Serum immunoglobulin E (IgE) levels and dietary intake of Korean infants and young children with atopic dermatitis
2
조회
0
다운로드
2
인용
0
참고문헌
키워드
초록
Atopic dermatitis (AD) has become a serious epidemic in Korean children. We aimed to investigate the association between vitamin C, E and other nutrients, and serum total IgE/specific IgE levels in children with AD. A total of 119 children (0-24 mo) diagnosed with AD were recruited for this cross-sectional study from a medical center in Seoul. A 24 h recall was used to assess dietary intakes. Serum total and six food-allergen specific IgE levels were measured by CAP-FEIA. Serum vitamin E was also measured but only in 25 out of the total 119 participants. Multiple linear regression analysis was performed to estimate the coefficients between serum IgE levels and dietary intake as well as serum vitamin E. Serum vitamin E levels showed a significantly inverse association with serum total IgE and all specific IgE levels (P < 0.05). Fat intake was inversely related with specific-IgEs for egg whites, milk, buck wheat, soy, and peanuts (P < 0.05). Positive associations were found between carbohydrate (CHO) intake and total IgE and specific IgEs to egg whites, milk, soy, and peanuts (P < 0.05). Vitamin C, E and n-3/n-6 fatty acids were not related with serum total IgE and specific IgE levels except for the association between buck wheat and vitamin E. In addition, there were no significant differences between males and females in dietary intake and serum IgE levels by student’s t-test. Although dietary vitamin E showed no association with serum IgE levels, serum vitamin E drew a significant inverse relationship with serum IgE levels. The evidence seems to suggest that vitamin E may possibly lower total and specific-IgEs in children with AD, and that it is important to maintain a relatively high serum vitamin E level in children with AD.
Abstract
Atopic dermatitis (AD) has become a serious epidemic in Korean children. We aimed to investigate the association between vitamin C, E and other nutrients, and serum total IgE/specific IgE levels in children with AD. A total of 119 children (0-24 mo) diagnosed with AD were recruited for this cross-sectional study from a medical center in Seoul. A 24 h recall was used to assess dietary intakes. Serum total and six food-allergen specific IgE levels were measured by CAP-FEIA. Serum vitamin E was also measured but only in 25 out of the total 119 participants. Multiple linear regression analysis was performed to estimate the coefficients between serum IgE levels and dietary intake as well as serum vitamin E. Serum vitamin E levels showed a significantly inverse association with serum total IgE and all specific IgE levels (P < 0.05). Fat intake was inversely related with specific-IgEs for egg whites, milk, buck wheat, soy, and peanuts (P < 0.05). Positive associations were found between carbohydrate (CHO) intake and total IgE and specific IgEs to egg whites, milk, soy, and peanuts (P < 0.05). Vitamin C, E and n-3/n-6 fatty acids were not related with serum total IgE and specific IgE levels except for the association between buck wheat and vitamin E. In addition, there were no significant differences between males and females in dietary intake and serum IgE levels by student’s t-test. Although dietary vitamin E showed no association with serum IgE levels, serum vitamin E drew a significant inverse relationship with serum IgE levels. The evidence seems to suggest that vitamin E may possibly lower total and specific-IgEs in children with AD, and that it is important to maintain a relatively high serum vitamin E level in children with AD.
