Effects of poly-gamma-glutamic acid and vitamin B6 supplements on sleep status: a randomized intervention study
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BACKGROUD/OBJECTIVES: Data regarding the effects of poly-γ-glutamic acid (γ-PGA) on sleep status are limited. This study aimed to test whether γ-PGA and vitamin B6 (VitB6) supplements improve sleep duration and quality. SUBJECTS/METHODS: A factorial randomized, double-blinded, placebo-controlled crossover study included 47 adults (25 men and 22 women) who were free of chronic disease. Stratified randomized allocation considered age and gender for three interventions, group A (supplementation with γ-PGA 600 mg; n = 16), group B (supplementation with VitB6 100 mg; n = 14), and group C (dual supplementation of both γ-PGA 600 mg and VitB6 100 mg; n = 17). Participants underwent a 1-mon intervention period, followed by a 1-mon washout period, and then a second 1-mon intervention period. Differences (mean ± SD) in nighttime sleep status before and after supplementation were compared between the placebo and intervention groups using nonparametric tests. RESULTS: Significant changes in sleep duration (0.27 ± 0.98 h, P < 0.05) and the Pittsburgh Sleep Quality Index global score (−0.52 ± 1.58, P < 0.05) indicating improved sleep status were observed in the intervention compared with the placebo of group C while no significant changes were observed in groups A and B. No statistical significance was detected between the intervention and the placebo; however, there was a greater increase in the group C intervention (4.59 ± 38.5 ng/mL) in serum serotonin concentrations than the groups A and B interventions. No side effects were observed. CONCLUSIONS: On the basis of these findings, the dual supplementation of γ-PGA and VitB6 may be effective as functional food components to improve nighttime sleep status. Trial Registration: Clinical Research Information Service Identifier: KCT0005083
Abstract
BACKGROUD/OBJECTIVES: Data regarding the effects of poly-γ-glutamic acid (γ-PGA) on sleep status are limited. This study aimed to test whether γ-PGA and vitamin B6 (VitB6) supplements improve sleep duration and quality. SUBJECTS/METHODS: A factorial randomized, double-blinded, placebo-controlled crossover study included 47 adults (25 men and 22 women) who were free of chronic disease. Stratified randomized allocation considered age and gender for three interventions, group A (supplementation with γ-PGA 600 mg; n = 16), group B (supplementation with VitB6 100 mg; n = 14), and group C (dual supplementation of both γ-PGA 600 mg and VitB6 100 mg; n = 17). Participants underwent a 1-mon intervention period, followed by a 1-mon washout period, and then a second 1-mon intervention period. Differences (mean ± SD) in nighttime sleep status before and after supplementation were compared between the placebo and intervention groups using nonparametric tests. RESULTS: Significant changes in sleep duration (0.27 ± 0.98 h, P < 0.05) and the Pittsburgh Sleep Quality Index global score (−0.52 ± 1.58, P < 0.05) indicating improved sleep status were observed in the intervention compared with the placebo of group C while no significant changes were observed in groups A and B. No statistical significance was detected between the intervention and the placebo; however, there was a greater increase in the group C intervention (4.59 ± 38.5 ng/mL) in serum serotonin concentrations than the groups A and B interventions. No side effects were observed. CONCLUSIONS: On the basis of these findings, the dual supplementation of γ-PGA and VitB6 may be effective as functional food components to improve nighttime sleep status. Trial Registration: Clinical Research Information Service Identifier: KCT0005083
참고문헌 (38)
- King PW, "Introducing Abraham Maslow and His Pyramid", pp.3~21 (2009), Troubador Publishing Ltd
- Park S, "Relationships of sleep duration with sociodemographic and health-related factors, psychiatric disorders and sleep disturbances in a community sample of Korean adults", J Sleep Res, 19, pp.567~577 (2010)
- Park SE, "The association between sleep duration and general and abdominal obesity in Koreans : data from the Korean National Health and Nutrition Examination Survey, 2001 and 2005", Obesity(Silver Spring), 17, pp.767~771 (2009)
- Abrams RM, "Sleep deprivation", Obstet Gynecol Clin North Am, 42, pp.493~506 (2015)
- 황세환, "The Association between Sleep Duration and Dizziness in Korean Women: The Korea National Health and Nutrition Examination Survey", Journal of Korean Medical Science, 34(33), pp.1~10 (2019), 대한의학회
- Cunnington D, "Insomnia: prevalence, consequences and effective treatment", Med J Aust., 199, pp.S36~S40 (2013)
- Morin CM, "Cognitive behavior therapy, singly and combined with medication, for persistent insomnia : acute and maintenance therapeutic effects", JAMA, 301, pp.2005~2015 (2011)
