Effects of green tea or Sasa quelpaertensis bamboo leaves on plasma and liver lipids, erythrocyte Na efflux, and platelet aggregation in ovariectomized rats
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This study was conducted to investigate the effects of Sasa quelpaertensis bamboo and green tea on plasma and liver lipids, platelet aggregation, and erythrocyte membrane Na channels in ovariectomized (OVX) rats. Thirty female rats were OVX, and ten female rats were sham-operated at the age of 6 weeks. The rats were divided into four groups at the age of 10 weeks and fed the experiment diets: sham-control, OVX-control, OVX-bamboo leaves (10%), or OVX-green tea leaves (10%) for four weeks. Final body weight increased significantly in the OVX groups compared with that in the sham-control, whereas body weight in the OVX-green tea group decreased significantly compared with that in the OVX-control (P < 0.01). High density lipoprotein (HDL)-cholesterol level decreased in all OVX groups compared with that in the sham-control rats (P < 0.05)but without a difference in plasma total cholesterol. Plasma triglycerides in the OVX-green tea group were significantly lower than those in the sham-control or OVX-control group (P < 0.05). Liver triglycerides increased significantly in the OVX-control compared with those in the sham-control (P < 0.01) but decreased significantly in the OVX-green tea group compared with those in the OVX-control or OVX-bamboo group (P < 0.01). Platelet aggregation in both maximum and initial slope tended to be lower in all OVX rats compared with that in the sham-control rats but was not significantly different. Na-K ATPase tended to increase and Na-K cotransport tended to decrease following ovariectomy. Na-K ATPase decreased significantly in the OVX-green tea group compared with that in the OVX-control group (P < 0.01), and Na-K cotransport increased significantly in the OVX-bamboo and OVX-green tea groups compared with that in the OVX-control (P < 0.05). Femoral bone mineral density tended to be lower in OVX rats than that in the sham-control, whereas the green tea and bamboo leaves groups recovered bone density to some extent. The results show that ovariectomy caused an increase in body weight and liver triglycerides, and that green tea was effective for lowering body weight and triglycerides in OVX rats. Ovariectomy induced an increase in Na efflux via Na-K ATPase and a decrease in Na efflux via Na-K cotransport. Furthermore, consumption of green tea and bamboo leaves affected Na efflux channels, controlling electrolyte and body water balance.
Abstract
This study was conducted to investigate the effects of Sasa quelpaertensis bamboo and green tea on plasma and liver lipids, platelet aggregation, and erythrocyte membrane Na channels in ovariectomized (OVX) rats. Thirty female rats were OVX, and ten female rats were sham-operated at the age of 6 weeks. The rats were divided into four groups at the age of 10 weeks and fed the experiment diets: sham-control, OVX-control, OVX-bamboo leaves (10%), or OVX-green tea leaves (10%) for four weeks. Final body weight increased significantly in the OVX groups compared with that in the sham-control, whereas body weight in the OVX-green tea group decreased significantly compared with that in the OVX-control (P < 0.01). High density lipoprotein (HDL)-cholesterol level decreased in all OVX groups compared with that in the sham-control rats (P < 0.05)but without a difference in plasma total cholesterol. Plasma triglycerides in the OVX-green tea group were significantly lower than those in the sham-control or OVX-control group (P < 0.05). Liver triglycerides increased significantly in the OVX-control compared with those in the sham-control (P < 0.01) but decreased significantly in the OVX-green tea group compared with those in the OVX-control or OVX-bamboo group (P < 0.01). Platelet aggregation in both maximum and initial slope tended to be lower in all OVX rats compared with that in the sham-control rats but was not significantly different. Na-K ATPase tended to increase and Na-K cotransport tended to decrease following ovariectomy. Na-K ATPase decreased significantly in the OVX-green tea group compared with that in the OVX-control group (P < 0.01), and Na-K cotransport increased significantly in the OVX-bamboo and OVX-green tea groups compared with that in the OVX-control (P < 0.05). Femoral bone mineral density tended to be lower in OVX rats than that in the sham-control, whereas the green tea and bamboo leaves groups recovered bone density to some extent. The results show that ovariectomy caused an increase in body weight and liver triglycerides, and that green tea was effective for lowering body weight and triglycerides in OVX rats. Ovariectomy induced an increase in Na efflux via Na-K ATPase and a decrease in Na efflux via Na-K cotransport. Furthermore, consumption of green tea and bamboo leaves affected Na efflux channels, controlling electrolyte and body water balance.
