노인인구에서 음주와 대장직장암 발생간의 연관성에 관한 코호트연구
Cohort Study on the A ssociation between Alcohol Consumption and the Risk of Colorectal Cancer in the Korean Elderly
2
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Objectives : We examined the association between alcohol consumption and incidence of colorectal cancer in elderly Koreans. Methods : The cohort members (n=14,304) consisted of 4,834 males and 9,470 females derived from the Korea Elderly Pharmacoepidemiologic Cohort (KEPEC), a population-based dynamic cohort. They were aged 65 years old or older and lived in Busan between 1993-1998; they were beneficiaries of the Korean Medical Insurance Corporation (KMIC). Baseline information was surveyed by a self-administered, mailed questionnaire. This study population was restricted to 14,304 participants who reported alcohol drinking habits on the questionnaire and had not been diagnosed with colorectal cancer at baseline. The adjusted hazard ratios (aHR) of status, type, frequency and daily average amount of alcohol consumption were computed with Cox’s proportional hazard model, with the never-drinkers as a reference group and controlling for age and gender. Results : After 4.82 person-years of mean follow-up 112 cases of colorectal cancer occurred. The incidence densities of colorectal cancer were 161 (95% CI=123-200) for never-drinkers, 219 (95% CI=125-339) for ex-drinkers, and 137 (95% CI=84-189) for current-drinkers per 100,000 person-year. The status, type, frequency, and daily average amount of alcohol consumption were not significantly related to the incidence of colorectal cancer after controlling for age and gender. Conclusions : There was no significant association between alcohol consumption and colorectal cancer among elderly people after controlling for age and gender.
Abstract
Objectives : We examined the association between alcohol consumption and incidence of colorectal cancer in elderly Koreans. Methods : The cohort members (n=14,304) consisted of 4,834 males and 9,470 females derived from the Korea Elderly Pharmacoepidemiologic Cohort (KEPEC), a population-based dynamic cohort. They were aged 65 years old or older and lived in Busan between 1993-1998; they were beneficiaries of the Korean Medical Insurance Corporation (KMIC). Baseline information was surveyed by a self-administered, mailed questionnaire. This study population was restricted to 14,304 participants who reported alcohol drinking habits on the questionnaire and had not been diagnosed with colorectal cancer at baseline. The adjusted hazard ratios (aHR) of status, type, frequency and daily average amount of alcohol consumption were computed with Cox’s proportional hazard model, with the never-drinkers as a reference group and controlling for age and gender. Results : After 4.82 person-years of mean follow-up 112 cases of colorectal cancer occurred. The incidence densities of colorectal cancer were 161 (95% CI=123-200) for never-drinkers, 219 (95% CI=125-339) for ex-drinkers, and 137 (95% CI=84-189) for current-drinkers per 100,000 person-year. The status, type, frequency, and daily average amount of alcohol consumption were not significantly related to the incidence of colorectal cancer after controlling for age and gender. Conclusions : There was no significant association between alcohol consumption and colorectal cancer among elderly people after controlling for age and gender.
참고문헌 (23)
- Klatsky, A.L., "The relations of alcoholic beverage use to colon and rectal cancer", Am J Epidemiol, 128(5), pp.1007~1015 (1988)
- Hirayama, T., "Association between alcohol consumption and cancer of the sigmoid colon observations from a Japanese cohort study", Lancet, 2(8665), pp.725~727 (1989)
- Slattery, M.L., "Tobacco, alcohol, coffee, and caffeine as risk factors for colon cancer in a low-risk population", Epidemiology, 1(2), pp.141~145 (1990)
- Longnecker M.P., "A meta-analysis of alcoholic beverage consumption in relation to risk of colorectal cancer", Cancer Causes Control, 1(1), pp.59~68 (1990)
- Park, B.J., "Construction of the Korea Elderly Pharmacoepidemiologic Cohort: Drug utilization review of cephalosporins in geriatric inpatients", Pharmacoepidemiol Drug Saf, 10(6), pp.487~492 (2001)
- Park, B.J., "Reliability and validity study of a life style questionnaire for elderly people", Korean J Prev Med, 31(1), pp.49~58 (1998)
- Freudenheim, J.L., "Lifetime alcohol intake and risk of rectal cancer in western New York", Nutr Cancer, 13(1-2), pp.101~109 (1990)
- Stemmermann G.N., "Prospective study of alcohol intake and large bowel cancer", Dig Dis Sci, 35(11), pp.1414~1420 (1990)
- Kune, S., "Case-control study of alcoholic beverages as etiological factors: The Melbourne Colorectal Cancer Study", Nutr Cancer, 9(1), pp.43~56 (1987)
- Peters, R.K., "A case-control study of occupational and dietary factors in colorectal cancer in young men by subsite", Cancer Res, 49(19), pp.5459~5468 (1989)
- Peters, R.K., "Diet and colon cancer in Los Angeles County, California", Cancer Causes Control, 3(5), pp.457~473 (1992)
- Kabat, G.C., "Beer consumption and rectal cancer", Int J Epidemiol, 15(4), pp.494~501 (1986)
- Bidoli, E., "Food consumption and cancer of the colon and rectum in north-eastern Italy", Int J Cancer, 50(2), pp.223~229 (1992)
- Pickle, L.W., "Colorectal cancer in rural Nebraska", Cancer Res, 44(1), pp.363~369 (1984)
- Cho, E., "Alcohol intake and colorectal cancer: A pooled analysis of 8 cohort studies", Ann Intern Med, 140(8), pp.603~613 (2004)
- Williams, R.R., "Association of cancer sites with tabacco and alcohol consumption and socioeconomic status of patients : Interview study from the Third National Cancer Survey", J Natl Cancer Inst, 58(3), pp.525~547 (1977)
- Newcomb, P.A., "Cancer of the large bowel in women in relation to alcohol consumption : A case-control study in Wisconsin", Cancer Causes Control, 4(5), pp.405~411 (1993)
- Meyer, F., "Alcohol and nutrients in relation to colon cancer in middle-aged adults", Am J Epidemiol, 138(4), pp.225~236 (1993)
- Chen, K., "Meta analysis of risk factors for colorectal cancer", World J Gastroenterol, 9(7), pp.1598~1600 (2003)
- Yuan, J.M., "Follow up study of moderate alcohol intake and mortality among middle aged men in Shanghai", China. BMJ, 314(7073), pp.18~23 (1997)
- Lee, H.P., "Colorectal cancer and diet in an Asian population-a case-control study among Singapore Chinese", Int J Cancer, 43(6), pp.1007~1016 (1989)
- Cho, Y.J., "Alcohol and Risk of Ischemic Stroke in the Elderly People: A Nested Case-control Study" (2004), Seoul National Univ
- 김화정, "노인 인구에서 흡연과 대장암 발생 위험간의 관련성", 예방의학회지, 39(2), pp.123~129 (2006), 대한예방의학회