Effects of zinc supplementation on catch-up growth in children with failure to thrive
1
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
BACKGROUND/OBJECTIVES: Although globally the numbers of children diagnosed with failure to thrive (FTT) have decreased, FTT is still a serious pediatric problem. We aimed to investigate the effects of zinc supplementation for 6 months on growth parameters of infants and children with FTT. SUBJECTS/METHODS: In this retrospective study, of the 114 participants aged between 4 months and 6 years, 89 were included in the zinc supplementation group and were provided with nutrition counseling plus an oral zinc supplement for 6 months. The caregivers of the 25 participants in the control group received nutrition counseling alone. Medical data of these children, including sex, age, height, weight, serum zinc level, and serum insulin-like growth factor 1 (IGF1) level were analyzed. RESULTS: Zinc supplementation for 6 months increased weight-for-age Z-score and serum zinc levels (5.5%) in the zinc supplementation group of underweight category children. As for stunting category, height-for-age Z-score of the participants in the zinc supplementation group increased when compared with the baseline, and serum zinc levels increased in the normal or mild stunting group. Serum IGF1 levels did not change significantly in any group. Thus, zinc supplementation was more effective in children in the underweight category than those in the stunted category; this effect differed according to the degree of the FTT. CONCLUSION: These findings suggest that zinc supplementation may have beneficial effects for growth of infants and children with FTT, and zinc supplementation would be required according to degree of FTT.
Abstract
BACKGROUND/OBJECTIVES: Although globally the numbers of children diagnosed with failure to thrive (FTT) have decreased, FTT is still a serious pediatric problem. We aimed to investigate the effects of zinc supplementation for 6 months on growth parameters of infants and children with FTT. SUBJECTS/METHODS: In this retrospective study, of the 114 participants aged between 4 months and 6 years, 89 were included in the zinc supplementation group and were provided with nutrition counseling plus an oral zinc supplement for 6 months. The caregivers of the 25 participants in the control group received nutrition counseling alone. Medical data of these children, including sex, age, height, weight, serum zinc level, and serum insulin-like growth factor 1 (IGF1) level were analyzed. RESULTS: Zinc supplementation for 6 months increased weight-for-age Z-score and serum zinc levels (5.5%) in the zinc supplementation group of underweight category children. As for stunting category, height-for-age Z-score of the participants in the zinc supplementation group increased when compared with the baseline, and serum zinc levels increased in the normal or mild stunting group. Serum IGF1 levels did not change significantly in any group. Thus, zinc supplementation was more effective in children in the underweight category than those in the stunted category; this effect differed according to the degree of the FTT. CONCLUSION: These findings suggest that zinc supplementation may have beneficial effects for growth of infants and children with FTT, and zinc supplementation would be required according to degree of FTT.
참고문헌 (33)
- 유석동, "Clinical Characteristics of Failure to Thrive in Infant and Toddler: Organic vs. Nonorganic", Pediatric Gastroenterology, Hepatology & Nutrition, 16(4), pp.261~268 (2013), 대한소아소화기영양학회
- Jaffe AC, "Failure to thrive: current clinical concepts", Pediatr Rev, 32, pp.100~107 (2011)
- Krugman SD, "Failure to thrive", Am Fam Physician, 68, pp.879~884 (2003)
- Marchand V, "Nutrition and Gastroenterology Committee. The toddler who is falling off the growth chart", Paediatr Child Health, 17, pp.447~454 (2012)
