Effects of phylloquinone supplementation on lipid profile in women with rheumatoid arthritis: a double blind placebo controlled study
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BACKGROUND/OBJECTIVES: Rheumatoid arthritis (RA) is associated with an excess mortality from cardiovascular disease whichis likely attributed to an atherogenic lipid profile. Among nutritional factors vitamin K has been recently focused as a pivotalnutrient in improvement of lipid related markers. Thus, this study was designed to determine the effects of vitamin K onlipid profile in this disease. SUBJECTS/METHODS: Fifty eight patients with definitive RA were participated in the present double blind placebo controlledstudy. They were randomly allocated into two groups to receive vitamin K1 as phylloquinone [10 mg/day] (n = 30) or placebopills (n = 28), for eight weeks. In order to control the effects of probable confounders dietary intakes, anthropometric measurementsincluding weight and height, clinical status using disease activity score-28 (DAS-28), physical activity and anxiety status wereevaluated at baseline. Moreover, serum levels of lipid related markers including total cholesterol (TC), low-density lipoproteincholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and triglyceride (TG) were measured at baseline and at theend of intervention. RESULTS: There were no significant differences between the two groups regarding any of the baseline characteristics. Afteradjusting for some relevant confounders, in comparison between two groups, we observed no significant changes in lipidrelated markers at the end of intervention. Also, there was no significant difference between before and after interventionvalues within groups (P > 0.05). CONCLUSIONS: Function of vitamin K1 in lipid profile modification remains still controversial. This study showed that vitaminK1 has no effect on lipid profile in women with rheumatoid arthritis. Further studies with a longer follow-up are requiredto determine the effects of vitamin K on atherogenic lipid profile.
Abstract
BACKGROUND/OBJECTIVES: Rheumatoid arthritis (RA) is associated with an excess mortality from cardiovascular disease whichis likely attributed to an atherogenic lipid profile. Among nutritional factors vitamin K has been recently focused as a pivotalnutrient in improvement of lipid related markers. Thus, this study was designed to determine the effects of vitamin K onlipid profile in this disease. SUBJECTS/METHODS: Fifty eight patients with definitive RA were participated in the present double blind placebo controlledstudy. They were randomly allocated into two groups to receive vitamin K1 as phylloquinone [10 mg/day] (n = 30) or placebopills (n = 28), for eight weeks. In order to control the effects of probable confounders dietary intakes, anthropometric measurementsincluding weight and height, clinical status using disease activity score-28 (DAS-28), physical activity and anxiety status wereevaluated at baseline. Moreover, serum levels of lipid related markers including total cholesterol (TC), low-density lipoproteincholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and triglyceride (TG) were measured at baseline and at theend of intervention. RESULTS: There were no significant differences between the two groups regarding any of the baseline characteristics. Afteradjusting for some relevant confounders, in comparison between two groups, we observed no significant changes in lipidrelated markers at the end of intervention. Also, there was no significant difference between before and after interventionvalues within groups (P > 0.05). CONCLUSIONS: Function of vitamin K1 in lipid profile modification remains still controversial. This study showed that vitaminK1 has no effect on lipid profile in women with rheumatoid arthritis. Further studies with a longer follow-up are requiredto determine the effects of vitamin K on atherogenic lipid profile.
참고문헌 (31)
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