참고문헌 (44)
- Heymsfield SB, "Menopausal changes in body composition and energy expenditure", Exp Gerontol, 29, pp.377~389 (1994)
- Ferrara CM, "Differences in adipose tissue metabolism between postmenopausal and perimenopausal women", J Clin Endocrinol Metab, 87, pp.4166~4170 (2002)
- Creatsas G, "Cardiovascular disease: screening and management of the a-symptomatic high-risk post-menopausal woman", Maturitas, 52(Suppl 1), pp.32~37 (2005)
- Gaspard U, "Hyperinsulinaemia, a key factor of the metabolic syndrome in postmenopausal women", Maturitas, 62, pp.362~365 (2009)
- Gorodeski EZ, "Epidemiology and risk factors of cardiovascular disease in post menopausal woman. In: Lobo RA, editor. Treatment of the Postmenopausal Woman: Basic and Clinical Aspects, 3rd ed", pp.405~452 (2007), Elsevier
- Uematsu K, "Nitric oxide production and blood corpuscle dynamics in response to the endocrine status of female rats", Thromb Res, 126, pp.504~510 (2010)
- de Aloysio D, "The effect of menopause on blood lipid and lipoprotein levels. The Icarus Study Group", Atherosclerosis, 147, pp.147~153 (1999)
- Lemay A, "Estrogen", progesterone replacement versus pravastatin and their sequential association in hypercholesterolemic postmenopausal women, 2001, pp.40, 247~257
- Aviram M, "The effect of human plasma on platelet function in familial hypercholesterolemia", Thromb Res, 26, pp.101~109 (1982)
- Sinzinger H, "Ex-vivo and in-vivo platelet function in patients with severe hypercholesterolemia undergoing LDL-apheresis", Thromb Res, 82, pp.291~301 (1996)
- Pochmann D, "Ovariectomy and estradiol replacement therapy alters the adenine nucleotide hydrolysis in rat blood serum", Thromb Res, 114, pp.275~281 (2004)
- Pechère-Bertschi A, "Female sex hormones, salt, and blood pressure regulation", Am J Hypertens, 17, pp.994~1001 (2004)
- Handa RK, "Plateletactivating factor and solute transport processes in the kidney", Am J Physiol Renal Physiol, 284, pp.274~281 (2003)
- Musselman TM, "Differential regulation of the bumetanide-sensitive cotransporter (NKCC2) by ovarian hormones", Steroids, 75, pp.760~765 (2010)
- Monteiro SC, "Ovariectomy increases Na+, K+-ATPase, acetylcholinesterase and catalase in rat hippocampus", Mol Cell Endocrinol, 236, pp.9~16 (2005)
- Schwarz SM, "Estrogen modulates ileal basolateral membrane lipid dynamics and Na+-K+-ATPase activity", Am J Physiol, 254, pp.687~694 (1988)
- Fu XC, "Vasodilatation produced by orientin and its mechanism study", Biol Pharm Bull, 28, pp.37~41 (2005)
- 이혜숙, "맹종죽의 angiotensin converting enzyme 활성억제와 항산화효능", 동의생리병리학회지, 21(3), pp.658~665 (2007), 대한동의병리학회
- Nasim Sultana, "New Phenylpropanoids from Sasa quelpaertensis Nakai with Tyrosinase Inhibition Activities", Bulletin of the Korean Chemical Society, 30(8), pp.1729~1732 (2009), 대한화학회
- Kuriyama S, "The relation between green tea consumption and cardiovascular disease as evidenced by epidemiological studies", J Nutr, 138, pp.1548~1553 (2008)
- Suzuki E, "Green tea consumption and mortality among Japanese elderly people: the prospective Shizuoka elderly cohort", Ann Epidemiol, 19, pp.732~739 (2009)
- Babu PV, "Green tea impedes dyslipidemia, lipid peroxidation, protein glycation and ameliorates Ca2+ -ATPase and Na+", K+ -ATPase activity in the heart of streptozotocin-diabetic rats, 2006, pp.162, 157~164
