production of immature myeloid cells in cancer patients : a mechanism of immunosuppression in cancer", J Immunol, 166, pp.678~689 (2001)
23. Kusmartsev SA, "Gr-1+ myeloid cells derived from tumor-bearing mice inhibit primary T cell activation induced through CD3", CD28 costimulation, 2000, pp.165, 779~785
24. Lechner MG, "Characterization of cytokine-induced myeloid-derived suppressor cells from normal human peripheral blood mononuclear cells", J Immunol, 185, pp.2273~2284 (2010)
25. Condamine T, "Transcriptional regulation of myeloid-derived suppressor cells", J Leukoc Biol, 98, pp.913~922 (2015)
26. Karin N, "The development and homing of myeloid-derived suppressor cells : From a two-stage model to a multistep narrative", Front Immunol, 11, pp.557586~ (2020)
27. Haist M, "The functional crosstalk between myeloid-derived suppressor cells and regulatory t cells within the immunosuppressive tumor microenvironment", Cancers(Basel), 13, pp.210~ (2021)
28. Bronte V, "Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards", Nat Commun, 7, pp.12150~ (2016)
29. Li K, "Myeloid-derived suppressor cells as immunosuppressive regulators and therapeutic targets in cancer", Signal Transduct Target Ther, 6, pp.362~ (2021)
30. Ku AW, "Tumor-induced MDSC act via remote control to inhibit L-selectin-dependent adaptive immunity in lymph nodes", eLife, 5, pp.e17375~ (2016)
31. Veglia F, "Myeloid-derived suppressor cells in the era of increasing myeloid cell diversity", Nat Rev Immunol, 21, pp.485~498 (2021)
32. Youn JI, "Epigenetic silencing of retinoblastoma gene regulates pathologic differentiation of myeloid cells in cancer", Nat Immunol, 14, pp.211~220 (2013)
33. Geltink RI, "Unraveling the complex interplay between t cell metabolism and function", Annu Rev Immunol, 36, pp.461~488 (2018)
34. Fu C, "CD205+ polymorphonuclear myeloid-derived suppressor cells suppress antitumor immunity by overexpressing GLUT3", Cancer Sci, 112, pp.1011~1025 (2021)
35. Obermajer N, "Positive feedback between PGE2 and COX2 redirects the differentiation of human dendritic cells toward stable myeloid-derived suppressor cells", Blood, 118, pp.5498~5505 (2011)
36. Aintablian A, "M-MDSC in vitro generation from mouse bone marrow with IL-3 reveals high expression and functional activity of arginase 1", Front Immunol, 14, pp.1130600~ (2023)
37. Li F, "Tumor-infiltrating Treg, MDSC, and IDO expression associated with outcomes of neoadjuvant chemotherapy of breast cancer", Cancer Biol Ther, 19, pp.695~705 (2018)
38. Srivastava MK, "Myeloid-derived suppressor cells inhibit T-cell activation by depleting cystine and cysteine", Cancer Res, 70, pp.68~77 (2010)
39. Roy DG, "Immunometabolism in the tumor microenvironment", Annual Review of Cancer Biology, 5, pp.137~159 (2021)
40. Tukiman MH, "Immunometabolism of immune cells in mucosal environment drives effector responses against mycobacterium tuberculosis", Int J Mol Sci, 23, pp.8531~ (2022)
41. Sun JX, "Effects of metabolism on macrophage polarization under different disease backgrounds", Front Immunol, 13, pp.880286~ (2022)
42. Peng Y, "Regulatory mechanism of M1", M2 macrophage polarization in the development of autoimmune diseases, 2023, pp.2023, 8821610~
43. Kieler M, "More than just protein building blocks : how amino acids and related metabolic pathways fuel macrophage polarization", FEBS J, 288, pp.3694~3714 (2021)
44. Hammami I, "Immunosuppressive activity enhances central carbon metabolism and bioenergetics in myeloid-derived suppressor cells in vitro models", BMC Cell Biol, 13, pp.18~ (2012)
45. Jian SL, "Glycolysis regulates the expansion of myeloid-derived suppressor cells in tumor-bearing hosts through prevention of ROS-mediated apoptosis", Cell Death Dis, 8, pp.e2779~ (2017)
46. Kim J, "Discovery of myeloid-derived suppressor cell-specific metabolism by metabolomic and lipidomic profiling", Metabolites, 13, pp.13~ (2023)
47. Huang M, "Prevention of tumor growth and dissemination by in situ vaccination with mitochondria-targeted atovaquone", Adv Sci(Weinh), 9, pp.e2101267~ (2022)
48. Dietrich O, "Dysregulated immunometabolism is associated with the generation of myeloid-derived suppressor cells in staphylococcus aureus chronic infection", J Innate Immun, 14, pp.257~274 (2022)
