본문 바로가기
KERD
논문KCI 등재

Effects of perilla oil on plasma concentrations of cardioprotective (n-3) fatty acids and lipid profiles in mice

2

조회

0

다운로드

3

인용

0

참고문헌

키워드

초록

The aim of this study was to examine the effects of perilla oil as well as several vegetable oils, including flaxseed oil, canola oil, and rice bran oil on plasma levels of cardioprotective (n-3) polyunsaturated fatty acids in mice by feeding each vegetable oil for a period of eight weeks. Concentrations of docosapentaenoic acid (DHA) and eicosapentaenoic acid (EPA), fish-based (n-3) polyunsaturated fatty acids, showed an increase in the plasma of mice fed perilla and flaxseed oils compared to those of mice in the control group (P < 0.05), whereas rice bran and canola oils did not alter plasma DPA and EPA concentrations. Arachidonic acid concentration was increased by feeding rice bran oil (P < 0.05), but not canola,flaxseed, or perilla oil. In addition, oleic acid, linoleic acid, and docosahexaenoic acid concentrations were altered by feeding dietary rice bran,canola, perilla, and flaxseed oils. Findings of this study showed that perilla oil, similar to flaxseed oil, is cardioprotective and could be used as an alternative to fish oil or even flaxseed oil in animal models.

Abstract

The aim of this study was to examine the effects of perilla oil as well as several vegetable oils, including flaxseed oil, canola oil, and rice bran oil on plasma levels of cardioprotective (n-3) polyunsaturated fatty acids in mice by feeding each vegetable oil for a period of eight weeks. Concentrations of docosapentaenoic acid (DHA) and eicosapentaenoic acid (EPA), fish-based (n-3) polyunsaturated fatty acids, showed an increase in the plasma of mice fed perilla and flaxseed oils compared to those of mice in the control group (P < 0.05), whereas rice bran and canola oils did not alter plasma DPA and EPA concentrations. Arachidonic acid concentration was increased by feeding rice bran oil (P < 0.05), but not canola,flaxseed, or perilla oil. In addition, oleic acid, linoleic acid, and docosahexaenoic acid concentrations were altered by feeding dietary rice bran,canola, perilla, and flaxseed oils. Findings of this study showed that perilla oil, similar to flaxseed oil, is cardioprotective and could be used as an alternative to fish oil or even flaxseed oil in animal models.

참고문헌 (45)