- Ebben M, "Effects of pyridoxine on dreaming : a preliminary study", Percept Mot Skills, 94, pp.135~140 (2002)
- Scholey A, "Exploring the effect of lactium™ and Zizyphus complex on sleep quality : a double-blind, randomized placebo-controlled trial", Nutrients, 9, pp.154~ (2017)
- 이혜성, "Effects of poly-γ-glutamic acid on serum and brain concentrations of glutamate and GABA in diet-induced obese rats", Nutrition Research and Practice, 4(1), pp.23~29 (2010), 한국영양학회
- Buysse DJ, "The Pittsburgh Sleep Quality Index : a new instrument for psychiatric practice and research", Psychiatry Res, 28, pp.193~213 (1989)
- Johns MW, "A new method for measuring daytime sleepiness : the Epworth Sleepiness Scale", Sleep, 14, pp.540~545 (1991)
- Spira AP, "Reliability and validity of the Pittsburgh Sleep Quality Index and the Epworth Sleepiness Scale in older men", J Gerontol A Biol Sci Med Sci, 67, pp.433~439 (2012)
- Beaudreau SA, "Validation of the Pittsburgh Sleep Quality Index and the Epworth Sleepiness Scale in older black and white women", Sleep Med, 13, pp.36~42 (2012)
- Sohn SI, "The reliability and validity of the Korean version of the Pittsburgh Sleep Quality Index", Sleep Breath, 16, pp.803~812 (2012)
- Korean Nutrition Society, "Dietary Reference Intakes for Koreans" (2015), Korean Nutrition Society
- Current Status of Functional Ingredients for Health Functional Food in Korea, "Ministry of Food and Drug Safety", Ministry of Food and Drug Safety, ~ (2016)
- Kim TW, "Oral administration of high molecular mass poly-gamma-glutamate induces NK cell-mediated antitumor immunity", J Immunol, 179, pp.775~780 (2007)
- Oyunbileg E, "Effects of poly-gamma-glutamic acid on inflammatory and metabolic biomarkers in sleep-restricted rats", Sleep Biol Rhythms, 16, pp.399~404 (2018)
- Luo Z, "Microbial synthesis of poly-γ-glutamic acid : current progress, challenges, and future perspectives", Biotechnol Biofuels, 9, pp.134~ (2016)
- Ito Y, "Glutamic acid independent production of poly(γ-glutamic acid)by Bacillus subtilis TAM-4", Biosci Biotechnol Biochem, 60, pp.1239~1242 (1996)
- Ogunleye A, "Poly-γ-glutamic acid : production, properties and applications", Microbiology(Reading), 161, pp.1~17 (2015)
- 박지호, "High Molecular Weight Poly-Gamma-Glutamic Acid Regulates Lipid Metabolism in Rats Fed a High-Fat Diet and Humans", Journal of Microbiology and Biotechnology, 21(7), pp.766~775 (2011), 한국미생물·생명공학회
- Tanimoto H, "Acute effect of poly-gamma-glutamic acid on calcium absorption in post-menopausal women", J Am Coll Nutr, 26, pp.645~649 (2007)
- Jun NR, "Effect of poly-gamma glutamic acid, magnesium and vitamin B6 supplementation on metabolic and inflammatory biomarkers and sleep status in caffeine intake rat", pp.2017
- Ciranna L, "Serotonin as a modulator of glutamate-and GABA-mediated neurotransmission : implications in physiological functions and in pathology", Curr Neuropharmacol, 4, pp.101~114 (2006)
- Yin D, "Glutamate activates the histaminergic tuberomammillary nucleus and increases wakefulness in rats", Neuroscience, 413, pp.86~98 (2019)
- Lopez-Rodriguez F, "Changes in extracellular glutamate levels in rat orbitofrontal cortex during sleep and wakefulness", Arch Med Res, 38, pp.52~55 (2007)
- Messripour M, "Effects of vitamin B6 on age associated changes of rat brain glutamate decarboxylase activity", Afr J Pharm Pharmacol, 5, pp.454~456 (2011)
- Almeida MR, "Maternal vitamin B6 deficient or supplemented diets on expression of genes related to GABAergic, serotonergic, or glutamatergic pathways in hippocampus of rat dams and their offspring", Mol Nutr Food Res, 60, pp.1615~1624 (2016)
- Boonstra E, "Neurotransmitters as food supplements : the effects of GABA on brain and behavior", Front Psychol, 6, pp.1520~ (2015)
- Knudsen GM, "Blood-brain barrier permeability in galactosamine-induced hepatic encephalopathy. No evidence for increased GABA-transport", J Hepatol, 6, pp.187~192 (1988)
- Daneman R, "The blood-brain barrier", Cold Spring Harb Perspect Biol, 7, pp.a020412~ (2015)
- Darine Froy N. Mabunga, "Treatment of GABA from Fermented Rice Germ Ameliorates Caffeine-Induced Sleep Disturbance in Mice", Biomolecules & Therapeutics, 23(3), pp.268~274 (2015), 한국응용약물학회[DOI]
- Zhao W, "A study on quality components and sleep-promoting effects of GABA black tea", Food Funct, 6, pp.3393~3398 (2015)
- Kim S, "GABA and l-theanine mixture decreases sleep latency and improves NREM sleep", Pharm Biol, 57, pp.65~73 (2019)
- Hong KB, "Sleep-promoting effects of a GABA", 5-HTP mixture : Behavioral changes and neuromodulation in an invertebrate model, 2016, pp.150, 42~49
- 진희은, "Prebiotic Effects of Poly-Gamma-Glutamate on Bacterial Flora in Murine Gut", Journal of Microbiology and Biotechnology, 27(2), pp.412~415 (2017), 한국미생물·생명공학회[DOI]