49. Wu T, "mTOR masters monocytic myeloid-derived suppressor cells in mice with allografts or tumors", Sci Rep, 6, pp.20250~ (2016)
50. Deng Y, "mTOR-mediated glycolysis contributes to the enhanced suppressive function of murine tumor-infiltrating monocytic myeloid-derived suppressor cells", Cancer Immunol Immunother, 67, pp.1355~1364 (2018)
51. Goldmann O, "Myeloid-derived suppressor cells impair CD4+ T cell responses during chronic Staphylococcus aureus infection via lactate metabolism", Cell Mol Life Sci, 80, pp.221~ (2023)
52. Husain Z, "Tumor-derived lactate modifies antitumor immune response : effect on myeloid-derived suppressor cells and NK cells", J Immunol, 191, pp.1486~1495 (2013)
53. Wang S, "Emerging roles of myeloid-derived suppressor cells in diabetes", Front Pharmacol, 12, pp.798320~ (2021)
54. Zou Z, "mTOR signaling pathway and mTOR inhibitors in cancer : progress and challenges", Cell Biosci, 10, pp.31~ (2020)
55. Taylor CT, "The effect of HIF on metabolism and immunity", Nat Rev Nephrol, 18, pp.573~587 (2022)
56. Faubert B, "AMPK is a negative regulator of the Warburg effect and suppresses tumor growth in vivo", Cell Metab, 17, pp.113~124 (2013)
57. Zhang C, "The mTOR signal regulates myeloid-derived suppressor cells differentiation and immunosuppressive function in acute kidney injury", Cell Death Dis, 8, pp.e2695~ (2017)
58. Li X, "mTOR signaling regulates the development and therapeutic efficacy of PMN-MDSCs in acute GVHD", Front Cell Dev Biol, 9, pp.741911~ (2021)
59. Li Y, "mTOR inhibitor INK128 promotes wound healing by regulating MDSCs", Stem Cell Res Ther, 12, pp.170~ (2021)
60. Kotze LA, "Evaluation of autophagy mediators in myeloid-derived suppressor cells during human tuberculosis", Cell Immunol, 369, pp.104426~ (2021)
61. Shi G, "IRF-8", miR-451a regulates M-MDSC differentiation via the AMPK, Cell Death Dis, pp.2021, 7[DOI]
62. Nakamura T, "Rapamycin prolongs cardiac allograft survival in a mouse model by inducing myeloid-derived suppressor cells", Am J Transplant, 15, pp.2364~2377 (2015)
63. Köstlin-Gille N, "HIF-1alpha-deficiency in myeloid cells leads to a disturbed accumulation of myeloid derived suppressor cells(MDSC)during pregnancy and to an increased abortion rate in mice", Front Immunol, 10, pp.161~ (2019)
64. Li J, "CD39", CD73 upregulation on myeloid-derived suppressor cells via TGF-β-mTOR-HIF-1 signaling in patients with non-small cell lung cancer, 2017, pp.6, e1320011~
65. Travelli C, "Nicotinamide phosphoribosyltransferase acts as a metabolic gate for mobilization of myeloid-derived suppressor cells", Cancer Res, 79, pp.1938~1951 (2019)
66. Yang X, "Lactate-modulated immunosuppression of myeloid-derived suppressor cells contributes to the radioresistance of pancreatic cancer", Cancer Immunol Res, 8, pp.1440~1451 (2020)
67. Lum JJ, "The transcription factor HIF-1alpha plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis", Genes Dev, 21, pp.1037~1049 (2007)
68. Noman MZ, "PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation", J Exp Med, 211, pp.781~790 (2014)
69. Corzo CA, "HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment", J Exp Med, 207, pp.2439~2453 (2010)
70. Trillo-Tinoco J, "AMPK alpha-1 intrinsically regulates the function and differentiation of tumor myeloid-derived suppressor cells", Cancer Res, 79, pp.5034~5047 (2019)
71. Rong Y, "Doxorubicin resistant cancer cells activate myeloid-derived suppressor cells by releasing PGE2", Sci Rep, 6, pp.23824~ (2016)
72. Trikha P, "Targeting myeloid-derived suppressor cells using a novel adenosine monophosphate-activated protein kinase(AMPK)activator", OncoImmunology, 5, pp.e1214787~ (2016)
73. Kim SH, "Phenformin inhibits myeloid-derived suppressor cells and enhances the anti-tumor activity of PD-1 blockade in melanoma", J Invest Dermatol, 137, pp.1740~1748 (2017)
74. Uehara T, "Metformin induces CD11b+-cell-mediated growth inhibition of an osteosarcoma : implications for metabolic reprogramming of myeloid cells and anti-tumor effects", Int Immunol, 31, pp.187~198 (2019)
75. Kang J, "Tumor-suppressive effect of metformin via the regulation of m2 macrophages and myeloid-derived suppressor cells in the tumor microenvironment of colorectal cancer", Cancers(Basel), 14, pp.2881~ (2022)