  1. Groff JL, "Advanced Nutrition and Human Metabolism", pp.123~ (2000), Wadsworth
  2. Neuhouser ML, "(n-6) PUFA increase and dairy foods decrease prostate cancer risk in heavy smokers", J Nutr, 137, pp.1821~1827 (2007)
  3. Jenkins TC, "Regulation of lipid metabolism in the rumen", J Nutr, 124, pp.1372S~1376S (1994)
  4. Reddy BS, "Nutritional factors and colon cancer", Crit Rev Food Sci Nutr, 35, pp.175~190 (1995)
  5. Damsgaard CT, "Fish oil in combination with high or low intakes of linoleic acid lowers plasma triacylglycerols but does not affect other cardiovascular risk markers in healthy men", J Nutr, 138, pp.1061~1066 (2008)
  6. World Health Organization, "Prevention of Coronary Heart Disease: Report of a WHO Expert Committee" (1982), World Health Organization
  7. Singh RB, "Randomized, double-blind, placebo-controlled trial of fish oil and mustard oil in patients with suspected acute myocardial infarction: the Indian experiment of infarct survival--4", Cardiovasc Drugs Ther, 11, pp.485~491 (1997)
  8. Cataldo CB, "Nutrition & Diet Therapy: Principles and Practice" (1995), West Publishing Company
  9. Burr ML, "Effects of changes in fat, fish, and fibre intakes on death and myocardial reinfarction: diet and reinfarction trial (DART)", Lancet, 2, pp.757~761 (1989)
  10. de Lorgeril M, "Mediterranean diet, traditional risk factors, and the rate of cardiovascular complications after myocardial infarction: final report of the Lyon Diet Heart Study", Circulation, 99, pp.779~785 (1999)
  11. Harper CR, "Flaxseed oil increases the plasma concentrations of cardioprotective (n-3) fatty acids in humans", J Nutr, 136, pp.83~87 (2006)
  12. Damsgaard CT, "Fish oil affects blood pressure and the plasma lipid profile in healthy Danish infants", J Nutr, 136, pp.94~99 (2006)
  13. primrose oil on plasma and hepatic lipid level and atherosclerosis in Japanese quail, "Exp Anim", 1996, 55~62
  14. Rao S, "Characteristics of high alpha-linolenic acid accumulation in seed oils", Lipids, 43, pp.749~755 (2008)
  15. Bhathena SJ, "Dietary flaxseed meal is more protective than soy protein concentrate against hypertriglyceridemia and steatosis of the liver in an animal model of obesity", J Am Coll Nutr, 22, pp.157~164 (2003)
  16. Lee JJ, "Effects of dietary lipid sources and levels on lecithin: cholesterol acyltansferase activity and cholesterol metabolism in rats", Korean J Nutr, 26, pp.131~144 (1993)
  17. Zhang L, "High dietary n-6", n-3 PUFA ratio promotes HDL cholesterol level, but does not suppress atherogenesis in apolipoprotein E-null mice 1, 2009, pp.16, 463~471
  18. Kelley DS, "Docosahexaenoic acid supplementation improves fasting and postprandial lipid profiles in hypertriglyceridemic men", Am J Clin Nutr, 86, pp.324~333 (2007)
  19. Goodnight SH, "Polyunsaturated fatty acids, hyperlipidemia, and thrombosis", Arteriosclerosis, 2, pp.87~113 (1982)
  20. Nogi A, "Plasma n-3 polyunsaturated fatty acid and cardiovascular disease risk factors in Japanese, Korean and Mongolian workers", J Occup Health, 49, pp.205~216 (2007)
  21. Carr TP, "Stearateenriched plant sterol esters lower serum LDL cholesterol concentration in normo- and hypercholesterolemic adults", J Nutr, 139, pp.1445~1450 (2009)
  22. Khosla P, "Decreased receptor-mediated LDL catabolism in casein-fed rabbits precedes the increase in plasma cholesterol levels", J Nutr Biochem, 2, pp.203~209 (1991)
  23. Lovati MR, "Studies on the mechanism of the cholesterol lowing activity of soy proteins", Nutr Metab Cardiovasc Dis, 1, pp.18~24 (1999)
  24. Nilsen DW, "Effects of a high-dose concentrate of n-3 fatty acids or corn oil introduced early after an acute myocardial infarction on serum triacylglycerol and HDL cholesterol", Am J Clin Nutr, 74, pp.50~56 (2001)
  25. Micallef MA, "The lipid-lowering effects of phytosterols and (n-3) polyunsaturated fatty acids are synergistic and complementary in hyperlipidemic men and women", J Nutr, 138, pp.1086~1090 (2008)
  26. Francois CA, "Supplementing lactating women with flaxseed oil does not increase docosahexaenoic acid in their milk", Am J Clin Nutr, 77, pp.226~233 (2003)
  27. Kestin M, "n-3 fatty acids of marine origin lower systolic blood pressure and triglycerides but raise LDL cholesterol compared with n-3 and n-6 fatty acids from plants", Am J Clin Nutr, 51, pp.1028~1034 (1990)
  28. Sanders TA, "Triglyceridelowering effect of marine polyunsaturates in patients with hypertriglyceridemia", Arteriosclerosis, 5, pp.459~465 (1985)
  29. Phillipson BE, "Reduction of plasma lipids, lipoproteins, and apoproteins by dietary fish oils in patients with hypertrigly-ceridemia", N Engl J Med, 312, pp.1210~1216 (1985)
  30. Mozaffarian D, "Effect of fish oil on heart rate in humans: a meta-analysis of randomized controlled trials", Circulation, 112, pp.1945~1952 (2005)
  31. Li TY, "Regular consumption of nuts is associated with a lower risk of cardiovascular disease in women with type 2 diabetes", J Nutr, 139, pp.1333~1338 (2009)
  32. Kris-Etherton PM, "Polyunsaturated fatty acids in the food chain in the United States", Am J Clin Nutr, 71, pp.179S~188S (2000)
  33. Sanders TA, "The influence of different types of omega 3 polyunsaturated fatty acids on blood lipids and platelet function in healthy volunteers", Clin Sci (Lond), 64, pp.91~99 (1983)
  34. Allman MA, "Supplementation with flaxseed oil versus sunflowerseed oil in healthy young men consuming a low fat diet: effects on platelet composition and function", Eur J Clin Nutr, 49, pp.169~178 (1995)
  35. Singer P, "Slow desaturation and elongation of linoleic and alpha-linolenic acids as a rationale of eicosapentaenoic acid-rich diet to lower blood pressure and serum lipids in normal, hypertensive and hyperlipemic subjects", Prostaglandins Leukot Med, 24, pp.173~193 (1986)
  36. Mantzioris E, "Differences exist in the relationships between dietary linoleic and alphalinolenic acids and their respective long-chain metabolites", Am J Clin Nutr, 61, pp.320~324 (1995)
  37. linoleic acid and alpha-linolenic acid in response to marked changes in their dietary intake in men, "J Lipid Res", 2005, 269~280
  38. Bemelmans WJ, "Effect of an increased intake of alpha-linolenic acid and group nutritional education on cardiovascular risk factors: the Mediterranean Alphalinolenic Enriched Groningen Dietary Intervention (MARGARIN) study", Am J Clin Nutr, 75, pp.221~227 (2002)
  39. Chan JK, "Effect of dietary alpha-linolenic acid and its ratio to linoleic acid on platelet and plasma fatty acids and thrombogenesis", Lipids, 28, pp.811~817 (1993)
  40. Sanderson P, "UK Food standards agency alpha-linolenic acid workshop report", Br J Nutr, 88, pp.573~579 (2002)
  41. Lauritzen L, "The essentiality of long chain n-3 fatty acids in relation to development and function of the brain and retina", Prog Lipid Res, 40, pp.1~94 (2001)
  42. Hibbeln JR, "Healthy intakes of n-3 and n-6 fatty acids: estimations considering worldwide diversity", Am J Clin Nutr, 83, pp.1483S~1493S (2006)
  43. Sanders TA, "Studies of vegans: the fatty acid composition of plasma choline phosphoglycerides, erythrocytes, adipose tissue, and breast milk, and some indicators of susceptibility to ischemic heart disease in vegans and omnivore controls", Am J Clin Nutr, 31, pp.805~813 (1978)
  44. Zaloga GP, "(n-3) long-chain polyunsaturated fatty acids prolong survival following myocardial infarction in rats", J Nutr, 136, pp.1874~1878 (2006)
  45. Venkatachalam M, "Chemical composition of selected edible nut seeds", J Agric Food Chem, 54, pp.4705~4714 (2006)

