Combined effect of folate and adiposity on homocysteine in children at three years of age
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BACKGROUND/OBJECTIVES: Cardiovascular diseases is a major cause of death and is responsible for 23.8% of deaths in Korea. Clinical symptoms manifest in adulthood, but susceptibility begins in utero. Elevated homocysteine levels and adiposity mightbe linked to a greater risk in children as well as adults. We hypothesized that those who have simultaneous risk for folateand adiposity would be affected with elevated homocysteine levels at 3 years of age. SUBJECTS/METHODS: From the ongoing birth cohort at Ewha Womans University Mok-Dong Hospital, we compared adiposityparameters, serum homocysteine, and folate levels in 238 children (118 boys and 120 girls) at three years of age. The relationshipbetween birth outcome, current weight and body mass index (BMI), postnatal growth, and homocysteine level were assessedusing correlation and general linear model. Additionally, we assessed the combined effect between blood folate status andadiposity on current homocysteine levels. RESULTS: Birth characteristics were not correlated with homocysteine. Current weight, BMI, upper-arm circumference, skinfoldthickness, waist circumference, and hip circumference were positively correlated with homocysteine at three years of age (P< 0.05). Folate level was negatively correlated with homocysteine at three years of age (P < 0.0001). A relative high anthropometricmeasure which is compatible with adiposity and low folate level was associated with high homocysteine levels. CONCLUSION: We found a combined effect of adiposity and folate levels with homocysteine levels at three years of age. Thisimplicates the beneficial role of folate supplementation in the high-risk population at an early age.
Abstract
BACKGROUND/OBJECTIVES: Cardiovascular diseases is a major cause of death and is responsible for 23.8% of deaths in Korea. Clinical symptoms manifest in adulthood, but susceptibility begins in utero. Elevated homocysteine levels and adiposity mightbe linked to a greater risk in children as well as adults. We hypothesized that those who have simultaneous risk for folateand adiposity would be affected with elevated homocysteine levels at 3 years of age. SUBJECTS/METHODS: From the ongoing birth cohort at Ewha Womans University Mok-Dong Hospital, we compared adiposityparameters, serum homocysteine, and folate levels in 238 children (118 boys and 120 girls) at three years of age. The relationshipbetween birth outcome, current weight and body mass index (BMI), postnatal growth, and homocysteine level were assessedusing correlation and general linear model. Additionally, we assessed the combined effect between blood folate status andadiposity on current homocysteine levels. RESULTS: Birth characteristics were not correlated with homocysteine. Current weight, BMI, upper-arm circumference, skinfoldthickness, waist circumference, and hip circumference were positively correlated with homocysteine at three years of age (P< 0.05). Folate level was negatively correlated with homocysteine at three years of age (P < 0.0001). A relative high anthropometricmeasure which is compatible with adiposity and low folate level was associated with high homocysteine levels. CONCLUSION: We found a combined effect of adiposity and folate levels with homocysteine levels at three years of age. Thisimplicates the beneficial role of folate supplementation in the high-risk population at an early age.
참고문헌 (34)
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