- Daniel M, "Etiology of failure to thrive in infants and toddlers referred to a pediatric endocrinology outpatient clinic", Clin Pediatr, 47, pp.762~765 (2008)
- Zenel JA Jr, "Failure to thrive: a general pediatrician's perspective", Pediatr Rev, 18, pp.371~378 (1997)
- de Onis M, "WHO Global Database on Child Growth and Malnutrition", World Health Organization, ~ (1997)
- Wright CM, "Identification and management of failure to thrive: a community perspective", Arch Dis Child, 82, pp.5~9 (2000)
- Cole SZ, "Failure to thrive: an update", Am Fam Physician, 83, pp.829~834 (2011)
- Bithoney WG, "Failure to thrive", growth deficiency, 1992, pp.13, 453~460
- Roy CC, "Pediatric Clinical Gastroenterology", pp.3~43 (1995), Mosby
- Gahagan S, "A stepwise approach to evaluation of undernutrition and failure to thrive", Pediatr Clin North Am, 45, pp.169~187 (1998)
- Brown KH, "Effect of supplemental zinc on the growth and serum zinc concentrations of prepubertal children: a meta-analysis of randomized controlled trials", Am J Clin Nutr, 75, pp.1062~1071 (2002)
- World Health Organization, "Vitamin and Mineral Requirements in Human Nutrition" (2004), World Health Organization
- Park JK, "Dietary intakes and serum minerals composition in obese children", J Korean Soc Study Obes, 10, pp.156~164 (2001)
- 이지선, "청소년기 운동선수의 식습관 및 영양섭취 상태와혈청 구리, 아연 함량에 관한 연구", Journal of Nutrition and Health, 38(6), pp.465~474 (2005), 한국영양학회
- Prasad AS, "Discovery of human zinc deficiency: its impact on human health and disease", Adv Nutr, 4, pp.176~190 (2013)
- Jung SK, "Lower zinc bioavailability may be related to higher risk of subclinical atherosclerosis in Korean adults", PLoS One, 8, pp.e80115~ (2013)
- Hess SY, "Effects of maternal zinc supplementation on pregnancy and lactation outcomes", Food Nutr Bull, 30(Suppl), pp.S60~S78 (2009)
- 유경희, "울산지역 유치원 어린이의 <한국인영양섭취기준>에 의한영양소섭취 실태 및 아연영양 상태에 관한 연구", Journal of Nutrition and Health, 40(4), pp.385~394 (2007), 한국영양학회
- Rocha ÉD, "Effect of Zinc supplementation on GH, IGF1, IGFBP3, OCN, and ALP in non-zinc-deficient children", J Am Coll Nutr, 34, pp.290~299 (2015)
- Ministry of Health and Welfare (KR), "Dietary Reference Intakes for Koreans 2015", Ministry of Health and Welfare, ~ (2016)
- United Nations Children's Fund, "Improving Child Nutrition: the Achievable Imperative for Global Progress" (2013), United Nations Children's Fund
- Cesur Y, "Serum insulin-like growth factor-I and insulin-like growth factor binding protein-3 levels in children with zinc deficiency and the effect of zinc supplementation on these parameters", J Pediatr Endocrinol Metab, 22, pp.1137~1143 (2009)
- Preedy VR, "Handbook of Anthropometry: Physical Measures of Human Form in Health and Disease" (2012), Springer
- Shah MD, "Failure to thrive in children", J Clin Gastroenterol, 35, pp.371~374 (2002)
- T. K. Goswami, "Role of Dietary Zinc as a Nutritional Immunomodulator", ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES, 18(3), pp.439~452 (2005), 아세아·태평양축산학회
- Sultan S, "Effect of iron chelator desferrioxamine on serum zinc levels in patients with beta thalassemia major", Malays J Pathol, 37, pp.35~38 (2015)
- Soldin SJ, "Pediatric Reference Ranges" (1999), American Association for Clinical Chemistry
- King JC, "Assessment of zinc status", J Nutr 1990;120 Suppl, 120(Suppl 11), pp.1474~1479 (1990)
- Sherlock M, "Aging and the growth hormone", insulin like growth factor-I axis, 2007, pp.10, 189~203
- McNall AD, "The impaired growth induced by zinc deficiency in rats is associated with decreased expression of the hepatic insulin-like growth factor I and growth hormone receptor genes", J Nutr, 125, pp.874~879 (1995)
- Cossack ZT, "Decline in somatomedin-C (insulin-like growth factor-1)with experimentally induced zinc deficiency in human subjects", Clin Nutr, 10, pp.284~291 (1991)