관련 논문AI추천

Effect of vegetable oils with different fatty acid composition on high-fat diet-induced obesity and colon inflammationCha Youn-Soo, Kim Kyung-Ah, Shalom Sara Thomas한국영양학회 · Nutrition Research and Practice2020 · 제14권 제5호Dietary Oxidized Linoleic Acids Modulate Fatty Acids in MiceChinedu C. Ochin, Mahdi Garelnabi, Thomas Wilson한국지질동맥경화학회 · 지질·동맥경화학회지2022 · 제11권 제2호Effects of dietary fish oil and trans fat on rat aorta histopathology and cardiovascular risk markers박선혜, 박용순한국영양학회 · Nutrition Research and Practice2009 · 제3권 제2호Growth and Fatty Acid Composition of Juvenile Olive Flounder Paralichthys olivaceus Fed Diets Containing Different Levels and Ratios of Eicosapentaenoic Acid and Docosahexaenoic Acid최진, 김경덕, 이상민, Zahra Aminikhoei한국수산과학회 · Fisheries and Aquatic Sciences2014 · 제17권 제1호Effects of simultaneous supplementation of laying hens with α-linolenic acid and eicosapentaenoic acid/docosahexaenoic acid resources on egg quality and n-3 fatty acid profileChuanqiu Tang, Hui Huang, Pingping Zhang, Yong Sun, Zongqing Ding아세아·태평양축산학회 · Animal Bioscience2017 · 제30권 제7호Deficiency or activation of peroxisome proliferator-activated receptor ⍺ reduces the tissue concentrations of endogenously synthesized docosahexaenoic acid in C57BL/6J miceHai-Ping Wu, Hui-Min Su, Kuan-Pin Su, Pei-Min Chao, Ru-Huei Fu, Szu-Han Chen, Wen-Ting Hsiao, Yi-Ling You한국영양학회 · Nutrition Research and Practice2019 · 제13권 제4호

이 간행물의 다른 논문 (13건)