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비타민 D 농도와 아토피피부염 환아의 중증도와의 상관관계

Correlation between serum 25-hydroxyvitamin D levels and severity of atopic dermatitis in children

김성원|박종하|성명순|신영혜
대한 소아알레르기 호흡기학회 (The Korean Academy Of Pediatric Allergy And Respiratory Disease)|2014.05|Allergy Asthma & Respiratory Disease (알레르기 천식 호흡기질환)|제2권 제2호|pp. 114-121

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참고문헌

키워드

25-hydroxyvitamin DAtopic dermatitisSCORAD index
주제분류소아과학

초록

Purpose: Vitamin D deficiency has been suggested to play a role in the pathogenesis of atopic dermatitis. In addition, inverse correlationship between serum 25-hydroxyvitamin D concentration and severity of atopic dermatitis has been suggested. Methods: Clinical and laboratory parameters including serum 25-hydroxyvitamin D level and serum total IgE of 251 patients with atopic dermatitis who were 13 months to 18 years were measured. Severity of atopic dermatitis was assessed with SCORing Atopic Dermatitis (SCORAD) index. Statistical analysis was performed using Pearson correlation coefficient, one-way analysis of variance test and chi-square test. Results: Among 251 patients, vitamin D deficiency (25-hydroxyvitamin D<20 ng/mL, group 1) was present in 76 subjects (30.3%), vitamin D insufficiency (25-hydroxyvitamin D 20–29 ng/mL, group 2) was present in 101 (40.2%), and vitamin D sufficiency (25-hydroxyvitamin D≥30 ng/mL, group 3) was present in 74 (29.5%). There was a statistically significant inverse correlation between serum concentration of 25-hydroxyvitamin D and values of SCORAD index (R=–0.24, P<0.000). Serum concentration of 25-hydroxyvitamin D were inversely correlated with total IgE (R=–0.29, P<0.000), and age (R=–0.49, P<0.000). Conclusion: The results from this study indicate that serum concentration of 25-hydroxyvitamin D is inversely correlated with clinical severity of atopic dermatitis in children.

Abstract

Purpose: Vitamin D deficiency has been suggested to play a role in the pathogenesis of atopic dermatitis. In addition, inverse correlationship between serum 25-hydroxyvitamin D concentration and severity of atopic dermatitis has been suggested. Methods: Clinical and laboratory parameters including serum 25-hydroxyvitamin D level and serum total IgE of 251 patients with atopic dermatitis who were 13 months to 18 years were measured. Severity of atopic dermatitis was assessed with SCORing Atopic Dermatitis (SCORAD) index. Statistical analysis was performed using Pearson correlation coefficient, one-way analysis of variance test and chi-square test. Results: Among 251 patients, vitamin D deficiency (25-hydroxyvitamin D<20 ng/mL, group 1) was present in 76 subjects (30.3%), vitamin D insufficiency (25-hydroxyvitamin D 20–29 ng/mL, group 2) was present in 101 (40.2%), and vitamin D sufficiency (25-hydroxyvitamin D≥30 ng/mL, group 3) was present in 74 (29.5%). There was a statistically significant inverse correlation between serum concentration of 25-hydroxyvitamin D and values of SCORAD index (R=–0.24, P<0.000). Serum concentration of 25-hydroxyvitamin D were inversely correlated with total IgE (R=–0.29, P<0.000), and age (R=–0.49, P<0.000). Conclusion: The results from this study indicate that serum concentration of 25-hydroxyvitamin D is inversely correlated with clinical severity of atopic dermatitis in children.

참고문헌 (40)

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관련 논문AI추천

알레르겐 유무에 따른 아토피피부염 환아의 중증도와 혈중 25-hydroxyvitamin D3 농도와의 상관관계김성원, 성명순, 최광해, 최진욱, 황영진대한 소아알레르기 호흡기학회 · Allergy Asthma & Respiratory Disease2015 · 제3권 제3호아토피피부염 환아에서 interleukin-31 및 25-hydroxyvitamin D의 혈청 수치와 아토피피부염의 중증도와의 상관관계김덕수, 박문수, 심재원, 심정연, 양윤석, 이정원, 정혜림대한 소아알레르기 호흡기학회 · Allergy Asthma & Respiratory Disease2015 · 제3권 제6호2세 이하 아토피피부염 환아에서 비타민 D 부족과 식품항원 감작의 연관성백종욱, 이소연, 이혜란, 황보준원대한 소아알레르기 호흡기학회 · Allergy Asthma & Respiratory Disease2013 · 제1권 제3호Vitamin D Status and Its Association with the SCORAD Score and Serum LL-37 Level in Korean Adults and Children with Atopic Dermatitis공태석, 김민호, 손숙자, 이현경, 채정돈, 한태영대한피부과학회 · Annals of Dermatology2015 · 제27권 제1호소아 아토피피부염에서 비타민 D의 역할염혜영대한 소아알레르기 호흡기학회 · Allergy Asthma & Respiratory Disease2015 · 제3권 제2호비타민 D와 아토피피부염박양대한 소아알레르기 호흡기학회 · Allergy Asthma & Respiratory Disease2013 · 제1권 제3호

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