류마티스관절염 치료에서 오메가-3 다가불포화지방산의 역할
Potential Role of Omega n-3 Polyunsaturated Fatty Acids and Its Use in Rheumatoid Arthritis
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Rheumatoid arthritis (RA) is a chronic inflammatory disease of unknown cause. It is characterized by polyarthritis. Currently, treatments for RA include the use of non-steroidal antiinflammatory drugs (NSAIDs), steroid, disease-modifying antirheumatic drugs (DMARDs), corticosteroid, and so on. New treatment options for RA have been actively developed. In this study, we determined pharmacological advantages of using omega n-3 polyunsaturated fatty acids (PUFAs) as adjunctive therapy in RA based on articles demonstrating the role of omega n-3 in the prevention and treatment of RA. Omega n-3 PUFAs can partially suppress a number of inflammatory reactions such as leukocyte chemotaxis and adhesion molecule expression. Mechanisms fundamental to the anti-inflammatory actions of omega n-3 PUFAs involve changing the compositions of cell membrane's phospholipid fatty acids. Omega n-3 PUFAs with inflammation control action may also result in the reduction of pain in rheumatoid arthritis. The benefit of n-3 PUFAs in RA has also been suggested in some clinical studies. In conclusion, omega n-3 PUFAs might be useful as an adjuvant therapy for the treatment of RA.
Abstract
Rheumatoid arthritis (RA) is a chronic inflammatory disease of unknown cause. It is characterized by polyarthritis. Currently, treatments for RA include the use of non-steroidal antiinflammatory drugs (NSAIDs), steroid, disease-modifying antirheumatic drugs (DMARDs), corticosteroid, and so on. New treatment options for RA have been actively developed. In this study, we determined pharmacological advantages of using omega n-3 polyunsaturated fatty acids (PUFAs) as adjunctive therapy in RA based on articles demonstrating the role of omega n-3 in the prevention and treatment of RA. Omega n-3 PUFAs can partially suppress a number of inflammatory reactions such as leukocyte chemotaxis and adhesion molecule expression. Mechanisms fundamental to the anti-inflammatory actions of omega n-3 PUFAs involve changing the compositions of cell membrane's phospholipid fatty acids. Omega n-3 PUFAs with inflammation control action may also result in the reduction of pain in rheumatoid arthritis. The benefit of n-3 PUFAs in RA has also been suggested in some clinical studies. In conclusion, omega n-3 PUFAs might be useful as an adjuvant therapy for the treatment of RA.
참고문헌 (42)
- Calabro A., "One year in review 2016 : novelties in the treatment of rheumatoid arthritis", Clinical and experimental rheumatology, 34(3), pp.357~372 (2016)
- Smolen J. S., "New therapies for treatment of rheumatoid arthritis", Lancet, 370(9602), pp.1861~1874 (2007)
- Joseph T. DiPiro, "A Pathophysiologic Approach" (2014), Mcgraw-Hill Education
- James M., "Fish oil and rheumatoid arthritis : past, present and future", The Proceedings of the Nutrition Society, 69(3), pp.316~323 (2010)
- Calder P.C., "Omega-3 polyunsaturated fatty acids and inflammatory processes: nutrition or pharmacology?", British journal of clinical pharmacology, 75(3), pp.645~662 (2013)
- Calder P.C., "Fatty acids and inflammation:The cutting edge between food and pharma", European journal of pharmacology, 668(Supplement 1), pp.S50~S58 (2011)
- Nutrition SACo, "Advice on fish consumption:benefits and risks" (2004), Stationery Office
- Fats and fatty acids in human nutrition: report of an Expert Consultation, "Fats ECo", Food and Agriculture Organization of the United Nations, ~ (2010)
- Singh J. A., "2015 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis", Arthritis care & research, 68(1), pp.1~25 (2016)
- Lewis R. A., "Leukotrienes and other products of the 5-lipoxygenase pathway. Biochemistry and relation to pathobiology in human diseases", The New England journal of medicine, 323(10), pp.645~655 (1990)
- Schmidt E. B., "n-3fatty acids and leukocyte chemotaxis. Effects in hyperlipidemia and dose-response studies in healthy men. Arteriosclerosis and thrombosis : a journal of vascular biology", American Heart Association, 11(2), pp.429~435 (1991)
- Sperling R. I., "Dietary omega-3 polyunsaturated fatty acids inhibit phosphoinositide formation and chemotaxis in neutrophils", The Journal of clinical investigation, 91(2), pp.651~660 (1993)
- Tilley S. L., "Mixed messages : modulation of inflammation and immune responses by prostaglandins and thromboxanes", The Journal of clinical investigation, 108(1), pp.15~23 (2001)
- Kroetz D. L., "Cytochrome P450pathways of arachidonic acid metabolism", Current opinion in lipidology, 13(3), pp.273~283 (2002)
- Peterson L. D., "Eicosapentaenoic and docosahexaenoic acids alter rat spleen leukocyte fatty acid composition and prostaglandin E2 production but have different effects on lymphocyte functions and cell-mediated immunity", Lipids, 33(2), pp.171~180 (1998)