- Lin JK, "Mechanisms of hypolipidemic and antiobesity effects of tea and tea polyphenols", Mol Nutr Food Res, 50, pp.211~217 (2006)
- Folch J, "Sloane Stanley GH. A simple method for the isolation and purification of total lipides from animal tissues", J Biol Chem, 226, pp.497~509 (1957)
- Kang JS, "Effect of calcium on blood pressure, platelet aggregation and erythrocyte sodium transport in Dahl salt-sensitive rats", J Hypertens, 8, pp.245~250 (1990)
- 오인숙, "성소의 제거와 고콜레스테롤 식이 급여가 흰쥐의 혈장과 간의 콜레스테롤, 중성지방 수준과 혈소판 응집성 및 간 조직에 미치는 영향에 있어서 암, 수의 차이", Journal of Nutrition and Health, 35(1), pp.15~23 (2002), 한국영양학회
- Pantaleão TU, "Effect of serum estradiol and leptin levels on thyroid function, food intake and body weight gain in female Wistar rats", Steroids, 75, pp.638~642 (2010)
- 강정애, "Pair Fed 흰쥐에 있어서 녹차의 항증체, 지질개선 및 항산화 효과", Journal of Nutrition and Health, 41(7), pp.602~611 (2008), 한국영양학회
- Diepvens K, "Westerterp- Plantenga MS. Effect of green tea on resting energy expenditure and substrate oxidation during weight loss in overweight females", Br J Nutr, 94, pp.1026~1034 (2005)
- Shimotoyodome A, "Exercise and green tea extract stimulate fat oxidation and prevent obesity in mice", Med Sci Sports Exerc, 37, pp.1884~1892 (2005)
- Vajo Z, "Increased intra-abdominal fat may lower HDL levels by increasing the fractional catabolic rate of Lp A-I in postmenopausal women", Atherosclerosis, 160, pp.495~501 (2002)
- Joles JA, "Ovariectomy decreases plasma triglyceride levels in analbuminaemic rats by lowering hepatic triglyceride secretion", Atherosclerosis, 117, pp.51~59 (1995)
- Liu CH, "Sources of triacylglycerol accumulation in livers of rats fed a cholesterol-supplemented diet", Lipids, 30, pp.527~531 (1995)
- Löest HB, "Green tea extract inhibits the lymphatic absorption of cholesterol and alpha-tocopherol in ovariectomized rats", J Nutr, 132, pp.1282~1288 (2002)
- Huang PY, "Aggregation and disaggregation kinetics of human blood platelets: Part II. Shear-induced platelet aggregation", Biophys J, 65, pp.344~353 (1993)
- Hubbard GP, "Ingestion of onion soup high in quercetin inhibits platelet aggregation and essential components of the collagen-stimulated platelet activation pathway in man: a pilot study", Br J Nutr, 96, pp.482~488 (2006)
- Gresele P, "Resveratrol, at concentrations attainable with moderate wine consumption, stimulates human platelet nitric oxide production", J Nutr, 138, pp.1602~1608 (2008)
- Lytton J, "Identification of two molecular forms of (Na+,K+)-ATPase in rat adipocytes. Relation to insulin stimulation of the enzyme", J Biol Chem, 260, pp.1177~1184 (1985)
- Banday AA, "Dopaminemediated inhibition of renal Na,K-ATPase is reduced by insulin", Hypertension, 41, pp.1353~1358 (2003)
- Wright CI, "Herbal medicines as diuretics: a review of the scientific evidence", J Ethnopharmacol, 114, pp.1~31 (2007)
- Ohta H, "Bone resorption versus estrogen loss following oophorectomy and menopause", Maturitas, 43, pp.27~33 (2002)
- García-Moreno C, "Heterogeneous decrease of bone mineral density in the vertebral column of ovariectomized rats", Bone, 16, pp.295~300 (1995)
- Mody N, "Oxidative stress modulates osteoblastic differentiation of vascular and bone cells", Free Radic Biol Med, 31, pp.509~519 (2001)
- Shen CL, "Green tea and bone metabolism", Nutr Res, 29, pp.437~456 (2009)