Effect of nutritional supplement formula on catch-up growth in young children with nonorganic faltering growth: a prospective multicenter study
1
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
BACKGROUND/OBJECTIVES: Inadequate nutrition in infants and young children affects physical growth and neurocognitive development. Therefore, early nutritional intervention is important to promote catch-up growth in young children with faltering growth. The aim of this study was to evaluate the effect of nutritional supplementation with a pediatric concentrated and balanced nutritional supplement formula on promoting growth and improving nutritional status in children with nonorganic faltering growth. SUBJECTS/METHODS: Children aged 12–36 months whose body weight-for-age was < 5th percentile on the Korean Growth Charts were enrolled. Children born premature or having organic diseases were excluded. Children were instructed to consume 400 mL of formula per day in addition to their regular diet for 6 months. Pediatricians and dietitians educated the parents and examined the subjects every 2 months. Anthropometric parameters were measured at baseline and at 2, 4, and 6 months, and laboratory tests were done at baseline and 6 months. The good consumption group included children who consumed ≥ 60% of the recommended dose of formula. RESULTS: Total 82 children completed the 6-month intervention. At baseline, there were no significant differences in all variables between the good consumption and poor consumption groups. Weight and weight z-scores were significantly improved in the good consumption group compared to the poor consumption group at the end of the intervention (P = 0.009, respectively). The good consumption group showed a significant trend for gaining weight (P < 0.05) and weight z-score (P < 0.05) compared to the poor consumption group during 6 months of formula intake. The concentration of blood urea nitrogen was significantly increased in the good consumption group (P = 0.001). CONCLUSIONS: Nutritional supplementation with a concentrated and balanced pediatric nutritional formula along with dietary education might be an effective approach to promote catch-up growth in children with nonorganic faltering growth.
Abstract
BACKGROUND/OBJECTIVES: Inadequate nutrition in infants and young children affects physical growth and neurocognitive development. Therefore, early nutritional intervention is important to promote catch-up growth in young children with faltering growth. The aim of this study was to evaluate the effect of nutritional supplementation with a pediatric concentrated and balanced nutritional supplement formula on promoting growth and improving nutritional status in children with nonorganic faltering growth. SUBJECTS/METHODS: Children aged 12–36 months whose body weight-for-age was < 5th percentile on the Korean Growth Charts were enrolled. Children born premature or having organic diseases were excluded. Children were instructed to consume 400 mL of formula per day in addition to their regular diet for 6 months. Pediatricians and dietitians educated the parents and examined the subjects every 2 months. Anthropometric parameters were measured at baseline and at 2, 4, and 6 months, and laboratory tests were done at baseline and 6 months. The good consumption group included children who consumed ≥ 60% of the recommended dose of formula. RESULTS: Total 82 children completed the 6-month intervention. At baseline, there were no significant differences in all variables between the good consumption and poor consumption groups. Weight and weight z-scores were significantly improved in the good consumption group compared to the poor consumption group at the end of the intervention (P = 0.009, respectively). The good consumption group showed a significant trend for gaining weight (P < 0.05) and weight z-score (P < 0.05) compared to the poor consumption group during 6 months of formula intake. The concentration of blood urea nitrogen was significantly increased in the good consumption group (P = 0.001). CONCLUSIONS: Nutritional supplementation with a concentrated and balanced pediatric nutritional formula along with dietary education might be an effective approach to promote catch-up growth in children with nonorganic faltering growth.
