Association of Homocysteine Levels With Blood Lead Levels and Micronutrients in the US General Population
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Objectives: Even though several epidemiological studies have observed positive associations between blood lead levels and homocysteine,no study has examined whether this association differs by the levels of micronutrients, such as folate, vitamin B6, and vitamin B12, which are involved in the metabolism of homocysteine. In this study, we examined the interactions between micronutrients and blood lead on homocysteine levels. Methods: This study was performed with 4089 adults aged ≥20 years old in the US general population using the National Health and Nutrition Examination Survey 2003-2004. Results: There were significant or marginally significant interactions between micronutrients and blood lead levels on mean homocysteine levels. Positive associations between blood lead and homocysteine were clearly observed among subjects with low levels of folate or low vitamin B6 (p-trend <0.01, respectively). However, in the case of vitamin B12, there was a stronger positive association between blood lead and homocysteine among subjects with high levels of vitamin B12, compared to those with low levels of vitamin B12. In fact, the levels of homocysteine were already high among subjects low in vitamin B12, irrespective of blood lead levels. When we used hyperhomocysteinemia (homocysteine>15 μmol/L) as the outcome, there were similar patterns of interaction, though pvalues for each interaction failed to reach statistical significance. Conclusions: In the current study, the association between blood lead and homocysteine differed based on the levels of folate, vitamin B6, or vitamin B12 present in the blood. It may be important to keep sufficient levels of these micronutrients to prevent the possible harmful effects of lead exposure on homocysteine levels.
Abstract
Objectives: Even though several epidemiological studies have observed positive associations between blood lead levels and homocysteine,no study has examined whether this association differs by the levels of micronutrients, such as folate, vitamin B6, and vitamin B12, which are involved in the metabolism of homocysteine. In this study, we examined the interactions between micronutrients and blood lead on homocysteine levels. Methods: This study was performed with 4089 adults aged ≥20 years old in the US general population using the National Health and Nutrition Examination Survey 2003-2004. Results: There were significant or marginally significant interactions between micronutrients and blood lead levels on mean homocysteine levels. Positive associations between blood lead and homocysteine were clearly observed among subjects with low levels of folate or low vitamin B6 (p-trend <0.01, respectively). However, in the case of vitamin B12, there was a stronger positive association between blood lead and homocysteine among subjects with high levels of vitamin B12, compared to those with low levels of vitamin B12. In fact, the levels of homocysteine were already high among subjects low in vitamin B12, irrespective of blood lead levels. When we used hyperhomocysteinemia (homocysteine>15 μmol/L) as the outcome, there were similar patterns of interaction, though pvalues for each interaction failed to reach statistical significance. Conclusions: In the current study, the association between blood lead and homocysteine differed based on the levels of folate, vitamin B6, or vitamin B12 present in the blood. It may be important to keep sufficient levels of these micronutrients to prevent the possible harmful effects of lead exposure on homocysteine levels.
참고문헌 (22)
- McCully KS, "Hyperhomocysteinemia and arteriosclerosis: historical perspectives", Clin Chem Lab Med, 43(10), pp.980~986 (2005)
- Homocysteine Studies Collaboration, "Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis", JAMA, 288(16), pp.2015~2022 (2002)
- McCully KS, "Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis", Am J Pathol, 56(1), pp.111~128 (1969)
- Vogel T, "Homocysteine, vitamin B12, folate and cognitive functions: a systematic and critical review of the literature", Int J Clin Pract, 63(7), pp.1061~1067 (2009)
- Ho RC, "Is high homocysteine level a risk factor for cognitive decline in elderly? A systematic review, meta-analysis, and meta-regression", Am J Geriatr Psychiatry, 19(7), pp.607~617 (2011)
- Refsum H, "Facts and recommendations about total homocysteine determinations: an expert opinion", Clin Chem, 50(1), pp.3~32 (2004)
- Ganji V, "Demographic, health, lifestyle, and blood vitamin determinants of serum total homocysteine concentrations in the third National Health and Nutrition Examination Survey, 1988-1994", Am J Clin Nutr, 77(4), pp.826~833 (2003)
- Yakub M, "Association of blood lead (Pb) and plasma homocysteine: a cross sectional survey in Karachi, Pakistan", PLoS One, 5(7), pp.11706~ (2010)
- Schafer JH, "Blood lead is a predictor of homocysteine levels in a population-based study of older adults", Environ Health Perspect, 113(1), pp.31~35 (2005)
- Chia SE, "Association of blood lead and homocysteine levels among lead exposed subjects in Vietnam and Singapore", Occup Environ Med, 64(10), pp.688~693 (2007)
- Krieg EF Jr, "Blood lead, serum homocysteine, and neurobehavioral test performance in the third National Health and Nutrition Examination Survey", Neurotoxicology, 30(2), pp.281~289 (2009)
- Bar-Or D, "Inhibitory effect of copper on cystathionine beta-synthase activity: protective effect of an analog of the human albumin N-terminus", Protein Pept Lett, 12(3), pp.271~273 (2005)
- Waly M, "Activation of methionine synthase by insulin-like growth factor-1 and dopamine: a target for neurodevelopmental toxins and thimerosal", Mol Psychiatry, 9(4), pp.358~370 (2004)
- Yakub M, "Polymorphisms in MTHFR, MS and CBS genes and homocysteine levels in a Pakistani population", PLoS One, 7(3), pp.33222~ (2012)
- "National Health and Nutrition Examination Survey: NHANES 2003-2004"[URL]
- Date AR, "Applications of Inductively Coupled Plasma Mass Spectrometry", pp.1~38 (1989), Chapman and Hall
- Korn EL, "Epidemiologic studies utilizing surveys: accounting for the sampling design", Am J Public Health, 81(9), pp.1166~1173 (1991)
- Graubard BI, "Analyzing health surveys for cancer-related objectives", J Natl Cancer Inst, 91(12), pp.1005~1016 (1999)
- Zhou J, "Contributions of hyperhomocysteinemia to atherosclerosis: causal relationship and potential mechanisms", Biofactors, 35(2), pp.120~129 (2009)
- Meier M, "Structure of human cystathionine beta-synthase: a unique pyridoxal 5’-phosphate-dependent heme protein", EMBO J, 20(15), pp.3910~3916 (2001)
- Flora SJ, "Heavy metal induced oxidative stress & its possible reversal by chelation therapy", Indian J Med Res, 128(4), pp.501~523 (2008)
- Quig D, "Cysteine metabolism and metal toxicity", Altern Med Rev, 3(4), pp.262~270 (1998)