참고문헌 (49)
- Zheng T, "The atopic march: progression from atopic dermatitis to allergic rhinitis and asthma", Allergy Asthma Immunol Res, 3, pp.67~73 (2011)
- Asher MI, "Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional surveys", Lancet, 368, pp.733~743 (2006)
- Hwang CY, "Prevalence of atopic dermatitis, allergic rhinitis and asthma in Taiwan: a national study 2000 to 2007", Acta Derm Venereol, 90, pp.589~594 (2010)
- 지혜미, "2006년 초등학생의 알레르기 질환 유병률의 전국적 역학조사", Allergy Asthma & Respiratory Diseases, 19(2), pp.165~172 (2009), 대한 소아알레르기 호흡기학회
- Leung DY, "Atopic dermatitis: new insights and opportunities for therapeutic intervention", J Allergy Clin Immunol, 105, pp.860~876 (2000)
- Novak N, "New insights into the mechanism and management of allergic diseases: atopic dermatitis", Allergy, 64, pp.265~275 (2009)
- Arikawa J, "Decreased levels of sphingosine, a natural antimicrobial agent, may be associated with vulnerability of the stratum corneum from patients with atopic dermatitis to colonization by Staphylococcus aureus", J Invest Dermatol, 119, pp.433~439 (2002)
- Palmer CN, "Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis", Nat Genet, 38, pp.441~446 (2006)
- 한동기, "Food Sensitization in Infants and Young Children with Atopic Dermatitis", Yonsei Medical Journal, 45(5), pp.803~809 (2004), 연세대학교의과대학
- Park JH, "Characteristics of extrinsic vs. intrinsic atopic dermatitis in infancy: correlations with laboratory variables", Br J Dermatol, 155, pp.778~783 (2006)
- Benhamou AH, "Atopic dermatitis and food allergies", Rev Med Suisse, 3, pp.1038~1043 (2007)
- Burks AW, "Atopic dermatitis and food hypersensitivity reactions", J Pediatr, 132, pp.132~136 (1998)
- Finch J, "Atopic dermatitis and nutrition", Clin Dermatol, 28, pp.605~614 (2010)
- Sausenthaler S, "Early diet and the risk of allergy: what can we learn from the prospective birth cohort studies GINIplus and LISAplus?", Am J Clin Nutr, 94, pp.2012~2017 (2011)
- Zutavern A, "Timing of solid food introduction in relation to eczema, asthma, allergic rhinitis, and food and inhalant sensitization at the age of 6 years: results from the prospective birth cohort study LISA", Pediatrics, 121, pp.44~52 (2008)
- Omata N, "Increased oxidative stress in childhood atopic dermatitis", Life Sci, 69, pp.223~228 (2001)
- Devereux G, "Diet as a risk factor for atopy and asthma", J Allergy Clin Immunol, 115, pp.1109~1117 (2005)
- Ellwood P, "Diet and asthma, allergic rhinoconjunctivitis and atopic eczema symptom prevalence: an ecological analysis of the International Study of Asthma and Allergies in Childhood (ISAAC) data. ISAAC Phase One Study Group", Eur Respir J, 17, pp.436~443 (2001)
- Nurmatov U, "Nutrients and foods for the primary prevention of asthma and allergy: systematic review and meta-analysis", J Allergy Clin Immunol, 127, pp.724~733 (2011)
- Sausenthaler S, "Vitamin E intake in relation to allergic sensitization and IgE serum concentration", Cent Eur J Public Health, 17, pp.79~85 (2009)
- Tricon S, "Nutrition and allergic disease", Clin Exp Allergy Rev, 6, pp.117~188 (2006)
- Eigenmann PA, "Clinical features and diagnostic criteria of atopic dermatitis in relation to age", Pediatr Allergy Immunol, 12(Suppl 14), pp.69~74 (2001)
- Perry TT, "The relationship of allergen-specific IgE levels and oral food challenge outcome", J Allergy Clin Immunol, 114, pp.144~149 (2004)
- Sampson HA, "Utility of food-specific IgE concentrations in predicting symptomatic food allergy", J Allergy Clin Immunol, 107, pp.891~896 (2001)