- Sanderson P., "Dietary fish oil diminishes the antigen presentation activity of rat dendritic cells", Journal of leukocyte biology, 62(6), pp.771~777 (1997)
- Volker D. H., "The eicosapentaenoic to docosahexaenoic acid ratio of diets affects the pathogenesis of arthritis in Lew", SSN rats, 2000, pp.130(3), 559~565
- Lee A.L., "The association between n-3 polyunsaturated fatty acid levels in erythrocytes and the risk of rheumatoid arthritis in Korean women", Annals of nutrition & metabolism, 63(1-2), pp.88~95 (2013)
- Jiang J., "Effect of Marine-Derived n-3 Polyunsaturated Fatty Acids on Major Eicosanoids: A Systematic Review and Meta-Analysis from 18 Randomized Controlled Trials", PloS one, 11(1), pp.e0147351~ (2016)
- Wada M., "Enzymes and receptors of prostaglandin pathways with arachidonic acid-derived versus eicosapentaenoic acid-derived substrates and products", The Journal of biological chemistry, 282(31), pp.22254~22266 (2007)
- Serhan C.N., "Anti-microinflammatory lipid signals generated from dietary N-3 fatty acids via cyclooxygenase-2 and transcellular processing: a novel mechanism for NSAID and N-3 PUFA therapeutic actions", Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 51(4 Pt 1), pp.643~654 (2000)
- Serhan C. N., "Novel functional sets of lipid-derived mediators with antiinflammatory actions generated from omega-3 fatty acids via cyclooxygenase 2-nonsteroidal antiinflammatory drugs and transcellular processing", The Journal of experimental medicine, 192(8), pp.1197~1204 (2000)
- Serhan C. N., "Resolvins : a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals", The Journal of experimental medicine, 196(8), pp.1025~1037 (2002)
- Serhan C. N., "Resolving inflammation : dual anti-inflammatory and pro-resolution lipid mediators", Nature reviews Immunology, 8(5), pp.349~361 (2008)
- Cleland L. G., "The role of fish oils in the treatment of rheumatoid arthritis", Drugs, 63(9), pp.845~853 (2003)
- Woolf C. J., "Neuronal plasticity : increasing the gain in pain", Science, 288(5472), pp.1765~1769 (2000)
- Tokuyama S., "Unsaturated fatty acids and pain", Biological & pharmaceutical bulletin, 34(8), pp.1174~1178 (2011)
- Miyazawa D., "Dietary alpha-linolenic acid suppresses the formation of lysophosphatidic acid, a lipid mediator, in rat platelets compared with linoleic acid", Life sciences, 73(16), pp.2083~2090 (2003)
- Nakamoto K., "Antinociceptive effects of docosahexaenoic acid against various pain stimuli in mice", Biological & pharmaceutical bulletin, 33(6), pp.1070~1072 (2010)
- Xiao Y. F., "Blocking effects of polyunsaturated fatty acids on Na+ channels of neonatal rat ventricular myocytes", Proceedings of the National Academy of Sciences of the United States of America, 92(24), pp.11000~11004 (1995)
- Matta J.A., "TRPV1 is a novel target for omega-3polyunsaturated fatty acids", The Journal of physiology, 578(Pt 2), pp.397~411 (2007)
- Nakamoto K., "Possible involvement of beta-endorphin in docosahexaenoic acid-induced antinociception", European journal of pharmacology, 666(1-3), pp.100~104 (2011)
- Morisseau C., "Naturally occurring monoepoxides of eicosapentaenoic acid and docosahexaenoic acid are bioactive antihyperalgesic lipids", Journal of lipid research, 51(12), pp.3481~3490 (2010)
- Schwab J. M., "Resolvin E1 and protectin D1 activate inflammation-resolution programmes", Nature, 447(7146), pp.869~874 (2007)
- Xu Z.Z., "Resolvins RvE1 and RvD1attenuate inflammatory pain via central and peripheral actions", Nature medicine, 16(5), pp.592~597 (2010)
- Cleland L. G., "Reduction of cardiovascular risk factors with longterm fish oil treatment in early rheumatoid arthritis", The Journal of rheumatology, 33(10), pp.1973~1979 (2006)
- Miles E.A., "Influence of marine n-3 polyunsaturated fatty acids on immune function and a systematic review of their effects on clinical outcomes in rheumatoid arthritis", The British journal of nutrition, 107(Suppl 2), pp.S171~S184 (2012)
- Lee Y. H., "Omega-3polyunsaturated fatty acids and the treatment of rheumatoid arthritis : a metaanalysis", Archives of medical research, 43(5), pp.356~362 (2012)
- Park Y., "Effect of n-3 polyunsaturated fatty acid supplementation in patients with rheumatoid arthritis : a 16-week randomized, double-blind, placebocontrolled, parallel-design multicenter study in Korea", The Journal of nutritional biochemistry, 24(7), pp.1367~1372 (2013)
- Proudman S. M., "Fish oil in recent onset rheumatoid arthritis : a randomised, double-blind controlled trial within algorithm-based drug use", Annals of the rheumatic diseases, 74(1), pp.89~95 (2015)
- Rontoyanni V. G., "Marine n-3 fatty acids for cardiovascular risk reduction and disease control in rheumatoid arthritis: “kill two birds with one stone”?", Current pharmaceutical design, 18(11), pp.1531~1542 (2012)
- Kris-Etherton P. M., "Fish consumption, fish oil, omega-3fatty acids, and cardiovascular disease", circulation, 106(21), pp.2747~2757 (2002)