참고문헌 (30)
- National Guideline Alliance (UK), "Faltering Growth: Recognition and Management. NICE Guideline", National Institute for Health and Care Excellence, ~ (2017)
- Cherry R, "Pediatric Gastrointestinal and Liver Disease", pp.137~143 (2016), Elsevier
- Olsen EM, "Failure to thrive: still a problem of definition", Clin Pediatr(Phila), 45, pp.1~6 (2006)
- 김재현, "The 2017 Korean National Growth Charts for children and adolescents: development, improvement, and prospects", Clinical and Experimental Pediatrics, 61(5), pp.135~149 (2018), 대한소아청소년과학회
- "2011 joint child malnutrition estimates - levels and trends" (2012)[URL]
- Olsen EM, "Failure to thrive : the prevalence and concurrence of anthropometric criteria in a general infant population", Arch Dis Child, 92, pp.109~114 (2007)
- Shrimpton R, "Worldwide timing of growth faltering : implications for nutritional interventions", Pediatrics, 107, pp.E75~ (2001)
- Larson-Nath C, "Clinical review of failure to thrive in pediatric patients", Pediatr Ann, 45, pp.e46~9 (2016)
- Carruth BR, "The phenomenon of"picky eater" : a behavioral marker in eating patterns of toddlers", J Am Coll Nutr, 17, pp.180~186 (1998)
- Spitz RA, "Hospitalism; an inquiry into the genesis of psychiatric conditions in early childhood", Psychoanal Study Child, 1, pp.53~74 (1945)
- Block RW, "Failure to thrive as a manifestation of child neglect", Pediatrics, 116, pp.1234~1237 (2005)
- Estrem HH, "Feeding problems in infancy and early childhood : evolutionary concept analysis", J Adv Nurs, 73, pp.56~70 (2017)
- Williams KE, "Food refusal in children : a review of the literature", Res Dev Disabil, 31, pp.625~633 (2010)
- Sharp WG, "Pediatric feeding disorders : a quantitative synthesis of treatment outcomes", Clin Child Fam Psychol Rev, 13, pp.348~365 (2010)
- Lebenthal Y, "Effect of a nutritional supplement on growth in short and lean prepubertal children : a prospective, randomized, double-blind, placebo-controlled study", J Pediatr, 165, pp.1190~1193.e1 (2014)
- Yackobovitch-Gavan M, "Effect of Nutritional supplementation on growth in short and lean prepubertal children after 1 year of intervention", J Pediatr, 179, pp.154~159.e1 (2016)
- Lundeen EA, "Growth faltering and recovery in children aged 1–8 years in four low-and middle-income countries : Young Lives", Public Health Nutr, 17, pp.2131~2137 (2014)
- 김정은, "Nutritional State of Children in the Democratic People’s Republic of Korea (DPRK): Based on the DPRK Final Report ofthe National Nutrition Survey 2012", Pediatric Gastroenterology, Hepatology & Nutrition, 17(3), pp.135~139 (2014), 대한소아소화기영양학회
- Mitchell WG, "Failure-to-thrive : a study in a primary care setting. Epidemiology and follow-up", Pediatrics, 65, pp.971~977 (1980)
- Larson-Nath CM, "Failure to thrive : a prospective study in a pediatric gastroenterology clinic", J Pediatr Gastroenterol Nutr, 62, pp.907~913 (2016)
- Daniel M, "Etiology of failure to thrive in infants and toddlers referred to a pediatric endocrinology outpatient clinic", Clin Pediatr(Phila), 47, pp.762~765 (2008)
- Kerzner B, "A practical approach to classifying and managing feeding difficulties", Pediatrics, 135, pp.344~353 (2015)
- Fewtrell MS, "Catch-up growth in small-for-gestational-age term infants : a randomized trial", Am J Clin Nutr, 74, pp.516~523 (2001)
- Clarke SE, "Randomized comparison of a nutrient-dense formula with an energy-supplemented formula for infants with faltering growth", J Hum Nutr Diet, 20, pp.329~339 (2007)
- Ramstack M, "Safety and efficacy of a new pediatric enteral product in the young child", JPEN J Parenter Enteral Nutr, 15, pp.89~92 (1991)
- Alarcon PA, "Effect of oral supplementation on catch-up growth in picky eaters", Clin Pediatr(Phila), 42, pp.209~217 (2003)
- Rivera JA, "The effect of micronutrient deficiencies on child growth : a review of results from community-based supplementation trials", J Nutr, 133, pp.4010S~4020S (2003)
- Brown KH, "Effect of supplemental zinc on the growth and serum zinc concentrations of prepubertal children : a meta-analysis of randomized controlled trials", Am J Clin Nutr, 75, pp.1062~1071 (2002)
- Fink G, "Home-and community-based growth monitoring to reduce early life growth faltering : an open-label, cluster-randomized controlled trial", Am J Clin Nutr, 106, pp.1070~1077 (2017)
- Ashworth A, "Catch-up growth in children", Nutr Rev, 44, pp.157~163 (1986)