76. Li L, "Metformin-induced reduction of CD39 and CD73 blocks myeloid-derived suppressor cell activity in patients with ovarian cancer", Cancer Res, 78, pp.1779~1791 (2018)
77. Salminen A, "AMPK activation inhibits the functions of myeloid-derived suppressor cells(MDSC) : impact on cancer and aging", J Mol Med(Berl), 97, pp.1049~1064 (2019)
78. Boyer T, "Influence of the metabolism on myeloid cell functions in cancers : clinical perspectives", Cells, 11, pp.11~ (2022)
79. Kornberg MD, "The immunologic Warburg effect : evidence and therapeutic opportunities in autoimmunity", Wiley Interdiscip Rev Syst Biol Med, 12, pp.e1486~ (2020)
80. Seth P, "Deletion of lactate dehydrogenase-a in myeloid cells triggers antitumor immunity", Cancer Res, 77, pp.3632~3643 (2017)
81. Mohammadpour H, "β2-adrenergic receptor signaling regulates metabolic pathways critical to myeloid-derived suppressor cell function within the TME", Cell Reports, 37, pp.109883~ (2021)
82. Baumann T, "Regulatory myeloid cells paralyze T cells through cell-cell transfer of the metabolite methylglyoxal", Nat Immunol, 21, pp.555~566 (2020)
83. Allaman I, "Methylglyoxal, the dark side of glycolysis", Front Neurosci, 9, pp.23~ (2015)
84. Qi J, "FcγRIIIA activation-mediated up-regulation of glycolysis alters MDSCs modulation in CD4+ T cell subsets of Sjögren syndrome", Cell Death Dis, 14, pp.86~ (2023)
85. Chen X, "mTOR signaling disruption from myeloid-derived suppressive cells protects against immune-mediated hepatic injury through the HIF1α-dependent glycolytic pathway", J Leukoc Biol, 100, pp.1349~1362 (2016)
86. Halaby MJ, "GCN2 drives macrophage and MDSC function and immunosuppression in the tumor microenvironment", Sci Immunol, 4, pp.eaax8189~ (2019)
87. Tohumeken S, "Palmitoylated proteins on AML-derived extracellular vesicles promote myeloid-derived suppressor cell differentiation via TLR2", Akt, Cancer Res, pp.2020, 80[DOI]
88. Zhang Z, "Gut fungi enhances immunosuppressive function of myeloid-derived suppressor cells by activating PKM2-dependent glycolysis to promote colorectal tumorigenesis", Exp Hematol Oncol, 11, pp.88~ (2022)
89. Roy S, "3-Bromopyruvate inhibits pancreatic tumor growth by stalling glycolysis, and dismantling mitochondria in a syngeneic mouse model", Am J Cancer Res, 12, pp.4977~4987 (2022)
90. Consiglio CR, "Enzalutamide, an androgen receptor antagonist, enhances myeloid cell-mediated immune suppression and tumor progression", Cancer Immunol Res, 8, pp.1215~1227 (2020)
91. Meng G, "Targeting aerobic glycolysis by dichloroacetate improves Newcastle disease virus-mediated viro-immunotherapy in hepatocellular carcinoma", Br J Cancer, 122, pp.111~120 (2020)
92. Shi ZY, "Inhibition of hexokinase 2 with 3-BrPA promotes MDSCs differentiation and immunosuppressive function", Cell Immunol, 385, pp.104688~ (2023)
93. Yan J, "Glycolysis inhibition ameliorates brain injury after ischemic stroke by promoting the function of myeloid-derived suppressor cells", Pharmacol Res, 179, pp.106208~ (2022)
94. Jia A, "The kinase AKT1 potentiates the suppressive functions of myeloid-derived suppressor cells in inflammation and cancer", Cell Mol Immunol, 18, pp.1074~1076 (2021)
95. Liu G, "SIRT1 limits the function and fate of myeloid-derived suppressor cells in tumors by orchestrating HIF-1α-dependent glycolysis", Cancer Res, 74, pp.727~737 (2014)
96. Hammami A, "HIF-1α is a key regulator in potentiating suppressor activity and limiting the microbicidal capacity of MDSC-like cells during visceral leishmaniasis", PLoS Pathog, 13, pp.e1006616~ (2017)
97. Lu Y, "Glucocorticoid receptor promotes the function of myeloid-derived suppressor cells by suppressing HIF1α-dependent glycolysis", Cell Mol Immunol, 15, pp.618~629 (2018)
98. Dong P, "Impaired immunosuppressive role of myeloid-derived suppressor cells in acquired aplastic anemia", Haematologica, 107, pp.2834~2845 (2022)
99. Pavlides S, "The reverse Warburg effect : aerobic glycolysis in cancer associated fibroblasts and the tumor stroma", Cell Cycle, 8, pp.3984~4001 (2009)
100. Xu Y, "The efficacy of PI3Kγ and EGFR inhibitors on the suppression of the characteristics of cancer stem cells", Sci Rep, 12, pp.347~ (2022)

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