- Anandan C, "Omega 3 and 6 oils for primary prevention of allergic disease: systematic review and meta-analysis", Allergy, 64, pp.840~848 (2009)
- Senapati S, "Evening primrose oil is effective in atopic dermatitis: a randomized placebo-controlled trial", Indian J Dermatol Venereol Leprol, 74, pp.447~452 (2008)
- Tsoureli-Nikita E, "Evaluation of dietary intake of vitamin E in the treatment of atopic dermatitis: a study of the clinical course and evaluation of the immunoglobulin E serum levels", Int J Dermatol, 41, pp.146~150 (2002)
- Javanbakht MH, "Randomized controlled trial using vitamins E and D supplementation in atopic dermatitis", J Dermatolog Treat, 22, pp.144~150 (2011)
- Hanifin JM, "Diagnostic features of atopic dermatitis", Acta Derm Venereol Suppl (Stockh), 59, pp.44~47 (1980)
- Devaney B, "Feeding infants and toddlers study: overview of the study design", J Am Diet Assoc, 104, pp.8~13 (2004)
- Fisher JO, "Overestimation of infant and toddler energy intake by 24-h recall compared with weighed food records", Am J Clin Nutr, 88, pp.407~415 (2008)
- Mediaty A, "Total and specific serum IgE decreases with age in patients with allergic rhinitis, asthma and insect allergy but not in patients with atopic dermatitis", Immun Ageing, 2, pp.9~ (2005)
- Wood RA, "Accuracy of IgE antibody laboratory results", Ann Allergy Asthma Immunol, 99, pp.34~41 (2007)
- Talegawkar SA, "Total alpha-tocopherol intakes are associated with serum alpha-tocopherol concentrations in African American adults", J Nutr, 137, pp.2297~2303 (2007)
- Okuda M, "Association of serum carotenoids and tocopherols with atopic diseases in Japanese children and adolescents", Pediatr Allergy Immunol, 21, pp.705~710 (2010)
- McKeever TM, "Serum nutrient markers and skin prick testing using data from the Third National Health and Nutrition Examination Survey", J Allergy Clin Immunol, 114, pp.1398~1402 (2004)
- Kamal-Eldin A, "The chemistry and antioxidant properties of tocopherols and tocotrienols", Lipids, 31, pp.671~701 (1996)
- Packer L, "Vitamin E is nature's master antioxidant", Sci Am Sci Med, 1, pp.54~63 (1994)
- Meydani SN, "Vitamin E and immune response in the aged: molecular mechanisms and clinical implications", Immunol Rev, 205, pp.269~284 (2005)
- Chan SC, "Altered prostaglandin E2 regulation of cytokine production in atopic dermatitis", J Immunol, 151, pp.3345~3352 (1993)
- Yamada K, "Effect of unsaturated fatty acids and antioxidants on immunoglobulin production by mesenteric lymph node lymphocytes of Sprague-Dawley rats", J Biochem, 120, pp.138~144 (1996)
- Fogarty A, "Dietary vitamin E, IgE concentrations, and atopy", Lancet, 356, pp.1573~1574 (2000)
- Patel S, "Dietary antioxidant intake, allergic sensitization and allergic diseases in young children", Allergy, 64, pp.1766~1772 (2009)
- Kompauer I, "Association of carotenoids, tocopherols and vitamin C in plasma with allergic rhinitis and allergic sensitisation in adults", Public Health Nutr, 9, pp.472~479 (2006)
- Oh SY, "Antioxidant nutrient intakes and corresponding biomarkers associated with the risk of atopic dermatitis in young children", EUROPEAN JOURNAL OF CLINICAL NUTRITION, 64(0), pp.245~252 (2010), NATURE PUBLISHING GROUP
- Solvoll K, "Dietary habits among patients with atopic dermatitis", Eur J Clin Nutr, 54, pp.93~97 (2000)
- Trak-Fellermeier MA, "Food and fatty acid intake and atopic disease in adults", Eur Respir J, 23, pp.575~582 (2004)
- Sampson HA, "The evaluation and management of food allergy in atopic dermatitis", Clin Dermatol, 21, pp.183~192 (2003)
- Imai T, "The national survey of immediate type of food allergy", Arerugi, 52, pp.1006~1013 (2003)